Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Alzheimer's disease: the amyloid cascade hypothesis

Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672 · see citing works

Critical Stability Constants

Martell, A. E., & Smith, R. M. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6761-5 · Cited by 6,011 · see citing works

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works

Free Radicals in Biology and Medicine

Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6448 · Cited by 3,506 · see citing works

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,420 · see citing works

The molecular pathology of Alzheimer's disease

Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708 · see citing works

Protein Oxidation and Aging

Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701 · see citing works

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

LeBel, C. P., Ischiropoulos, H., & Bondy, S. C. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00026a012 · Cited by 2,694 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178 · see citing works

Hydrogen peroxide mediates amyloid β protein toxicity

Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Jarrett, J. T., Berger, E. P., & Lansbury, P. T. (1993) · Biochemistry · doi:10.1021/bi00069a001 · Cited by 2,022 · see citing works

Amyloid β-peptide is produced by cultured cells during normal metabolism

Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921 · see citing works

Free Radicals in Biology

Pryor, W. A. (1976) · Cited by 1,857 · see citing works

Spin Trapping: ESR parameters of spin adducts 1474 1528V

Buettner, G. R. (1987) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(87)80033-3 · Cited by 1,827 · see citing works

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731 · see citing works

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.-H., Mistl, C., Rothacher, S., Ledermann, B., Bürki, K., Frey, P., Paganetti, P. A., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13287 · Cited by 1,507 · see citing works

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

Lorenzo, A., & Yankner, B. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.12243 · Cited by 1,324 · see citing works

Age-related changes in oxidized proteins.

Oliver, C. N., Ahn, B. W., Moerman, E. J., Goldstein, S., & Stadtman, E. R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45598-6 · Cited by 1,306 · see citing works

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10540 · Cited by 1,296 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

NMDA-dependent superoxide production and neurotoxicity

Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183 · see citing works

Oxidative stress: the paradox of aerobic life

Davies, K. J. A. (1995) · Biochemical Society Symposia · doi:10.1042/bss0610001 · Cited by 1,150 · see citing works

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Huang, X., Atwood, C., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J. T., Moir, R. D., et al. (1999) · Biochemistry · doi:10.1021/bi990438f · Cited by 1,107 · see citing works

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086 · see citing works

Amyloid β-Protein Fibrillogenesis

Walsh, D. M., Hartley, D. M., Kusumoto, Y., Fezoui, Y., Condron, M. M., Lomakin, A., Benedek, G. B., Selkoe, D. J., & Teplow, D. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25945 · Cited by 1,046 · see citing works

Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M. E., Romano, D. M., Hartshorn, M. A., Tanzi, R. E., & Bush, A. I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.12817 · Cited by 1,009 · see citing works

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

Yankner, B. A., Dawes, L. R., Fisher, S., Villa-Komaroff, L., Oster-Granite, M. L., & Neve, R. L. (1989) · Science · doi:10.1126/science.2474201 · Cited by 907 · see citing works

Oxidative damage in Alzheimer's

Smith, M. A., Perry, G. L., Richey, P. L., Sayrec, L. M., Anderson, V. E., Beal, M. F., & Kowall, N. W. (1996) · Nature · doi:10.1038/382120b0 · Cited by 897 · see citing works

Oxidation of methionyl residues in proteins: Tools, targets, and reversal

Vogt, W. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00158-g · Cited by 883 · see citing works

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

Goodman, Y., Bruce‐Keller, A. J., Cheng, B., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66051836.x · Cited by 830 · see citing works

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

Pike, C. J., Walencewicz, A. J., Glabe, C. G., & Cotman, C. W. (1991) · Brain Research · doi:10.1016/0006-8993(91)91553-d · Cited by 829 · see citing works

Advanced glycation end products contribute to amyloidosis in Alzheimer disease

Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4766 · Cited by 806 · see citing works

Amyloid β-Protein and the Genetics of Alzheimer's Disease

Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works

Oxidative Alterations in Alzheimer's Disease

Markesbery, W. R., & Carney, J. M. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00215.x · Cited by 789 · see citing works

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010255.x · Cited by 781 · see citing works

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · see citing works

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.52.37111 · Cited by 762 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · see citing works

Alzheimer's Disease: A Central Role for Amyloid

Selkoe, D. J. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00003 · Cited by 752 · see citing works

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

Golde, T. E., Estus, S., Younkin, L. H., Selkoe, D. J., & Younkin, S. G. (1992) · Science · doi:10.1126/science.1738847 · Cited by 737 · see citing works

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 719 · see citing works

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

Smith, M. A., Taneda, S., Richey, P. L., Miyata, S., Yan, S. D., Stern, D., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5710 · Cited by 715 · see citing works

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

Pike, C. J., Walencewicz‐Wasserman, A. J., Kosmoski, J., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010253.x · Cited by 699 · see citing works

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease

Markesbery, W. R., & Lovell, M. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00009-8 · Cited by 680 · see citing works

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

IRIZARRY, M. C., MCNAMARA, M., FEDORCHAK, K., HSIAO, K., & HYMAN, B. T. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199709000-00002 · Cited by 649 · see citing works

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

Lovell, M. A., Ehmann, W. D., Butler, S. M., & Markesbery, W. R. (1995) · Neurology · doi:10.1212/wnl.45.8.1594 · Cited by 644 · see citing works

Protein-bound acrolein: Potential markers for oxidative stress

Uchida, K., Kanematsu, M., Sakai, K., Matsuda, T., Hattori, N., Mizuno, Y., Suzuki, D., Miyata, T., Noguchi, N., Niki, E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.4882 · Cited by 632 · see citing works

Water-soluble Aβ(N-40, N-42) oligomers in normal and Alzheimer disease brains

Kuo, Y.-M., Emmerling, M. R., Vigo-Pelfrey, C., Kasunic, T. C., Kirkpatrick, J. B., Murdoch, G. H., Ball, M. J., & Roher, A. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4077 · Cited by 618 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

Evidence of neuronal oxidative damage in Alzheimer's disease.

Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works

Microglial response to amyloid plaques in APPsw transgenic mice.

Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B. T., Saido, T. C., Hsiao, K., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 592 · see citing works

Vitamin E protects nerve cells from amyloid βprotein toxicity

Behl, C., Davis, J. B., Cole, G. M., & Schubert, D. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90837-b · Cited by 582 · see citing works

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569 · see citing works

The isoprostanes: Unique bioactive products of lipid peroxidation

Morrow, J. D., & Roberts, L. J. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00001-5 · Cited by 556 · see citing works

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

Mark, R. J., Hensley, K., Butterfield, D. A., & Mattson, M. P. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06239.1995 · Cited by 553 · see citing works

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

Mark, R. J., Pang, Z., Geddes, J. W., Uchida, K., & Mattson, M. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01046.1997 · Cited by 551 · see citing works

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

Smith, M. A., Hirai, K., Hsiao, K., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M., & Perry, G. L. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052212.x · Cited by 547 · see citing works

Acrolein Is a Product of Lipid Peroxidation Reaction

Uchida, K., Kanematsu, M., Morimitsu, Y., Osawa, T., Noguchi, N., & Niki, E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16058 · Cited by 546 · see citing works

Evidence for a membrane defect in Alzheimer disease brain.

Nitsch, R. M., Blusztajn, J. K., Pittas, A. G., Slack, B. E., Growdon, J. H., & Wurtman, R. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1671 · Cited by 536 · see citing works

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

Lyras, L., Cairns, N. J., Jenner, A., Jenner, P., & Halliwell, B. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052061.x · Cited by 531 · see citing works

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 525 · see citing works

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

Guela, C., Wu, C.-K., Saroff, D., Lorenzo, A., Yuan, M., & Yankner, B. A. (1998) · Nature Medicine · doi:10.1038/nm0798-827 · Cited by 520 · see citing works

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

Mattson, M. P., Barger, S. W., Cheng, B., Lieberburg, I. M., Smith‐Swintosky, V. L., & Rydel, R. E. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90009-b · Cited by 516 · see citing works

Alzheimer neuropathologic alterations in aged cognitively normal subjects

Davis, D. G., Schmitt, F. A., Wekstein, D. R., & Markesbery, W. R. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199904000-00008 · Cited by 516 · see citing works

Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6750 · Cited by 513 · see citing works

Neuron loss in APP transgenic mice

Calhoun, M. E., Wiederhold, K.-H., Abramowski, D., Phinney, A. L., Probst, A., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., & Jucker, M. (1998) · Nature · doi:10.1038/27351 · Cited by 502 · see citing works

Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

Roher, A. E., Chaney, M. O., Kuo, Y., Webster, S. D., Stine, W. B., Haverkamp, L. J., Woods, A. S., Cotter, R. J., Tuohy, J. M., Krafft, G. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20631 · Cited by 494 · see citing works

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

Uchida, K., & Stadtman, E. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4544 · Cited by 492 · see citing works

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

Gabbita, S. P., Lovell, M. A., & Markesbery, W. R. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052034.x · Cited by 479 · see citing works

Relative Abundance of Alzheimer A Beta Amyloid Peptide Variants in Alzheimer Disease and normal Aging

Näslund, J., Schierhorn, A., Hellman, U., Lannfelt, L., Roses, A. D., Tjernberg, L. O., Silberring, J., Gandy, S. E., Winblad, B., & Greengard, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8378 · Cited by 468 · see citing works

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

Subbarao, K. V., Richardson, J. S., & Ang, L. C. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb08858.x · Cited by 463 · see citing works

Radical AGEing in Alzheimer's disease

Smith, M. A., Sayre, L. M., Monnier, V. M., & Perry, G. L. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93897-7 · Cited by 462 · see citing works

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

Volterra, A., Trotti, D., Tromba, C., FLORIDI, S., & Racagni, G. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02924.1994 · Cited by 457 · see citing works

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

Behl, C. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00055-0 · Cited by 444 · see citing works

Regional Membrane Phospholipid Alterations in Alzheimer's Disease

Prasad, M. R., Lovell, M. A., Yatin, M., Dhillon, H. S., & Markesbery, W. R. (1998) · Neurochemical Research · doi:10.1023/a:1022457605436 · Cited by 440 · see citing works

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

Keller, J. N., Pang, Z., Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010273.x · Cited by 439 · see citing works

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

Estus, S., Golde, T. E., Kunishita, T., Blades, D. A., Lowery, D. E., Eisen, M., Usiak, M., QU, X., Tabira, T., Greenberg, B., et al. (1992) · Science · doi:10.1126/science.1738846 · Cited by 431 · see citing works

Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*

Roberts, L., Montine, T., Markesbery, W., Tapper, A. R., Hardy, P., Chemtob, S., Dettbarn, W., & Morrow, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13605 · Cited by 430 · see citing works

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 427 · see citing works

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

Lovell, M. A., Ehmann, W. D., Mattson, M. P., & Markesbery, W. R. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00108-5 · Cited by 413 · see citing works

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409 · see citing works

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

Braak, H., & Braak, E. (1996) · Acta Neuropathologica · doi:10.1007/s004010050508 · Cited by 406 · see citing works

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

Butterfield, D. A., Hensley, K., Harris‐White, M. E., Mattson, M. P., & Carney, J. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1508 · Cited by 404 · see citing works

Protein‐Bound Acrolein

Calingasan, N. Y., Uchida, K., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720751.x · Cited by 400 · see citing works

Protein oxidation and proteolysis during aging and oxidative stress

Starke-Reed, P. E., & Oliver, C. N. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90402-5 · Cited by 398 · see citing works

Chapter 7 Protein Oxidation Processes in Aging Brain

Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390 · see citing works

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

Masliah, E., Sisk, A., Mallory, M. E., Mucke, L., Schenk, D., & Games, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-18-05795.1996 · Cited by 387 · see citing works

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

Maret, W., Jacob, C., Vallée, B. L., & Fischer, E. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1936 · Cited by 385 · see citing works

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

Snyder, S. W., Ladror, U. S., Wade, W. S., Wang, G. T., Barrett, L. W., Matayoshi, E. D., Huffaker, H. J., Krafft, G. A., & Holzman, T. F. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80591-0 · Cited by 381 · see citing works

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

Simmons, L. K., May, P. C., Tomaselli, K. J., Rydel, R. E., Fuson, K. S., Brigham, E. F., Wright, S., Lieberburg, I. M., Becker, G. W., & Brems, D. N. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10007-2 · Cited by 371 · see citing works

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer’s Disease

Butterfield, D. A. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960130e · Cited by 364 · see citing works

Advances in Alzheimer's disease

Katzman, R., & Saitoh, T. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.3.2001787 · Cited by 357 · see citing works

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

Oda, T., Wals, P., Osterburg, H. H., Johnson, S. A., Pasinetti, G. M., Morgan, T. E., Rozovsky, I., Stine, W. B., Snyder, S. W., Holzman, T. F., et al. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1080 · Cited by 352 · see citing works

Methionine residues may protect proteins from critical oxidative damage

Levine, R. L., Berlett, B. S., Moskovitz, J., Mosoni, L., & Stadtman, E. R. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00152-3 · Cited by 338 · see citing works

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

Harris‐White, M. E., Hensley, K., Butterfield, D. A., Leedle, R. A., & Carney, J. M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90041-1 · Cited by 331 · see citing works

Discussion

(1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00056-1 · Cited by 330 · see citing works

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

Roses, A. D. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199409000-00002 · Cited by 329 · see citing works

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

Pappolla, M. A., Chyan, Y., Omar, R. A., Hsiao, K., Perry, G. L., Smith, M. A., & Bozner, P. (1998) · Europe PMC (PubMed Central) · Cited by 328 · see citing works

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

Svennerholm, L. T., & Gottfries, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031039.x · Cited by 327 · see citing works

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

Teller, J. K., Russo, C., DeBusk, L. M., Angelini, G., Zaccheo, D., Dagna-Bricarelli, F., Scartezzini, P., Bertolini, S., Mann, D. M. A., Tabaton, M., et al. (1996) · Nature Medicine · doi:10.1038/nm0196-93 · Cited by 326 · see citing works

Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

Huang, X., Atwood, C., Moir, R. D., Hartshorn, M. A., Vonsattel, J., Tanzi, R. E., & Bush, A. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.42.26464 · Cited by 313 · see citing works

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

Münch, G. W., Schinzel, R., Loske, C., Wong, A. O., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G. L., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050069 · Cited by 302 · see citing works

Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin

Tomiyama, T., Shoji, A., Kataoka, K.-I., Suwa, Y., Asano, S., Kaneko, H., & Endo, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.6839 · Cited by 295 · see citing works

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

Lovell, M. A., Gabbita, S. P., & Markesbery, W. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720771.x · Cited by 291 · see citing works

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

Estévez, Á. G., Radí, R., Barbeito, L., Shin, J. T., Thompson, J. A., & Beckman, J. S. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041543.x · Cited by 287 · see citing works

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

Lovell, M. A., Xie, C., & Markesbery, W. R. (1998) · Neurology · doi:10.1212/wnl.51.6.1562 · Cited by 275 · see citing works

Advanced glycation endproducts in ageing and Alzheimer's disease

Münch, G. W., Thome, J., Foley, P. B., Schinzel, R., & Riederer, P. F. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00016-1 · Cited by 275 · see citing works

The Lipid Peroxidation Product, 4‐Hydroxy‐2‐<i>trans</i>‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins

Subramaniam, R., Roediger, F., Jordan, B., Mattson, M. P., Keller, J. N., Waeg, G., & Butterfield, D. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031161.x · Cited by 270 · see citing works

Vitamin E and Alzheimer disease: the basis for additional clinical trials

Grundman, M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.630s · Cited by 267 · see citing works

Decrease in Peptide Methionine Sulfoxide Reductase in Alzheimer's Disease Brain

Gabbita, S. P., Aksenov, M. Y., Lovell, M. A., & Markesbery, W. R. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731660.x · Cited by 256 · see citing works

Cerebrospinal fluid F2‐isoprostane levels are increased in Alzheimer's disease

Montine, T., Markesbery, W., Morrow, J., & Roberts, L. (1998) · Annals of Neurology · doi:10.1002/ana.410440322 · Cited by 254 · see citing works

Effects of injected Alzheimer beta-amyloid cores in rat brain.

Frautschy, S. A., Baird, A., & Cole, G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8362 · Cited by 254 · see citing works

Vitamin E Prevents Alzheimer's Amyloid ß-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production

Yatin, S. M., Varadarajan, S., & Butterfield, D. A. (2000) · Journal of Alzheimer s Disease · doi:10.3233/jad-2000-2212 · Cited by 239 · see citing works

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

Butterfield, D. A., Howard, B. J., Yatin, S. M., Allen, K. L., & Carney, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.674 · Cited by 231 · see citing works

Amyloid β Peptide (25–35) Inhibits Na+‐Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures

Harris‐White, M. E., Wang, Y., Pedigo, N. W., Hensley, K., Butterfield, D. A., & Carney, J. M. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67010277.x · Cited by 230 · see citing works

Modified-Peptide Inhibitors of Amyloid β-Peptide Polymerization

Findeis, M. A., Musso, G. M., Arico-Muendel, C. C., Benjamin, H. W., Hundal, A. M., Lee, J.-J., Chin, J., Kelley, M., WAKEFIELD, J. D., Hayward, N. J., et al. (1999) · Biochemistry · doi:10.1021/bi982824n · Cited by 221 · see citing works

beta-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger

Bruce, A. J., Malfroy, B., & Baudry, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2312 · Cited by 216 · see citing works

α 2 -macroglobulin associates with β-amyloid peptide and prevents fibril formation

Hughes, S. R., Khorkova, O., Goyal, S., Knäblein, J., Heroux, J. A., Riedel, N. G., & Sahasrabudhe, S. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3275 · Cited by 212 · see citing works

A Critical Review of Spin Trapping in Biological Systems

Janzen, E. G. (1980) · Free Radicals in Biology · doi:10.1016/b978-0-12-566504-9.50011-8 · Cited by 210 · see citing works

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

Kelly, J. F., Furukawa, K., Barger, S. W., Rengen, M., Mark, R. J., Blanc, E. M., Roth, G. S., & Mattson, M. P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6753 · Cited by 209 · see citing works

Aggregation State and Neurotoxic Properties of Alzheimer Beta-Amyloid Peptide

Howlett, D. R., JENNINGS, K. H., Lee, D. C., Clark, M. S. G., Brown, F., Wetzel, R. B., Wood, S. J., Camilleri, P., & Roberts, G. W. (1995) · Neurodegeneration · doi:10.1006/neur.1995.0003 · Cited by 204 · see citing works

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation

Goodman, Y., Steiner, M. R., Steiner, S. M., & Mattson, M. P. (1994) · Brain Research · doi:10.1016/0006-8993(94)91586-5 · Cited by 202 · see citing works

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Mullaart, E., Boerrigter, M. E. T. I., Ravid, R., Swaab, D. F., & Vijg, J. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90542-8 · Cited by 201 · see citing works

Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease

Butterfield, D. A., Hensley, K., Cole, P. S., Ramachandran, S., Aksenov, M. Y., Aksenova, M. V., Bummer, P. M., Haley, B. E., & Carney, J. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68062451.x · Cited by 191 · see citing works

Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide

Bruce‐Keller, A. J., Begley, J. G., Fu, W., Butterfield, D. A., Bredesen, D. E., Hutchins, J. B., Hensley, K., & Mattson, M. P. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70010031.x · Cited by 188 · see citing works

Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red

Podlisny, M. B., Walsh, D. M., Amarante, P., Ostaszewski, B. L., Stimson, E. R., Maggio, J. E., Teplow, D. B., & Selkoe, D. J. (1998) · Biochemistry · doi:10.1021/bi972029u · Cited by 186 · see citing works

Alzheimer .beta.-Amyloid Peptide 25-35: Electrostatic Interactions with Phospholipid Membranes

Terzi, E., Hoelzemann, G., & Seelig, J. (1994) · Biochemistry · doi:10.1021/bi00189a051 · Cited by 173 · see citing works

Methionine residue 35 is important in amyloid β-peptide-associated free radical oxidative stress

Varadarajan, S., Yatin, S. M., Kański, J., Jahanshahi, F., & Butterfield, D. A. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00093-3 · Cited by 169 · see citing works

Peroxynitrite‐Induced Alterations in Synaptosomal Membrane Proteins

Koppal, T., Drake, J., Yatin, S. M., Jordan, B., Varadarajan, S., Bettenhausen, L., & Butterfield, D. A. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720310.x · Cited by 167 · see citing works

In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain

Pocernich, C. B., Fontaine, M. L., & Butterfield, D. A. (2000) · Neurochemistry International · doi:10.1016/s0197-0186(99)00126-6 · Cited by 165 · see citing works

ALZHEIMER'S DISEASE AND RELATED DISORDERS

Raskind, M. A., & Peskind, E. R. (2001) · Medical Clinics of North America · doi:10.1016/s0025-7125(05)70341-2 · Cited by 161 · see citing works

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

Maret, W. (1995) · Neurochemistry International · doi:10.1016/0197-0186(94)00173-r · Cited by 160 · see citing works

Amyloid β-peptide polymerization studied using fluorescence correlation spectroscopy

Tjernberg, L. O., Pramanik, A., Björling, S. C., Thyberg, P., Thyberg, J., Nordstedt, C., Berndt, K. D., Terenius, L. Y., & Rigler, R. W. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80020-9 · Cited by 159 · see citing works

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

Stephenson, D. T., Rash, K. S., Smalstig, B., Roberts, E. F., Johnstone, E., Sharp, J., Panetta, J., Little, S. P., Kramer, R. M., & Clemens, J. A. (1999) · Glia · doi:10.1002/(sici)1098-1136(199908)27:2 · Cited by 152 · see citing works

Alzheimer's disease: Advances in clinical and basic research

Absher, J. R. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90166-x · Cited by 152 · see citing works

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

Pettegrew, J. W., Moossy, J. J., Withers, G., McKeag, D., & Panchalingam, K. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198805000-00004 · Cited by 150 · see citing works

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

(1998) · Europe PMC (PubMed Central) · Cited by 145 · see citing works

Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia

Samuel, W., Terry, R. D., DeTeresa, R. M., Butters, N., & Masliah, E. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540200048015 · Cited by 140 · see citing works

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

Montine, T. J., Amarnath, K., Martin, M. E., Strittmatter, W. J., & Graham, D. G. (1996) · Europe PMC (PubMed Central) · Cited by 136 · see citing works

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

Bruce‐Keller, A. J., Li, Y., Lovell, M. A., Kraemer, P. J., Gary, D. S., Brown, R. R., Markesbery, W. R., & Mattson, M. P. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199803000-00007 · Cited by 133 · see citing works

Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells

Gridley, K. E., Green, P. S., & Simpkins, J. W. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01056-1 · Cited by 132 · see citing works

Free radicals in Alzheimer’s disease

Retz, W., Gsell, W., Münch, G. W., Rösler, M., & Riederer, P. F. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-7508-8_22 · Cited by 125 · see citing works

Protein Oxidation in Aging Braina

Smith, C. D., Carney, J. M., TATSUMO, T., Stadtman, E. R., Floyd, R. A., & Markesbery, W. R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38654.x · Cited by 124 · see citing works

β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants

Pike, C. J., Ramezan‐Arab, N., & Cotman, C. W. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041601.x · Cited by 124 · see citing works

Alzheimer's disease : advances in clinical and basic research

Corain, B. (1993) · Medical Entomology and Zoology · Cited by 122 · see citing works

EPR Spin-Trapping Studies of the Hydroxyl Radical Scavenging Activity of Carnosine and Related Dipeptides

Chan, W. K. M., Decker, E. A., Lee, J. B., et al. (1994) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf00043a003 · Cited by 122 · see citing works

Transgenic mice expressing Alzheimer amyloid precursor proteins

Hsiao, K. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00045-x · Cited by 119 · see citing works

Alzheimer's disease and related disorders

(1990) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(90)90072-r · Cited by 118 · see citing works

β-amyloid peptide in vitro toxicity: Lot-to-lot variability

May, P. C., Gitter, B. D., Waters, D. C., Simmons, L. K., Becker, G. W., Small, J. S., & Robison, P. M. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90064-5 · Cited by 116 · see citing works

Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

Kennedy, J. F., & Knill, C. J. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(01)00197-7 · Cited by 113 · see citing works

The expression of key oxidative stress-handling genes in different brain regions in alzheimer’s disease

Aksenov, M., Tucker, H., Nair, P., Aksenova, M. V., Butterfield, D., Estus, S., & Markesbery, W. (1998) · Journal of Molecular Neuroscience · doi:10.1385/jmn:11:2:151 · Cited by 113 · see citing works

Redox control of secondary structure in a designed peptide

Dado, G. P., & Gellman, S. H. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00079a060 · Cited by 113 · see citing works

β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease

Harris‐White, M. E., Carney, J. M., Cole, P. S., Hensley, K., Howard, B. J., Martin, L., Bummer, P. M., Wang, Y., Pedigo, N. W., & Butterfield, D. A. (1995) · Neuroreport · doi:10.1097/00001756-199510020-00013 · Cited by 112 · see citing works

The Antioxidant Vitamin E Modulates Amyloid β-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer's Disease

Yatin, S. M., Aksenov, M. Y., & Butterfield, D. A. (1999) · Neurochemical Research · doi:10.1023/a:1020997903147 · Cited by 112 · see citing works

Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

Daniel, L. G., & Colton, C. A. (2013) · Cited by 108 · see citing works

Amyloid β‐Peptides Increase Annular and Bulk Fluidity and Induce Lipid Peroxidation in Brain Synaptic Plasma Membranes

Avdulov, N. A., Chochina, S. V., Igbavboa, U., O‘Hare, E., Schroeder, F., Cleary, J. P., & Wood, W. G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052086.x · Cited by 106 · see citing works

Oxidation of Cytosolic Proteins and Expression of Creatine Kinase BB in Frontal Lobe in Different Neurodegenerative Disorders

Aksenova, M. V., Aksenov, M. Y., Payne, R. M., Trojanowski, J. Q., Schmidt, M. L., Carney, J. M., Butterfield, D. A., & Markesbery, W. R. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017098 · Cited by 105 · see citing works

Alzheimer's Disease Amyloid β Peptide 25-35 Is Localized in the Membrane Hydrocarbon Core: X-Ray Diffraction Analysis

Mason, R. P., Estermyer, J. D., Kelly, J. F., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0699 · Cited by 105 · see citing works

Spin Labeling in Disease

Butterfield, D. A. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6540-6_1 · Cited by 104 · see citing works

The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

Aksenov, M. Y., Tucker, H. M., Nair, P., Aksenova, M. V., Butterfield, D. A., Estus, S., & Markesbery, W. R. (1999) · Neurochemical Research · doi:10.1023/a:1020783614031 · Cited by 102 · see citing works

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer’s disease

Cecchi, C., Latorraca, S., Sorbi, S., Iantomasi, T., Favilli, F., Vincenzini, M. T., & Liguri, G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00751-x · Cited by 101 · see citing works

The Free Radical Antioxidant Vitamin E Protects Cortical Synaptosomal Membranes from Amyloid β-Peptide(25-35) Toxicity But Not from Hydroxynonenal Toxicity: Relevance to the Free Radical Hypothesis of Alzheimer's Disease

Subramaniam, R., Koppal, T., Green, M., Yatin, S. M., Jordan, B., Drake, J., & Butterfield, D. A. (1998) · Neurochemical Research · doi:10.1023/a:1020754807671 · Cited by 100 · see citing works

[48] Amyloid β-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease

Butterfield, D. A., Yatin, S. M., Varadarajan, S., & Koppal, T. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)09050-3 · Cited by 98 · see citing works

Vitamin Ε as an Antioxidant/Free Radical Scavenger Against Amyloid β-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease

Butterfield, D. A., Koppal, T., Subramaniam, R., & Yatin, S. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.141 · Cited by 97 · see citing works

Altered energy metabolism in Alzheimer's disease.

Ogawa, M., Fukuyama, H., Ouchi, Y., Yamauchi, H., & Kimura, J. (1996) · Journal of Neurological Sciences · doi:10.1016/0022-510x(96)00033-0 · Cited by 97 · see citing works

Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E

Yatin, S. M., Yatin, M., Aulick, T., Ain, K. B., & Butterfield, D. A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00101-9 · Cited by 96 · see citing works

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

Hajimohammadreza, I., & Brammer, M. J. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90226-y · Cited by 96 · see citing works

Amyloid β Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides

Dikalov, S., Vitek, M. P., Maples, K. R., & Mason, R. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9392 · Cited by 95 · see citing works

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease.

Chandrasekaran, K., Hatanpaa, K., Rapoport, S., & Brady, D. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(96)00191-x · Cited by 95 · see citing works

Inhibitors of free radical formation fail to attenuate direct β‐amyloid25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

Lockhart, B. P., Bénicourt, C., Junien, J., & Privat, A. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490390416 · Cited by 92 · see citing works

Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure

Hensley, K., Carney, J. M., Hall, N. C., Shaw, W., & Butterfield, D. A. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90018-3 · Cited by 92 · see citing works

Increased Susceptibility of Alzheimer's Disease Temporal Cortex to Oxygen Free Radical-Mediated Processes

McIntosh, L. J., Trush, M. A., & Troncoso, J. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00573-4 · Cited by 91 · see citing works

Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity

Yatin, S. M., Yatin, M., Varadarajan, S., Ain, K. B., & Butterfield, D. A. (2001) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20010301)63:5 · Cited by 89 · see citing works

β-Amyloid toxicity in organotypic cultures : protection by EUK-8, a synthetic catalytic free radical scavenger

Bruce, A. F. (1996) · Medical Entomology and Zoology · Cited by 85 · see citing works

Melatonin prevents β‐amyloid‐induced lipid peroxidation

Daniels, W. M. U., van Rensburg, S. J., van Zyl, J. M., & Taljaard, J. J. F. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00370.x · Cited by 84 · see citing works

3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease

Fontaine, M. A. L., Geddes, J. W., Banks, A., & Butterfield, D. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)01948-x · Cited by 84 · see citing works

Actions of Neurotoxic β‐Amyloid on Calcium Homeostasis and Viability of PC12 Cells Are Blocked by Antioxidants but Not by Calcium Channel Antagonists

Zhou, Y., Gopalakrishnan, V., & Richardson, J. S. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67041419.x · Cited by 81 · see citing works

Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide

Aksenov, M. Y., Aksenova, M. V., Carney, J. M., & Butterfield, D. A. (1997) · Free Radical Research · doi:10.3109/10715769709065765 · Cited by 81 · see citing works

Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition

Koppal, T., Subramaniam, R., Drake, J., Prasad, M. R., Dhillon, H. S., & Butterfield, D. A. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01466-2 · Cited by 77 · see citing works

Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX

Tsai, A., Palmer, G., Xiao, G., Swinney, D. C., & Kulmacz, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.3888 · Cited by 77 · see citing works

Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)

Howard, B. J., Yatin, S. M., Hensley, K., Allen, K. L., Kelly, J. P., Carney, J. M., & Butterfield, D. A. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67052045.x · Cited by 74 · see citing works

Chapter 26 Reduced neuronal activity and reactivation in Alzheimer's disease

Swaab, D. F., Lucassen, P. J., Salehi, A., Scherder, E., Someren, E. J. W. V., & Verwer, R. W. H. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)64027-3 · Cited by 73 · see citing works

Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity

Xie, C., Lovell, M. A., & Markesbery, W. R. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00186-5 · Cited by 72 · see citing works

Amyloid Beta: Structure, Biology and Structure-Based Therapeutic Development

Chen, G.-F., Xu, T.-H., Yan, Y., Zhou, Y.-R., Jiang, Y., Melcher, K., & Xu, H. E. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.28 · Cited by 1,965 · see citing works

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works

Curcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro

Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

Nandi, A., Yan, L.-J., Jana, C. K., & Das, N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/9613090 · Cited by 1,185 · see citing works

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide

Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works

Role of oxidative stress in Alzheimer’s disease

HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works

Amyloid <i>β</i> -Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression

Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00451.x · Cited by 464 · see citing works

The antioxidants α‐lipoic acid and <i>N</i> ‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

Farr, S. A., Poon, H. F., Dogrukol‐Ak, D., Drake, J., Banks, W. A., Eyerman, E., Butterfield, D. A., & Morley, J. E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01580.x · Cited by 459 · see citing works

REVIEW: Curcumin and Alzheimer’s disease

Hamaguchi, T., Ono, K., & Yamada, M. (2010) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/j.1755-5949.2010.00147.x · Cited by 450 · see citing works

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

Butterfield, D. A., & Boyd-Kimball, D. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170543 · Cited by 403 · see citing works

Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid β-peptide (1–42) in a transgenic Caenorhabditis elegans model

Drake, J. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00225-7 · Cited by 371 · see citing works

Identification of nitrated proteins in Alzheimer’s disease brain using a redox proteomics approach

Sultana, R., Poon, H. F., Cai, J., Pierce, W. M., Merchant, M., Klein, J. B., Markesbery, W. R., & Butterfield, D. A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.10.004 · Cited by 364 · see citing works

Oxidative Stress Signaling in Alzheimers Disease

Su, B., Wang, X., Nunomura, A., Moreira, P., Lee, H.-G., Perry, G., Smith, M., & Zhu, X. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898451 · Cited by 344 · see citing works

Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05088.2003 · Cited by 337 · see citing works

Causes of oxidative stress in Alzheimer disease

Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7218-4 · Cited by 336 · see citing works

Management of oxidative stress and other pathologies in Alzheimer’s disease

Simunkova, M., Alwasel, S. H., Alhazza, I. M., Jomova, K., Kollar, V., Rusko, M., & Valko, M. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02538-y · Cited by 303 · see citing works

Air Pollution, Oxidative Stress, and Alzheimer's Disease

Moulton, P. V., & Yang, W. (2012) · Journal of Environmental and Public Health · doi:10.1155/2012/472751 · Cited by 265 · see citing works

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263 · see citing works

Engineered nanoparticles for biomolecular imaging

Mahmoudi, M., Serpooshan, V., & Laurent, S. (2011) · Nanoscale · doi:10.1039/c1nr10326a · Cited by 262 · see citing works

SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid β Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease

Murakami, K., Murata, N., Noda, Y., Tahara, S., Kaneko, T., Kinoshita, N., Hatsuta, H., Murayama, S., Barnham, K. J., Irie, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279208 · Cited by 241 · see citing works

Iron and neurodegenerative disorders

Thompson, K. J., Shoham, S., & Connor, J. R. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00510-x · Cited by 235 · see citing works

Calcium signals induced by amyloid β peptide and their consequences in neurons and astrocytes in culture

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.006 · Cited by 223 · see citing works

Aβ-peptides enhance vasoconstriction in cerebral circulation

Niwa, K., Porter, V. A., Kazama, K., Cornfield, D., Carlson, G. A., & Iadecola, C. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.6.h2417 · Cited by 202 · see citing works

Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease

Agis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works

The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders

Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works

Apolipoprotein E4 Potentiates Amyloid β Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells

Ji, Z.-S., Miranda, R. D., Newhouse, Y. M., Weisgraber, K. H., Huang, Y., & Mahley, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112109200 · Cited by 177 · see citing works

Lewy Body Pathology in Alzheimer's Disease

Kotzbauer, P. T., Tojanowski, J. Q., & Lee, V. M. V. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:225 · Cited by 177 · see citing works

The emerging role of glutathione in Alzheimer’s disease

Saharan, S., & Mandal, P. K. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132483 · Cited by 168 · see citing works

Glycation—a sweet tempter for neuronal death

Kikuchi, S. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00273-4 · Cited by 169 · see citing works

The 2013 SFRBM Discovery Award: Selected discoveries from the Butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment

Butterfield, D. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.006 · Cited by 126 · see citing works

In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1–42-induced oxidative stress

Perluigi, M., Joshi, G., Sultana, R., Calabrese, V., De Marco, C., Coccia, R., Cini, C., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20879 · Cited by 125 · see citing works

Methionine-35 of A <i>β</i> (1–42): Importance for Oxidative Stress in Alzheimer Disease

Butterfield, D. A., & Sultana, R. (2011) · Journal of Amino Acids · doi:10.4061/2011/198430 · Cited by 124 · see citing works

Alzheimer’s amyloid β-peptide (1–42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35

Clementi, M. E., Pezzotti, M., Orsini, F., Sampaolese, B., Mezzogori, D., Grassi, C., Giardina, B., & Misiti, F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.137 · Cited by 105 · see citing works

Aβ₄₀, either Soluble or Aggregated, Is a Remarkably Potent Antioxidant in Cell-Free Oxidative Systems

Baruch-Suchodolsky, R., & Fischer, B. (2009) · Biochemistry · doi:10.1021/bi802361k · Cited by 98 · see citing works

The Oxygen Paradox, the French Paradox, and age-related diseases

Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0002-y · Cited by 82 · see citing works

Oxidative stress damage and oxidative stress responses in the choroid plexus in Alzheimer’s disease

Perez-Gracia, E., Blanco, R., Carmona, M., Carro, E., & Ferrer, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0574-4 · Cited by 63 · see citing works

Iron Pathophysiology in Alzheimer’s Diseases

Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

Webster, N. J., Green, K. N., Peers, C., & Vaughan, P. F. T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01236.x · Cited by 56 · see citing works

Protective Effect of D609 Against Amyloid-Beta1-42-Induced Oxidative Modification of Neuronal Proteins: Redox Proteomics Study

Sultana, R., Newman, S. F., Abdul, H. M., Cai, J., Pierce, W. M., Klein, J. B., Merchant, M., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20876 · Cited by 53 · see citing works

Screening Assay for Metal-Catalyzed Oxidation Inhibitors Using Liquid Chromatography−Mass Spectrometry with an N-Terminal β-Amyloid Peptide

Inoue, K., Nakagawa, A., Hino, T., & Oka, H. (2009) · Analytical Chemistry · doi:10.1021/ac802162n · Cited by 32 · see citing works

“Boomerang Neuropathology” of Late-Onset Alzheimer’s Disease is Shrouded in Harmful “BDDS”: Breathing, Diet, Drinking, and Sleep During Aging

Daulatzai, M. A. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9528-x · Cited by 12 · see citing works

Nanoparticles, Neurotoxicity and Neurodegenerative Diseases

Mushtaq, G., Khan, J. A., Joseph, E., & Kamal, M. A. (2015) · Current Drug Metabolism · doi:10.2174/1389200216666150812122302 · Cited by 66 · see citing works

Inflammatory Pathways

Griffin, W. S. T., Sheng, J. G., & Mrak, R. E. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-471-9_10 · Cited by 4 · see citing works

Alzheimer's disease: Mismatch between amyloid plaques and neuritic plaques

Braak, H., Braak, E., Ohm, T. G., & Böhl, J. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90479-5 · Cited by 90 · see citing works

Mechanism of Congo Red Binding to Amyloid Proteins with a Beta Pleated Sheet Structure

Elhaddaoui, A., Delacourte, A., Pigorsch, E., et al. (1993) · Springer eBooks · doi:10.1007/978-94-011-1934-4_58 · Cited by 3 · see citing works

Protective effects of melatonin on cortico-hippocampal neurotoxicity induced by amyloid beta-peptide 25-35.

Shen, Y., Wei, W., & Xu, S. (2002) · PubMed · Cited by 16 · see citing works