β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer’s Disease
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVOpen ForumNEXTβ-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's DiseaseD. Allan ButterfieldView Author Information Department of Chemistry, Center of Membrane Sciences, and Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40506-0055 Cite this: Chem. Res. Toxicol. 1997, 10, 5, 495–506Publication Date (Web):May 19, 1997Publication History Received30 July 1996Published online19 May 1997Published inissue 1 May 1997https://pubs.acs.org/doi/10.1021/tx960130ehttps://doi.org/10.1021/tx960130ediscussionACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1136Altmetric-Citations283LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electron paramagnetic resonance spectroscopy,Free radicals,Membranes,Peptides and proteins,Toxicology Get e-Alerts
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Overproduction of reactive oxygen species and a decrease in antioxidant defenses can lead to oxidative stress.
“Thus, the overproduction of ROS and a decrease in antioxidant defenses can lead to oxidative stress (OS) [17].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [17]
Oxidative damage is an early event in the pathogenesis of Alzheimer's disease, occurring before the onset of clinical symptoms, and is also a factor contributing to disease progression.
“Past and recent studies have demonstrated that oxidative damage is not only an early event in the pathogenesis of AD, occurring before the onset of clinical symptoms but also a factor contributing to the disease progression [17,18,19,20,21].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [17]
Cites
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
Bhunia, C. T. (1997) · IETE Journal of Education · doi:10.1080/09747338.1997.11415666 · Cited by 2,720 · see citing works
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377 · see citing works
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
Burdick, D., Soreghan, B., Kwon, M., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C., & Glabe, C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48529-8 · Cited by 1,014 · see citing works
Amyloid β-Protein and the Genetics of Alzheimer's Disease
Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works
Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · see citing works
Self-citationAlzheimer's Disease: A Central Role for Amyloid
Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works
Mattson, M. P., Lovell, M. A., Furukawa, K., & Markesbery, W. R. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041740.x · Cited by 615 · see citing works
Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
Volterra, A., Trotti, D., Tromba, C., FLORIDI, S., & Racagni, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02924.1994 · Cited by 457 · see citing works
Goodman, Y., & Mattson, M. P. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1107 · Cited by 449 · see citing works
Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin
Tomiyama, T., Shoji, A., Kataoka, K.-I., Suwa, Y., Asano, S., Kaneko, H., & Endo, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6839 · Cited by 295 · see citing works
Estévez, Á. G., Radí, R., Barbeito, L., Shin, J. T., Thompson, J. A., & Beckman, J. S. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041543.x · Cited by 287 · see citing works
Alzheimer's disease: Advances in clinical and basic research
Absher, J. R. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90166-x · Cited by 152 · see citing works
Janzen, E. G., Krygsman, P. H., Lindsay, D. A., et al. (1990) · Journal of the American Chemical Society · doi:10.1021/ja00179a010 · Cited by 119 · see citing works
Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach
Kennedy, J. F., & Knill, C. J. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(01)00197-7 · Cited by 113 · see citing works
Harris‐White, M. E., Carney, J. M., Cole, P. S., Hensley, K., Howard, B. J., Martin, L., Bummer, P. M., Wang, Y., Pedigo, N. W., & Butterfield, D. A. (1995) · Neuroreport · doi:10.1097/00001756-199510020-00013 · Cited by 112 · see citing works
Self-citationOxygen Radicals and the Disease Process
Thomas, C. E., & Kalyanaraman, B. (1998) · Cited by 107 · see citing works
Mason, R. P., Estermyer, J. D., Kelly, J. F., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0699 · Cited by 105 · see citing works
Induction of Superoxide Anion and Nitric Oxide Production in Cultured Microgliaa
Colton, C. A., Snell, J. C., Chernyshev, O. N., & Gilbert, D. L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21789.x · Cited by 93 · see citing works
Lockhart, B. P., Bénicourt, C., Junien, J., & Privat, A. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390416 · Cited by 92 · see citing works
Howard, B. J., Yatin, S. M., Hensley, K., Allen, K. L., Kelly, J. P., Carney, J. M., & Butterfield, D. A. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052045.x · Cited by 74 · see citing works
Self-citationAksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Hensley, K., Vigo‐Pelfrey, C., & Carney, J. M. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66052050.x · Cited by 59 · see citing works
Self-citationSmith‐Swintosky, V. L., Zimmer, S. G., Fenton, J. W., & Mattson, M. P. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031415.x · Cited by 58 · see citing works
Faller, B., & Nick, H. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00088a022 · Cited by 52 · see citing works
Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase
Aksenov, M. Y., Aksenova, M. V., Harris‐White, M. E., Hensley, K., Butterfield, D. A., & Carney, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041899.x · Cited by 40 · see citing works
Self-citationInhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells
Puttfarcken, P. S., Manelli, A. M., Neilly, J. P., et al. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0048 · Cited by 40 · see citing works
Aksenova, M. V., Aksenov, M. Y., Butterfield, D. A., & Carney, J. M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12717-8 · Cited by 39 · see citing works
Self-citationBhardwaj, A., Lee, J., Glauner, K., et al. (1996) · Journal of Membrane Science · doi:10.1016/0376-7388(96)00124-x · Cited by 37 · see citing works
Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins
Bellary, S. (1995) · Life Sciences · doi:10.1016/0024-3205(94)00418-r · Cited by 34 · see citing works
Hall, N. C., Carney, J. M., Plante, O. J., et al. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00430-7 · Cited by 33 · see citing works
Kumar, U., Dunlop, D. M., & Richardson, J. S. (1994) · International Journal of Neuroscience · doi:10.3109/00207459408986079 · Cited by 30 · see citing works
Umhauer, S., Isbell, D. T., & Butterfield, D. A. (1992) · Analytical Letters · doi:10.1080/00032719208016122 · Cited by 27 · see citing works
Self-citationAksenov, M. Y., Aksenova, M. V., Jm, C., & Butterfield, D. A. (1996) · PubMed · Cited by 21 · see citing works
Self-citationAksenov, M. Y., Aksenova, M. V., Carney, J. M., & Butterfield, D. A. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13082-2 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works
Self-citationAllan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
Varadarajan, S., Yatin, S., Aksenova, M., & Butterfield, D. A. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4274 · Cited by 735 · see citing works
Self-citationOxidative stress hypothesis in Alzheimer’s disease: a reappraisal
Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606 · see citing works
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564 · see citing works
Self-citationButterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Self-citationChapter 7 Protein Oxidation Processes in Aging Brain
Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390 · see citing works
Self-citationSubramaniam, R., Roediger, F., Jordan, B., Mattson, M. P., Keller, J. N., Waeg, G., & Butterfield, D. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031161.x · Cited by 270 · see citing works
Self-citationDi Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253 · see citing works
Self-citationBuccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
Ji, Z.-S., Miranda, R. D., Newhouse, Y. M., Weisgraber, K. H., Huang, Y., & Mahley, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112109200 · Cited by 177 · see citing works
Butterfield, D. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.006 · Cited by 126 · see citing works
Self-citationOxidative modification of lipoic acid by HNE in Alzheimer disease brain
Hardas, S. S., Sultana, R., Clark, A. M., Beckett, T. L., Szweda, L. I., Murphy, M. P., & Butterfield, D. A. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.002 · Cited by 120 · see citing works
Self-citationRedox proteomics and amyloid β-peptide: Insights into Alzheimer disease
Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105 · see citing works
Self-citationKowalik-Jankowska, T., Ruta, M., Wiśniewska, K., Łankiewicz, L., & Dyba, M. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.03.001 · Cited by 92 · see citing works
Sultana, R., Newman, S. F., Abdul, H. M., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20876 · Cited by 53 · see citing works
Self-citationFormation of a protein-bound pyrazinium free radical cation during glycation of histone H1
Wondrak, G. T., Varadarajan, S., Butterfield, D. A., & Jacobson, M. K. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00406-8 · Cited by 16 · see citing works
Self-citationProtective effect of ecdysterone on PC12 cells cytotoxicity induced by Beta-amyloid25–35
Su-fen, Y., Zhong-jun, W., Zheng-qin, Y., Qin, W., Qi-hai, G., Qi-xin, Z., & Jing-shan, S. (2005) · Chinese Journal of Integrative Medicine · doi:10.1007/bf02835792 · Cited by 10 · see citing works
- Authors
- Butterfield, D. A.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Butterfield, D. Allan
- Venue
- Chemical Research in Toxicology
- Publisher
- American Chemical Society (ACS)
- Published
- 1997-05-01
- Volume
- 10
- Issue
- 5
- Pages
- 495-506
- ISSN
- 0893-228X (ISSN-L)
- 1520-5010
- OpenAlex
- W2019871046
- Cited by
- 364
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 12 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 14 · 2012: 13
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Research in Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG010836, P01AG005119, AG 10836, AG0 5119)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta, free radicals, oxidative stress, neurotoxicity, Alzheimer's disease, amyloid fibrils, lipid peroxidation, membrane damage, protein oxidation
- MeSH terms
- Alzheimer Disease, Animals, Humans, Amyloid beta-Peptides, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review