Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Caspases: Enemies Within

Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

Apoptosis in the nervous system

Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works

Apolipoprotein E: Far More Than a Lipid Transport Protein

Mahley, R. W., & Rall, S. C. (2000) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.1.1.507 · Cited by 1,836 · see citing works

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731 · see citing works

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

Goldstein, J. L., Basu, S. K., & Brown, M. S. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)98152-1 · Cited by 1,623 · see citing works

Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction

Berridge, M. V., & Tan, A. S. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1311 · Cited by 1,443 · see citing works

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

Pike, C., Burdick, D., Walencewicz, A., Glabe, C., & Cotman, C. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01676.1993 · Cited by 1,417 · see citing works

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works

Molten Globule and Protein Folding

Ptitsyn, O. B. (1995) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60546-x · Cited by 1,222 · see citing works

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Huang, X., Atwood, C., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J. T., Moir, R. D., et al. (1999) · Biochemistry · doi:10.1021/bi990438f · Cited by 1,107 · see citing works

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,022 · see citing works

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works

The structural basis of protein folding and its links with human disease

Dobson, C. M. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0758 · Cited by 927 · see citing works

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907 · see citing works

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Miyata, M., & Smith, J. D. (1996) · Nature Genetics · doi:10.1038/ng0996-55 · Cited by 889 · see citing works

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871 · see citing works

Apolipoprotein E: Structure-Function Relationships

Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830 · see citing works

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795 · see citing works

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

Lomakin, A., Chung, D. S., Benedek, G. B., Kirschner, D. A., & Teplow, D. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1125 · Cited by 784 · see citing works

Alzheimer's Disease: A Central Role for Amyloid

Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works

Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

Varadarajan, S., Yatin, S., Aksenova, M., & Butterfield, D. A. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4274 · Cited by 735 · see citing works

Lysosomal Protease Pathways to Apoptosis

Stoka, V., Turk, B., Schendel, S. L., Kim, T., Cirman, T., Snipas, S. J., Ellerby, L., Bredesen, D. E., Freeze, H. H., Abrahamson, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008944200 · Cited by 673 · see citing works

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

Paresce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80187-7 · Cited by 663 · see citing works

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

Blacker, D., Wilcox, M., Laird, N. M., Rodes, L., Horvath, S. M., Go, R. C. P., Perry, R. T., Watson, B., Bassett, S. S., McInnis, M. G., et al. (1998) · Nature Genetics · doi:10.1038/1243 · Cited by 642 · see citing works

Cathepsin B Acts as a Dominant Execution Protease in Tumor Cell Apoptosis Induced by Tumor Necrosis Factor

Foghsgaard, L., Wissing, D., Mauch, D., Lademann, U. A., Bastholm, L., Boes, M. L., Elling, F., Leist, M., & Jäättelä, M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.999 · Cited by 629 · see citing works

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569 · see citing works

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

Krajewski, S., Krajewska, M., Ellerby, L., Welsh, K., Xie, Z., Deveraux, Q. L., Salvesen, G. S., Bredesen, D. E., Rosenthal, R. E., Fiskum, G. M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5752 · Cited by 542 · see citing works

Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

Saunders, A. M., Roses, A. D., Pericak‐Vance, M. A., Dole, K. C., Strittmatter, W. J., Schmechel, D. E., Szymanski, M. H., McCown, N., Manwaring, M., Schmader, K. E., et al. (1993) · The Lancet · doi:10.1016/0140-6736(93)91709-u · Cited by 498 · see citing works

Apolipoprotein E is essential for amyloid deposition in the <i>APP</i> ^V717F transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15233 · Cited by 486 · see citing works

β-Amyloid Induces Neuronal Apoptosis Via a Mechanism that Involves the c-Jun N-Terminal Kinase Pathway and the Induction of Fas Ligand

MORISHIMA, Y., Gotoh, Y., Zieg, J., Barrett, T., Takano, H., Flavell, R. A., Davis, R. J., Shirasaki, Y., & Greenberg, M. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07551.2001 · Cited by 484 · see citing works

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441 · see citing works

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404 · see citing works

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

Huang, Y., Liu, X. Q., Wyss-Coray, T., Brecht, W. J., Sanan, D. A., & Mahley, R. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151254698 · Cited by 392 · see citing works

Sphingosine-induced apoptosis is dependent on lysosomal proteases

Kågedal, K., Ming, Z. H. A. O., Svensson, I., & Brunk, U. T. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590335 · Cited by 379 · see citing works

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer’s Disease

Butterfield, D. A. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960130e · Cited by 364 · see citing works

Isoform-specific effects of human apolipoprotein E on brain function revealed in <i>ApoE</i> knockout mice: Increased susceptibility of females

Raber, J., Wong, D., Buttini, M., Orth, M., Bellosta, S., Pitas, R. E., Mahley, R. W., & Mucke, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10914 · Cited by 364 · see citing works

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Kang, D. E., Pietrzik, C. U., Baum, L., Chevallier, N., Merriam, D. E., Kounnas, M. Z., Wagner, S. L., Troncoso, J. C., Kawas, C. H., Katzman, R., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11013 · Cited by 354 · see citing works

Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

Troy, C. M., Rabacchi, S. A., Friedman, W., Frappier, T. F., Brown, K. R., & Shelanski, M. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01386.2000 · Cited by 354 · see citing works

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease

Cataldo, A., Hamilton, D. J., Barnett, J. L., Paskevich, P. A., & Nixon, R. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00186.1996 · Cited by 350 · see citing works

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., & Schwartz, A. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9480 · Cited by 349 · see citing works

Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., & Agard, D. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31797-0 · Cited by 320 · see citing works

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

Slooter, A. J. C. (1997) · JAMA · doi:10.1001/jama.277.10.818 · Cited by 317 · see citing works

Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain

Morrow, J. A., Segall, M. L., Lund-Katz, S., Phillips, M. C., Knapp, M., Rupp, B., & Weisgraber, K. H. (2000) · Biochemistry · doi:10.1021/bi000099m · Cited by 315 · see citing works

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

Bellosta, S., Nathan, B. P., Orth, M., Dong, L.-M., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27063 · Cited by 313 · see citing works

Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients

Shimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works

Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer's Disease

LeBlanc, A. C., Liu, H., Goodyer, C. G., Bergeron, C., & Hammond, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23426 · Cited by 279 · see citing works

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

Nathan, B. P., Chang, K.-C., Bellosta, S., Brisch, E., Ge, N., Mahley, R. W., & Pitas, R. E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19791 · Cited by 276 · see citing works

Sphingosine-induced apoptosis is dependent on lysosomal proteases

Kågedal, K., Ming, Z. H. A. O., Svensson, I., et al. (2001) · Biochemical Journal · doi:10.1042/bj3590335 · Cited by 273 · see citing works

Fibrillogenesis in Alzheimer's disease of amyloid <i>β</i> peptides and apolipoprotein E

Castano, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, R. A., Soto, C., & Frangione, B. (1995) · Biochemical Journal · doi:10.1042/bj3060599 · Cited by 267 · see citing works

α2‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

Narita, M., Holtzman, D. M., Schwartz, A. L., & Bu, G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69051904.x · Cited by 259 · see citing works

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

Estus, S., Tucker, H. M., van Rooyen, C., Wright, S., Brigham, E. F., Wogulis, M. D., & Rydel, R. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07736.1997 · Cited by 255 · see citing works

Caspase-9

Kuida, K. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00024-2 · Cited by 250 · see citing works

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

Ji, Z. S., Brecht, W. J., Miranda, R. D., Hussain, M. M., Innerarity, T. L., & Mahley, R. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82186-x · Cited by 240 · see citing works

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer’s disease is related to the apolipoprotein E genotype

Ramassamy, C., Averill‐Bates, D. A., Beffert, U., Bastianetto, S., Théroux, L., Lussier‐Cacan, S., Cohn, J. S., Christen, Y., Davignon, J., Quirion, R., et al. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00102-1 · Cited by 240 · see citing works

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.

Fagan, A. M., Bu, G., Sun, Y., Daugherty, A., & Holtzman, D. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.30121 · Cited by 226 · see citing works

Lysosomal release of Cathepsin D precedes relocation of Cytochrome C and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress

Roberg, K. B., Johansson, U., & Öllinger, K. M. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00146-x · Cited by 226 · see citing works

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

Troy, C. M., Rabacchi, S. A., Xu, Z., Maroney, A. C., Connors, T. J., Shelanski, M. L., & Greene, L. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00218.x · Cited by 223 · see citing works

Review: Modulating Factors in Amyloid-β Fibril Formation

McLaurin, J., Yang, D.-S., Yip, C. M., & Fraser, P. E. (2000) · Journal of Structural Biology · doi:10.1006/jsbi.2000.4289 · Cited by 217 · see citing works

α 2 -macroglobulin associates with β-amyloid peptide and prevents fibril formation

Hughes, S. R., Khorkova, O., Goyal, S., Knäblein, J., Heroux, J. A., Riedel, N. G., & Sahasrabudhe, S. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3275 · Cited by 212 · see citing works

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

Hussain, M. M., Maxfield, F. R., Mas‐Oliva, J., Tabas, I. A., Ji, Z. S., Innerarity, T. L., & Mahley, R. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92792-4 · Cited by 211 · see citing works

Aggregation State and Neurotoxic Properties of Alzheimer Beta-Amyloid Peptide

Howlett, D. R., JENNINGS, K. H., Lee, D. C., Clark, M. S. G., Brown, F., Wetzel, R. B., Wood, S. J., Camilleri, P., & Roberts, G. W. (1995) · Neurodegeneration · doi:10.1006/neur.1995.0003 · Cited by 204 · see citing works

Overexpression and Accumulation of Apolipoprotein E as a Cause of Hypertriglyceridemia

Huang, Y., Liu, X. Q., Rall, S. C., Taylor, J. M., von Eckardstein, A., Assmann, G., & Mahley, R. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26388 · Cited by 204 · see citing works

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

Jordán, J., Galindo, M. F., Miller, R. J., Reardon, C. A., Getz, G. S., & LaDu, M. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00195.1998 · Cited by 178 · see citing works

Caspases, Apoptosis, and Alzheimer Disease: Causation, Correlation, and Confusion

Roth, K. A. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.9.829 · Cited by 175 · see citing works

β-Amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells

Li, Y., Bushnell, A. F., Lee, C., Perlmutter, L. S., & Wong, S. K.-F. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00733-0 · Cited by 150 · see citing works

Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases

Isahara, K., Ohsawa, Y., Kanamori, S., Shibata, M., Waguri, S., Sato, N., Gotow, T., Watanabe, T., Momoi, T., Urase, K., et al. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00566-1 · Cited by 149 · see citing works

A Novel Action of Alzheimer's Amyloid β-Protein (Aβ): Oligomeric Aβ Promotes Lipid Release

Michikawa, M., Gong, J., Fan, Q.-W., Sawamura, N., & Yanagisawa, K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07226.2001 · Cited by 144 · see citing works

Phase transition release, a new approach to the interaction of proteins with lipid vesicles Application to lipoproteins

Weinstein, J. N., Klausner, R. D., Innerarity, T. L., Ralston, E., & Blumenthal, R. P. (1981) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(81)90255-8 · Cited by 142 · see citing works

alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.

Du, Y., Ni, B., Glinn, M. A., Dodel, R. C., Bales, K. R., Zhang, Z., Hyslop, P. A., & Paul, S. M. (1997) · PubMed · Cited by 132 · see citing works

Bilirubin and Amyloid-β Peptide Induce Cytochrome c Release Through Mitochondrial Membrane Permeabilization

Rodrigues, C. M. P., Solá, S., Silva, R. F. M., & Brites, D. M. T. O. (2000) · Molecular Medicine · doi:10.1007/bf03401828 · Cited by 131 · see citing works

α2‐Macroglobulin Enhances the Clearance of Endogenous Soluble β‐Amyloid Peptide via Low‐Density Lipoprotein Receptor‐Related Protein in Cortical Neuron

Qiu, Z. J., Strickland, D. K., Hyman, B. T., & Rebeck, G. W. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731393.x · Cited by 131 · see citing works

A Mechanism for the Neuroprotective Effect of Apolipoprotein E

Pedersen, W. A., Chan, S. L., & Mattson, M. P. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741426.x · Cited by 130 · see citing works

Activation of Neuronal Caspase-3 by Intracellular Accumulation of Wild-Type Alzheimer Amyloid Precursor Protein

Uetsuki, T., Takemoto, K., Nishimura, I., Okamoto, M., Niinobe, M., Momoi, T., Miura, M., & Yoshikawa, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06955.1999 · Cited by 129 · see citing works

Amyloid β Peptide–Induced Cerebral Endothelial Cell Death Involves Mitochondrial Dysfunction and Caspase Activation

Xu, J., Chen, S., Ku, G., Ahmed, S. H., Xu, J., Chen, H., & Hsu, C. Y. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200106000-00008 · Cited by 127 · see citing works

Tubular lysosomes accompany stimulated pinocytosis in macrophages.

Swanson, J. A., Burke, E., & Silverstein, S. C. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.104.5.1217 · Cited by 126 · see citing works

The Nonfibrillar Amyloid β‐Peptide Induces Apoptotic Neuronal Cell Death

Pillot, T., Drouet, B., Queillé, S., Labeur, C., Vandekerckhove, J. S., Rosseneu, M., Pinçon‐Raymond, M., & Chambaz, J. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731626.x · Cited by 120 · see citing works

α2‐Macroglobulin as a β‐Amyloid Peptide‐Binding Plasma Protein

Du, Y., Ni, B., Glinn, M. A., Dodel, R. C., Bales, K. R., Zhang, Z., Hyslop, P. A., & Paul, S. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010299.x · Cited by 114 · see citing works

Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.

LaFerla, F. M., Hall, C. K., Ngo, L. T., & Jay, G. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118957 · Cited by 112 · see citing works

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, Aβ1–42, in differentiated PC12 cells

Burdick, D., Kosmoski, J. V., Knauer, M. F., & Glabe, C. G. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01262-0 · Cited by 112 · see citing works

Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner

Yang, D.-S., Small, D. H., Seydel, U., Smith, J. D., Hallmayer, J. F., Gandy, S., & Martins, R. N. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00561-2 · Cited by 108 · see citing works

Amyloid β protein-induced neuronal cell death: neurotoxic properties of aggregated amyloid β protein

Ueda, K., Fukui, Y., & Kageyama, H. (1994) · Brain Research · doi:10.1016/0006-8993(94)91736-1 · Cited by 104 · see citing works

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

Buttini, M., Akeefe, H., Lin, C. J., Mahley, R. W., Pitas, R. E., Wyss‐Coray, T., & Mucke, L. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00069-5 · Cited by 98 · see citing works

Amyloid β‐Protein, APOE Genotype and Head Injury

Nicoll, J. A. R., Roberts, G. W., & Graham, D. I. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb34431.x · Cited by 96 · see citing works

Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid

友也, 田., 定也, 美., & 貴史, 伊. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003508200 · Cited by 95 · see citing works

Relocalization of Cathepsin D and Cytochrome c Early in Apoptosis Revealed by Immunoelectron Microscopy

Roberg, K. B. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780222 · Cited by 91 · see citing works

The Serpin-Enzyme Complex Receptor Recognizes Soluble, Nontoxic Amyloid-β Peptide but Not Aggregated, Cytotoxic Amyloid-β Peptide

Boland, K., Behrens, M. I., Choi, D. W., Manias, K., & Perlmutter, D. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18032 · Cited by 89 · see citing works

β‐Amyloid Peptide Interacts Specifically with the Carboxyl‐Terminal Domain of Human Apolipoprotein E

Pillot, T., Goethals, M., Najib, J., Labeur, C., Lins, L., Chambaz, J., Brasseur, R., Vandekerckhove, J. S., & Rosseneu, M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720230.x · Cited by 84 · see citing works

Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids

Jolivalt, C. G., Leininger‐Muller, B., Bertrand, P., Herber, R., Christen, Y., & Siest, G. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00232-4 · Cited by 76 · see citing works

Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain

Carter, D. B., Dunn, E., McKinley, D. D., Stratman, N. C., Boyle, T. P., Kuiper, S. L., Oostveen, J. A., Weaver, R. J., Boller, J. A., & Gurney, M. E. (2001) · Annals of Neurology · doi:10.1002/ana.1134 · Cited by 68 · see citing works

ApoE protects cortical neurones against neurotoxicity induced by the non‐fibrillar C‐terminal domain of the amyloid‐β peptide

Drouet, B., Fifre, A., Pinçon‐Raymond, M., Vandekerckhove, J. S., Rosseneu, M., Guéant, J., Chambaz, J., & Pillot, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00047.x · Cited by 56 · see citing works

LRP in Alzheimer’s disease: friend or foe?

Ulery, P. G., & Strickland, D. K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11455 · Cited by 41 · see citing works

Apolipoprotein E polymorphism in Pick’s disease and in Huntington’s disease

Kalman, J. L., Juhász, A., Majtényi, K., Rimanóczy, Á., Jakab, K. T., Gárdián, G., Raskó, I., & Janka, Z. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00150-0 · Cited by 39 · see citing works

Specific Modulation of the Fusogenic Properties of the Alzheimer β‐Amyloid Peptide by Apolipoprotein E Isoforms

Pillot, T., Goethals, M., Vanloo, B., Lins, L., Brasseur, R., Vandekerckhove, J. S., & Rosseneu, M. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00650.x · Cited by 35 · see citing works

Functions of the LDL Receptor Gene Family

Herz, J., & Willnow, T. E. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44298.x · Cited by 34 · see citing works

Contribution of Cysteine 158, the Glycosylation Site Theonine 194, the Amino- and Carboxy-Terminal Domains of Apolipoprotein E in the Binding to Amyloid Peptide β (1−40)

Aleshkov, S. B., Li, X., Lavrentiadou, S. N., & Zannis, V. I. (1999) · Biochemistry · doi:10.1021/bi982002q · Cited by 27 · see citing works

Resistance to the apoptotic effect of aggregated amyloid-β peptide in several different cell types including neuronal- and hepatoma-derived cell lines

Mazziotti, M. V., & Perlmutter, D. H. (1998) · Biochemical Journal · doi:10.1042/bj3320517 · Cited by 25 · see citing works

No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo

Lendon, C. L., Han, B. H., Salimi, K., Fagan, A. M., Behrens, M. I., Muller, M. C., & Holtzman, D. M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00113.x · Cited by 23 · see citing works

The interaction of apolipoprotein A-I with small unilamellar vesicles of L-alpha-dipalmitoylphosphatidylcholine.

Klausner, R. D., Blumenthal, R. P., Innerarity, T. L., & Weinstein, J. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38785-9 · Cited by 18 · see citing works

Association of human, rat, and rabbit apolipoprotein E with β‐amyloid

LaDu, M. J., Lukens, J. R., Reardon, C. A., & Getz, G. S. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970701)49:1

Untitled work

(1998) · doi:10.1002/(sici)1097-4547(19980615)52:6

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Alzheimer Mechanisms and Therapeutic Strategies

Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works

Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability

Dahlgren, K. N., Manelli, A. M., Stine, W. B., Baker, L. K., Krafft, G. A., & LaDu, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201750200 · Cited by 1,452 · see citing works

Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600549103 · Cited by 912 · see citing works

Autophagy failure in Alzheimer's disease—locating the primary defect

Nixon, R. A., & Yang, D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.021 · Cited by 634 · see citing works

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580 · see citing works

Apolipoprotein E structure: insights into function

Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583 · see citing works

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

Colacurcio, D. J., & Nixon, R. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.004 · Cited by 548 · see citing works

Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus

Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., & Huang, Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5476-05.2006 · Cited by 524 · see citing works

Diversity in the Mechanisms of Neuronal Cell Death

Yuan, J., Lipinski, M. M., & Degterev, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00601-9 · Cited by 467 · see citing works

Regulation of apoptosis-associated lysosomal membrane permeabilization

Johansson, A., Appelqvist, H., Nilsson, C., Kågedal, K., Roberg, K. B., & Öllinger, K. M. (2010) · APOPTOSIS · doi:10.1007/s10495-009-0452-5 · Cited by 463 · see citing works

Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease

Nixon, R. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700359 · Cited by 400 · see citing works

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

Brecht, W. J., Harris, F. M., Chang, S., Tesseur, I., Yu, G.-Q., Xu, Q., Dee Fish, J., Wyss-Coray, T., Buttini, M., Mucke, L., et al. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4315-03.2004 · Cited by 403 · see citing works

Neurodegenerative lysosomal disorders: A continuum from development to late age

Nixon, R. A., Yang, D.-S., & Lee, J.-H. (2008) · Autophagy · doi:10.4161/auto.6259 · Cited by 362 · see citing works

Apolipoprotein E: From lipid transport to neurobiology

Hauser, P. S., Narayanaswami, V., & Ryan, R. O. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.09.001 · Cited by 320 · see citing works

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

Chang, S., Ma, T. R., Miranda, R. D., Balestra, M. E., Mahley, R. W., & Huang, Y. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508254102 · Cited by 319 · see citing works

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

Pasternak, S., Bagshaw, R. D., Guiral, M., Zhang, S., Ackerley, C. A., Pak, B. J., Callahan, J. W., & Mahuran, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304009200 · Cited by 314 · see citing works

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298 · see citing works

Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes

Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Umeda, T., Tomiyama, T., Sakama, N., Tanaka, S., Lambert, M. P., Klein, W. L., & Mori, H. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22640 · Cited by 264 · see citing works

Apolipoprotein E: Diversity of Cellular Origins, Structural and Biophysical Properties, and Effects in Alzheimer's Disease

Huang, Y., Weisgraber, K. H., Mucke, L., & Mahley, R. W. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:3:189 · Cited by 242 · see citing works

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Abondio, P., Sazzini, M., Garagnani, P., Boattini, A., Monti, D., Franceschi, C., Luiselli, D., & Giuliani, C. (2019) · Genes · doi:10.3390/genes10030222 · Cited by 226 · see citing works

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

Van Acker, Z. P., Bretou, M., & Annaert, W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0323-7 · Cited by 222 · see citing works

Lysosomal cell death mechanisms in aging

Gómez-Sintes, R., Ledesma, M. D., & Boya, P. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.009 · Cited by 216 · see citing works

Cell type‐specific roles of APOE4 in Alzheimer disease

Blumenfeld, J., Yip, O., Kim, M. J., & Huang, Y. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00776-9 · Cited by 202 · see citing works

Apolipoprotein E4 Forms a Molten Globule

Morrow, J. A., Hatters, D. M., Lu, B., Höchtl, P., Oberg, K. A., Rupp, B., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204898200 · Cited by 204 · see citing works

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works

Impact of APOE in mild cognitive impairment

Farlow, M. R., He, Y., Tekin, S., Xu, J., Lane, R. M., & Charles, H. C. (2004) · Neurology · doi:10.1212/01.wnl.0000144279.21502.b7 · Cited by 199 · see citing works

APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review

Emrani, S., Arain, H. A., DeMarshall, C. A., & Nuriel, T. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00712-4 · Cited by 192 · see citing works

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006361 · Cited by 190 · see citing works

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation

Buttini, M., Yu, G.-Q., Shockley, K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, F. M., & Mucke, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10539.2002 · Cited by 183 · see citing works

Autophagy and Neuronal Cell Death in Neurological DisordersPreprint

Nixon, R. A., & Yang, D.-S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008839 · Cited by 179 · see citing works

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

HOOK, V. Y. H., Yoon, M. C., Mosier, C., Ito, G., Podvin, S., Head, B. P., Rissman, R. A., O’Donoghue, A. J., & Hook, G. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140428 · Cited by 174 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

Chen, H.-K., Liu, Z., Meyer-Franke, A., Brodbeck, J., Miranda, R. D., McGuire, J. G., Pleiss, M. A., Ji, Z.-S., Balestra, M. E., Walker, D. W., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276162 · Cited by 163 · see citing works

The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system

Hawkes, C. A., & Kar, S. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.11.002 · Cited by 159 · see citing works

Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure

Zhong, N., & Weisgraber, K. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800009200 · Cited by 159 · see citing works

Neuronal macroautophagy: from development to degeneration.

Boland, B., & Nixon, R. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.009 · Cited by 181 · see citing works

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase

Harris, F. M., Brecht, W. J., Xu, Q., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408127200 · Cited by 151 · see citing works

The endosomal-lysosomal pathway is dysregulated by APOE4 expression in vivo

Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., et al. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00702 · Cited by 140 · see citing works

Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells

Harris, F. M., Tesseur, I., Brecht, W. J., Xu, Q., Mullendorff, K., Chang, S., Wyss-Coray, T., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309475200 · Cited by 135 · see citing works

Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature

Lathe, R., Tsitrina, A. A., & Kotelevtsev, Y. V. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-36 · Cited by 136 · see citing works

System X_c⁻and Apolipoprotein E Expressed by Microglia Have Opposite Effects on the Neurotoxicity of Amyloid-β Peptide 1–40

Qin, S., Colin, C., Hinners, I., Gervais, A., Cheret, C., & Mallat, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5186-05.2006 · Cited by 135 · see citing works

Alzheimer's Mechanisms in Ischemic Brain Degeneration

Pluta, R. M., Ułamek, M., & Jabłoński, M. (2009) · The Anatomical Record · doi:10.1002/ar.21018 · Cited by 132 · see citing works

Activation of Multiple Pathways during Photoreceptor Apoptosis in the rd Mouse

Doonan, F., Donovan, M., & Cotter, T. G. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0248 · Cited by 133 · see citing works

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology: Miniperspective

Mahley, R. W., & Huang, Y. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm3008618 · Cited by 132 · see citing works

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

Nishitsuji, K., Tomiyama, T., Ishibashi, K., Ito, K., Teraoka, R., Lambert, M. P., Klein, W. L., & Mori, H. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080480 · Cited by 127 · see citing works

Reactivity of Apolipoprotein E4 and Amyloid β Peptide

Ji, Z.-S., Müllendorff, K., Cheng, I. H., Miranda, R. D., Huang, Y., & Mahley, R. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506646200 · Cited by 127 · see citing works

The bile acid TUDCA and neurodegenerative disorders: An overview

Zangerolamo, L., Vettorazzi, J. F., Rosa, L. R. D. O., Carneiro, E. M., & Barbosa, H. C. L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119252 · Cited by 127 · see citing works

Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS

Xu, Q., Walker, D., Bernardo, A., Brodbeck, J., Balestra, M. E., & Huang, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3253-07.2008 · Cited by 122 · see citing works

Genetic architecture of Alzheimer's disease

Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works

The role of the endosomal/ lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: Reexamining the spatial paradox from a lysosomal perspective

Pasternak, S., Callahan, J. W., & Mahuran, D. J. (2003) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6107 · Cited by 122 · see citing works

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

Fuentealba, R. A., Liu, Q., Zhang, J., Kanekiyo, T., Hu, X., Lee, J.-M., LaDu, M. J., & Bu, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011884 · Cited by 116 · see citing works

Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils

Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105 · see citing works

Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review

Yamashima, T. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.02.004 · Cited by 107 · see citing works

Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

Belinson, H., Lev, D., Masliah, E., & Michaelson, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5633-07.2008 · Cited by 101 · see citing works

Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes

Pluta, R. M., Jabłoński, M., Ułamek-Kozioł, M., Kocki, J., Brzozowska, J., Januszewski, S., Furmaga-Jabłońska, W., Bogucka‐Kocka, A., Maciejewski, R., & Czuczwar, S. J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8439-1 · Cited by 99 · see citing works

Apolipoprotein E4 Impairs Macrophage Efferocytosis and Potentiates Apoptosis by Accelerating Endoplasmic Reticulum Stress

Cash, J. G., Kuhel, D. G., Basford, J. E., Jaeschke, A., Chatterjee, T. K., Weintraub, N. L., & Hui, D. Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377549 · Cited by 97 · see citing works

Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer’s disease brain

Smith, J. L., Xiong, S., Markesbery, W. R., & Lovell, M. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.049 · Cited by 94 · see citing works

Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice

Levi, O., & Michaelson, D. M. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04189.x · Cited by 94 · see citing works

Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease

Sjödin, S., Brinkmalm, G., Öhrfelt, A., Parnetti, L., Paciotti, S., Hansson, O., Hardy, J., Blennow, K., Zetterberg, H., & Brinkmalm, A. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0533-9 · Cited by 91 · see citing works

Amyloid‐beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation

Hu, W. T., Gray, N. W., & Brimijoin, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01855.x · Cited by 86 · see citing works

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

Peng, W., Minakaki, G., Nguyen, M., & Krainc, D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00742-3 · Cited by 79 · see citing works

Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology

Mahley, R. W., & Huang, Y. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00679.x · Cited by 82 · see citing works

Apolipoprotein E4 Domain Interaction Occurs in Living Neuronal Cells as Determined by Fluorescence Resonance Energy Transfer

Xu, Q., Brecht, W. J., Weisgraber, K. H., Mahley, R. W., & Huang, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311256200 · Cited by 80 · see citing works

Cholesterol

Raffaı̈, R. L., & Weisgraber, K. H. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300007-jlr200 · Cited by 76 · see citing works

Infection and Alzheimer's Disease: The APOE ε4 Connection and Lipid Metabolism

Urosevic, N., & Martins, R. N. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13407 · Cited by 68 · see citing works

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Keeling, E., Lotery, A. J., Tumbarello, D. A., & Ratnayaka, J. A. (2018) · Cells · doi:10.3390/cells7020016 · Cited by 68 · see citing works

The generation and function of soluble apoE receptors in the CNS

Rebeck, G. W., LaDu, M. J., Estus, S., Bu, G., & Weeber, E. J. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-15 · Cited by 66 · see citing works

Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: Bridging Niemann–Pick disease type C and Alzheimer's disease

Koh, C. H. V., & Cheung, N. S. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.04.006 · Cited by 67 · see citing works

Amyloid and Alzheimer's Disease: Inside and Out

Tam, J. H. K., & Pasternak, S. (2012) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100013408 · Cited by 64 · see citing works

Apolipoprotein E and central nervous system disorders: Reviews of clinical findings

Takeda, M., Martínez, R., Kudo, T., Tanaka, T., Okochi, M., Tagami, S., Morihara, T., Hashimoto, R., & Cacabelos, R. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02148.x · Cited by 65 · see citing works

Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease

Kim, S., Cho, Y.-S., Kim, Y., Park, J., Yoo, S., Gwak, J., Kim, Y., Gwon, Y., Kam, T., & Jung, Y. (2023) · Autophagy · doi:10.1080/15548627.2023.2181614 · Cited by 65 · see citing works

Membrane Localization of β-Amyloid 1–42 in Lysosomes

Liu, R., Zhou, Q., Ji, S., Zhou, Q., Feng, D., Wu, Y., & Sui, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036798 · Cited by 64 · see citing works

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease

Theendakara, V., Peters-Libeu, C. A., Bredesen, D. E., & Rao, R. V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0757-2 · Cited by 63 · see citing works

Protective Role of Endogenous Gangliosides for Lysosomal Pathology in a Cellular Model of Synucleinopathies

Wei, J., Fujita, M., Nakai, M., Waragai, M., Sekigawa, A., Sugama, S., Takenouchi, T., Masliah, E., & Hashimoto, M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080680 · Cited by 63 · see citing works

An <i>apolipoprotein E</i> variant may protect against age‐related macular degeneration through cytokine regulation

Bojanowski, C. M., Shen, D., Chew, E. Y., Ning, B., Csaky, K. G., Green, W. R., Chan, C., & Tuo, J. (2006) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20233 · Cited by 62 · see citing works

Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases

Zhang, Z.-T., Xie, M., & Ye, K. (2016) · Expert opinion on therapeutic targets · doi:10.1080/14728222.2016.1182990 · Cited by 55 · see citing works

Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58 · see citing works

Aryl Hydrocarbon Receptor Modulation of Tumor Necrosis Factor-α-induced Apoptosis and Lysosomal Disruption in a Hepatoma Model That Is Caspase-8-independent

Caruso, J. A., Mathieu, P., Joiakim, A., Zhang, H., & Reiners, J. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508383200 · Cited by 52 · see citing works

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

Huang, Y. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390924 · Cited by 48 · see citing works

Alzheimer's disease genes and autophagy

Yoon, S., & Kim, D. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.018 · Cited by 47 · see citing works

Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy

Caruso, J. A., Mathieu, P., & Reiners, J. J. (2005) · Biochemical Journal · doi:10.1042/bj20050313 · Cited by 48 · see citing works

Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease

Martiskainen, H., Haapasalo, A., Kurkinen, K. M. A., Pihlajamäki, J., Soininen, H. S., & Hiltunen, M. O. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.789862 · Cited by 45 · see citing works

Mouse models of Alzheimer's disease: The long and filamentous road

Phinney, A. L., Horne, P., Yang, J., Janus, C., Bergeron, C., & Westaway, D. A. (2003) · Neurological Research · doi:10.1179/016164103101202020 · Cited by 45 · see citing works

Mitochondrial DNA variants in a Japanese population of patients with Alzheimer’s disease

Tanaka, N., Goto, Y., Akanuma, J., Kato, M., Kinoshita, T., Yamashita, F., Tanaka, M., & Asada, T. (2009) · Mitochondrion · doi:10.1016/j.mito.2009.08.008 · Cited by 45 · see citing works

Androgens, ApoE, and Alzheimer's Disease

Raber, J. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.11.re2 · Cited by 46 · see citing works

Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis

Quinn, C. M., Kågedal, K., Terman, A., STROIKIN, U., Brunk, U. T., Jessup, W., & Garner, B. (2004) · Biochemical Journal · doi:10.1042/bj20031352 · Cited by 45 · see citing works

Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology

Kar, S., Poirier, J., Guevara, J., Dea, D., Hawkes, C. A., Robitaille, Y., & Quirion, R. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.005 · Cited by 44 · see citing works

Function and Comorbidities of Apolipoprotein E in Alzheimer′s Disease

Leduc, V., Domenger, D., Beaumont, L. D., Lalonde, D., Jasmin, S. B., & Poirier, J. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/974361 · Cited by 45 · see citing works

Effect of Carboxyl-Terminal Truncation on Structure and Lipid Interaction of Human Apolipoprotein E4

Tanaka, M., Vedhachalam, C., Sakamoto, T., Dhanasekaran, P., Phillips, M. C., Lund-Katz, S., & Saito, H. (2006) · Biochemistry · doi:10.1021/bi060023b · Cited by 43 · see citing works

Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer’s disease

Mançano, A. S. F., Pina, J. G., Froes, B. R., & Sciani, J. M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1490275 · Cited by 44 · see citing works

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis

Persson, T., Lattanzio, F., Calvo‐Garrido, J., Rimondini, R., Rubio-Rodrigo, M., Sundström, E., Maioli, S., Matton, A., & Cedazo-Mı́nguez, Á. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150738 · Cited by 41 · see citing works

ApoE ɛ4 genotype and the age at onset of temporal lobe epilepsy: A case–control study and meta-analysis

Kauffman, M. A., Consalvo, D., Morón, D. G., Lereis, V. P., & Kochen, S. S. (2010) · Epilepsy Research · doi:10.1016/j.eplepsyres.2010.05.007 · Cited by 40 · see citing works

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months

Thai, C., Lim, Y. Y., Villemagne, V. L., Laws, S. M., Ames, D. J., Ellis, K. A., Rainey‐Smith, S. R., Martins, R. N., Masters, C. L., Rowe, C. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139082 · Cited by 39 · see citing works

β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

Goodchild, S. C., Sheynis, T., Thompson, R. F., Tipping, K. W., Xue, W., Ranson, N. A., Beales, P. A., Hewitt, E. W., & Radford, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104492 · Cited by 39 · see citing works

Engineering Conformational Destabilization into Mouse Apolipoprotein E

Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503910200 · Cited by 38 · see citing works

Apolipoprotein E (APOE) ε4 genotype is associated with reduced neuropsychological performance in military veterans with a history of mild traumatic brain injury

Merritt, V. C., Clark, A. L., Sorg, S. F., Evangelista, N. D., Werhane, M. L., Bondi, M. W., Schiehser, D. M., & Delano‐Wood, L. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1508555 · Cited by 37 · see citing works

The Interplay Between Apolipoprotein E4 and the Autophagic–Endocytic–Lysosomal Axis

Schmukler, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0892-4 · Cited by 35 · see citing works

Reactivity of Apolipoprotein E4 and Amyloid β Peptide

Ji, Z.-S., Müllendorff, K., Cheng, I. H., Miranda, R. D., Huang, Y., & Mahley, R. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506646200 · Cited by 127 · see citing works

An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42

Dafnis, I., Stratikos, E., Tzinia, A., Tsilibary, E. C., Zannis, V. I., & Chroni, A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06756.x · Cited by 41 · see citing works

Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases

Hashimoto, Y., Jiang, H., Niikura, T., Ito, Y., Hagiwara, A., Umezawa, K., Abe, Y., Murayama, Y., & Nishimoto, I. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08401.2000 · Cited by 86 · see citing works

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

Jordán, J., Galindo, M. F., Miller, R. J., Reardon, C. A., Getz, G. S., & LaDu, M. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00195.1998 · Cited by 178 · see citing works

P3–209: ApoE4 induces Aβ mediated apoptosis in vivo

Belinson, H., & Michaelson, D. M. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1478