Bimodal Tumor-Targeting from Microenvironment Responsive Hyaluronan Layer-by-Layer (LbL) Nanoparticles
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Active targeting of nanoscale drug carriers can improve tumor-specific delivery; however, cellular heterogeneity both within and among tumor sites is a fundamental barrier to their success. Here, we describe a tumor microenvironment-responsive layer-by-layer (LbL) polymer drug carrier that actively targets tumors based on two independent mechanisms: pH-dependent cellular uptake at hypoxic tumor pH and hyaluronan-directed targeting of cell-surface CD44 receptor, a well-characterized biomarker for breast and ovarian cancer stem cells. Hypoxic pH-induced structural reorganization of hyaluronan-LbL nanoparticles was a direct result of the nature of the LbL electrostatic complex, and led to targeted cellular delivery in vitro and in vivo, with effective tumor penetration and uptake. The nanoscale drug carriers selectively bound CD44 and diminished cancer cell migration in vitro, while co-localizing with the CD44 receptor in vivo. Multimodal targeting of LbL nanoparticles is a powerful strategy for tumor-specific cancer diagnostics and therapy that can be accomplished using a single bilayer of polyamine and hyaluronan that, when assembled, produce a dynamic and responsive cell–particle interface.
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Low oxygen and pH levels induce hyaluronic acid LbL nanoparticles to effectively target and penetrate hypoxic cells in vitro and in vivo.
“Low oxygen and pH levels induce hyaluronic acid LbL nanoparticles to effectively target and penetrate hypoxic cells in vitro and in vivo.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [188]
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- Authors
- Dreaden, E. C., Morton, S. W., Shopsowitz, K. E., Choi, J.-H., Deng, Z. J., Cho, N.-J., & Hammond, P. T.
- Affiliations
- Nanyang Technological University (SG)
- Corresponding author
- Hammond, Paula T.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-08-06
- Volume
- 8
- Issue
- 8
- Pages
- 8374-8382
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- PMC
- PMC4148172
- OpenAlex
- W2047101821
- Cited by
- 179
- References
- 60
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 6 · 2023: 12 · 2022: 18 · 2021: 14 · 2020: 26 · 2019: 16 · 2018: 15 · 2017: 11 · 2016: 21 · 2015: 22
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- ACS Nano (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- National Science Foundation (NA)
- National Institutes of Health (1F32EB017614-02)
- National Cancer Institute (P30-CA14051)
- Division of Materials Research (DMR-0819762)
- Janssen Research and Development (NA)
- Natural Sciences and Engineering Research Council of Canada (NA)
- National Health and Medical Research Council (NA)
- National Research Foundation-Prime Minister's office, Republic of Singapore (NRF-NRFF2011-01)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- layer-by-layer nanoparticles, hyaluronic acid, CD44 receptor, tumor microenvironment, pH-responsive drug delivery, tumor hypoxia, active tumor targeting, cancer stem cells, breast cancer, ovarian cancer, polyamines, tumor cell migration, tumor penetration
- MeSH terms
- Animals, Biological Transport, Cell Transformation, Neoplastic, Drug Carriers, Hyaluronic Acid, Hydrogen-Ion Concentration, Polylysine, Cell Hypoxia, Hyaluronan Receptors, Cell Line, Tumor, Mice, Nanoparticles, Tumor Microenvironment
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