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Cited by 65Skin Protection and Agingmelanin and skin pigmentationAdvanced Glycation End Products research

Photoaging and oxidative stress

Nishigori, Chikako, Hattori, Yukari, Arima, Yaeno, Miyachi, Yoshiki·2003·Experimental Dermatology
DOI 10.1034/j.1600-0625.12.s2.3.x
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Abstract

Photoaging is significantly different from chronological aging in both clinical and histological appearance. It has been suggested that oxidative stress, generated by ultraviolet radiation (UVR), leads to photoaging over a long period. The presence of 8-OHdG, and oxidatively modified proteins such as 4-hydroxy-2-nonenal-modified protein, 3-L-nitro-tyrosine and N(-epsilon) (carboxymethyl)lysine in UV-exposed skin specimens, supports this theory. The pathophysiology of photoaging of the skin caused by chronic inflammation after UVR is reviewed and discussed, with a focus on oxidative stress.

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Crossref · 10.1034/j.1600-0625.12.s2.3.x

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15 of 15 references verified0 citation errors · 0 not checkable

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  • Skin ageing is influenced by two mechanisms: intrinsic (genetic, chronological) ageing and extrinsic ageing (photoaging) caused by environmental factors including UV radiation, environmental pollution and cigarette smoke.

    “One of the most common dermatological and cosmetic concerns is skin ageing: a natural, complex process influenced by two mechanisms—intrinsic (genetic, chronological) ageing resulting from the passage of time, and extrinsic ageing (photoaging), caused by environmental factors (including UV radiation, environmental pollution and cigarette smoke) [5,6,7,8].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [7]

  • Oxidative stress may result in cell damage, leading to the development of many types of diseases and aging.

    “Oxidative stress may result in cell damage, thus leading to the development of many types of diseases, as well as aging [1].”

    From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [1]

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Authors
Nishigori, C., Hattori, Y., Arima, Y., & Miyachi, Y.
Affiliations
  • Kobe University (JP)
  • Kyoto University (JP)
Corresponding author
Nishigori, Chikako
ORCID
Venue
Experimental Dermatology
Publisher
Wiley
Published
2003-10
Volume
12
Issue
s2
Pages
18-21
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
DOI
10.1034/j.1600-0625.12.s2.3.x
OpenAlex
W2098182055
Cited by
65
References
15
Citations by year
2026: 2 · 2025: 1 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 4 · 2018: 4 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
3.34
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 33 d)
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords
photoaging, oxidative stress, ultraviolet radiation, 8-hydroxy-2'-deoxyguanosine, 4-hydroxynonenal, nitrotyrosine, oxidized proteins, chronic inflammation, skin aging, chronological aging
MeSH terms
8-Hydroxy-2'-Deoxyguanosine, Animals, Arginine, Cells, Cultured, Deoxyguanosine, Fibroblasts, Humans, Lysine, Mice, Hairless, Skin, Tyrosine, Ultraviolet Rays, Skin Aging, Oxidative Stress, Mice

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