Cited by 104Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesAttention Deficit Hyperactivity Disorder

Psychostimulants and motivated behavior: Arousal and cognition

Berridge, Craig W., Arnsten, Amy F.T.·2013·Neuroscience & Biobehavioral Reviews

Abstract

Motivated, goal-directed behavior requires the coordination of multiple behavioral processes that facilitate interacting with the environment, including arousal, motivation, and executive function. Psychostimulants exert potent modulatory influences on these processes, providing a useful tool for understanding the neurobiology of motivated behavior. The neural mechanisms underlying the reinforcing effects of psychostimulants have been extensively studied over the past 50 years. In contrast, the study of the neurobiology of the arousal-enhancing and executive-modulating actions of psychostimulants was only initiated relatively recently. This latter work identifies a series of dose-dependent actions of psychostimulants within a network of prefrontal cortical and subcortical sites that coordinate the arousal-promoting and cognition-modulating effects of these drugs. These actions are dependent on a variety of catecholamine receptor subtypes, including noradrenergic α1 and α2 receptors and dopaminergic D1 receptors. In the prefrontal cortex, psychostimulants exert inverted-U shaped modulatory actions that are apparent at the levels of the neuron and behavior. Collectively, these observations provide new insight into the neurobiology underlying motivated, goal-directed behavior.

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Crossref · 10.1016/j.neubiorev.2012.11.005

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  • Noradrenaline is a major component of the inverted-U shaped physiologic response to stress, and alpha2a adrenergic receptors in the prefrontal cortex mediate many aspects of cognitive control.

    “Noradrenaline is a major component of the inverted-U shaped physiologic response to stress, and alpha2a adrenergic receptors in the prefrontal cortex127 mediate many aspects of cognitive control128.”

    From Paying attention to attention in depression (2019) · cites this paper as [128]

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Authors
Berridge, C. W., & Arnsten, A. F. T.
Affiliations
  • University of Wisconsin–Madison (US)
  • Yale University (US)
Corresponding author
Berridge, Craig W.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2013-11
Volume
37
Issue
9
Pages
1976-1984
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2023558016
Cited by
104
References
106
Citations by year
2026: 5 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 8 · 2016: 21 · 2015: 9 · 2014: 3 · 2013: 2
FWCI
0.47
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
psychostimulants, arousal, prefrontal cortex, executive function, catecholamine receptors, dose-response relationship, stress, goal-directed behavior, motivation, cognitive enhancement
MeSH terms
Central Nervous System Stimulants, Animals, Arousal, Cognition, Humans, Memory, Short-Term, Methylphenidate, Motivation

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