The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning males versus females.
Abstract
Exposure to an acute stressful experience facilitates classical conditioning in male rats but impairs conditioning in female rats (T. J. Shors, C. Lewczyk, M. Paczynski, P. R. Mathew, & J. Pickett, 1998; G. E. Wood & T. J. Shors, 1998). The authors report that these effects extend to performance on the hippocampal-dependent task of trace conditioning. The stress-induced impairment of conditioning in females was evident immediately, 24 hr and 48 hr after stress, depending on the stage of estrus. Moreover, the effect could be reactivated days later by reexposure to the stressful context. Corticosterone levels correlated with overall performance in males but not in females. Unlike the effect seen in males, adrenalectomy did not prevent the stress-induced effect on conditioning in females. These data indicate that exposure to the same experience can have opposite effects on learning in males versus females and that these opposing effects are mediated by differing hormonal systems.
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“in tests of acute stress or aversive conditioning, stress enhances learning in males and impairs it in females89, 90”
From Neurobiology of resilience (2012) · cites this paper as [90]
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Cites
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Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
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“In contrast, acute tail shock stress during classical eyeblink conditioning improves performance in males, but suppresses it in females(100) by mechanisms influenced by gonadal hormones in development and in adult life.(101,102) However, giving male and female rats control over the shock abolishes both the stress effe…”
BackgroundNeurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853
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Metadata
- Authors
- Wood, G. E., Beylin, A. V., & Shors, T. J.
- Affiliations
- Rockefeller University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2001
- Volume
- 115
- Issue
- 1
- Pages
- 175-187
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2039652271
- Cited by
- 198
- References
- 97
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH059740, MH-59970, MH-59740, R01MH059970)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- stress, trace conditioning, sex differences, hippocampus-dependent learning, corticosterone, adrenalectomy, estrous cycle, reproductive hormones, adrenal hormones, classical conditioning, rats
- MeSH terms
- Adrenalectomy, Animals, Conditioning, Psychological, Corticosterone, Estrogens, Female, Hippocampus, Male, Progesterone, Sex Factors, Stress, Psychological, Rats, Sprague-Dawley, Rats
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