The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
Open accessAbstract
Liposomes modified with TAT peptide (TATp-liposomes) showed fast and efficient translocation into the cell cytoplasm with subsequent migration into the perinuclear zone. TATp-liposomes containing a small quantity (≤10 mol %) of a cationic lipid formed firm noncovalent complexes with DNA. Here, we present results demonstrating both in vitro and in vivo transfection with TATp-liposome–DNA complexes. Mouse NIH/3T3 fibroblasts and rat H9C2 cardiomyocytes were transfected with such complexes in vitro . The transfection with the TATp-liposome-associated pEGFP-N1 plasmid encoding for the green fluorescent protein (GFP) was high, whereas the cytotoxicity was lower than that of commonly used cationic lipid-based gene-delivery systems. Intratumoral injection of TATp-liposome–DNA complexes into the Lewis lung carcinoma tumor of mice also resulted in an expression of GFP in tumor cells. This transfection system should be useful for various protocols of cell treatment in vitro or ex vivo as well as for localized in vivo gene therapy.
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Mechanism of oligonucleotide release from cationic liposomes.
Zelphati, O., & Szoka, F. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11493 · Cited by 634
Oxygen Radical-Mediated Pulmonary Toxicity Induced by Some Cationic Liposomes
Dokka, S., Toledo, D., Shi, X., Castranova, V., & Rojanasakul, Y. (2000) · Pharmaceutical Research · doi:10.1023/a:1007504613351 · Cited by 349
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Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029
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Metadata
- Authors
- Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos-Sternberg, B., & D'Souza, G. G. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-02-05
- Volume
- 100
- Issue
- 4
- Pages
- 1972-1977
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2160902183
- Cited by
- 419
- References
- 2
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Torchilin, V. P., Levchenko, T. S., Rammohan, R., Volodina, N., Papahadjopoulos-Sternberg, B., & D'Souza, G. G. M. (2003). Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0435906100
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