The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Gold, Poly(β-amino ester) Nanoparticles for Small Interfering RNA Delivery
Open accessAbstract
The safe and effective delivery of RNA therapeutics remains the major barrier to their broad clinical application. Here we develop a new nanoparticulate delivery system based on inorganic particles and biodegradable polycations. First, gold nanoparticles were modified with the hydrophilic polymer poly(ethylene glycol) (PEG), and then small interfering RNA (siRNA) was conjugated to the nanoparticles via biodegradable disulfide linkages, with approximately 30 strands of siRNA per nanoparticle. The particles were then coated with a library of end-modified poly(beta-amino ester)s (PBAEs), previously identified as capable of facilitating intracellular DNA delivery. Nanoparticulate formulations developed here facilitate high levels of in vitro siRNA delivery, facilitating delivery as good or better than the commercially available lipid reagent, Lipofectamine 2000.
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Daniel, M.-C., & Astruc, D. (2004) · Chemical Reviews · doi:10.1021/cr030698+ · Cited by 12,446
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology
Love, J. C., Estroff, L. A., Kriebel, J. K., Nuzzo, R. G., & Whitesides, G. M. (2005) · Chemical Reviews · doi:10.1021/cr0300789 · Cited by 8,282
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,683
Boussif, O., Lezoualc'h, F., Zanta, M. A., Mergny, M. D., Scherman, D., Demeneix, B., & Behr, J. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,247
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,680
Knocking down barriers: advances in siRNA delivery
Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115
Self-citationGold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity
Connor, E. E., Mwamuka, J., Gole, A., Murphy, C. J., & Wyatt, M. D. (2005) · Small · doi:10.1002/smll.200400093 · Cited by 2,406
Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation
Rosi, N. L., Giljohann, D. A., Thaxton, C. S., Lytton-Jean, A. K. R., Han, M. S., & Mirkin, C. A. (2006) · Science · doi:10.1126/science.1125559 · Cited by 1,988
Gene silencing in mammals by small interfering RNAs
McManus, M. T., & Sharp, P. A. (2002) · Nature Reviews Genetics · doi:10.1038/nrg908 · Cited by 1,399
Cited by
Biju, V. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60273g · Cited by 1,186
DNA Nanotechnology-Enabled Drug Delivery Systems
Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,118
A Review on the Synthesis and Functionalization of Gold Nanoparticles as a Drug Delivery Vehicle
Amina, S. J., & Guo, B. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s279094 · Cited by 561
A holistic approach to targeting disease with polymeric nanoparticles
Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480
Guo, S., Huang, Y., Jiang, Q., Sun, Y., Deng, L., Liang, Z., Du, Q., Xing, J., Zhao, Y., Wang, P. C., et al. (2010) · ACS Nano · doi:10.1021/nn101638u · Cited by 401
Metadata
- Authors
- Lee, J.-S., Green, J. J., Love, K. T., Sunshine, J., Langer, R., & Anderson, D. G.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-05-07
- Volume
- 9
- Issue
- 6
- Pages
- 2402-2406
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W1990377587
- Cited by
- 276
- References
- 47
- FWCI
- 11.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Lee, J.-S., Green, J. J., Love, K. T., Sunshine, J., Langer, R., & Anderson, D. G. (2009). Gold, Poly(β-amino ester) Nanoparticles for Small Interfering RNA Delivery. Nano Letters. https://doi.org/10.1021/nl9009793
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
