The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles
Abstract
In the last few decades, nanoparticles (NPs) have been recognized as promising candidates for starting a new revolution in science and technology due to their unusual properties, attracting the attention of physicists, chemists, biologists, and engineers. The aim of this study is to evaluate the toxicities (at both cellular and molecular levels) of three forms of superparamagnetic iron oxide nanoparticles (SPIONs) of various surface chemistries (COOH, plain, and NH(2)) through the comparison with gene expression patterns of three cell types (i.e., human heart, brain, and kidney). For this purpose, both an MTT assay and a DNA microarray analysis were applied in three human cell lines--HCM (heart), BE-2-C (brain), and 293T (kidney)--under the exposure to SPIONs-COOH, SPIONs-NH(2), and bare SPIONs. The specific gene alteration and hierarchical clustering revealed that SPIONs-COOH altered genes associated with cell proliferative responses due to their reactive oxygen species (ROS) properties. It was also found that the cell type can have quite a significant role in the definition of suitable pathways for detoxification of NPs, which has deep implications for the safe and high yield design of NPs for biomedical applications and will require serious consideration in the future.
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Cites
In vitro toxicity of nanoparticles in BRL 3A rat liver cells
Hussain, S. M., Hess, K. L., Gearhart, J. M., Geiss, K. T., & Schlager, J. J. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.06.034 · Cited by 2,025
Mahmoudi, M., Sant, S., Wang, B., Laurent, S., & Sen, T. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.006 · Cited by 1,881
Self-citationKarlsson, H. L., Cronholm, P., Gustafsson, J., & Möller, L. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800064j · Cited by 1,480
Brunner, T. J., Wick, P., Manser, P., Spohn, P., Grass, R. N., Limbach, L. K., Bruinink, A., & Stark, W. J. (2006) · Environmental Science & Technology · doi:10.1021/es052069i · Cited by 1,385
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
Laurent, S., Dutz, S., Häfeli, U. O., & Mahmoudi, M. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.04.003 · Cited by 1,326
Self-citationControl of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,204
Nagata, S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4834 · Cited by 905
Effects of nanomaterial physicochemical properties on in vivo toxicity
Aillon, K. L., Xie, Y., El-Gendy, N., Berkland, C. J., & Forrest, M. L. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.010 · Cited by 811
Gupta, A. K., Naregalkar, R. R., Vaidya, V. D., & Gupta, M. (2007) · Nanomedicine · doi:10.2217/17435889.2.1.23 · Cited by 708
Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications
Cheng, F.-Y., Su, C.-H., Yang, Y.-S., Yeh, C.-S., Tsai, C.-Y., Wu, C.-L., Wu, M.-T., & Shieh, D.-B. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.03.016 · Cited by 668
Cited by
Sharifi, S., Behzadi, S., Laurent, S., Laird Forrest, M., Stroeve, P., & Mahmoudi, M. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15188f · Cited by 1,460
Self-citationSuperparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers
Wahajuddin, & Arora (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s30320 · Cited by 1,117
Applications and potential toxicity of magnetic iron oxide nanoparticles
Liu, G., Gao, J., Ai, H., & Chen, X. (2013) · Small · doi:10.1002/smll.201201531 · Cited by 570
Kus-Liśkiewicz, M., Fickers, P., & Ben Tahar, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010952 · Cited by 404
Environmental transformations and ecological effects of iron-based nanoparticles
Lei, C., Sun, Y., Tsang, D. C. W., & Lin, D. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.09.052 · Cited by 347
Metadata
- Authors
- Mahmoudi, M., Laurent, S., Shokrgozar, M. A., & Hosseinkhani, M.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2011-08-22
- Volume
- 5
- Issue
- 9
- Pages
- 7263-7276
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2001071466
- Cited by
- 349
- References
- 48
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mahmoudi, M., Laurent, S., Shokrgozar, M. A., & Hosseinkhani, M. (2011). Toxicity Evaluations of Superparamagnetic Iron Oxide Nanoparticles: Cell “Vision” versus Physicochemical Properties of Nanoparticles. ACS Nano. https://doi.org/10.1021/nn2021088
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