Cited by 12Neurotransmitter Receptor Influence on BehaviorGenomics and Chromatin DynamicsNeuroendocrine regulation and behavior

From Transcriptional Regulation to Aggressive Behavior

D'Souza, Ursula M., Kel, Alexander, Sluyter, Frans·2003·Behavior Genetics

Abstract

Gene expression in higher organisms, is, to a large degree, controlled at the level of transcription, where DNA-binding proteins (transcription factors) play an influential role in gene regulation. This is achieved through various mechanisms, including those that involve silencer and enhancer regions. Variation in those regulatory regions, as well as in the genes encoding the transcription factors, has been shown to generate functional effects at the molecular, cellular, and neurobehavioral levels. The aim of the present paper is two-fold. First, for the sake of clarity and to reintroduce the terminology to Behavior Genetics readers, we review the concepts of gene structure, gene expression, and gene regulation. Second, using distinct bioinformatic tools, we set out to identify transcription factors that could be involved in the transcriptional regulation of genes known to be associated with aggressive behavior in mice. The results of this in silico study reveal common putative transcription factor binding sites among the set of genes investigated (especially for SRY), suggesting similar molecular transcriptional mechanisms.

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Crossref · 10.1023/a:1025778817885

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  • DRD2 has been widely studied in schizophrenia, for which SNPs located in the gene promoter affect its transcriptional activity.

    “The D2 dopamine receptor (DRD2) was identified as one of the top ranked genes and has been widely studied in schizophrenia, for which SNPs located in the gene promoter affect its transcriptional activity [58].”

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Authors
D'Souza, U. M., Kel, A., & Sluyter, F.
Venue
Behavior Genetics
Published
2003-09
Volume
33
Issue
5
Pages
549-562
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
OpenAlex
W1552366906
Cited by
12
References
93
Citations by year
2021: 2 · 2020: 1
FWCI
0.35
Type
journal article
Language
en
Open access
closed
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
transcriptional regulation, aggression, transcription factors, gene expression, enhancers, silencers, transcription factor binding sites, SRY, gene structure, mice, in silico analysis
MeSH terms
Aggression, Animals, Base Sequence, Enhancer Elements, Genetic, Exons, Gene Expression Regulation, Genes, Humans, Introns, Models, Genetic, Molecular Sequence Data, Promoter Regions, Genetic, Sequence Homology, Nucleic Acid, Transcription Factors, Transcription, Genetic, Sequence Alignment, Silencer Elements, Transcriptional, Mice, Rats

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