Effects of sleep and arousal on the processing of visual information in the cat
Abstract
Single units in the cat lateral geniculate nucleus and primary visual cortex show changes in both spontaneous and visually evoked firing as a function of the state of wakefulness. On arousal spontaneous firing is smoother and often reduced, whereas evoked responses are usually enhanced; the result is an increase in the signal-to-noise ratio. Single- and double-label 2-deoxyglucose autoradiographs show further that slow-wave sleep differentially depresses visually evoked activity in the deeper layers of the visual cortex.
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Variations in behavioral state strongly affect the magnitude of evoked cortical activity.
“Variations in behavioral state strongly affect the magnitude of evoked cortical activity.”
From Waking state: rapid variations modulate neural and behavioral responses (2015) · cites this paper as Livingstone and Hubel, 1981
Gain modulation mechanisms are robustly engaged by changes in internal state.
“Gain modulation mechanisms are also robustly engaged by changes in internal state32–35.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [35]
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- Authors
- Livingstone, M. S., & Hubel, D. H.
- Affiliations
- Harvard University (US)
- Venue
- Nature
- Published
- 1981-06
- Volume
- 291
- Issue
- 5816
- Pages
- 554-561
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2029325913
- Cited by
- 583
- References
- 41
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 15 · 2023: 9 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 12 · 2015: 18 · 2014: 9 · 2013: 12 · 2012: 5
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns007848-19, 5r01ey000605-43)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- sleep, arousal, visual processing, lateral geniculate nucleus, primary visual cortex, single-unit activity, spontaneous firing, visual evoked potentials, signal-to-noise ratio, slow-wave sleep, 2-deoxyglucose autoradiography, cats
- MeSH terms
- Action Potentials, Animals, Arousal, Autoradiography, Axonal Transport, Carbon Radioisotopes, Cats, Deoxyglucose, Evoked Potentials, Geniculate Bodies, Sleep, Tritium, Vision, Ocular, Visual Cortex, Visual Perception
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