Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.
Abstract
Voluntary exercise has been associated with reduced anxiety across several animal models. Manipulation of central 5-HT can alter anxiety-like behaviors and administration of the 5-HT agonist metachlorophenylpiperazine (mCPP) increases anxiety in rodents and humans. To examine whether the anxiolytic effect of exercise is associated with an alteration in 5-HT systems, we examined the anxiogenic effect of mCPP in exercising and nonexercising mice. C57BL/6J mice were given 2 weeks of free access to either a functioning or nonfunctioning running wheel. Mice were then tested for acoustic startle following systemic injection of either 0, 0.1, 0.3, or 1 mg/kg of mCPP. Consistent with its anxiogenic properties, mCPP produced a dose-dependent increase in acoustic startle in nonexercising mice. However, this anxiogenic effect was blunted in exercising mice. These findings suggest that exercise may help to reduce anxiety by altering 5-HT systems, perhaps by down-regulating postsynaptic 5HT 2B/2C receptors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A review of available data suggests that tonic immobility, peritraumatic dissociation, and dissociative PTSD may be mediated by a shared neural network involving amygdala deactivation, absence of sympathetically mediated arousal symptoms, parasympathetic activation, and analgesia.
“A review of available data suggests that tonic immobility, peritraumatic dissociation, and dissociative PTSD may be mediated by a shared neural network involving amygdala deactivation, absence of sympathetically mediated arousal symptoms (decreased skin conductance and an absence of heart rate increases), parasympathetic activation (a decrease in heart rate in some studies, presumably reflecting a”
From Fear and the Defense Cascade (2015) · cites this paper as [119]
Cites
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Physical exercise and psychological well being: a critical review.
Scully, D., Kremer, J., Meade, M. M., Graham, R., & Dudgeon, K. (1998) · British Journal of Sports Medicine · doi:10.1136/bjsm.32.2.111 · Cited by 771 · see citing works
Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.14 · Cited by 405 · see citing works
Effects of long-term voluntary exercise on the mouse hypothalamic–pituitary–adrenocortical axis
Droste, S. K., Gesing, A., Ulbricht, S., Müller, M. B., Linthorst, A. C. E., & Reul, J. M. H. M. (2003) · Endocrinology · doi:10.1210/en.2003-0097 · Cited by 324 · see citing works
Darkness facilitates the acoustic startle reflex in humans
Grillon, C., Pellowski, M., Merikangas, K. R., & Davis, M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00466-0 · Cited by 193 · see citing works
Light-enhanced startle: further pharmacological and behavioral characterization
Walker, D. L., & Davis, M. (2002) · Psychopharmacology · doi:10.1007/s002130100913 · Cited by 101 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kozlowska, K., Walker, P., McLean, L., & Carrive, P. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000065 · Cited by 468 · see citing works
Brocardo, P. S., Boehme, F., Patten, A., Cox, A., Gil-Mohapel, J., & Christie, B. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.10.006 · Cited by 186 · see citing works
Hammack, S. E., Cooper, M. A., & Lezak, K. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.024 · Cited by 142 · see citing works
Self-citationStamatakis, A. M., Sparta, D. R., Jennings, J. H., McElligott, Z. A., Decot, H., & Stuber, G. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.046 · Cited by 132 · see citing works
Hare, B. D., Beierle, J. A., Toufexis, D. J., Hammack, S. E., & Falls, W. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.329 · Cited by 85 · see citing works
Self-citationRaber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62 · see citing works
“Consistent with these findings, the 5-HT receptor agonist meta-chlorophenylpiperazine (mCPP) dose dependently increases acoustic startle responses in rats (Fox et al., 2008).”
The role of biogenic amine signaling in the bed nucleus of the stria terminals in alcohol abuse
Kash, T. L. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.12.004 · Cited by 58 · see citing works
“Conversely, studies from the Hammack lab have shown that mCPP, a 5HT2 agonist, administered in to the BNST leads to increased anxiety-like behavior (Fox et al., 2008), suggesting that 5HT2 receptor activation in the BNST has similar behavioral effects as 5HT2 receptor activation in the amygdala (Cornelio and Nunes-de-…”
- Authors
- Fox, J. H., Hammack, S. E., & Falls, W. A.
- Affiliations
- University of Vermont (US)
- Venue
- Behavioral Neuroscience
- Published
- 2008
- Volume
- 122
- Issue
- 4
- Pages
- 943-948
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1966814964
- Cited by
- 53
- References
- 7
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 10
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- voluntary exercise, mCPP, anxiety, acoustic startle response, serotonin, running wheel, serotonin receptor agonists
- MeSH terms
- Acoustic Stimulation, Analysis of Variance, Animals, Anxiety, Behavior, Animal, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Piperazines, Reflex, Startle, Serotonin Receptor Agonists, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
