The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tea Polyphenol (−)-Epigallocatechin-3-Gallate: A New Trapping Agent of Reactive Dicarbonyl Species
Open accessAbstract
Previous studies have demonstrated that reactive dicarbonyl compounds [e.g., methylglyoxal (MGO) and glyoxal (GO)] irreversibly and progressively modify proteins over time and yield advanced glycation end products (AGEs), which are thought to contribute to the development of diabetes mellitus and its subsequent complications. Thus, decreasing the levels of MGO and GO will be an effective approach to reduce the formation of AGEs and the development of diabetic complications. In our studies to find nontoxic trapping agents of reactive dicarbonyl species from dietary sources, we found that (-)-epigallocatechin-3-gallate (EGCG), the major bioactive green tea polyphenol, could efficiently trap reactive dicarbonyl compounds (MGO or GO) to form mono- and di-MGO or GO adducts under physiological conditions (pH 7.4, 37 degrees C). The products formed from EGCG and MGO (or GO), combined at different ratios, were analyzed using LC/MS. We also developed a method to purify the two major mono-MGO adducts of EGCG without derivatization, and their structures were identified as stereoisomers of mono-MGO adducts of EGCG based on their 1D and 2D NMR spectra. Our LC/MS and NMR data showed that positions 6 and 8 of the EGCG A-ring were the major active sites for trapping reactive dicarbonyl compounds. We also found that EGCG lost its trapping efficacy under acidic conditions (pH
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Cites
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
Baynes, J. W., & Thorpe, S. R. (1999) · Diabetes · doi:10.2337/diabetes.48.1.1 · Cited by 2,441
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854
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Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action
Vauzour, D., Rodriguez-Mateos, A., Corona, G., Oruna-Concha, M. J., & Spencer, J. P. E. (2010) · Nutrients · doi:10.3390/nu2111106 · Cited by 855
Polyphenolic Chemistry of Tea and Coffee: A Century of Progress
Wang, Y., & Ho, C.-T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf804025c · Cited by 388
Self-citationPolyphenols with antiglycation activity and mechanisms of action: A review of recent findings
Yeh, W.-J., Hsia, S.-M., Lee, W.-H., & Wu, C.-H. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.10.017 · Cited by 353
Antioxidant-rich natural fruit and vegetable products and human health
Jideani, A. I. O., Silungwe, H., Takalani, T., Omolola, A. O., Udeh, H. O., & Anyasi, T. A. (2021) · International Journal of Food Properties · doi:10.1080/10942912.2020.1866597 · Cited by 298
Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal
Li, X., Zheng, T., Sang, S., & Lv, L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf504132x · Cited by 288
Self-citationCuletu, A., Fernandez-Gomez, B., Ullate, M., del Castillo, M. D., & Andlauer, W. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.097 · Cited by 51
Sampath, C., Zhu, Y., Sang, S., & Ahmedna, M. (2016) · Phytomedicine · doi:10.1016/j.phymed.2015.12.013 · Cited by 48
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Metadata
- Authors
- Sang, S., Shao, X., Bai, N., Lo, C.-Y., Yang, C. S., & Ho, C.-T.
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-11-15
- Volume
- 20
- Issue
- 12
- Pages
- 1862-1870
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2007324558
- Cited by
- 212
- References
- 3
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- green
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