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Cited by 37Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and related disorders

Strain Differences in Sleep Patterns of Healthy and Influenza-Infected Inbred Mice

Toth, L. A., Verhulst, S. J.·2003·Behavior Genetics
DOI 10.1023/a:1023402709896
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Abstract

Influenza-infected C57BL/6J and BALB/cByJ mice respectively develop increased slow-wave sleep (SWS) during the dark phase and reduced SWS during the light phase of the 24 hour circadian cycle. To determine whether similar or alternative variations in SWS develop after influenza infection in other inbred strains of mice, we characterized the sleep patterns of additional strains both before and after influenza infection. Three strains (A/J, BALB/cByJ, and C3H/HeJ) showed light-phase SWS suppression, two strains (C57BL/6J and DBA/2J) showed dark-phase SWS enhancement, and one strain (A/J) showed dark-phase SWS suppression. Three strains (AKR/J, C57BR/cdJ, and FVB/NJ) did not show significant changes in SWS time on day two post-inoculation. Core temperatures were correlated to change in SWS time after infection, but were not correlated to SWS during the baseline period. These data support and expand the existing literature that indicates genetic modulation of sleep both in healthy mice and in mice undergoing viral infection.

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  • Strain differences in mice responses indicate a genetic component affecting the sleep response to influenza virus.

    “There are strain differences in responses of mice to this challenge (Toth and Verhulst, 2003), indicating a genetic component affecting the sleep response to influenza virus (Trammell and Toth, 2008).”

    From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Toth and Verhulst, 2003

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Authors
Toth, L. A., & Verhulst, S. J.
Affiliations
SIU Medicine (US)
Corresponding author
Toth, L. A.
Venue
Behavior Genetics
Publisher
Springer Science and Business Media LLC
Published
2003-05
Volume
33
Issue
3
Pages
325-336
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
DOI
10.1023/a:1023402709896
OpenAlex
W122971914
Cited by
37
References
40
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
1.18
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Lebanese Syrian Associated Charities
  • National Institutes of Health (5r01ns040220-09, 5r01ns026429-10)
  • National Heart, Lung, and Blood Institute (HL-70522, R01HL070522)
  • National Cancer Institute (CA21765, P30CA021765)
  • National Institute of Neurological Disorders and Stroke (NS-26429, NS-40220)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
influenza, slow-wave sleep, inbred mouse strains, core body temperature, C57BL/6J mice, BALB/cByJ mice
MeSH terms
Animals, Disease Models, Animal, Male, Mice, Inbred A, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Orthomyxoviridae Infections, Reference Values, Sleep, Species Specificity, Mice

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