The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
[Ecdysterone modulates antitumor activity of cytostatics and biosynthesis of macromolecules in tumor-bearing animals].
Abstract
The influence of therapeutic and half doses of cisplatin and adriamicin combination with the anabolic drug ecdisteron (20-hydroecdison) on development of subcutaneously and intraperitonially transplanted P388 and L1210 leukemia and metastasizing B16 melanoma was studied. Ecdisteron significantly stimulated the chemotherapeutic effect of low doses of the cytostatics: inhibition of tumor growth, mice survival rate, their lifespan, and the antimetastatic activity index were comparable or better than after therapy with high doses of the antitumor drugs. The influence of high and low doses of cisplatin and its low dose in combination with ecdisteron on the dynamics of protein and DNA biosynthesis in the liver, pancreas, thymus, spleen, and adrenals of tumor-bearing mice were also studied. Although the therapeutic effect of 4 mg/kg cisplatin by activated protein biosynthesis and DNA repair is comparable or better than that of its low dose (2 mg/kg) in combination with ecdisteron, in terms of chemotherapy the combination looks preferable since the therapeutic dose of cisplatin is toxic for the intact tissues.
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“20-HE improves antimetastatic and antitumor activity.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
In the citing paper
“It was found that mechanistically low doses of PEs and cisplatin affect cells biochemical dynamics, altering DNA and protein biosynthesis in the thymus, liver, pancreas, spleen, and adrenals of tumor-bearing mice.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
In the citing paper
“Moreover, high doses of PEs and cisplatin affect metastatic activity [161].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
In the citing paper
“We and others have shown that 20E and its derivates sensibilize breast cancer cells to genotoxic stress, induce autophagy, and attenuate multiple drug resistance [12,13,14,15,16,17,18,19].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
In the citing paper
“Recent studies have shown that 20E may also possess antineoplastic activity.”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
In the citing paper
“Furthermore, it has been shown previously that 20E and its derivates modulate the resistance of cancer cells to genotoxic drugs and mitigate multidrug resistance [12,13,14,15,16,17,18,19].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
Citations
Cites
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Nitroxyl radicals decrease toxicity of cytostatic agents
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[Stimulation of DNA replication in rat liver cells as a result of protein synthesis inhibition].
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[The radiosensitizer AK-2123 enhances sensitivity of MDR-tumors to Mitomycin C].
Гончарова, С. А., Раевская, Т. А., Konovalova, N. P., & Kagiya, V. T. (2000) · PubMed · Cited by 4
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Cited by
Sorted by citations
Practical uses for ecdysteroids in mammals including humans: and update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.7 · Cited by 196
“More recently, Konovalova et al. (2002) showed that injected 20E had a synergistic effect with low doses of an antitumour drug (cis-platin).”
BackgroundPractical uses for ecdysteroids in mammals including humans: And update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1673/031.003.0701 · Cited by 196
“More recently, Konovalova et al. (2002) showed that injected 20E had a synergistic effect with low doses of an antitumour drug (cis-platin).”
The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115
“reptans(122), 21-hydroxyshidasterone (172), 11b-hydroxy-20-deoxyshidasterone (173) and 2,3-acetonide-24-hydroxyecdysone (174), isolated from Vitex doniana(123), 24-epi-pinnatasterone (175)(124) and scabrasterone (176)(124), isolated from Vitex scabra, 26-”
BackgroundEffect of Ecdysterone on Glucose Metabolism in vitro
Chen, Q., Xia, Y., & Qiu, Z. (2006) · Life Sciences · doi:10.1016/j.lfs.2005.06.031 · Cited by 51
Arif, Y., Singh, P., Bajguz, A., & Hayat, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158664 · Cited by 50
“Moreover, high doses of PEs and cisplatin affect metastatic activity [161].”
Background
Metadata
- Authors
- Konovalova
- Venue
- Biology Bulletin
- Published
- 2002
- Volume
- 29
- Issue
- 6
- Pages
- 530-536
- ISSN
- 1062-3590 (ISSN-L)
- OpenAlex
- W271337829
- Cited by
- 20
- References
- 10
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2015: 2 · 2014: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- ru
- Open access
- closed
- Locations
- Biology Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- 20-hydroxyecdysone, cisplatin, doxorubicin, combination chemotherapy, low-dose chemotherapy, P388 leukemia, L1210 leukemia, B16 melanoma, metastasis, tumor-bearing mice, protein synthesis, DNA synthesis, DNA repair, liver, thymus, spleen, adrenal gland, pancreas
- MeSH terms
- Adrenal Glands, Animals, Antineoplastic Combined Chemotherapy Protocols, Cisplatin, DNA, Dose-Response Relationship, Drug, Doxorubicin, Drug Synergism, Ecdysterone, Leukemia L1210, Leukemia P388, Liver, Lung Neoplasms, Melanoma, Mice, Inbred Strains, Pancreas, Proteins, Spleen, Thymus Gland, Protein Biosynthesis, Survival Rate, Mice
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