The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy
Open accessAbstract
Hydrophobically modified maghemite (γ-Fe(2)O(3)) nanoparticles were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(l-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formation method gives simple access to highly magnetic nanoparticles (MNPs) (loaded up to 70 wt %) together with good control over the vesicles size (100-400 nm). The simultaneous loading of maghemite nanoparticles and doxorubicin was also achieved by nanoprecipitation. The deformation of the vesicle membrane under an applied magnetic field has been evidenced by small angle neutron scattering. These superparamagnetic hybrid self-assemblies display enhanced contrast properties that open potential applications for magnetic resonance imaging. They can also be guided in a magnetic field gradient. The feasibility of controlled drug release by radio frequency magnetic hyperthermia was demonstrated in the case of encapsulated doxorubicin molecules, showing the viability of the concept of magneto-chemotherapy. These magnetic polymersomes can be used as efficient multifunctional nanocarriers for combined therapy and imaging.
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Metadata
- Authors
- Sanson, C., Diou, O., Thévenot, J., Ibarboure, E., Soum, A., Brûlet, A., Miraux, S., Thiaudière, E., Tan, S., Brisson, A., Dupuis, V., Sandre, O., & Lecommandoux, S.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-01-10
- Volume
- 5
- Issue
- 2
- Pages
- 1122-1140
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2057255825
- Cited by
- 489
- References
- 101
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- green
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
