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Cited by 42Child and Adolescent Psychosocial and Emotional DevelopmentGenetic Associations and EpidemiologyTreatment of Major Depression

Clinical features of major depressive disorder in adolescents and their relatives: Impact on familial aggregation, implications for phenotype definition, and specificity of transmission

Klein, Daniel N., Lewinsohn, Peter M., Rohde, Paul, Seeley, John R., Durbin, C. Emily·2002·Journal of Abnormal Psychology
DOI 10.1037/0021-843x.111.1.98
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Abstract

Three questions were addressed using family study data from a community sample: (a) Which clinical features of major depressive disorder (MDD) in adolescents are associated with elevated rates of MDD in relatives? (b) Which features of MDD in relatives distinguish family members of depressed adolescents from relatives of adolescents without mood disorders (NMD)? and (c) Do depressed adolescents with particular features have higher proportions of depressed relatives with the same features? Participants included 268 MDD adolescents, 401 NMD adolescents, and their 2,202 first-degree relatives. Rates of MDD were highest among relatives of depressed adolescents with recurrent episodes and greater impairment. Depression severity best distinguished the relatives of depressed adolescents from relatives of controls. Specific clinical features did not aggregate in families.

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  • Higher tendency towards neuroticism is associated with a higher risk of recurrence of MDD.

    “Individuals with a higher tendency towards neuroticism, which was not measured in our study, were being consistently reported to be associated with a higher risk of recurrence [56, 57].”

    From Predictors of recurrence of major depressive disorder (2020) · cites this paper as [57]

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Authors
Klein, D. N., Lewinsohn, P. M., Rohde, P., Seeley, J. R., & Durbin, C. E.
Affiliations
State University of New York (US)
ORCID
Venue
Journal of Abnormal Psychology
Publisher
American Psychological Association (APA)
Published
2002-02
Volume
111
Issue
1
Pages
98-106
ISSN
  • 0021-843X (ISSN-L)
  • 1939-1846
DOI
10.1037/0021-843x.111.1.98
OpenAlex
W2011553596
Cited by
42
References
47
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Abnormal Psychology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH052858, R01MH040501, MH40501, MH 50522, R01MH050522, MH 52858)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
major depressive disorder, adolescents, familial aggregation, family studies, clinical features, recurrence, depression severity, impairment, phenotype definition, mood disorders
MeSH terms
Adolescent, Psychology, Adolescent, Adult, Major Depressive Disorder, Family, Female, Humans, Male, Parent-Child Relations, Phenotype

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