Anxiety and Depression Are Related to Autonomic Nervous System Function in Women with Irritable Bowel Syndrome

Jarrett, Monica E.; Burr, Robert L.; Cain, Kevin C.; Hertig, Vicky; Weisman, Pam; Heitkemper, Margaret M.

doi:10.1023/a:1021904216312

Cited by 94Gastrointestinal motility and disordersHeart Rate Variability and Autonomic ControlVagus Nerve Stimulation Research

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Anxiety and Depression Are Related to Autonomic Nervous System Function in Women with Irritable Bowel Syndrome

Jarrett, Monica E., Burr, Robert L., Cain, Kevin C., Hertig, Vicky, Weisman, Pam, Heitkemper, Margaret M.·2003·Digestive Diseases and Sciences

DOI 10.1023/a:1021904216312

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Abstract

This study compared women with irritable bowel syndrome who had a history of an anxiety or depressive disorder to those without symptoms of either disorder on indicators of cardiac parasympathetic activity, autonomic nervous system balance, and general autonomic activity. The Diagnostic Interview Schedule was used to determine anxiety or depressive disorders, and a Holter monitor was used to record R-R intervals over 24 hr. A similar comparison was done with healthy controls. Among women with irritable bowel syndrome, those with a positive history had lower parasympathetic and general activity throughout the 24-hr period than did women without a diagnosis. Indicators of autonomic balance were slightly higher in women with a positive history compared to those without a history. Similar differences were seen in controls. Thus, a history of anxiety and depressive disorders is associated with lower parasympathetic activity, both in women with IBS and healthy controls. Further exploration is needed to understand if lower parasympathetic activity influences the pain and stool pattern changes seen in persons with irritable bowel syndrome.

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Jarrett et al. suggested anxiety and depressive disorders were related to decreased parasympathetic activity, both in women with IBS and control groups.
“Jarrett et al42 suggested anxiety and depressive disorders were related to decreased parasympathetic activity, both in women with IBS and control groups.”
From Effects of cognitive behavior therapy on heart rate variability in young females with constipation-predominant irritable bowel syndrome: A parallel-group trial (2017) · cites this paper as [42]

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Authors: Jarrett, M. E., Burr, R. L., Cain, K. C., Hertig, V., Weisman, P., & Heitkemper, M. M.
Affiliations: University of Washington (US)
ORCID: Burr, Robert L.
Cain, Kevin C.
Heitkemper, Margaret M.
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2003-02
Volume: 48
Issue: 2
Pages: 386-394
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1023/a:1021904216312
OpenAlex: W1605288549
Cited by: 94
References: 45
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 9 · 2014: 7 · 2013: 4 · 2012: 6
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Nursing Research (P30NR004001, R01 NR04101, P30-NR04001, R01NR004101)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: irritable bowel syndrome, anxiety disorders, depression, autonomic nervous system, parasympathetic activity, cardiac autonomic balance, heart rate variability, women, Holter monitoring, RR interval
MeSH terms: Adolescent, Adult, Anxiety, Autonomic Nervous System, Colonic Diseases, Functional, Depressive Disorder, Female, Humans, Middle Aged, Probability, Prognosis, Reference Values, Comorbidity, Incidence, Case-Control Studies, Age Distribution, Risk Assessment

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Anxiety and Depression Are Related to Autonomic Nervous System Function in Women with Irritable Bowel Syndrome

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