The DOI matches its Crossref record; 124 of the 125 references it cites were found in a registry or an index.
Tumors and inflammatory infiltrates: Friends or foes?
Abstract
The recognition of a role for inflammation in the natural history of a tumor has a long record, stretching from the mid-19th century. From the times of Virkow, who postulated that cancer originates from inflamed tissues, to Metchnikoff and many others, this field has continued to excite (and divide) the scientific community. The question as to whether the inflammatory infiltrate helps or hinders tumors is still open. In a sense, modern molecular biology has, if anything, worsened this dualism, and the literature on this issue shows a plethora of conflicting reports. We would like to provide another contribution to this topic, which was the subject of a recent brilliant review (Balkwill F and Mantovani A. Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches.
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“TAMs have a dual role in neoplasms — although they may kill neoplastic cells following activation by IL-2, interferon and IL-12 (refs 15, 16), TAMs produce a number of potent angiogenic and lymphangiogenic growth factors, cytokines and proteases, all of which are mediators that potentiate neoplastic progression17.”
From Inflammation and cancer (2002) · cites this paper as [15]
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Inflammation and cancer: back to Virchow?
Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“ATP synthase-inhibitors, such as Piceatannol [67] and Resveratrol [68] are effective inhibitors of tumor growth.”
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909.909_909_928 · Cited by 2,126
Ulcerative Colitis and Colorectal Cancer
Ekbom, A., Helmick, C. G., Zack, M. M., & Adami, H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231802 · Cited by 1,794
The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S.-I., et al. (1998) · Nature · doi:10.1038/31261 · Cited by 1,547
Flagged first, then by citations
1 of the 125 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Rollins BJ. Chemokines. Blood 1997; 90: 909–28. · DOI
- Richard D, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem 2000; 275: 26765–71. · DOI
- Johnson W, Anderson K, Lazovich D et al. Association of aspirin and other NSAID use with incidence of postmenopausal breast cancer. In Proceedings of AACR, New Orleans 2001; 763.
- Cao Y, Prescott S. Fatty acid CoA-ligase 4 and cyclooxygenase 2 promote carcinogenesis by lowering the intracellular level of free arachidonic acid. In Proceedings of AACR, New Orleans 2001; 591.
Cited by
Sorted by citations
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Tumour-educated macrophages promote tumour progression and metastasis
Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413
Cancer and the chemokine network
Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
Talmadge, J. E., & Fidler, I. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1040 · Cited by 1,242
Inflammation, a Key Event in Cancer Development
Lu, H., Ouyang, W., & Huang, C. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0261 · Cited by 1,049
Metadata
- Authors
- Brigati, C., Noonan, D. M., Albini, A., & Benelli, R.
- Corresponding author
- Brigati, Claudio
- Venue
- Clinical & Experimental Metastasis
- Published
- 2002-05
- Volume
- 19
- Issue
- 3
- Pages
- 247-258
- ISSN
- 0262-0898 (ISSN-L)
- 1573-7276
- OpenAlex
- W1550108534
- Cited by
- 230
- References
- 125
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 19
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Clinical & Experimental Metastasis (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- Funders
- Compagnia di San Paolo
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- tumor inflammation, inflammatory cell infiltration, tumor invasion, tumor microenvironment
- MeSH terms
- Humans, Inflammation, Models, Biological, Neoplasms, Prostaglandin-Endoperoxide Synthases, Transcription Factors, Cytokines, Receptors, Cytoplasmic and Nuclear, Chemokines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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