Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial: Photoprotection by lycopene
Open accessAbstract
BACKGROUND: Previous epidemiological, animal and human data report that lycopene has a protective effect against ultraviolet radiation (UVR)-induced erythema. OBJECTIVES: We examined whether tomato paste--rich in lycopene, a powerful antioxidant--can protect human skin against UVR-induced effects partially mediated by oxidative stress, i.e. erythema, matrix changes and mitochondrial DNA (mtDNA) damage. METHODS: In a randomized controlled study, 20 healthy women (median age 33 years, range 21-47; phototype I/II) ingested 55 g tomato paste (16 mg lycopene) in olive oil, or olive oil alone, daily for 12 weeks. Pre- and postsupplementation, UVR erythemal sensitivity was assessed visually as the minimal erythema dose (MED) and quantified with a reflectance instrument. Biopsies were taken from unexposed and UVR-exposed (3 × MED 24 h earlier) buttock skin pre- and postsupplementation, and analysed immunohistochemically for procollagen (pC) I, fibrillin-1 and matrix metalloproteinase (MMP)-1, and by quantitative polymerase chain reaction for mtDNA 3895-bp deletion. RESULTS: Mean ± SD erythemal D(30) was significantly higher following tomato paste vs. control (baseline, 26·5 ± 7·5 mJ cm(-2); control, 23 ± 6·6 mJ cm(-2); tomato paste, 36·6 ± 14·7 mJ cm(-2); P = 0·03), while the MED was not significantly different between groups (baseline, 35·1 ± 9·9 mJ cm(-2); control, 32·6 ± 9·6 mJ cm(-2); tomato paste, 42·2 ± 11·3 mJ cm(-2)). Presupplementation, UVR induced an increase in MMP-1 (P = 0·01) and a reduction in fibrillin-1 (P = 0·03). Postsupplementation, UVR-induced MMP-1 was reduced in the tomato paste vs. control group (P = 0·04), while the UVR-induced reduction in fibrillin-1 was similarly abrogated in both groups, and an increase in pCI deposition was seen following tomato paste (P = 0·05). mtDNA 3895-bp deletion following 3 × MED UVR was significantly reduced postsupplementation with tomato paste (P = 0·01). CONCLUSIONS: Tomato paste containing lycopene provides protection against acute and potentially longer-term aspects of photodamage.
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Oral administration of tomato paste containing lycopene provides protection against photodamage, as shown by reduced MMP-1 expression and mtDNA damage in upper buttock skin in a 12-week randomized controlled trial.
“The tomato paste group showed reduced expression of MMP-1 and mtDNA damage in the upper buttock skin, suggesting that oral administration of tomato paste containing lycopene provides protection against photodamage [99].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [99]
Consumption of tomato paste protects against acute and long-term photodamage.
“Accordingly, consumption of tomato paste has been shown, in a randomized controlled study, to protect against acute and long-term photodamage [112].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [112]
Supplementation of tomato paste before UV exposure dampened skin erythema and reduced mitochondrial DNA damage.
“In particular, supplementation of tomato paste before UV exposure was able to dampen skin erythema and to reduce mitochondrial DNA damage [112, 113].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [112]
Lycopene is able to protect human skin against UVR-induced effects partially mediated by oxidative stress such as dermal erythema and mitochondrial DNA damage.
“One study showed that lycopene, a carotenoid antioxidant found in red fruit and vegetables, is able to protect human skin against UVR-induced effects partially mediated by oxidative stress such as dermal erythema and mitochondrial DNA damage [48].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [48]
Tomato paste can protect human skin against UVR-induced effects partially mediated by oxidative stress such as erythema and extracellular changes such as mtDNA damage.
“In addition, a study showed that tomato paste can protect human skin against UVR-induced effects partially mediated by oxidative stress such as erythema (skin redness) and extracellular changes such as mtDNA damage [Rizwan et al., 2011].”
From Oxidative stress and ageing (2016) · cites this paper as Rizwan et al., 2011
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- Authors
- Rizwan, M., Rodriguez-Blanco, I., Harbottle, A., Birch-Machin, M. A., Watson, R. E. B., & Rhodes, L. E.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Newcastle University (GB)
- Corresponding author
- Rhodes, L.E.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11-29
- Volume
- 164
- Issue
- 1
- Pages
- 154-162
- ISSN
- 0007-0963 (ISSN-L)
- OpenAlex
- W2142441374
- Cited by
- 167
- References
- 48
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 11 · 2021: 16 · 2020: 9 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 17 · 2012: 11
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- British Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- lycopene, tomato paste, ultraviolet radiation, erythema, oxidative stress, mitochondrial DNA damage, MMP-1, fibrillin-1, type I procollagen, dietary supplementation, antioxidants, skin aging, sun protection, olive oil vehicle, skin biopsy histopathology
- MeSH terms
- Fibrillins, Fibrillin-1, Lycopene, Adult, Antioxidants, Biopsy, Buttocks, Carotenoids, DNA Damage, DNA, Mitochondrial, Dose-Response Relationship, Radiation, Erythema, Female, Humans, Immunohistochemistry, Microfilament Proteins, Middle Aged, Procollagen, Skin, Ultraviolet Rays, Polymerase Chain Reaction, Sequence Deletion, Solanum lycopersicum, Dietary Supplements, Matrix Metalloproteinase 1, Plant Preparations, Adipokines, Young Adult
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