Contextual fear discrimination is impaired by damage to the postrhinal or perirhinal cortex
Abstract
Postrhinal (POR) or perirhinal (PER) cortex damage impairs acquisition and expression of contextual fear, but the nature of the impairment remains unclear. This study used a contextual fear discrimination paradigm that biased subjects toward using a configural, rather than an elemental, strategy to distinguish between 2 contexts, I of which was paired with a mild footshock. Control rats discriminated between 2 contexts when a combination of several cues could be used (Experiment 1), but not when individual sensory cues were manipulated (Experiment 2). Rats with POR or PER lesions could not discriminate between the shock and no-shock contexts when multiple cues differentiated the contexts (Experiment 3). The results indicate that both the POR and PER have a role in configural learning of contextual fear.
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PRC lesions disrupt some forms of context memory, including object-context associations, positional changes in object arrays, and contextual fear.
“PRC lesions have been shown to disrupt some forms of context memory, including object–context associations (Norman and Eacott, 2005), positional changes in object arrays (Norman and Eacott, 2005), and contextual fear (Bucci et al., 2002)”
From Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval (2015) · cites this paper as Bucci et al., 2002
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Self-citation
- Authors
- Bucci, D. J., Saddoris, M. P., & Burwell, R. D.
- Affiliations
- Brown University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2002
- Volume
- 116
- Issue
- 3
- Pages
- 479-488
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1973669512
- Cited by
- 109
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 14 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (F32MH012426, F32-MH12426)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- contextual fear, fear discrimination, postrhinal cortex, perirhinal cortex, configural learning, hippocampal formation, fear memory
- MeSH terms
- Animals, Discrimination, Psychological, Fear, Immobilization, Male, Temporal Lobe, Rats, Long-Evans, Rats
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