From Transcriptional Regulation to Aggressive Behavior
Abstract
Gene expression in higher organisms, is, to a large degree, controlled at the level of transcription, where DNA-binding proteins (transcription factors) play an influential role in gene regulation. This is achieved through various mechanisms, including those that involve silencer and enhancer regions. Variation in those regulatory regions, as well as in the genes encoding the transcription factors, has been shown to generate functional effects at the molecular, cellular, and neurobehavioral levels. The aim of the present paper is two-fold. First, for the sake of clarity and to reintroduce the terminology to Behavior Genetics readers, we review the concepts of gene structure, gene expression, and gene regulation. Second, using distinct bioinformatic tools, we set out to identify transcription factors that could be involved in the transcriptional regulation of genes known to be associated with aggressive behavior in mice. The results of this in silico study reveal common putative transcription factor binding sites among the set of genes investigated (especially for SRY), suggesting similar molecular transcriptional mechanisms.
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DRD2 has been widely studied in schizophrenia, for which SNPs located in the gene promoter affect its transcriptional activity.
“The D2 dopamine receptor (DRD2) was identified as one of the top ranked genes and has been widely studied in schizophrenia, for which SNPs located in the gene promoter affect its transcriptional activity [58].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [58]
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- Authors
- D'Souza, U. M., Kel, A., & Sluyter, F.
- ORCID
- Kel, Alexander
- Venue
- Behavior Genetics
- Published
- 2003-09
- Volume
- 33
- Issue
- 5
- Pages
- 549-562
- ISSN
- 0001-8244 (ISSN-L)
- 1573-3297
- OpenAlex
- W1552366906
- Cited by
- 12
- References
- 93
- Citations by year
- 2021: 2 · 2020: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Behavior Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- transcriptional regulation, aggression, transcription factors, gene expression, enhancers, silencers, transcription factor binding sites, SRY, gene structure, mice, in silico analysis
- MeSH terms
- Aggression, Animals, Base Sequence, Enhancer Elements, Genetic, Exons, Gene Expression Regulation, Genes, Humans, Introns, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Sequence Homology, Nucleic Acid, Transcription Factors, Transcription, Genetic, Sequence Alignment, Silencer Elements, Transcriptional, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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