The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting
Open accessAbstract
A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 (MMP2) in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs. The system represents a surface-functionalized liposomal nanocarrier, for which two functional polyethylene glycol (PEG)-lipid conjugates were synthesized and characterized. The functionalized liposome was further modified with the tumor cell-specific antinucleosome monoclonal antibody (mAb 2C5). In the resulting system, several drug delivery strategies were combined in the same nanocarrier in a simple way and coordinated in an optimal fashion. The functions of the nanocarrier include (i) the hydrophilic and flexible long PEG chains to prevent nanocarrier nonspecific interactions and prolong its circulation time; (ii) a nanoscale size of the system that allows for its passive tumor targeting via the enhanced permeability and retention (EPR) effect; (iii) a mAb 2C5 to allow for the specific targeting of tumor cells; (iv) a matrix metalloprotease 2-sensitive bond between PEG and lipid that undergoes cleavage in the tumor by the highly expressed extracellular MMP2 for the removal of PEG chains; (v) cell-penetrating peptide (TATp) triggering of the enhanced intracellular delivery of the system after long-chain PEG removal and exposure of the previously hidden surface-attached TATp. It is shown that such a design can enhance the targetability and internalization of nanocarriers in cancer cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Self-citationRGD AND OTHER RECOGNITION SEQUENCES FOR INTEGRINS
Ruoslahti, E. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.697 · Cited by 3,191
Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)81016-h · Cited by 2,027
Self-citationVascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.
Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,711
Self-citationTORCHILIN, V (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.009 · Cited by 1,273
Self-citationLocoregional cancer treatment with magnetic drug targeting.
Alexiou, C., Arnold, W. J., Klein, R. J., Parak, F., Hulin, P., Bergemann, C., Erhardt, W. D., Wagenpfeil, S., & Lübbe, A. S. (2000) · PubMed · Cited by 863
Torchilin, V. P., Rammohan, R., Weissig, V., & Levchenko, T. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151247498 · Cited by 777
Self-citationTargeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 762
Self-citationNeedham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746
Mishra, S., Webster, P., & Davis, M. E. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00363 · Cited by 730
“SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical Nanocarriers
Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., & Torchilin, V. P. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060080h · Cited by 540
Self-citationKlibanov, A. L., Maruyama, K., Beckerleg, A. M., Torchilin, V. P., & Huang, L. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90385-l · Cited by 480
Self-citationGabizon, A., Horowitz, A. T., Goren, D., Tzemach, D., Mandelbaum-Shavit, F., Qazen, M. M., & Zalipsky, S. (1999) · Bioconjugate Chemistry · doi:10.1021/bc9801124 · Cited by 468
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos-Sternberg, B., & D'Souza, G. G. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0435906100 · Cited by 419
Self-citationAnti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.
Friden, P. M., Walus, L. R., Musso, G. F., Taylor, M. A., Malfroy, B., & Starzyk, R. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4771 · Cited by 402
Ultrasound triggered release of cisplatin from liposomes in murine tumors
Schroeder, A., Honen, R., Turjeman, K., Gabizon, A., Kost, J., & Barenholz, Y. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.007 · Cited by 305
Lukyanov, A. N., Elbayoumi, T. A., Chakilam, A. R., & Torchilin, V. P. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.007 · Cited by 294
Self-citationAwasthi, V., Garcia, D., Goins, B., & Phillips, W. T. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00703-2 · Cited by 215
Terada, T., Iwai, M., Kawakami, S., Yamashita, F., & Hashida, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.023 · Cited by 197
Mansour, A. M., Drevs, J., Esser, N., Hamada, F. M. A., Badary, O. A., Unger, C., Fichtner, I., & Kratz, F. (2003) · PubMed · Cited by 197
Basel, M. T., Shrestha, T. B., Troyer, D. L., & Bossmann, S. H. (2011) · ACS Nano · doi:10.1021/nn103362n · Cited by 141
ElBayoumi, T. A., & Torchilin, V. P. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.05.113 · Cited by 106
Self-citationSynthesis and Characterization of Poly(ethylene glycol)−Insulin Conjugates
Hinds, K. D., Koh, J. J., Joss, L., Liu, F., Baudyš, M., & Kim, S. W. (2000) · Bioconjugate Chemistry · doi:10.1021/bc9901189 · Cited by 103
Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes
Zhu, L., Huo, Z., Wang, L., Tong, X., Xiao, Y. Z., & Ni, K. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.12.003 · Cited by 102
Self-citationTargeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation
Zhu, L., & Mahato, R. I. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100346n · Cited by 91
Self-citationIakoubov, L. Z., & Torchilin, V. P. (1997) · PubMed · Cited by 83
Self-citationWan, Y., Angleson, J. K., & Kutateladze, A. G. (2002) · Journal of the American Chemical Society · doi:10.1021/ja016874i · Cited by 63
Cited by
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Danhier, F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.015 · Cited by 1,288
Current Trends in The Use of Liposomes for Tumor Targeting
Deshpande, P. P., Biswas, S., & Torchilin, V. P. (2013) · Nanomedicine · doi:10.2217/nnm.13.118 · Cited by 657
Self-citationMoradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514
Metadata
- Authors
- Zhu, L., Kate, P., & Torchilin, V. P.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-03-14
- Volume
- 6
- Issue
- 4
- Pages
- 3491-3498
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2038449477
- Cited by
- 489
- References
- 28
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
