[Ecdysterone modulates antitumor activity of cytostatics and biosynthesis of macromolecules in tumor-bearing animals].
Abstract
The influence of therapeutic and half doses of cisplatin and adriamicin combination with the anabolic drug ecdisteron (20-hydroecdison) on development of subcutaneously and intraperitonially transplanted P388 and L1210 leukemia and metastasizing B16 melanoma was studied. Ecdisteron significantly stimulated the chemotherapeutic effect of low doses of the cytostatics: inhibition of tumor growth, mice survival rate, their lifespan, and the antimetastatic activity index were comparable or better than after therapy with high doses of the antitumor drugs. The influence of high and low doses of cisplatin and its low dose in combination with ecdisteron on the dynamics of protein and DNA biosynthesis in the liver, pancreas, thymus, spleen, and adrenals of tumor-bearing mice were also studied. Although the therapeutic effect of 4 mg/kg cisplatin by activated protein biosynthesis and DNA repair is comparable or better than that of its low dose (2 mg/kg) in combination with ecdisteron, in terms of chemotherapy the combination looks preferable since the therapeutic dose of cisplatin is toxic for the intact tissues.
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20-HE improves antimetastatic and antitumor activity.
“20-HE improves antimetastatic and antitumor activity.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
Low doses of PEs and cisplatin affect cells biochemical dynamics, altering DNA and protein biosynthesis in thymus, liver, pancreas, spleen, and adrenals of tumor-bearing mice.
“It was found that mechanistically low doses of PEs and cisplatin affect cells biochemical dynamics, altering DNA and protein biosynthesis in the thymus, liver, pancreas, spleen, and adrenals of tumor-bearing mice.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
High doses of PEs and cisplatin affect metastatic activity.
“Moreover, high doses of PEs and cisplatin affect metastatic activity [161].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [161]
20E and its derivatives sensitize breast cancer cells to genotoxic stress, induce autophagy, and attenuate multiple drug resistance.
“We and others have shown that 20E and its derivates sensibilize breast cancer cells to genotoxic stress, induce autophagy, and attenuate multiple drug resistance [12,13,14,15,16,17,18,19].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
20E may possess antineoplastic activity.
“Recent studies have shown that 20E may also possess antineoplastic activity.”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
20E and its derivatives modulate the resistance of cancer cells to genotoxic drugs and mitigate multidrug resistance.
“Furthermore, it has been shown previously that 20E and its derivates modulate the resistance of cancer cells to genotoxic drugs and mitigate multidrug resistance [12,13,14,15,16,17,18,19].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [15]
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- Authors
- Konovalova
- Venue
- Biology Bulletin
- Published
- 2002
- Volume
- 29
- Issue
- 6
- Pages
- 530-536
- ISSN
- 1062-3590 (ISSN-L)
- OpenAlex
- W271337829
- Cited by
- 20
- References
- 10
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2015: 2 · 2014: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- ru
- Open access
- closed
- Locations
- Biology Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- 20-hydroxyecdysone, cisplatin, doxorubicin, combination chemotherapy, low-dose chemotherapy, P388 leukemia, L1210 leukemia, B16 melanoma, metastasis, tumor-bearing mice, protein synthesis, DNA synthesis, DNA repair, liver, thymus, spleen, adrenal gland, pancreas
- MeSH terms
- Adrenal Glands, Animals, Antineoplastic Combined Chemotherapy Protocols, Cisplatin, DNA, Dose-Response Relationship, Drug, Doxorubicin, Drug Synergism, Ecdysterone, Leukemia L1210, Leukemia P388, Liver, Lung Neoplasms, Melanoma, Mice, Inbred Strains, Pancreas, Proteins, Spleen, Thymus Gland, Protein Biosynthesis, Survival Rate, Mice
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