Cited by 33Neurotransmitter Receptor Influence on BehaviorBullying, Victimization, and AggressionNeuroendocrine regulation and behavior

Genes and Gene Networks Implicated in Aggression Related Behaviour

Open access
Malki, Karim, Pain, Oliver, Du Rietz, Ebba, Tosto, Maria Grazia, Paya-Cano, Jose, Sandnabba, Kenneth N., de Boer, Sietse, Schalkwyk, Leonard C. +1 more·2014·neurogenetics

Abstract

Aggressive behaviour is a major cause of mortality and morbidity. Despite of moderate heritability estimates, progress in identifying the genetic factors underlying aggressive behaviour has been limited. There are currently three genetic mouse models of high and low aggression created using selective breeding. This is the first study to offer a global transcriptomic characterization of the prefrontal cortex across all three genetic mouse models of aggression. A systems biology approach has been applied to transcriptomic data across the three pairs of selected inbred mouse strains (Turku Aggressive (TA) and Turku Non-Aggressive (TNA), Short Attack Latency (SAL) and Long Attack Latency (LAL) mice and North Carolina Aggressive (NC900) and North Carolina Non-Aggressive (NC100)), providing novel insight into the neurobiological mechanisms and genetics underlying aggression. First, weighted gene co-expression network analysis (WGCNA) was performed to identify modules of highly correlated genes associated with aggression. Probe sets belonging to gene modules uncovered by WGCNA were carried forward for network analysis using ingenuity pathway analysis (IPA). The RankProd non-parametric algorithm was then used to statistically evaluate expression differences across the genes belonging to modules significantly associated with aggression. IPA uncovered two pathways, involving NF-kB and MAPKs. The secondary RankProd analysis yielded 14 differentially expressed genes, some of which have previously been implicated in pathways associated with aggressive behaviour, such as Adrbk2. The results highlighted plausible candidate genes and gene networks implicated in aggression-related behaviour.

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Crossref · 10.1007/s10048-014-0417-x

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Authors
Malki, K., Pain, O., Du Rietz, E., Tosto, M. G., Paya-Cano, J., Sandnabba, K. N., de Boer, S., Schalkwyk, L. C., & Sluyter, F.
Affiliations
  • King's College London (GB)
  • National Research Tomsk State University (RU)
  • Åbo Akademi University (FI)
  • University of Essex (GB)
  • University of Portsmouth (GB)
Corresponding author
Malki, Karim
Venue
neurogenetics
Published
2014-08-22
Volume
15
Issue
4
Pages
255-266
ISSN
  • 1364-6745 (ISSN-L)
  • 1364-6753
OpenAlex
W2013818267
Cited by
33
References
57
Citations by year
2026: 2 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 6
FWCI
1.98
Type
journal article
Language
en
Open access
Locations
  • Neurogenetics (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
  • Research Portal (King's College London) (submittedVersion)
  • Åbo Akademi University Research Portal (submittedVersion)
  • Open Access at Essex (University of Essex) (submittedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
aggression, gene co-expression network, attack latency, NF-κB signaling, MAPK signaling, candidate genes
MeSH terms
Aggression, Animals, Disease Models, Animal, Female, Male, Mice, Inbred Strains, Genetic Variation, Prefrontal Cortex, Gene Expression Profiling, MAP Kinase Signaling System, Mice, Gene Regulatory Networks

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