The DOI matches its Crossref record; 18 of the 19 references it cites were found in a registry or an index.
Some Consequences of the RNA World Hypothesis
Abstract
It is now generally accepted that our familiar biological world was preceded by an RNA world in which ribosome-catalyzed, nucleic-acid coded protein synthesis played no part. If the RNA world was the first biological world there is little that one can learn from biochemistry about prebiotic chemistry, except that the formation and polymerization of nucleotides were once prebiotic processes. If the RNA world was not the first biological world, the above conclusion may not be justified, and one can speculate that the monomers of earlier genetic polymers might be recognizable as important biochemicals. This suggests that the construction of replicating polymers from simple, not necessarily standard, aminoacids should be explored.
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“Alternatively, polyesters, which have a considerably lower energy for bond formation (~0 kcal mol−1 [54]), have been considered as possible ancestral precursors of peptides [36,55].”
From Polyesters as a Model System for Building Primitive Biologies from Non-Biological Prebiotic Chemistry (2020) · cites this paper as [55]
Citations
Cites
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1 of the 19 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Cairns-Smith, A. G. and Davies, C. J.: 1977, The Design of Novel Replicating Polymers, in R. Duncan and N. Weston-Smith (eds), Encyclopaedia of Ignorance, Pergamon Press, Oxford/New York.
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Items 101–124 of 124
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.023
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.001
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.016
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.019
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.025
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.011
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.005
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.006
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.020
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.013
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.024
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.018
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.022
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.021
(2013) · Elsevier eBooks · doi:10.1016/b978-0-12-404613-9.00027-7
RetractedDuve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.007
(2006) · Springer eBooks · doi:10.1007/3-540-27666-1_7
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.012
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.010
Xue, J. Z., Chindelevitch, L., & Guichard, F. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.18.500397
Hypotheses and Birthplaces of the Chemical Evolution
Kricheldorf, H. R. (2025) · Springer eBooks · doi:10.1007/978-3-662-70752-4_2
The Energy Dissipation Model of the Evolutionary Imperative
Irwin, L. N. (2026) · Entropy · doi:10.3390/e28090948
Rauchfuss, H., & Mitchell, T. N. (2008) · Springer eBooks · doi:10.1007/978-3-540-78823-2_6
Duve, C. D. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511614736.008
Metadata
- Authors
- Orgel, L. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- Corresponding author
- Orgel, Leslie E.
- Venue
- Origins of life and evolution of the biosphere
- Published
- 2003-04
- Volume
- 33
- Issue
- 2
- Pages
- 211-218
- ISSN
- 0169-6149 (ISSN-L)
- 1573-0875
- OpenAlex
- W1567188373
- Cited by
- 124
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2017: 6 · 2016: 2 · 2015: 9 · 2014: 3 · 2013: 1 · 2012: 7
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Origins of Life and Evolution of Biospheres (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- RNA world, prebiotic chemistry, origin of life, nucleotide polymerization, amino acids, ribozymes, protein synthesis
- MeSH terms
- Amino Acids, Models, Theoretical, Polymers, RNA
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