Cited by 230Immune cells in cancerInflammatory mediators and NSAID effectsInflammatory Biomarkers in Disease Prognosis

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Tumors and inflammatory infiltrates: Friends or foes?

Brigati, Claudio, Noonan, Douglas M., Albini, Adriana, Benelli, Roberto·2002·Clinical & Experimental Metastasis

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Abstract

The recognition of a role for inflammation in the natural history of a tumor has a long record, stretching from the mid-19th century. From the times of Virkow, who postulated that cancer originates from inflamed tissues, to Metchnikoff and many others, this field has continued to excite (and divide) the scientific community. The question as to whether the inflammatory infiltrate helps or hinders tumors is still open. In a sense, modern molecular biology has, if anything, worsened this dualism, and the literature on this issue shows a plethora of conflicting reports. We would like to provide another contribution to this topic, which was the subject of a recent brilliant review (Balkwill F and Mantovani A. Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches.

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Authors: Brigati, C., Noonan, D. M., Albini, A., & Benelli, R.
Corresponding author: Brigati, Claudio
ORCID: Noonan, Douglas M.
Albini, Adriana
Benelli, Roberto
Venue: Clinical & Experimental Metastasis
Publisher: Springer Science and Business Media LLC
Published: 2002-05
Volume: 19
Issue: 3
Pages: 247-258
ISSN: 0262-0898 (ISSN-L)
1573-7276
DOI: 10.1023/a:1015587423262
OpenAlex: W1550108534
Cited by: 230
References: 125
Citations by year: 2025: 2 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 19
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Clinical & Experimental Metastasis (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
IrInSubria (University of Insubria) (submittedVersion)
Funders: Compagnia di San Paolo
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords: tumor inflammation, inflammatory cell infiltration, tumor invasion, tumor microenvironment
MeSH terms: Humans, Inflammation, Models, Biological, Neoplasms, Prostaglandin-Endoperoxide Synthases, Transcription Factors, Cytokines, Receptors, Cytoplasmic and Nuclear, Chemokines

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Tumors and inflammatory infiltrates: Friends or foes?

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