Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting

Schäfer, Volker; von Briesen, Hagen; Andreesen, Reinhard; Steffan, Anne-Marie; Royer, Cathy; Tröster, Sabine; Kreuter, Jörg; Rübsamen-Waigmann, Helga

doi:10.1023/a:1015852732512

Cited by 146Nanoparticle-Based Drug DeliveryHIV Research and TreatmentAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting

Schäfer, Volker, von Briesen, Hagen, Andreesen, Reinhard, Steffan, Anne-Marie, Royer, Cathy, Tröster, Sabine, Kreuter, Jörg, Rübsamen-Waigmann, Helga·1992·Pharmaceutical Research

DOI 10.1023/a:1015852732512

Open this paper in CoChat — free account

Abstract

Human monocytes/macrophages (MO/MAC) were isolated from peripheral blood and cultivated on hydrophobic Teflon membranes. This culture system is suitable for HIV infection of MO/MAC in vitro. After transfer into 24-well plates the mature macrophages (infected or uninfected) were used for measurements of phagocytosis. The uptake of different, radioactively labeled nanoparticles (NP) made of polyalkylcyanoacrylate, polymethylmethacrylate (PMMA), and human serum albumin (HSA) by the macrophages was determined. In addition, the influence on phagocytosis of size and composition, concentration, and surface of the NP was studied. Further, macrophages of different state of activation were tested. NP made of polyhexylcyanoacrylate (PHCA) or human serum albumin with a diameter of about 200 nm were found most useful for targeting antiviral substances such as azidotymidine to macrophages. Cells infected in vitro with HIV-1D117/III, a monocytotropic HIV isolate from a perinatally infected child, possessed an even higher phagocytotic activity than noninfected cells. Macrophages isolated from HIV-infected patients also showed good incorporation of NP. Thus, the concept of a specific targeting of antiviral substances to macrophages in HIV-infected individuals appears quite promising.

Integrity signals

Registry

Crossref · 10.1023/a:1015852732512

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The macrophage size sensitivity resembles phagocytosis, in which micron-scale particles are internalized more than nanoscale particles, with peak phagocytosis near 2 μm diameter.
“The phenomenon appears to mirror that of phagocytosis, where macrophages preferentially internalize particulates in the micron range over the nanometric range, with peak phagocytosis observed with particles of approximately 2 μm in diameter [46-48].”
From Characterization of topographical effects on macrophage behavior in a foreign body response model (2010) · cites this paper as [47]

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.
Gendelman, H. E., Orenstein, J. M., Martin, M. A., Ferrua, C., Mitra, R., Phipps, T. J., Wahl, L. A., Lane, H. C., Fauci, A. S., & Burke, D. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.4.1428 · Cited by 781
Monocytes and Macrophages
Johnston, R. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181205 · Cited by 697
Nanoparticles--a new colloidal drug delivery system.
Marty, J. J., Oppenheim, R. C., & Speiser, P. P. (1978) · PubMed · Cited by 337
Magnetic Microspheres: Synthesis of a Novel Parenteral Drug Carrier
Widder, K. J., Flouret, G. R., & Senyei, A. E. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600680124 · Cited by 195
Macrophages and the human immunodeficiency virus
Meltzer, M. S., Skillman, D. R., Hoover, D. L., Hanson, B. D., Turpin, J. A., Kalter, D. C., & Gendelman, H. E. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90086-o · Cited by 168
Primary cultures of human blood-born macrophages grown on hydrophobic teflon membranes
Andreesen, R., Picht, J., & Löhr, G. W. (1983) · Journal of Immunological Methods · doi:10.1016/s0022-1759(83)80019-2 · Cited by 164
Self-citation
Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants
Tröster, S. D., Müller, U., & Kreuter, J. (1990) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(90)90047-8 · Cited by 163
Self-citation
Human macrophage maturation and heterogeneity: analysis with a newly generated set of monoclonal antibodies to differentiation antigens
Andreesen, R., Bross, K., Osterholz, J., & Emmrich, F. (1986) · Blood · doi:10.1182/blood.v67.5.1257.1257 · Cited by 137
Self-citation
Role of the Mononuclear Phagocyte System in the Development of Acquired Immunodeficiency Syndrome (AIDS)
Roy, S., & Wainberg, M. A. (1988) · Journal of Leukocyte Biology · doi:10.1002/jlb.43.1.91 · Cited by 113
Distribution and Elimination of Poly(methyl-2-14C-methacrylate) Nanoparticle Radioactivity after Injection in Rats and Mice
Kreuter, J., Täuber, U., & Illi, V. (1979) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600681129 · Cited by 109
Self-citation
Distribution and Elimination of Coated Polymethyl [2-14C]Methacrylate Nanoparticles After Intravenous Injection in Rats
Leu, D., Manthey, B., Kreuter, J., Speiser, P. P., & Delucax, P. P. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600731028 · Cited by 88
Self-citation
Isolation of variants of lymphocytopathic retroviruses from the peripheral blood and cerebrospinal fluid of patients with ARC or AIDS
Rübsamen‐Waigmann, H., Becker, W. B., Helm, E. B., Brodt, R. H., Fischer, H., Henco, K., & Brede, H. D. (1986) · Journal of Medical Virology · doi:10.1002/jmv.1890190406 · Cited by 73
Self-citation
Molecular cloning of two west African human immunodeficiency virus type 2 isolates that replicate well in macrophages: a Gambian isolate, from a patient with neurologic acquired immunodeficiency syndrome, and a highly divergent Ghanian isolate.
Kühnel, H., von Briesen, H., Dietrich, U., Adamski, M., Mix, D., BIESERT, L., Kreutz, R., Immelmann, A., Henco, K., & Meichsner, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2383 · Cited by 71
Localization of colloidal particles (liposomes, hexylcyanoacrylate nanoparticles and albumin nanoparticles) by histology and autoradiography in mice
Waser, P. G., Müller, U., Kreuter, J., Berger, S., Munz, K., Kaiser, E., & Pfluger, B. (1987) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(87)90219-5 · Cited by 58
Self-citation
Secretory Repertoire of HIV-Infected Human Monocytes/Macrophages
Esser, R., VONBRIESEN, H., Brugger, W., Ceska, M., Glienke, W., ller, S. M. U., Rehm, A., Rübsamen‐Waigmann, H., & Andreesen, R. (2008) · Pathobiology · doi:10.1159/000163649 · Cited by 50
Self-citation
Phagocytosis of Bioactive Microspheres
Ikada, Y., & Tabata, Y. (1986) · Journal of Bioactive and Compatible Polymers · doi:10.1177/088391158600100104 · Cited by 44
Infection of monocytes/macrophages by HIV in vitro
von Briesen, H., Andreesen, R., Esser, R., Brugger, W., Meichsner, C., Becker, K., & Rübsamen‐Waigmann, H. (1990) · Research in Virology · doi:10.1016/0923-2516(90)90025-e · Cited by 43
Self-citation
REVERSAL OF HIV-PHENOTYPE TO FULMINANT REPLICATION ON MACROPHAGES IN PERINATAL TRANSMISSION
Rübsamen‐Waigmann, H., Willems, W. R., Bertram, U., & von Briesen, H. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91518-3 · Cited by 37
Self-citation
Classification of Infections with Human Immunodeficiency Virus
Burke, D. S., & Redfield, R. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-6-968_1 · Cited by 11
Scintigraphy of Lymphokinetics and Lymphatic Neoplasia
Hör, G., Munz, D. L., Brandhorst, I., Maul, F. D., Holzmann, H., Altmeyer, P. J., & Baum, R. P. (1986) · Springer eBooks · doi:10.1007/978-3-642-70947-0_16 · Cited by 6

Flagged first, then by citations

Research works printed but not linked: 5

R. van Furth. Phagocytic cells. Development and distribution of mononuclear phagocytes in normal steady state and inflammation. In J. Gallen, M. Golstein, and R. Snyderman (eds.), Inflammation, Raven Press, New York, 1988, p. 281.
C. Scheibenbogen, W. Brugger, C. Rordorf, and R. Andreesen. Developmental regulation and stimulus specificity of cytokine release by human macrophages. Exp. Cell Biol. 57:118 (1989).
D. L. Munz, R. Standke, and G. Hör. Measurement of phagocytic and proteolytic function of macrophages in liver, spleen and bone marrow. In P. H. Cox (ed.), Progress in Radiopharmacology 2:261–266 (1981).
Centers for Disease Control (CDC). Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Morbid. Mortal. Week. Rep. 37(suppl. no. 1S):3S–15S (1987).
J. Kreuter. Evaluation of nanoparticles as a drug delivery system I. J. Pharm. Acta Helv. 58:196–208 (1983).

Sorted by citations

Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Encapsulation of polyphenols – a review
Fang, Z., & Bhandari, B. (2010) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2010.08.003 · Cited by 1,589
Nanocarriers’ entry into the cell: relevance to drug delivery
Hillaireau, H., & Couvreur, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0053-z · Cited by 1,620
Nanoparticle uptake: The phagocyte problem
Gustafson, H. H., Holt‐Casper, D., Grainger, D. W., & Ghandehari, H. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.006 · Cited by 1,458
Food protein-based materials as nutraceutical delivery systems
Chen, L., Remondetto, G. E., & Subirade, M. (2006) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.12.011 · Cited by 1,183
Desolvation process and surface characterisation of protein nanoparticles
Weber, C., Coester, C., Kreuter, J., & Langer, K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00370-1 · Cited by 605
Self-citation
Targeting to macrophages: role of physicochemical properties of particulate carriers–liposomes and microspheres – on the phagocytosis by macrophages
Ahsan, F. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00549-1 · Cited by 570
Nano and microparticles as controlled drug delivery devices.
Kumar, M. N. R. (2000) · PubMed · Cited by 532
Engineered nanoparticles as precise drug delivery systems
Yih, T. C., & Al-Fandi, M. G. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20796 · Cited by 393
Characterization of topographical effects on macrophage behavior in a foreign body response model
Chen, S., Jones, J. A., Xu, Y., Low, H.-Y., Anderson, J. M., & Leong, K. W. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.074 · Cited by 389
Biopolymeric nanoparticles
Sundar, S., Kundu, J., & Kundu, S. C. (2010) · Science and Technology of Advanced Materials · doi:10.1088/1468-6996/11/1/014104 · Cited by 329
Microglial Response to Gold Nanoparticles
Hutter, E., Boridy, S., Labrecque, S., Lalancette–Hébert, M., Križ, J., Winnik, F. M., & Maysinger, D. (2010) · ACS Nano · doi:10.1021/nn901869f · Cited by 328
Protein nanoparticle: A unique system as drug delivery vehicles
Jahanshahi, M., & Babaei, Z. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v7i25.59701 · Cited by 319
Natural phytochemicals and probiotics as bioactive ingredients for functional foods: Extraction, biochemistry and protected-delivery technologies
da Silva, B. V., Barreira, J. C. M., & Oliveira, M. B. P. P. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2015.12.007 · Cited by 248
Therapeutic potential of nanoparticulate systems for macrophage targeting
Chellat, F., Merhi, Y., Moreau, A., & Yahia, L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.044 · Cited by 237
Delivery systems to increase the selectivity of antibiotics in phagocytic cells
Briones, E., Colino, C. I., & Lanao, J. M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.027 · Cited by 226
Nanoparticles and microparticles for drug and vaccine delivery.
Kreuter, J. (1996) · Europe PMC (PubMed Central) · Cited by 204
Self-citation
Nanoparticulate Delivery Systems for Antiviral Drugs
Lembo, D., & Cavalli, R. (2010) · Antiviral chemistry & chemotherapy · doi:10.3851/imp1684 · Cited by 207
Targeting potential and anti-HIV activity of lamivudine loaded mannosylated poly (propyleneimine) dendrimer
Dutta, T., & Jain, N. K. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.12.007 · Cited by 200
Nanotechnology-based systems for the treatment and prevention of HIV/AIDS
das Neves, J., Amiji, M. M., Bahia, M. F., & Sarmento, B. F. C. C. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.017 · Cited by 197
Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers
Verrecchia, T., Spenlehauer, G., Bazile, D., Murry‐Brelier, A., Archimbaud, Y., & Veillard, M. (1995) · Journal of Controlled Release · doi:10.1016/0168-3659(95)00053-b · Cited by 189
Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs
Sharma, P., & Garg, S. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.019 · Cited by 166
Desolvation process and surface characteristics of HSA-nanoparticles
Weber, C., Kreuter, J., & Langer, K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(99)00420-2 · Cited by 158
Self-citation
Non-polymeric nano-carriers in HIV/AIDS drug delivery and targeting
Gupta, U. D., & Jain, N. K. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.018 · Cited by 156
Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophagesin vitro
Dutta, T., Agashe, H. B., Garg, M., Balasubramanium, P., Kabra, M., & Jain, N. K. (2007) · Journal of drug targeting · doi:10.1080/10611860600965914 · Cited by 157
Efficiency of nanoparticles as a carrier system for antiviral agents in human immunodeficiency virus-infected human monocytes/macrophages in vitro
Bender, A. R., von Briesen, H., Kreuter, J., Duncan, I. B. R., & Rübsamen‐Waigmann, H. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.6.1467 · Cited by 155
Self-citation
Surface modifications of nanocarriers for effective intracellular delivery of anti-HIV drugs
Gunaseelan, S., Gunaseelan, K., Deshmukh, M., Zhang, X., & Sinko, P. J. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.021 · Cited by 155
Drug targeting with nanoparticles
Kreuter, J. (1994) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03188928 · Cited by 153
Self-citation
Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery
Ofokansi, K. C., Winter, G., Fricker, G., & Coester, C. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.04.008 · Cited by 149
Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro
Dutta, T., Garg, M., & Jain, N. K. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.04.002 · Cited by 140
Antibody-Conjugated Nanoparticles for Therapeutic Applications
Cardoso, M. M., Peça, I. N., & Roque, A. C. A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800784667 · Cited by 138
Exploring the use of novel drug delivery systems for antiretroviral drugs
Ojewole, E. B., Mackraj, I., Naidoo, P., & Govender, T. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.06.020 · Cited by 136
Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms
Verri, W. A., Jr., Vicentini, F. T. M. C., Baracat, M. M., Georgetti, S. R., Cardoso, R. D. R., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., Fonseca, M. J. V., & Casagrande, R. (2012) · Studies in natural products chemistry · doi:10.1016/b978-0-444-53836-9.00026-8 · Cited by 136
Ionic liquids for the preparation of biopolymer materials for drug/gene delivery: a review
Chen, J., Xie, F., Li, X., & Chen, L. (2018) · Green Chemistry · doi:10.1039/c8gc01120f · Cited by 125
Body distribution of azidothymidine bound to hexyl-cyanoacrylate nanoparticles after i.v. injection to rats
Löbenberg, R. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00105-3 · Cited by 109
Surface modified nevirapine nanosuspensions for viral reservoir targeting: In vitro and in vivo evaluation
Shegokar, R., & Singh, K. K. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.09.041 · Cited by 103
Serum Albumin Nanoparticles: Problems and Prospects
Hornok, V. (2021) · Polymers · doi:10.3390/polym13213759 · Cited by 104
Engineered nanomaterials for biomedical applications and their toxicity: a review
Umapathi, A., Kumawat, M., & Daima, H. K. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01307-7 · Cited by 90
Antihypertensive Peptides Derived from Soy Protein by Fermentation
Vallabha, V. S., & Tiku, P. K. (2013) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-013-9377-5 · Cited by 89
Preparation of surface modified protein nanoparticles by introduction of sulfhydryl groups
Weber, C., Reiss, S., & Langer, K. (2000) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(00)00590-1 · Cited by 84
Bacterial ghosts as drug carrier and targeting vehicles
Huter, V., Szostak, M. P., Gampfer, J., Prethaler, S., Wanner, G., Gabor, F., & Lubitz, W. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00099-1 · Cited by 76
Pharmacokinetics of a Novel HIV-1 Protease Inhibitor Incorporated into Biodegradable or Enteric Nanoparticles following Intravenous and Oral Administration to Mice
Leroux, J., Cozens, R. M., Roesel, J. L., Galli, B., Kubel, F., Doelker, É., & Gurny, R. (1995) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600841202 · Cited by 75
Drug Delivery Systems
Paolino, D., Sinha, P. M., Fresta, M., & Mauro Ferrari, B. (2006) · Encyclopedia of Medical Devices and Instrumentation · doi:10.1002/0471732877.emd274 · Cited by 73
Fabrication of silk fibroin nanoparticles for controlled drug delivery
Zhao, Z., Chen, A., Li, Y., Hu, J., Liu, X., Li, J., Zhang, Y., Li, G., & Zheng, Z. (2012) · Journal of Nanoparticle Research · doi:10.1007/s11051-012-0736-5 · Cited by 72
Vaginal drug delivery: strategies and concerns in polymeric nanoparticle development
Wong, T. W., Dhanawat, M., & Rathbone, M. J. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.924499 · Cited by 75
Macrophage Targeting of Azidothymidine: A Promising Strategy for AIDS Therapy*
Löbenberg, R., & Kreuter, J. (1996) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1996.12.1709 · Cited by 70
Self-citation
Recent advances in long-acting nanoformulations for delivery of antiretroviral drugs
Surve, D. H., & Jindal, A. B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.022 · Cited by 68
Targeting of 3′-Azido 3′-Deoxythymidine (AZT)-Loaded Poly(Isohexylcyanoacrylate) Nanospheres to the Gastrointestinal Mucosa and Associated Lymphoid Tissues
Dembri, A., Montisci, M., Gantier, J.-C., Chacun, H., & Ponchel, G. (2001) · Pharmaceutical Research · doi:10.1023/a:1011050209986 · Cited by 68
Intracellular Delivery of Polymeric Nanocarriers: a Matter of size, shape, charge, Elasticity and Surface Composition
Agarwal, R., & Roy, K. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.37 · Cited by 61
Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules
Hillaireau, H., Ledoan, T., Besnard, M., Chacun, H., Janin, J., & Couvreur, P. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.07.006 · Cited by 60
Pathogen-mimetic stealth nanocarriers for drug delivery: a future possibility
Cavadas, M. A. S., González‐Fernández, Á., & Franco, R. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.04.006 · Cited by 61
Inhibition of HIV in vitro by antiviral drug-targeting using nanoparticles
Bender, A., Schäfer, V., Steffan, A., Royer, C., Kreuter, J., Rübsamen‐Waigmann, H., & von Briesen, H. (1994) · Research in Virology · doi:10.1016/s0923-2516(07)80025-2 · Cited by 60
Self-citation
Polymeric Nanoparticles for Enhancing Antiretroviral Drug Therapy
Govender, T., Ojewole, E. B., Naidoo, P., & Mackraj, I. (2008) · Drug Delivery · doi:10.1080/10717540802321776 · Cited by 54
Bone marrow-targeted liposomal carriers
Sou, K., Goins, B., Oyajobi, B. O., Travi, B. L., & Phillips, W. T. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.553218 · Cited by 53
Localized delivery of methylprednisolone sodium succinate with polymeric nanoparticles in experimental injured spinal cord model
Karabey-Akyurek, Y., Gürçay, A. G., Gürcan, O., Türkoğlu, Ö. F., Ciftci, S. Y., Eroğlu, H., Sargon, M. F., Bilensoy, E., & Öner, L. (2016) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2016.1143002 · Cited by 51
Food-protein-derived materials and their use as carriers and delivery systems for active food components
Subirade, M., & Chen, L. (2008) · Elsevier eBooks · doi:10.1533/9781845694210.2.251 · Cited by 49
Polymeric Nanoparticles for the Selective Therapy of Inflammatory Bowel Disease
Wachsmann, P., & Lamprecht, A. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-391860-4.00019-7 · Cited by 46
Lipid-based Nanosystems for CD44 Targeting in Cancer Treatment: Recent Significant advances, Ongoing Challenges and Unmet Needs
Nascimento, T. L., Hillaireau, H., Vergnaud, J., & Fattal, E. (2016) · Nanomedicine · doi:10.2217/nnm-2016-5000 · Cited by 43
Generation of Silk Fibroin Nanoparticles via Solution-Enhanced Dispersion by Supercritical CO2
Zhao, Z., Li, Y., Chen, A., Zheng, Z., Hu, J., Li, J., & Li, G. (2013) · Industrial & Engineering Chemistry Research · doi:10.1021/ie301907f · Cited by 42
The legacy of nanotechnology: Revolution and prospects in neurosurgery
Khawaja, A. M. (2011) · International Journal of Surgery · doi:10.1016/j.ijsu.2011.10.002 · Cited by 42
Nanomedicines for treatment of viral diseases.
Mehendale, R., Joshi, M., & Patravale, V. (2013) · Critical reviews in therapeutic drug carrier systems · doi:10.1615/critrevtherdrugcarriersyst.2013005469 · Cited by 34
Potential of polymeric nanoparticles in AIDS treatment and prevention
Khalil, N. M., Carraro, E., Cótica, L. F., & Mainardes, R. M. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.543673 · Cited by 40
A toolbox for the upscaling of ethanolic human serum albumin (HSA) desolvation
Wacker, M. G., Zensi, A., Kufleitner, J., Ruff, A., Schütz, J., Stockburger, T., Marstaller, T., & Vogel, V. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.04.046 · Cited by 39
From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies
Kim, Y., Oreffo, R. O. C., & Dawson, J. I. (2022) · Bone · doi:10.1016/j.bone.2022.116389 · Cited by 38
Polymeric nanoparticles of siRNA prepared by a double-emulsion solvent-diffusion technique: Physicochemical properties, toxicity, biodistribution and efficacy in a mammary carcinoma mice model
Ben-David-Naim, M., Grad, E., Aizik, G., Nordling‐David, M. M., Moshel, O., Granot, Z., & Golomb, G. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.036 · Cited by 37
Micro- and nanoparticles-based immunoregulation of macrophages for tissue repair and regeneration
Ding, J., Venkatesan, R., Zhai, Z., Muhammad, W., Nakkala, J. R., & Gao, C. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111075 · Cited by 36
d-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery
Lam, P.-L., Kok, S., Bian, Z., Lam, K. H., Tang, J. C. O., Lee, K. K., Gambari, R., & Chui, C. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.02.041 · Cited by 36
Exploring the potential of vaginal drug delivery: innovations, efficacy, and therapeutic prospects
Armengol, E. S., Veider, F., Millotti, G., Kali, G., Bernkop‐Schnürch, A., & Laffleur, F. (2025) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgaf045 · Cited by 33
Bisphosphonate-coated BSA nanoparticles lack bone targeting after systemic administration
Wang, G., Kucharski, C., Lin, X., & Uludağ, H. (2010) · Journal of drug targeting · doi:10.3109/10611861003622560 · Cited by 31
Past, Present, and Future Drug Delivery Systems for Antiretrovirals
Kirtane, A. R., Langer, R., & Traverso, G. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2016.09.015 · Cited by 28
Biodegradable gentamicin delivery systems for parenteral use for the treatment of intracellular bacterial infections
Gamazo, C., Prior, S., Lecároz, M. C., Vitas, A. I., Campanero, M. Á., Pérez, G., González, D., & Blanco‐Prieto, M. J. (2007) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.4.6.677 · Cited by 28
Development of phenolic compounds encapsulation techniques as a major challenge for food industry and for health and nutrition fields
Botelho, G., Canas, S., & Lameiras, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804304-2.00014-7 · Cited by 28
Targeted Delivery with Peptidomimetic Conjugated Self-Assembled Nanoparticles
Jabbari, E. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9802-1 · Cited by 27
Topically Applied Chitosan-Coated Poly(isobutylcyanoacrylate) Nanoparticles Are Active Against Cutaneous Leishmaniasis by Accelerating Lesion Healing and Reducing the Parasitic Load
Malli, S., Pomel, S., Ayadi, Y., Deloménie, C., Costa, A. D., Loiseau, P. M., & Bouchemal, K. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00263 · Cited by 25
Xyloglucan-based diblock co-oligomer: Synthesis, self-assembly and steric stabilization of proteins
Gauche, C., Soldi, V., Fort, S., Borsali, R., & Halila, S. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.07.064 · Cited by 23
FABRICATION AND EVALUATION OF HUMAN SERUM ALBUMIN (HSA) NANOPARTICLES FOR DRUG DELIVERY APPLICATION
Mehravar, R., Jahanshahi, M., & Saghatoleslami, N. (2009) · International Journal of Nanoscience · doi:10.1142/s0219581x09006080 · Cited by 20
Improving bioavailability and biodistribution of anti-HIV chemotherapy
Giacalone, G., Hillaireau, H., & Fattal, E. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.04.011 · Cited by 21
Pharmaceutical Approaches to HIV Treatment and Prevention
Yavuz, B., Morgan, J. L., Showalter, L., Crakes, K. R., Dandekar, S., Herrera, C., LiWang, P. J., & Kaplan, D. L. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800054 · Cited by 22
Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies
Jbara-Agbaria, D., Blondzik, S., Burger‐Kentischer, A., Agbaria, M., Nordling‐David, M. M., Giterman, A., Aizik, G., Rupp, S., & Golomb, G. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030633 · Cited by 18
Potentiation of liposome-induced complement activation by surface-bound albumin
Sávay, S., Szebeni, J., Baranyi, L., & Alving, C. R. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00408-4 · Cited by 17
Protein-based biomaterials for combating viral infections: Current status and future prospects for development
Han, Y., Pan, J., Ma, Y., Zhou, D., & Xü, W. (2022) · Biosafety and Health · doi:10.1016/j.bsheal.2022.03.005 · Cited by 16
Magnetic nanoparticles–serum proteins bioconjugates for binding of irinotecan
Tamyurek, E., Maltaş, E., Baş, S. Z., Özmen, M., & Yildiz, S. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.10.061 · Cited by 16
Protein micro/nanoparticles for controlled nutraceutical delivery in functional foods
Chen, L. (2009) · Elsevier eBooks · doi:10.1533/9781845696603.3.572 · Cited by 15
Nanoparticle troopers: Infiltrating cancer cells for targeted therapies
Rajput, S., Malviya, R., Prajapati, B. G., Sridhar, S. B., & Shareef, J. (2025) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2025.101453 · Cited by 14
Macrophage-Targeted Nanoparticle Delivery Systems
Jain, S., & Amiji, M. M. (2012) · Nanostructure science and technology · doi:10.1007/978-1-4614-2305-8_4 · Cited by 14
Ethylcellulose nanoparticles with bimodal size distribution as precursors for the production of very small nanoparticles
Wachsmann, P., & Lamprecht, A. (2014) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2014.935393 · Cited by 14
Poly(lactic-co-glycolic acid) nanoparticle fabrication, functionalization, and biological considerations for drug delivery
Marecki, E. K., Oh, K. W., Knight, P. R., & Davidson, B. A. (2024) · Biomicrofluidics · doi:10.1063/5.0201465 · Cited by 13
Interaction, uptake, and processing of LbL-coated microcarriers by PMNs
Rathmann, S., Schönberg, M., Leßig, J., & Reibetanz, U. (2011) · Cytometry Part A · doi:10.1002/cyto.a.21145 · Cited by 12
Nanoreticulations of etherified locust bean polysaccharide for controlled oral delivery of lamivudine
Maiti, S., Mondol, R., & Sa, B. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.01.036 · Cited by 12
Influence of HIV-infection on the phagocytic activity of monocytes/macrophages and granulocytes
Schäfer, V., Kreuter, J., Rübsamen‐Waigmann, H., Gerte, S., & von Briesen, H. (1994) · Clinical and Diagnostic Virology · doi:10.1016/0928-0197(94)90058-2 · Cited by 12
Self-citation
The emergence of multiple particle tracking in intracellular trafficking of nanomedicines
Kim, A. J., & Hanes, J. S. (2012) · Biophysical Reviews · doi:10.1007/s12551-012-0066-y · Cited by 11
Inflammation Caused by Nanosized Delivery Systems: Is There a Benefit?
Sarfraz, M., Roa, W., Bou‐Chacra, N. A., & Löbenberg, R. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00530 · Cited by 11
PAMAM Dendrimers and Branched Polyethyleneglycol (Nanoparticles) Prodrugs of (-)-β-D-(2R, 4R)-dioxolane-thymine (DOT) and Their Anti-HIV Activity
Liang, Y., Janarthanan, N., Rapp, K. L., Schinazi, R. F., & Chu, C. K. (2006) · Antiviral chemistry & chemotherapy · doi:10.1177/095632020601700602 · Cited by 11
Antiretroviral Therapy through Barriers: A Prominent Role for Nanotechnology in HIV-1 Eradication from Sanctuaries
Corsi, F., Sorrentino, L., Mazzucchelli, S., Truffi, M., Capetti, A. F., Rizzardini, G., & Fiandra, L. (2016) · Journal of Pharmacy and Pharmacology · doi:10.17265/2328-2150/2016.07.007 · Cited by 10
Vaginal Drug Delivery
Krogstad, E. A., Rathbone, M. J., & Woodrow, K. A. (2013) · Advances in delivery science and technology · doi:10.1007/978-1-4614-9434-8_27 · Cited by 10
Antioxidant Response Activating nanoParticles (ARAPas) localize to atherosclerotic plaque and locally activate the Nrf2 pathway
Maiocchi, S. L., Cartaya, A., Thai, S., Akerman, A. W., & Bahnson, E. M. (2022) · Biomaterials Science · doi:10.1039/d1bm01421h · Cited by 9
Nanobiomaterial-based delivery of drugs in various cancer therapies
Pandurangan, A. K., Kanagesan, S., Narayanaswamy, R., Esa, N. M., & Padmanabhan, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-42863-7.00011-6 · Cited by 9
Synthesis of a new nanoparticle system based on electrostatic alginate-piperazine interactions
Román, J. V., Rodríguez-Rodríguez, J. A., del Valle, E. M. M., & Galán, M. Á. (2015) · Polymers for Advanced Technologies · doi:10.1002/pat.3731 · Cited by 8
Sonochemically born proteinaceous micro- and nanocapsules
Vassileva, E., & Koseva, N. S. (2010) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-381264-3.00006-0 · Cited by 8
New Trends in the Antimicrobial Agents Delivery Using Nanoparticles
Bermúdez, J. M., Cid, A. G., Romero, A. I., Villegas, M., Villegas, N. Á., & Palma, S. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-52733-0.00001-x · Cited by 8

Inhibition of HIV in vitro by antiviral drug-targeting using nanoparticles
Bender, A., Schäfer, V., Steffan, A., Royer, C., Kreuter, J., Rübsamen‐Waigmann, H., & von Briesen, H. (1994) · Research in Virology · doi:10.1016/s0923-2516(07)80025-2 · Cited by 60
Self-citation
Gold Nanocarriers for Macrophage‐Targeted Therapy of Human Immunodeficiency Virus
Gómez, H. Z., Colino, C. I., Warzecha, K. T., Hoß, M., Gbureck, U., Trautwein, C., Tacke, F., Lanao, J. M., & Bartneck, M. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600359 · Cited by 25
Targeting antiviral nucleotide analogues to macrophages
Magnani, M., Rossi, L., Fraternale, A., Casabianca, A., Brandi, G., Benatti, U., & FLORA, A. D. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.1.133 · Cited by 22
αEnv-decorated phosphatidylserine liposomes trigger phagocytosis of HIV-virus-like particles in macrophages
Gramatica, A., Petazzi, R. A., Lehmann, M. J., Ziomkowska, J., Herrmann, A., & Chiantia, S. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.02.008 · Cited by 15
Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages
Dou, H., Morehead, J., Destache, C. J., Kingsley, J. D., Shlyakhtenko, L. S., Zhou, Y., Chaubal, M. V., Werling, J. O., Kipp, J., Rabinow, B. E., et al. (2006) · Virology · doi:10.1016/j.virol.2006.08.012 · Cited by 90

Authors: Schäfer, V., von Briesen, H., Andreesen, R., Steffan, A.-M., Royer, C., Tröster, S., Kreuter, J., & Rübsamen-Waigmann, H.
Affiliations: Goethe University Frankfurt (DE)
University of Freiburg (DE)
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 1992-04
Volume: 9
Issue: 4
Pages: 541-546
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1023/a:1015852732512
OpenAlex: W1498773598
Cited by: 146
References: 20
Citations by year: 2026: 4 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 8
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: phagocytosis, nanoparticles, HIV-infected macrophages, human serum albumin, poly(methyl methacrylate), macrophage activation, HIV-1, monocytes/macrophages
MeSH terms: Antiviral Agents, Cells, Cultured, HIV, Humans, Macrophages, Microscopy, Electron, Scanning, Phagocytosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug Targeting

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks