The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Three-Dimensional Hierarchical Plasmonic Nano-Architecture Enhanced Surface-Enhanced Raman Scattering Immunosensor for Cancer Biomarker Detection in Blood Plasma
Open accessAbstract
A three-dimensional (3D) hierarchical plasmonic nano-architecture has been designed for a sensitive surface-enhanced Raman scattering (SERS) immunosensor for protein biomarker detection. The capture antibody molecules are immobilized on a plasmonic gold triangle nanoarray pattern. On the other hand, the detection antibody molecules are linked to the gold nanostar@Raman reporter@silica sandwich nanoparticles. When protein biomarkers are present, the sandwich nanoparticles are captured over the gold triangle nanoarray, forming a confined 3D plasmonic field, leading to the enhanced electromagnetic field in intensity and in 3D space. As a result, the Raman reporter molecules are exposed to a high density of "hot spots", which amplifies the Raman signal remarkably, improving the sensitivity of the SERS immunosensor. This SERS immunosensor exhibits a wide linear range (0.1 pg/mL to 10 ng/mL) and a low limit of detection (7 fg/mL) toward human immunoglobulin G protein in the buffer solution. This biosensor has been successfully used for detection of the vascular endothelial growth factor in the human blood plasma from clinical breast cancer patient samples.
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Cited by
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Metadata
- Authors
- Li, M., Cushing, S. K., Zhang, J., Suri, S., Evans, R., Petros, W. P., Gibson, L. F., Ma, D., Liu, Y., & Wu, N.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-05-14
- Volume
- 7
- Issue
- 6
- Pages
- 4967-4976
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2039211723
- Cited by
- 275
- References
- 35
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- green
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