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Cited by 565Bipolar Disorder and TreatmentSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review

Bearden, Carrie E, Hoffman, Kathleen M, Cannon, Tyrone D·2001·Bipolar Disorders
DOI 10.1034/j.1399-5618.2001.030302.x
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Abstract

UNLABELLED: Bearden CE, Hoffman KM, Cannon TD. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord 2001: 3: 106 150. C Munksgaard, 2001 OBJECTIVES: To present a comprehensive review of the existing neuropsychological and neuroimaging literature on bipolar affective disorder. This review critically evaluates two common conceptions regarding the neuropsychology of bipolar disorder: 1) that, in contrast to schizophrenia, bipolar affective disorder is not associated with general cognitive impairment independent of illness episodes, and 2) relative right hemisphere (RH) dysfunction is implicated in bipolar illness patients, supported by reports of relatively greater impairment in visuospatial functioning, lateralization abnormalities, and mania secondary to RH lesions. METHODS: The major computerized databases (Medline and PSYCInfo) were consulted in order to conduct a comprehensive, integrated review of the literature on the neuropsychology and neuroanatomy of bipolar disorder. Articles meeting specified criteria were included in this review. RESULTS: In a critical evaluation of the above notions, this paper determines that: 1) while there is little evidence for selective RH dysfunction, significant cognitive impairment may be present in bipolar illness, particularly in a subgroup of chronic, elderly or multiple-episode patients, suggesting a possible toxic disease process, and 2) the underlying functional correlate of these cognitive deficits may be white matter lesions ('signal hyperintensities') in the frontal lobes and basal ganglia, regions critical for executive function, attention, speeded information processing, learning and memory, and affect regulation. While this hypothesized neural correlate of cognitive impairment in bipolar disorder is speculative, preliminary functional neuroimaging evidence supports the notion of frontal and subcortical hypometabolism in bipolar illness. CONCLUSIONS: The etiology of the structural brain abnormalities commonly seen in bipolar illness, and their corresponding functional deficits, remains unknown. It is possible that neurodevelopmental anomalies may play a role, and it remains to be determined whether there is also some pathophysiological progression that occurs with repeated illness episodes. More research is needed on first-episode patients, relatives of bipolar probands, and within prospective longitudinal paradigms in order to isolate disease-specific impairments and genetic markers of neurocognitive function in bipolar disorder.

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Crossref · 10.1034/j.1399-5618.2001.030302.x

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Citations

Cites

Research works printed but not linked: 11

  1. Flor‐Henry P, 1983, Functional hemispheric asymmetry and psychopathology, Integr Psychiatry, 1, 46
  2. Flor‐Henry P, 1979, Neuropsychological investigation of schizophrenia and manic‐depressive psychoses
  3. Wechsler D, 1981, Wechsler Adult Intelligence Scale – Revised Manual
  4. Wade J, 1988, Neuropsychological dysfunction in schizophrenia and bipolar disorder, J Clin Exper Neuropsychol, 10, 71
  5. Callaghan JE: The effect of electroconvulsive therapy on the test performances of hospitalized depressed patients. Unpublished doctoral dissertation University of London 1952.
  6. 10.1037//0021-843X.94.4.470 · DOI
  7. Hauser P (Ed), 1991, Brain Imaging in Affective Disorders
  8. 10.1037//0033-2909.118.2.183 · DOI · Paper page
  9. Appel B, 1988, White matter diseases or leuko‐araiosis of degenerative origin., J Belge Radiol, 71, 67
  10. Olson S, 1990, Sulcal, medial temporal and ventricular abnormalities by MRI: comparing major psychoses, Biological Psychiatry, 27, 41A
  11. Guze BH, 1991, Brain Imaging in Affective Disorders. Progress in Psychiatry Series, No. 34, 63

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Metadata

Authors
Bearden, C. E., Hoffman, K. M., & Cannon, T. D.
Affiliations
  • University of Pennsylvania (US)
  • Children's Hospital of Philadelphia (US)
  • University of California, Los Angeles (US)
Corresponding author
Bearden, Carrie E
ORCID
Venue
Bipolar Disorders
Publisher
Wiley
Published
2001-06
Volume
3
Issue
3
Pages
106-150
ISSN
  • 1398-5647 (ISSN-L)
  • 1399-5618
DOI
10.1034/j.1399-5618.2001.030302.x
OpenAlex
W2009485462
Cited by
565
References
196
Citations by year
2026: 3 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 25 · 2013: 37 · 2012: 24
FWCI
3.97
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 226 d)
Locations
  • Bipolar Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
bipolar disorder, neuropsychology, neuroanatomy, cognitive impairment, right hemisphere dysfunction, visuospatial impairment, white matter lesions, frontal lobe hypometabolism, basal ganglia, executive function, neurodevelopmental anomalies, disease progression, mania
MeSH terms
Adult, Basal Ganglia, Bipolar Disorder, Brain, Cognition Disorders, Female, Frontal Lobe, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Severity of Illness Index, Mood Disorders

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