Cited by 239Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsPsychological Treatments and Assessments

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Meta-Analysis of Cognitive-Behavioral Treatments for Generalized Anxiety Disorder: A Comparison With Pharmacotherapy.

Mitte, Kristin·2005·Psychological Bulletin

DOI 10.1037/0033-2909.131.5.785

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Abstract

The efficacy of (cognitive) behavioral therapy ([C]BT) for generalized anxiety disorder was investigated and compared with the efficacy of pharmacological therapy using meta-analytic techniques. A total of 65 (C)BT studies and pharmacological studies were included. (C)BT was more effective than control conditions. The results of the comparison between (C)BT and pharmacotherapy varied according to the meta-analytic methods used. Conclusions about differences in efficacy between therapy approaches are limited when all available studies are included owing to a number of factors that influence effect sizes. When only those studies that directly compared both therapies were included in the analysis, there were no significant differences in efficacy. Attrition rates were lower for (C)BT, indicating that it is better tolerated by patients.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646
An inventory for measuring clinical anxiety: Psychometric properties.
Beck, A. T., Epstein, N., Brown, G., & Steer, R. A. (1988) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.56.6.893 · Cited by 14,407
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,377
Statistical Methods for Rates and Proportions.
Everitt, B. S., & Fleiss, J. L. (1981) · Biometrics · doi:10.2307/2530193 · Cited by 9,034
Diagnostic and Statistical Manual of Mental Disorders, 3rd ed
Cooper, A. M., & Michels, R. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.1.128 · Cited by 7,419
Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.) Diagnostic and Statistical Manual of Mental Disorders (3rd ed. rev.) American Psychiatric Association (1987). American Psychiatric Press, Inc., 1400 K Street, NW, Washington, DC 20005. 567 pp., $39.95 hardcover; $29.95 softcover.
Drake, M. M. (1988) · American Journal of Occupational Therapy · doi:10.5014/ajot.42.10.683b · Cited by 5,303
Development and validation of the Penn State Worry Questionnaire
Meyer, T. J., Miller, M. L., Metzger, R. L., & Borkovec, T. D. (1990) · Behaviour Research and Therapy · doi:10.1016/0005-7967(90)90135-6 · Cited by 5,099
Statistical Methods for Rates and Proportions, 2nd ed
GROVE, W. A. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.12.1644-a · Cited by 3,756
The Handbook of Research Synthesis.
Howel, D., Cooper, H., & Hedges, L. V. (1995) · Biometrics · doi:10.2307/2533295 · Cited by 3,657
Methods of Meta-Analysis
Hunter, J., & Schmidt, F. (2004) · doi:10.4135/9781412985031 · Cited by 3,023
Fixed-and random-effects models in meta-analysis.
Hedges, L. V., & Vevea, J. L. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.4.486 · Cited by 2,977
Statistical Methods for Meta-Analysis
(1985) · Elsevier eBooks · doi:10.1016/c2009-0-03396-0 · Cited by 2,570
The benefits of psychotherapy
Smith, M. L., Glass, G. V., & Miller, T. I. (1980) · Medical Entomology and Zoology · Cited by 2,123
The efficacy of psychological, educational, and behavioral treatment: Confirmation from meta-analysis.
Lipsey, M. W., & Wilson, D. B. (1993) · American Psychologist · doi:10.1037/0003-066x.48.12.1181 · Cited by 2,033
Parametric measures of effect size.
Rosenthal, R. (1994) · Cited by 1,856
Emotional disorders and metacognition: innovative cognitive therapy: Adrian Wells John Wiley & Sons Ltd, 2000, 254 pages, £22.50 ISBN 0‐471‐49169‐1
(2002) · Journal of Psychiatric and Mental Health Nursing · doi:10.1046/m.1365-2850.2002.00006.x · Cited by 1,143
The Handbook of Research Synthesis
Hanka, R. (1994) · BMJ · doi:10.1136/bmj.309.6952.488a · Cited by 1,065
DSM-III-R Generalized Anxiety Disorder in the National Comorbidity Survey
Wittchen, H.-U. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950050015002 · Cited by 967
Synthesizing standardized mean‐change measures
Becker, B. J. (1988) · British Journal of Mathematical and Statistical Psychology · doi:10.1111/j.2044-8317.1988.tb00901.x · Cited by 889
Efficacy of applied relaxation and cognitive-behavioral therapy in the treatment of generalized anxiety disorder
Borkovec, T. D., & Costello, E. (1993) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.61.4.611 · Cited by 756
Biofeedback and Self-Regulation
Bergum, B. O., Birbaumer, N., & Kimmel, H. D. (1980) · The American Journal of Psychology · doi:10.2307/1422377 · Cited by 709
The handbook of psychotherapy and behaviour change
Eysenck, H. J. (1979) · Behaviour Research and Therapy · doi:10.1016/0005-7967(79)90071-8 · Cited by 622
Expanding our conceptualization of and treatment for generalized anxiety disorder: integrating mindfulness/acceptance-based approaches with existing cognitive-behavioral models
Roemer, L., & Orsillo, S. M. (2002) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.9.1.54 · Cited by 621
A component analysis of cognitive-behavioral therapy for generalized anxiety disorder and the role of interpersonal problems.
Borkovec, T. D., Newman, M. G., Pincus, A. L., & Lytle, R. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.2.288 · Cited by 565
Benzodiazepines: use, abuse, and consequences.
Woods, J. H., Katz, J. L., & Winger, G. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00468-5 · Cited by 560
A meta-analysis of treatment outcome for panic disorder
Gould, R. A., Ott, M. W., & Pollack, M. H. (1995) · Clinical Psychology Review · doi:10.1016/0272-7358(95)00048-8 · Cited by 520
Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication.
Kirsch, I., & Sapirstein, G. (1998) · Prevention & Treatment · doi:10.1037/1522-3736.1.1.12a · Cited by 509
Stochastically dependent effect sizes.
Gleser, L. J., & Olkin, I. (1994) · Cited by 485
Untitled work
(1994) · Cited by 463
Efficacy of a cognitive-behavioral treatment for generalized anxiety disorder: Evaluation in a controlled clinical trial
Ladouceur, R., Dugas, M. J., Freeston, M. H., Léger, E., Gagnon, F., & Thibodeau, N. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.6.957 · Cited by 446
Fixed effects models.
Hedges, L. V. (1994) · Cited by 397
A comparison of fixed-effects and mixed (random-effects) models for meta-analysis tests of moderator variable effects.
Overton, R. C. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.3.354 · Cited by 365
Comparison of behavior therapy and cognitive behavior therapy in the treatment of generalized anxiety disorder
Butler, G., Fennell, M., Robson, P., & Gelder, M. (1991) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.59.1.167 · Cited by 365
Cognitive behavioral and pharmacological treatment of generalized anxiety disorder: A preliminary meta-analysis
Gould, R. A., Otto, M. W., Pollack, M. H., & Yap, L. (1997) · Behavior Therapy · doi:10.1016/s0005-7894(97)80048-2 · Cited by 352
Using odds ratios as effect sizes for meta-analysis of dichotomous data: A primer on methods and issues.
Haddock, C., Rindskopf, D., & Shadish, W. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.3.339 · Cited by 349
Assessing psychotherapy outcomes and processes.
Lambert, M. J., & Hill, C. E. (1994) · Cited by 231
Behavioral treatment of generalized anxiety disorder
Barlow, D. H., Rapee, R. M., & Brown, T. A. (1992) · Behavior Therapy · doi:10.1016/s0005-7894(05)80221-7 · Cited by 221
Researcher allegiance and meta-analysis: The case of cognitive therapy for depression.
Gaffan, E. A., Tsaousis, I., & Kemp-Wheeler, S. M. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.63.6.966 · Cited by 194
THEORETICAL FOUNDATIONS OF COGNITIVE-BEHAVIOR THERAPY FOR ANXIETY AND DEPRESSION
Brewin, C. R. (1996) · Annual Review of Psychology · doi:10.1146/annurev.psych.47.1.33 · Cited by 184
Panic and generalized anxiety disorders: Nature and treatment
Barlow, D. H., Cohen, A. S., Waddell, M. T., Vermilyea, B. B., Klosko, J. S., Blanchard, E. B., & Nardo, P. A. D. (1984) · Behavior Therapy · doi:10.1016/s0005-7894(84)80048-9 · Cited by 175
Cooper, Harris, and Larry V. Hedges, eds., The Handbook of Research Synthesis. New York: Russell Sage Foundation, 1994.
Cooper, H. M., & Hedges, L. V. (1994) · Journal of International Crisis and Risk Communication Research · Cited by 170
A controlled comparison of cognitive- behaviour therapy, Diazepam, and placebo, alone and in combination, for the treatment of generalised anxiety disorder
Power, K., Simpson, R., Swanson, V., Wallace, L. A., Feistner, A. T. C., & Sharp, D. (1990) · Journal of Anxiety Disorders · doi:10.1016/0887-6185(90)90026-6 · Cited by 166
The effects of relaxation training with cognitive or nondirective therapy and the role of relaxation-induced anxiety in the treatment of generalized anxiety.
Borkovec, T. D., Mathews, A., Chambers, A., Ebrahimi, S., Lytle, R. A., & Nelson, R. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.6.883 · Cited by 151
How interchangeable are different estimators of effect size?
Ray, J. W., & Shadish, W. R. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.6.1316 · Cited by 137
A Meta-analytic Review of the Efficacy of Drug Treatment in Generalized Anxiety Disorder
Mitte, K., Noack, P., Steil, R., & Hautzinger, M. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000155821.74832.f9 · Cited by 137
Self-citation
Anxiety Management for Persistent Generalised Anxiety
Butler, G., Cullington, A., Hibbert, G. A., Klimeš, I., & Gelder, M. (1987) · The British Journal of Psychiatry · doi:10.1192/bjp.151.4.535 · Cited by 130
Random versus nonrandom assignment in controlled experiments: Do you get the same answer?
Shadish, W. R., & Ragsdale, K. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.6.1290 · Cited by 126
Assignment methods in experimentation: When do nonrandomized experiments approximate answers from randomized experiments?
Heinsman, D. T., & Shadish, W. R. (1996) · Psychological Methods · doi:10.1037/1082-989x.1.2.154 · Cited by 125
Clinical Uses of Benzodiazepines
Hollister, L. E., Müller-Oerlinghausen, B., Rickels, K., & Shader, R. I. (1993) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199312001-00001 · Cited by 125
Stress Control: A Controlled Comparative Investigation of Large Group Therapy for Generalized Anxiety Disorder
White, J., Keenan, M., & Brooks, N. H. (1992) · Behavioural Psychotherapy · doi:10.1017/s014134730001689x · Cited by 119
A Meta-Analysis of Common Factor and Specific Treatment Effects Across the Outcome Domains of the Phase Model of Psychotherapy
Stevens, S. E., Hynan, M. T., & Allen, M. R. (2000) · Clinical Psychology Science and Practice · doi:10.1093/clipsy.7.3.273 · Cited by 118
Biofeedback treatments of generalized anxiety disorder: Preliminary results
Rice, K. M., Blanchard, E. B., & Purcell, M. (1993) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf01848110 · Cited by 117
Generalised anxiety: A controlled treatment study
Blowers, C. M., Cobb, J. P., & Mathews, A. (1987) · Behaviour Research and Therapy · doi:10.1016/0005-7967(87)90057-x · Cited by 90
A controlled trial of treatments for generalized anxiety
Lindsay, W. R., Gamsu, C. V., McLaughlin, E., Hood, E. M., & Espie, C. A. (1987) · British Journal of Clinical Psychology · doi:10.1111/j.2044-8260.1987.tb00718.x · Cited by 83
An empirical study of Hedge's homogeneity test.
Harwell, M. R. (1997) · Psychological Methods · doi:10.1037/1082-989x.2.2.219 · Cited by 66
A Controlled Comparison of Cognitive—Behaviour Therapy, Diazepam and Placebo in the Management of Generalized Anxiety
Power, K., Jerrom, D. W. A., Simpson, R., Mitchell, M. J., & Swanson, V. (1989) · Behavioural Psychotherapy · doi:10.1017/s0141347300015597 · Cited by 66
Cognitive restructuring treatment: A controlled trial with anxious patients
Woodward, R., & Jones, R. B. (1980) · Behaviour Research and Therapy · doi:10.1016/0005-7967(80)90005-4 · Cited by 60
A self-help treatment program for anxiety state patients
Jannoun, L., Oppenheimer, C., & Gelder, M. (1982) · Behavior Therapy · doi:10.1016/s0005-7894(82)80053-1 · Cited by 59
A Meta-Analysis of Common Factor and Specific Treatment Effects Across the Outcome Domains of the Phase Model of Psychotherapy
Stevens, S. E. (2000) · Clinical Psychology Science and Practice · doi:10.1093/clipsy/7.3.273 · Cited by 55
Untitled work
(2001) · PubMed · Cited by 54
Efficacy of self-examination therapy in the treatment of generalized anxiety disorder
Bowman, D. O., Scogin, F., Floyd, M., Patton, E., & Gist, L. (1997) · Journal of Counseling Psychology · doi:10.1037/0022-0167.44.3.267 · Cited by 47
Control groups in pharmacotherapy and psychotherapy evaluations.
Klein, D. F. (1997) · Prevention & Treatment · doi:10.1037/1522-3736.1.1.11a · Cited by 28
Wirksamkeit der kognitiven Verhaltenstherapie bei generalisierten Angsterkrankungen – Ergebnisseder Berliner KVT-GAD-Studie
Linden, M., Bär, T., Zubrägel, D., Ahrens, B., & Schlattmann, P. (2002) · Verhaltenstherapie · doi:10.1159/000066568 · Cited by 27
Anxiety management training and relaxation as self-control in the treatment of generalized anxiety in medical outpatients.
Cragan, M. K., & Deffenbacher, J. L. (1984) · Journal of Counseling Psychology · doi:10.1037/0022-0167.31.2.123 · Cited by 25
Cognitive behaviour therapy in generalised anxiety disorder.
Biswas, A., Biswas, D., & Chattopadhyay, P. K. (1995) · Indian journal of clinical psychology · Cited by 6
Control groups in psychotherapy research revisited.
Crits-Christoph, P. F. (1997) · Prevention & Treatment · doi:10.1037//1522-3736.1.1.12c · Cited by 4
The use of pill placebo as a control strategy in the evaluation of psychotherapy: Reply to Klein.
Heimberg, R. G. (1997) · Prevention & Treatment · doi:10.1037/1522-3736.1.1.13c · Cited by 3
Control groups in psychotherapy research revisited.
Crits-Christoph, P. F. (1997) · Prevention & Treatment · doi:10.1037/1522-3736.1.1.12c · Cited by 2
On a Proper Meta-Analytic Model for CorrelationsPreprint
Erez, A., Bloom, M., & Wells, M. T. (1995) · eCommons (Cornell University) · Cited by 1

Research works printed but not linked: 6

1980, Diagnostic and statistical manual of mental disorders
Begg, 1994, Publication bias., 399
Kessler, 2001, The association between chronic medical conditions and work impairment., 403
10.1093/clipsy/9.1.54 · DOI · Paper page
Shadish, 1994, Combining estimates of effect size., 261
Wells, 2000, Emotional disorders and metacognition: Innovative cognitive therapy.

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Hoffman, S. G., & Smits, J. A. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0415 · Cited by 1,420
Response rates for CBT for anxiety disorders: need for standardized criteria
Loerinc, A. G., Meuret, A. E., Twohig, M. P., Rosenfield, D., Bluett, E. J., & Craske, M. G. (2015) · Clinical Psychology Review · doi:10.1016/j.cpr.2015.08.004 · Cited by 592
The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta‐analysis of direct comparisons
Cuijpers, P., Sijbrandij, M., Koole, S. L., Andersson, G., Beekman, A. T., & Reynolds, C. F. (2013) · World Psychiatry · doi:10.1002/wps.20038 · Cited by 540
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Cuijpers, P., Sijbrandij, M., Koole, S., Huibers, M., Berking, M., & Andersson, G. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.01.002 · Cited by 527
Prediction as a Humanitarian and Pragmatic Contribution from Human Cognitive Neuroscience
Gabrieli, J. D. E., Ghosh, S., & Whitfield, S. (2015) · Neuron · doi:10.1016/j.neuron.2014.10.047 · Cited by 547

See all 239

Authors: Mitte, K.
Affiliations: Friedrich Schiller University Jena (DE)
Corresponding author: Mitte, Kristin
ORCID: Mitte, Kristin
Venue: Psychological Bulletin
Publisher: American Psychological Association (APA)
Published: 2005
Volume: 131
Issue: 5
Pages: 785-795
ISSN: 0033-2909 (ISSN-L)
1939-1455
DOI: 10.1037/0033-2909.131.5.785
OpenAlex: W1998351820
Semantic Scholar: 2d83d21bf41faf87e4501603548b126f73934a96
Cited by: 239
References: 77
Citations by year: 2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 14 · 2017: 21 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 20 · 2012: 20
FWCI: 1.69
Type: journal article
Language: en
Open access: closed
Locations: Psychological Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
Keywords: generalized anxiety disorder, cognitive behavioral therapy, pharmacotherapy, psychotherapy versus medication, treatment efficacy, attrition rates, treatment tolerability, meta-analytic methods
MeSH terms: Anxiety Disorders, Drug Therapy, Humans, Cognitive Behavioral Therapy

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Meta-Analysis of Cognitive-Behavioral Treatments for Generalized Anxiety Disorder: A Comparison With Pharmacotherapy.

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