A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder

Robinson, Lucy J.; Thompson, Jill M.; Gallagher, Peter; Goswami, Utpal; Young, Allan H.; Ferrier, I. Nicol; Moore, P. Brian

doi:10.1016/j.jad.2006.02.016

Cited by 962Bipolar Disorder and TreatmentSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder

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Robinson, Lucy J., Thompson, Jill M., Gallagher, Peter, Goswami, Utpal, Young, Allan H., Ferrier, I. Nicol, Moore, P. Brian·2006·Journal of Affective Disorders

DOI 10.1016/j.jad.2006.02.016

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Abstract

Background A number of studies have reported evidence of cognitive deficits in euthymic bipolar patients. Qualitative reviews of the literature have indicated impairments in executive functions and declarative memory are most consistently reported. However, not all primary studies conducted to date have had sufficient power to detect statistically significant differences and there have been few attempts to quantify the magnitude of impairments. This review aims to combine data from available studies to identify the profile of neuropsychological deficits in euthymic bipolar patients and quantify their magnitude. Method Systematic literature review and meta-analysis. Results Large effect sizes (d>or=0.8) were noted for aspects of executive function (category fluency, mental manipulation) and verbal learning. Medium effect sizes (0.5<or=d<0.8) were found for aspects of immediate and delayed verbal memory, abstraction and set-shifting, sustained attention, response inhibition, and psychomotor speed. Small effect sizes (0.2<or=d<0.5) were reported for verbal fluency by letter, immediate memory, and sustained attention. Limitations Sufficient data were not available to investigate all domains. For example analyses did not include measures of visuospatial function. Conclusion Euthymic bipolar patients demonstrate relatively marked impairment in aspects of executive function and verbal memory. It is not yet clear whether these are two discrete areas of impairment or are related to one another. Future investigations should clarify the functional significance of deficits and indicate whether patients will benefit from ameliorative interventions.

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The DSST has demonstrated strong correlation with overall cognitive functioning and functional outcomes in patients with acute depression, schizophrenia, and bipolar disorders.
“The DSST, a cognitive performance measure that assesses a variety of cognitive functions including processing speed and executive functions, has demonstrated strong correlation with overall cognitive functioning and functional outcomes in patients with acute depression (Raskin et al, 2007), schizophrenia (Dickinson et al, 2007), and bipolar disorders (Robinson et al, 2006).”
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Authors: Robinson, L. J., Thompson, J. M., Gallagher, P., Goswami, U., Young, A. H., Ferrier, I. N., & Moore, P. B.
Affiliations: Royal Victoria Infirmary (GB)
West Park Hospital (GB)
Corresponding author: Ferrier, I. Nicol
ORCID: Robinson, Lucy J.
Gallagher, Peter
Young, Allan H.
Ferrier, I. Nicol
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2006-07
Volume: 93
Issue: 1-3
Pages: 105-115
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2006.02.016
OpenAlex: W2097812147
Cited by: 962
References: 4
Citations by year: 2026: 25 · 2025: 33 · 2024: 29 · 2023: 25 · 2022: 28 · 2021: 55 · 2020: 39 · 2019: 53 · 2018: 37 · 2017: 47 · 2016: 54 · 2015: 69 · 2014: 65 · 2013: 75 · 2012: 66
FWCI: 6.85
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Newcastle University ePrints (Newcastle Univesity)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: bipolar disorder, euthymic bipolar patients, cognitive impairment, executive function, verbal memory, verbal learning, semantic fluency, set-shifting, response inhibition, sustained attention, psychomotor speed, neuropsychological deficits
MeSH terms: Affect, Bipolar Disorder, Cognition Disorders, Humans, Neuropsychological Tests

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A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder

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