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Highly Sensitive Multiplexed Heavy Metal Detection Using Quantum-Dot-Labeled DNAzymes

Wu, Chung-Shieh, Khaing Oo, Maung Kyaw, Fan, Xudong·2010·ACS Nano
DOI 10.1021/nn1021988
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Abstract

We developed highly sensitive and specific nanosensors based on quantum dots (QDs) and DNAzyme for multiplexed detection of heavy metal ions in liquid. The QDs were coated with a thin silica layer for increased stability and higher quantum yield while maintaining a relatively small size for highly efficient energy transfer. The QD-DNAzyme nanosensors were constructed by conjugating quencher-labeled DNAzymes onto the surface of carboxyl-silanized QDs. In the presence of metal ions, the emission is restored due to the cleavage of DNAzymes. The detection could be completed within 25 min with a single laser excitation source. The detection limit of 0.2 and 0.5 nM was experimentally achieved for Pb(2+) and Cu(2+), respectively, which is a 50- and 70-fold improvement over the recent results obtained with dye molecules. Multiplexed detection was also demonstrated using two different colors of QDs, showing negligible cross-talk between the Pb(2+) detection and Cu(2+) detection.

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Metadata

Authors
Wu, C.-S., Khaing Oo, M. K., & Fan, X.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2010-10-06
Volume
4
Issue
10
Pages
5897-5904
ISSN
  • 1936-0851 (ISSN-L)
  • 1936-086X
DOI
10.1021/nn1021988
OpenAlex
W2317472117
Cited by
223
References
0
FWCI
5.91
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Highly Sensitive Multiplexed Heavy Metal Detection Using Quantum-Dot-Labeled DNAzymes. https://app.cochat.ai/papers/10.1021/nn1021988
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Wu, C.-S., Khaing Oo, M. K., & Fan, X. (2010). Highly Sensitive Multiplexed Heavy Metal Detection Using Quantum-Dot-Labeled DNAzymes. ACS Nano. https://doi.org/10.1021/nn1021988

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