The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
NMR Study of the Solution Structure of Curcumin
Abstract
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is derived from the rhizomes of Curcuma longa. Although early studies concluded that curcumin exists predominantly as a keto-enol tautomer, 1b, in several recent articles the solution structure of curcumin has been represented as a beta-diketone tautomer, 1a. We have investigated the structure of curcumin in solvents ranging in polarity from CDCl3 to mixtures of DMSO-d6 in water, and in buffered aqueous DMSO-d6 solutions with pH values varying from 3 to 9. The solution structure of curcumin was determined on the basis of NMR techniques, including DEPT, HMQC, HMBC, and COSY. The results of the NMR studies show definitely that curcumin exists in solution as keto-enol tautomers, 1b.
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Cites
Antioxidant activity of curcumin and related compounds
Sharma, O. P. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90421-4 · Cited by 851
Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent
Srimal, R. C., & Dhawan, B. N. (1973) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1973.tb09131.x · Cited by 674
H-Atom Transfer Is A Preferred Antioxidant Mechanism of Curcumin
Jovanovic, S. V., Steenken, S., Boone, C. W., & Simic, M. G. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991446m · Cited by 452
Molecular Orbital Basis for Yellow Curry Spice Curcumin's Prevention of Alzheimer's Disease
Balasubramanian, K. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0603533 · Cited by 188
Some Perspectives on Dietary Inhibition of Carcinogenesis: Studies with Curcumin and Tea
Conney, A. H., Lou, Y. R., Xie, J. G., Osawa, T., Newmark, H. L., Liu, Y., Chang, R. L., & Huang, M. (1997) · Experimental Biology and Medicine · doi:10.3181/00379727-216-44173 · Cited by 126
Interplay between MRP Inhibition and Metabolism of MRP Inhibitors: The Case of Curcumin
Wortelboer, H. M., Usta, M., van der Velde, A. E., Boersma, M. G., Spenkelink, B., van Zanden, J. J., Rietjens, I. M. C. M., van BLADEREN, P. J., & Cnubben, N. H. P. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034101x · Cited by 118
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The Essential Medicinal Chemistry of Curcumin
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00975 · Cited by 1,956
Curcumin—From Molecule to Biological Function
Esatbeyoglu, T., Huebbe, P., Ernst, I. M. A., Chin, D., Wagner, A. E., & Rimbach, G. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107724 · Cited by 904
Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects
Kotha, R. R., & Luthria, D. L. (2019) · Molecules · doi:10.3390/molecules24162930 · Cited by 890
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
Basnet, P., & Skalko-Basnet, N. (2011) · Molecules · doi:10.3390/molecules16064567 · Cited by 733
The effect of curcumin (turmeric) on Alzheimer’s disease: An overview
Mishra, S., & Palanivelu, K. (2008) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.40220 · Cited by 599
Metadata
- Authors
- Payton, F., Sandusky, P., & Alworth, W. L.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-01-19
- Volume
- 70
- Issue
- 2
- Pages
- 143-146
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2020374958
- Cited by
- 381
- References
- 6
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
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