Green Tea Extract Suppresses the Age-Related Increase in Collagen Crosslinking and Fluorescent Products in C57BL/6 Mice
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Collagen crosslinking during aging in part results from Maillard reaction endproducts of glucose and oxoaldehydes. Because of the tight link between oxidative and carbonyl stress, we hypothesized that natural antioxidants and "nutriceuticals" could block collagen aging in C57BL/6 mice. Six groups of young and adult mice received vitamin C, vitamin E, vitamin C&E, blueberry, green tea extract (GTE), or no treatment for a period of 14 weeks. Body weights and collagen glycation were unaltered by the treatment. However, GTE or vitamin C&E combined blocked tendon crosslinking at 10 months of age (p < 0.05, adult group). GTE also blocked fluorescent products at 385 and 440 nm (p = 0.052 and < 0.05, respectively) and tended to decrease skin pentosidine levels. These results suggest that green tea is able to delay collagen aging by an antioxidant mechanism that is in part duplicated by the combination of vitamin C and E.
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A study in C57BL/6 mice showed that green tea extract reduced collagen cross-linking and UVB-induced oxidative changes in the structures of proteins.
“A study in C57BL/6 mice showed that green tea extract reduced collagen cross-linking and UVB-induced oxidative changes in the structures of proteins [216].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [216]
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Banakar, F., Ebrahim‐Habibi, A., Amoli, M. M., Kheirbakhsh, R., Afjeh, M. S., Shahriari, S., & Larijani, B. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00794-3 · Cited by 1 · see citing works
“GT has also been suggested to have protective effects against Parkinson’s disease, Alzheimer’s disease [22], and ischemic damage [23], as well as anti-diabetic, antioxidants [24], and anti-aging effects [25] in experimental models.”
BackgroundDiscovering the Link Between Nutrition and Skin Aging
Liakou, A. Ι., Pappas, A., & Zouboulis, C. C. (2016) · Springer eBooks · doi:10.1007/978-3-662-47398-6_134 · Cited by 1 · see citing works
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Trapping of Methylglyoxal by Tea Polyphenols
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Oral and Other Non-sunscreen Photoprotective Agents
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Detecting and Monitoring Nutrients on Skin Using Noninvasive Methods
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Discovering the Link Between Nutrition and Skin Aging
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Trapping of Methylglyoxal by Tea Polyphenols
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“Collagen crosslinking was studied in C57BL/6 mice [28].”
BackgroundChelu, M., Popa, M., Anastasescu, M., Aricov, L., Cusu, J. P., Marinescu, G., Ștefan, L. M., Seciu‐Grama, A., Plangu, A., & Moreno, J. M. C. (2026) · Materials Today Communications · doi:10.1016/j.mtcomm.2026.115371
- Authors
- Rutter, Sell, Fraser, Obrenovich, Zito, Starke-Reed, & Monnier
- Affiliations
- Yorktown High School, Arlington, VA 22207, USA
- National Institutes of Health (US)
- Case Western Reserve University (US)
- National Institute of Diabetes, Digestive and Kidney Diseases, NIH, 31 Center Drive, MSC 2560, Bethesda, MD 20892-2560, USA
- Venue
- International Journal for Vitamin and Nutrition Research
- Publisher
- IMR Press
- Published
- 2003-12-01
- Volume
- 73
- Issue
- 6
- Pages
- 453-460
- ISSN
- 0020-9406 (ISSN-L)
- 0300-9831
- 1664-2821
- PMC
- PMC3561737
- OpenAlex
- W2017574505
- Cited by
- 76
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- International Journal for Vitamin and Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG 18629, R01AG018629)
- National Eye Institute (R01EY007099)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Keywords
- green tea extract, collagen cross-linking, collagen aging, Maillard reaction, advanced glycation end products, pentosidine, vitamin C, vitamin E, antioxidants, nutraceuticals, tendons, skin, oxidative stress, carbonyl stress, C57BL/6 mice
- MeSH terms
- Aging, Animals, Antioxidants, Ascorbic Acid, Body Weight, Collagen, Cross-Linking Reagents, Fluorescence, Mice, Inbred C57BL, Plant Extracts, Random Allocation, Tea, Vitamin E, Maillard Reaction, Mice
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