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Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins.

Todd, R. D., Neuman, R. J., Lobos, E., Jong, Y. I., Reich, W., & Heath, A. C. (2001) · American journal of medical genetics · doi:10.1002/ajmg.1403 · Cited by 86 · see citing works

The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding

Young, J. W., Powell, S. B., Scott, C. N., Zhou, X., & Geyer, M. A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.054 · Cited by 80 · see citing works

A Candidate Gene Analysis of Methylphenidate Response in Attention-Deficit/Hyperactivity Disorder

McGough, J. J., McCracken, J. T., Loo, S. K., Manganiello, M. D., Leung, M. C., Tietjens, J. R., Trinh, T., Baweja, S., Suddath, R., Smalley, S. L., et al. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3181bc72e3 · Cited by 78 · see citing works

Attention deficit/hyperactivity disorder (ADHD): Complex phenotype, simple genotype?

Acosta, M., Arcos‐Burgos, M., & Muenke, M. (2004) · Genetics in Medicine · doi:10.1097/01.gim.0000110413.07490.0b · Cited by 78 · see citing works

Molecular genetic aspects of attention-deficit/hyperactivity disorder

Heiser, P., Friedel, S., Dempfle, A., Konrad, K., SMIDT, J., Grabarkiewicz, J., Herpertz‐Dahlmann, B., Remschmidt, H., & Hebebrand, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.010 · Cited by 74 · see citing works

Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention‐deficit/hyperactivity disorder in Chilean families

Carrasco, X., Rothhammer, P., Moraga, M., Henríquez, H., Chakraborty, R., Aboitiz, F., & Rothhammer, F. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30259 · Cited by 74 · see citing works

Integrating Social Science and Genetics: News from the Political Front

Hatemi, P., Dawes, C. T., Frost-Keller, A., Settle, J. E., & Verhulst, B. (2011) · Biodemography and Social Biology · doi:10.1080/19485565.2011.568276 · Cited by 72 · see citing works

Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate

Arcos-Burgos, M., Castellanos, F., Konecki, D., Lopera, F., Pineda, D., Palacio, J., Rapoport, J., Berg, K., Bailey-Wilson, J., & Muenke, M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001396 · Cited by 68 · see citing works

A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5

Hsiung, G. R., Kaplan, B. J., Petryshen, T. L., Lu, S., & Field, L. L. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20082 · Cited by 64 · see citing works

Functional polymorphisms in dopamine and serotonin pathway genes

D’Souza, U. M., & Craig, I. (2005) · Human Mutation · doi:10.1002/humu.20278 · Cited by 62 · see citing works

Attention Deficit Hyperactivity Disorder

Kuntsi, J., McLoughlin, G., & Asherson, P. J. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:461 · Cited by 61 · see citing works

2-[(4-Phenylpiperazin-1-yl)methyl]imidazo(di)azines as Selective D4-Ligands. Induction of Penile Erection by 2-[4-(2-Methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a Potent and Selective D4Partial Agonist

Enguehard‐Gueiffier, C., Hübner, H., Hakmaoui, A. E., Allouchi, H., Gmeiner, P., Argiolas, A., Melis, M. R., & Gueiffier, A. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060166w · Cited by 61 · see citing works

Genes and attention deficit hyperactivity disorder

Swanson, J. M., Posner, M. I., Fusella, J., Wasdell, M. B., Sommer, T., & Fan, J. (2001) · Current Psychiatry Reports · doi:10.1007/s11920-001-0005-2 · Cited by 60 · see citing works

ADHD: a scientific fact or a factual opinion? A critique of the veracity of Attention Deficit Hyperactivity Disorder

Visser, J., & Jehan, Z. (2009) · Emotional and Behavioural Difficulties · doi:10.1080/13632750902921930 · Cited by 63 · see citing works

Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies

Peña, I. D., Pan, M. C., Thai, C. G., & Alisso, T. (2020) · Brain Sciences · doi:10.3390/brainsci10050292 · Cited by 63 · see citing works

Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-Dependent Kinase 5 Cofactor p35

Drerup, J. M., Hayashi, K., Cui, H., Mettlach, G., Long, M. A., Marvin, M. A., Sun, X., Goldberg, M. S., Lutter, M. L., & Bibb, J. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.016 · Cited by 58 · see citing works

Dopamine receptor gene polymorphisms in Parkinson's disease patients reporting “sleep attacks”

Rissling, I., Geller, F., Bandmann, O., Stiasny-Kolster, K., Körner, Y., Meindorfner, C., Krüger, H., Oertel, W. H., & Möller, J. C. (2004) · Movement Disorders · doi:10.1002/mds.20245 · Cited by 58 · see citing works

A Family Based Association Study of DRD4, DAT1, and 5HTT and Continuous Traits of Attention-Deficit Hyperactivity Disorder

Bidwell, L. C., Willcutt, E. G., McQueen, M. B., DeFries, J. C., Olson, R. K., Smith, S. D., & Pennington, B. F. (2011) · Behavior Genetics · doi:10.1007/s10519-010-9437-y · Cited by 57 · see citing works

Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity

Nigg, J. T., Nikolas, M. A., Friderici, K. H., Park, L. C., & Zucker, R. A. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000387 · Cited by 56 · see citing works

A Combination of Dopamine Genes Predicts Success by Professional Wall Street Traders

Sapra, S., Beavin, L. E., & Zak, P. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030844 · Cited by 54 · see citing works

Association between the 120‐bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: Genetic and molecular analyses

Kereszturi, É., Király, O., Csapó, Z., Tárnok, Z., Gádoros, J., Sasvári‐Székely, M., & Nemoda, Z. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30444 · Cited by 53 · see citing works

Association of a duplicated repeat polymorphism in the 5′‐untranslated region of the DRD4 gene with novelty seeking

Rogers, G. R., Joyce, P. R., Mulder, R., Sellman, D., Miller, A. L., Allington, M. D. E., Olds, R. J., Wells, E., & Kennedy, M. A. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20133 · Cited by 53 · see citing works

Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: Evidence of linkage and association with the SNP −616

Lowe, N., Kirley, A., Mullins, C., Fitzgerald, M., Gill, M., & Hawi, Z. (2004) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30071 · Cited by 52 · see citing works

Amphetamine improves mouse and human attention in the 5-choice continuous performance test

MacQueen, D. A., Minassian, A., Kenton, J. A., Geyer, M. A., Perry, W., Brigman, J. L., & Young, J. W. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.034 · Cited by 50 · see citing works

DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder

Bonvicini, C., Cortese, S., Maj, C., Baune, B. T., Faraone, S. V., & Scassellati, C. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0755-4 · Cited by 51 · see citing works

Functional genetic polymorphisms in serotonin and dopamine gene systems and their significance in behavioural disorders.

D'Souza, U., & Craig, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00904-7 · Cited by 51 · see citing works

The DRD4 receptor Exon 3 VNTR and 5′ SNP variants and mRNA expression in human post‐mortem brain tissue

Simpson, J., Vetuz, G., Wilson, M., Brookes, K. J., & Kent, L. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31084 · Cited by 47 · see citing works

Family‐based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals

Lasky-Su, J., Lange, C., Biederman, J., Tsuang, M., Doyle, A., Smoller, J. W., Laird, N., & Faraone, S. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30567 · Cited by 52 · see citing works

An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD

Boonstra, A., Kooij, J. J. S., Buitelaar, J., Oosterlaan, J., Sergeant, J., Heister, J. G. A. M. A., & Franke, B. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30595 · Cited by 47 · see citing works

Quantitative electroencephalographic measures in homicidal men with antisocial personality disorder

Lindberg, N., Tani, P., Virkkunen, M. E., Porkka‐Heiskanen, T., Appelberg, B., Naukkarinen, H., & Salmi, T. K. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.05.005 · Cited by 46 · see citing works

Discovery of 3-Methyl- N -(1-oxy-3‘,4‘,5‘,6‘-tetrahydro-2‘ H -[2,4‘-bipyridine]-1‘-ylmethyl)benzamide (ABT-670), an Orally Bioavailable Dopamine D 4 Agonist for the Treatment of Erectile Dysfunction

Patel, M. A., Kolasa, T., Mortell, K. H., Matulenko, M. A., Hakeem, A. A., Rohde, J. J., Nelson, S. L., Cowart, M., Nakane, M., Miller, L. N., et al. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060662k · Cited by 45 · see citing works

Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder

Çaylak, E. (2012) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32077 · Cited by 44 · see citing works

Quantitative and Molecular Genetics of ADHD

Asherson, P., & Gurling, H. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_155 · Cited by 43 · see citing works

Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population

Bhaduri, N., Das, M., Sinha, S., Chattopadhyay, A., Gangopadhyay, P., Chaudhuri, K., Singh, M., & Mukhopadhyay, K. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30225 · Cited by 41 · see citing works

Friendships Moderate an Association Between a Dopamine Gene Variant and Political IdeologyPreprint

Settle, J. E., Dawes, C. T., Christakis, N. A., & Fowler, J. H. (2008) · SSRN Electronic Journal · doi:10.2139/ssrn.1142623 · Cited by 44 · see citing works

Gene–gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia

Rajagopal, V. M., Rajkumar, A. P., Jacob, K. S., & Jacob, M. (2017) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000314 · Cited by 41 · see citing works

High sucrose consumption during pregnancy induced ADHD-like behavioral phenotypes in mice offspring

Choi, C. S., Kim, P., Park, J. H., Gonzales, E. L., Kim, K. C., Cho, K. S., Ko, M. J., Yang, S. M., Seung, H., Han, S., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.07.018 · Cited by 41 · see citing works

Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes.

Loo, S., Rich, E. C., Ishii, J., McGough, J., McCracken, J., Nelson, S., & Smalley, S. (2008) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2008.01928.x · Cited by 48 · see citing works

No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity

Kereszturi, É., Király, O., Barta, C., Molnár, N., Sasvári‐Székely, M., & Csapó, Z. (2006) · BMC Molecular Biology · doi:10.1186/1471-2199-7-18 · Cited by 40 · see citing works

Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder

Mill, J. S., Fisher, N., Curran, S. R., Richards, S., Taylor, E. A., & Asherson, P. J. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00011 · Cited by 40 · see citing works

No evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study

Brookes, K., Xu, X.-H., Chen, C.-K., Huang, Y.-S., Wu, Y., & Asherson, P. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-31 · Cited by 40 · see citing works

Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder

Biederman, J., Petty, C. R., Ten Haagen, K. S., Small, J., Doyle, A. E., Spencer, T., Mick, E., Monuteaux, M. C., Smoller, J. W., & Faraone, S. V. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.12.016 · Cited by 38 · see citing works

Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves

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The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study

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Association of the dopamine receptor D1 gene, DRD1, with inattention symptoms in families selected for reading problems

Luca, P., Laurin, N., Misener, V. L., Wigg, K., Anderson, B. J., Cate‐Carter, T., Tannock, R., Humphries, T., Lovett, M. W., & Barr, C. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001972 · Cited by 37 · see citing works

Double dissociation between lab measures of inattention and impulsivity and the dopamine transporter gene (DAT1) and dopamine D4 receptor gene (DRD4)

Gizer, I. R., & Waldman, I. D. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0028225 · Cited by 36 · see citing works

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists

Matulenko, M. A., Hakeem, A. A., Kolasa, T., Nakane, M., Terranova, M. A., Uchic, M. E., Miller, L. N., Chang, R., Donnelly‐Roberts, D. L., Namovic, M. T., et al. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.04.035 · Cited by 36 · see citing works

A case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: Evidence of association with the −521 C/T SNP

Yang, J.-W., Jang, W.-S., Hong, S. D., Ji, Y., Kim, D. H., Park, J., Kim, S. W., & Joung, Y. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.016 · Cited by 35 · see citing works

Relations between multi-informant assessments of ADHD symptoms, DAT1, and DRD4.

Gizer, I., Waldman, I., Abramowitz, A. J., Barr, C., Feng, Y., Wigg, K., Misener, V., & Rowe, D. C. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013297 · Cited by 33 · see citing works

Personality Mediation of Genetic Effects on Attention-Deficit/Hyperactivity Disorder

Martel, M. M., Nikolas, M. A., Jernigan, K. A., Friderici, K. H., & Nigg, J. T. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9392-3 · Cited by 35 · see citing works

Gender differences in genetic linkage and association on 11p15 in obsessive–compulsive disorder families

Wang, Y., SAMUELS, J. F., Chang, Y.-P. C., Grados, M. A., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Rauch, S. L., Murphy, D. L., Rasmussen, S. A., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30760 · Cited by 34 · see citing works

Diversity in Pathways to Common Childhood Disruptive Behavior Disorders

Martel, M. M., Nikolas, M., Jernigan, K. A., Friderici, K., & Nigg, J. (2012) · Journal of Abnormal Child Psychology · doi:10.1007/s10802-012-9646-3 · Cited by 32 · see citing works

Meta‐analysis of the heterogeneity in association of DRD4 7‐repeat allele and AD/HD: Stronger association with AD/HD combined type

Smith, T. F. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31090 · Cited by 33 · see citing works

Molecular genetics of attention-deficit hyperactivity disorder (ADHD): an update

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2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356

Bergauer, M., Hübner, H., & Gmeiner, P. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)00316-5 · Cited by 31 · see citing works

Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy

Löber, S., Tarek Aboul-fadl, A., Hübner, H., & Gmeiner, P. (2002) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(01)00814-9 · Cited by 31 · see citing works

The dopamine receptor DRD4 gene

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Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5

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Association of dopamine D4 receptor (DRD4) polymorphisms with attention deficit hyperactivity disorder in Indian population

Bhaduri, N., Das, M., Sinha, S., Chattopadhyay, A., Gangopadhyay, P., Chaudhuri, K., Singh, M., & Mukhopadhyay, K. (2006) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30225 · Cited by 41 · see citing works

The broad autism phenotype: A complementary strategy for molecular genetic studies of autism

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Dopamine DRD4 receptor polymorphism and attention deficit hyperactivity disorder

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