Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise
Abstract
Prenatal ethanol exposure can damage the developing nervous system, producing long-lasting impairments in both brain structure and function. In this study we analyzed how exposure to this teratogen during the period of brain development affects the intracellular redox state in the brain as well as the development of anxiety- and depressive-like phenotypes. Furthermore, we also tested whether aerobic exercise might have therapeutic potential for fetal alcohol spectrum disorders (FASD) by increasing neuronal antioxidant capacity and/or by alleviating ethanol-induced behavioral deficits. Sprague-Dawley rats were administered ethanol across all three-trimester equivalents (i.e., throughout gestation and during the first 10 days of postnatal life). Ethanol-exposed and control animals were assigned to either sedentary or running groups at postnatal day (PND) 48. Runners had free access to a running wheel for 12 days and at PND 60 anxiety- and depressive-like behaviors were assessed. Perinatal ethanol exposure resulted in the occurrence of depressive and anxiety-like behaviors in adult rats without affecting their locomotor activity. Voluntary wheel running reversed the depressive-like behaviors in ethanol-exposed males, but not in ethanol-exposed females. Levels of lipid peroxidation and protein oxidation were significantly increased in the hippocampus and cerebellum of ethanol-exposed rats, and there was a concomitant reduction in the levels of the endogenous antioxidant glutathione. Voluntary exercise was able to reverse the deficits in glutathione both in ethanol-exposed males and females. Thus, while voluntary physical exercise increased glutathione levels in both sexes, its effects at the behavioral level were sex dependent, with only ethanol-exposed male runners showing a decrease in depressive-like behaviors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Brocardo's team demonstrated increased levels of oxidative damage in a rat model of fetal alcohol exposure with anxiety- and depression-like behaviour.
“Brocardo's team, for example, demonstrated the presence of increased levels of oxidative damage in a rat model of fetal alcohol exposure, in which they created the conditions of anxiety- and depression-like behaviour.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [104]
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Tietze, F. (1969) · Analytical Biochemistry · doi:10.1016/0003-2697(69)90064-5 · Cited by 6,077 · see citing works
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Walf, A. A., & Frye, C. A. (2007) · Nature Protocols · doi:10.1038/nprot.2007.44 · Cited by 3,035 · see citing works
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Carlberg, I., & Mannervik, B. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13062-4 · Cited by 3,009 · see citing works
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works
[51] Assays for differentiation of glutathione S-Transferases
Habig, W. H., & Jakoby, W. B. (1981) · Methods in Enzymology · doi:10.1016/s0076-6879(81)77053-8 · Cited by 2,419 · see citing works
Diversity of structures and properties among catalases
Chelikani, P., Fita, I., & Loewen, P. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3206-5 · Cited by 1,701 · see citing works
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works
Physical activity, exercise, depression and anxiety disorders
Ströhle, A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0092-x · Cited by 1,269 · see citing works
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Is the forced swimming test a suitable model for revealing antidepressant activity?
Borsini, F., & Meli, A. (1988) · Psychopharmacology · doi:10.1007/bf00176837 · Cited by 1,054 · see citing works
Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders
Floyd, R. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-140.x · Cited by 824 · see citing works
Physical Activity Reduces the Risk of Subsequent Depression for Older Adults
Strawbridge, W. J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf047 · Cited by 818 · see citing works
Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works
Castagné, V., Moser, P., Roux, S., & Porsolt, R. D. (2011) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0810as55 · Cited by 702 · see citing works
The Glutathione S ‐Transferases: A Group of Multifunctional Detoxification Proteins
Jakoby, W. B. (1978) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122914.ch6 · Cited by 686 · see citing works
Floyd, R. A., & Carney, J. M. (1992) · Annals of Neurology · doi:10.1002/ana.410320706 · Cited by 541 · see citing works
Social isolation delays the positive effects of running on adult neurogenesis
Stranahan, A. M., Khalil, D., & Gould, E. (2006) · Nature Neuroscience · doi:10.1038/nn1668 · Cited by 467 · see citing works
Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders
Streissguth, A. P., & O’Malley, K. D. (2000) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2000.6729 · Cited by 466 · see citing works
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465 · see citing works
Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 460 · see citing works
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works
Superoxide dismutase: The first twenty years (1968–1988)
McCord, J. M., & Fridovich, I. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90109-8 · Cited by 381 · see citing works
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works
Oxidative stress in anxiety and comorbid disorders
Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works
Mental Illness in Adults With Fetal Alcohol Syndrome or Fetal Alcohol Effects
Famy, C., Streissguth, A. P., & Unis, A. S. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.4.552 · Cited by 357 · see citing works
Hellemans, K. G. C., Sliwowska, J. H., Verma, P., & Weinberg, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.004 · Cited by 344 · see citing works
Comparison of Aerobic Exercise, Clomipramine, and Placebo in the Treatment of Panic Disorder
Broocks, A., Bandelow, B., Pekrun, G., George, A., Meyer, T., Bartmann, U., Hillmer-Vogel, U., & Rüther, E. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.5.603 · Cited by 330 · see citing works
Weinberg, J., Sliwowska, J. H., Lan, N., & Hellemans, K. G. C. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01669.x · Cited by 329 · see citing works
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works
Fuss, J., Ben Abdallah, N. M. ‐., Vogt, M. A., Touma, C., Pacifici, P. G., Palme, R., Witzemann, V., Hellweg, R., & Gass, P. (2010) · Hippocampus · doi:10.1002/hipo.20634 · Cited by 240 · see citing works
Behavioral and Psychosocial Profiles of Alcohol‐Exposed Children
Roebuck, T. M., Mattson, S. N., & Riley, E. P. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04227.x · Cited by 235 · see citing works
Population-based case-control study of teratogenic potential of corticosteroids.
Czeizel, A., & Rockenbauer, M. (1997) · Teratology · doi:10.1002/(sici)1096-9926(199711)56:5 · Cited by 235 · see citing works
Responses of glutathione system and antioxidant enzymes to exhaustive exercise and hydroperoxide
Ji, L., & Fu, R. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.2.549 · Cited by 221 · see citing works
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., Jiang, Z., Wang, H., Wang, Z., Cornelisson, G., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.007 · Cited by 212 · see citing works
Amplified behavioral and endocrine responses to forced swim stress in the Wistar–Kyoto rat
Rittenhouse, P. A., López‐Rubalcava, C., Stanwood, G. D., & Lucki, I. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00052-x · Cited by 207 · see citing works
Dissection of Hippocampal Dentate Gyrus from Adult Mouse
Hagihara, H., Toyama, K., Yamasaki, N., & Miyakawa, T. (2009) · Journal of Visualized Experiments · doi:10.3791/1543 · Cited by 203 · see citing works
Effects of exercise training on anxiety: A meta-analysis
Long, B. C., & van Stavel, R. (1995) · Journal of Applied Sport Psychology · doi:10.1080/10413209508406963 · Cited by 199 · see citing works
Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats
Salim, S., Sarraj, N., Taneja, M., Saha, K., Tejada-Simon, M. V., & Chugh, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.039 · Cited by 191 · see citing works
Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice
Binder, E., Droste, S. K., Ohl, F., & Reul, J. M. H. M. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.017 · Cited by 188 · see citing works
The role of oxidative stress in fetal alcohol spectrum disorders
Brocardo, P. S., Gil‐Mohapel, J., & Christie, B. R. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.02.001 · Cited by 185 · see citing works
Self-citationLong-Term Psychopathological and Cognitive Outcome of Children with Fetal Alcohol Syndrome
Steinhausen, H. ‐., Willms, J., & Spohr, H. (1993) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199309000-00016 · Cited by 170 · see citing works
Glutathione Reductase from Human Erythrocytes
Krohne‐Ehrich, G., Schirmer, R. H., & Untucht‐Grau, R. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11856.x · Cited by 170 · see citing works
Walf, A. A., & Frye, C. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300708 · Cited by 160 · see citing works
Vinitha, R., Perez, A., Chen, J., Duraisamy, S., Schenker, S., & Henderson, G. I. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02292.x · Cited by 159 · see citing works
Devi, S. A., & Kiran, T. R. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00112-x · Cited by 154 · see citing works
Christie, B. R., Swann, S. E., Fox, C. J., Froc, D. J., Lieblich, S. E., Redila, V. A., & Webber, A. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04004.x · Cited by 154 · see citing works
Self-citationRedila, V. A., Olson, A. K., Swann, S. E., Mohaddes, G., Webber, A. J., Weinberg, J., & Christie, B. R. (2006) · Hippocampus · doi:10.1002/hipo.20164 · Cited by 141 · see citing works
Self-citationDie Glutathionperoxidase: Enzymologie und biologische Aspekte
Floh�, L. (1971) · Journal of Molecular Medicine · doi:10.1007/bf01487101 · Cited by 136 · see citing works
Huang, J., & Philbert, M. A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00209-9 · Cited by 129 · see citing works
O’Connor, M. J., & Paley, B. (2005) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsj021 · Cited by 128 · see citing works
In Utero Ethanol Exposure Elicits Oxidative Stress in the Rat Fetus
Henderson, G. I., Devi, B. G., Perez, A., & Schenker, S. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01572.x · Cited by 127 · see citing works
Effect of exercise training on antioxidant system in brain regions of rat
Rybak, L. P., Somani, S. M., & Ravi, R. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00357-2 · Cited by 125 · see citing works
Developmental changes in alcohol-dehydrogenase activity in rat and guinea-pig liver
Räihä, N. C. R., Koskinen, M., & Pikkarainen, P. H. (1967) · Biochemical Journal · doi:10.1042/bj1030623 · Cited by 123 · see citing works
Possible connections among job stress, depressive symptoms, lipid modulation and antioxidants
Tsuboi, H., Tatsumi, A., Yamamoto, K., Kobayashi, F., Shimoi, K., & Kinae, N. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.010 · Cited by 119 · see citing works
Caldwell, K. E., Sheema, S., Paz, R., Samudio‐Ruiz, S. L., LAUGHLIN, M., SPENCE, N., Roehlk, M. J., Alcon, S. N., & Allan, A. M. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.05.004 · Cited by 116 · see citing works
Weinberg, J., Taylor, A. N., & Gianoulakis, C. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01054.x · Cited by 116 · see citing works
Prenatal ethanol effects: Sex differences in offspring stress responsiveness
Weinberg, J. (1992) · Alcohol · doi:10.1016/0741-8329(92)90057-h · Cited by 111 · see citing works
Behavioral and neurochemical effects on rat offspring after prenatal exposure to ethanol
Carneiro, L. M. V., Diógenes, J. P. L., Vasconcelos, S. M. M., Aragão, G. F., Noronha, E. C., Gomes, P. B., & Viana, G. S. D. B. (2005) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2005.06.006 · Cited by 110 · see citing works
Chu, J., Tong, M., & de la Monte, S. M. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0199-4 · Cited by 109 · see citing works
Prenatal Alcohol Exposure and Depressive Features in Children
O’Connor, M. J., & Kasari, C. L. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb04654.x · Cited by 103 · see citing works
Helfer, J. L., Goodlett, C. R., Greenough, W. T., & Klintsova, A. Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.090 · Cited by 102 · see citing works
Heaton, M. B., Paiva, M., Madorsky, I., & Shaw, G. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.08.005 · Cited by 100 · see citing works
Increased Open Field Locomotion and Decreased Striatal GABAA Binding After Activity Wheel Running
Dishman, R. K., Dunn, A. L., Youngstedt, S. D., Davis, J. M., Burgess, M. L., Wilson, S. P., & Wilso, M. A. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(96)00102-3 · Cited by 99 · see citing works
Daily Exercise Reduces Fat, Protein and Body Mass in Male but not Female Rats
Cortright, R. N., Chandler, M. P., Lemon, P. W. R., & DiCarlo, S. E. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00148-0 · Cited by 91 · see citing works
Sun, X., Shih, A. Y., Johannssen, H. C., Erb, H., Li, P., & Murphy, T. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601567200 · Cited by 89 · see citing works
Osborn, J., Kim, C. K., Steiger, J., & Weinberg, J. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb04312.x · Cited by 86 · see citing works
Thomas, J. D., Sather, T., & Whinery, L. A. (2008) · Behavioral Neuroscience · doi:10.1037/a0013271 · Cited by 85 · see citing works
Kalani, R., Judge, S., Carter, C., Pahor, M., & Leeuwenburgh, C. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.3.211 · Cited by 85 · see citing works
Wilcoxon, J. S., Kuo, A., Disterhoft, J. F., & Redei, E. E. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001694 · Cited by 81 · see citing works
Alteration of gene expression by alcohol exposure at early neurulation
Zhou, F., Zhao, Q., Liu, Y., Goodlett, C. R., Liang, T., McClintick, J. N., Edenberg, H. J., & Li, L. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-124 · Cited by 79 · see citing works
Blood glutathione status during exercise: effect of carbohydrate supplementation
Ji, L. L., Katz, A., Fu, R., Griffiths, M. A., & SPENCER, M. K. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.74.2.788 · Cited by 79 · see citing works
Ehret, F., Gil‐Mohapel, J., Cox, A., Patten, A. R., Giles, E., Brocardo, P. S., & Christie, B. R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07676.x · Cited by 76 · see citing works
Self-citationOxidative Stress Induced by Intense and Exhaustive Exercise Impairs Murine Cognitive Function
Rosa, E. F., Takahashi, S., Aboulafia, J., Nouailhetas, V. L. A., & Oliveira, M. G. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01158.2006 · Cited by 72 · see citing works
Bjørnebekk, A., Mathé, A. A., & Brené, S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300820 · Cited by 69 · see citing works
Behavioural phenotype in foetal alcohol syndrome and foetal alcohol effects
Steinhausen, H., Willms, J., Metzke, C. W., & Spohr, H. (2003) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162203000343 · Cited by 67 · see citing works
Heritability of treadmill running endurance in rats
Koch, L. G., Meredith, T. A., Fraker, T. D., Metting, P. J., & Britton, S. L. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1455 · Cited by 66 · see citing works
Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome
Gil‐Mohapel, J., Ehret, F., Patten, A. R., Cox, A., Kainer, L., Giles, E., Brocardo, P. S., & Christie, B. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.116 · Cited by 66 · see citing works
Self-citationBOLD Response During Spatial Working Memory in Youth With Heavy Prenatal Alcohol Exposure
Spadoni, A. D., Bazinet, A. D., Fryer, S. L., Tapert, S. F., Mattson, S. N., & Riley, E. P. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01046.x · Cited by 65 · see citing works
Treatment of a Situational Phobia—A Case for Running
Orwin, A. (1974) · The British Journal of Psychiatry · doi:10.1192/bjp.125.1.95 · Cited by 61 · see citing works
Intragastric Intubation of Alcohol During the Perinatal Period
Kelly, S. J., & Lawrence, C. R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-242-7_8 · Cited by 58 · see citing works
4–Hydroxynonenal Levels Are Enhanced in Fetal Liver Mitochondria By In Utero Ethanol Exposure
Chen, J. J., Schenker, S., & Henderson, G. I. (1997) · Hepatology · doi:10.1002/hep.510250126 · Cited by 58 · see citing works
Lew, H., & Quintanilha, A. T. (1991) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03189876 · Cited by 54 · see citing works
Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.
Fox, J. H., Hammack, S. E., & Falls, W. A. (2008) · Behavioral Neuroscience · doi:10.1037/0735-7044.122.4.943 · Cited by 53 · see citing works
Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure
Coles, C. D., & Li, Z. (2011) · Neuropsychology Review · doi:10.1007/s11065-011-9165-y · Cited by 53 · see citing works
Beiswanger, C. M., Diegmann, M. H., NOVAK, R. F., Philbert, M. A., Graessle, T. L., Reuhl, K. R., & Lowndes, H. E. (1995) · PubMed · Cited by 53 · see citing works
Effects of In Utero Administration of Alcohol on Glutathione Levels in Brain and Liver
Reyes, E., Ott, S., & Robinson, B. (1993) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1993.tb00857.x · Cited by 52 · see citing works
Greenwood, B. N., Strong, P. V., Brooks, L., & Fleshner, M. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1167-y · Cited by 51 · see citing works
Dembélé, K., Yao, X., Chen, L., & Nyomba, B. L. G. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00633.2005 · Cited by 50 · see citing works
Correlates of Psychopathology and Intelligence in Children with Fetal Alcohol Syndrome
Steinhausen, H. ‐., Willms, J., & Spohr, H. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01165.x · Cited by 47 · see citing works
Prenatal and Early Postnatal Exposure to Ethanol Permanently Alters the Rat Hippocampus
West, J. R., Dewey, S. L., Pierce, D. R., & Black, A. C. (1984) · Novartis Foundation symposium · doi:10.1002/9780470720868.ch2 · Cited by 47 · see citing works
Behavioural phenotype in foetal alcohol syndrome and foetal alcohol effects
Steinhausen, H., & Winkler, C. (2003) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2003.tb00927.x · Cited by 46 · see citing works
Miller, M. W., & SPEAR, L. P. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00177.x · Cited by 43 · see citing works
Perez, M. J., Velasco, E., Monte, M. J., González-Buitrago, J. M., & Marı́n, J. J. G. (2006) · Toxicology · doi:10.1016/j.tox.2006.05.015 · Cited by 38 · see citing works
Midtgaard, J., Stage, M., Møller, T., Andersen, C., Quist, M., Rørth, M. R., Herrstedt, J., Vistisen, K. K., Christiansen, B., & Adamsen, L. (2011) · Acta Oncologica · doi:10.3109/0284186x.2010.543145 · Cited by 37 · see citing works
Maternal alcohol and adrenalectomy:
Slone, J. L., & Redei, E. E. (2002) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(01)00186-6 · Cited by 35 · see citing works
4-hydroxynonenal levels are enhanced in fetal liver mitochondria by in utero ethanol exposure
Chen, J. (1997) · Hepatology · doi:10.1053/jhep.1997.v25.pm0008985280 · Cited by 28 · see citing works
Long‐term depression in vivo: Effects of sex, stress, diet, and prenatal ethanol exposure
Titterness, A. K., & Christie, B. R. (2008) · Hippocampus · doi:10.1002/hipo.20407 · Cited by 27 · see citing works
Self-citationSelenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
Akıl, M., Biçer, M., Menevşe, E., Baltacı, A. K., & Moğulkoç, R. (2011) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03657450 · Cited by 26 · see citing works
Schroeder, M., Shbiro, L., Gelber, V., & Weller, A. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.02.008 · Cited by 25 · see citing works
Green, C. R., Watts, L. T., Kobus, S. M., Henderson, G. I., Reynolds, J. N., & Brien, J. F. (2006) · Reproduction Fertility and Development · doi:10.1071/rd05128 · Cited by 23 · see citing works
[Lipid peroxidation changes in the brain in fetal alcohol syndrome].
Vv, P., Stoyanovski, D., Petkov, V. D., & Iu, V. (1992) · PubMed · Cited by 17 · see citing works
Effects of in utero administration of alcohol on alcohol sensitivity in adult rats
Reyes, E., Duran, E., & Switzer, S. H. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90466-7 · Cited by 16 · see citing works
Alves, C. J., Magalhães, A., Summavielle, T., Melo, P., de Sousa, L., Ferreira, M. A., & Monteiro, P. R. R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1432.047 · Cited by 16 · see citing works
Changes in brain lipid peroxidation in the fetal alcohol syndrome
Petkov, V. V., Stoyanovski, D., Petkov, V. D., & Vyglenova, Y. (1992) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf00783755 · Cited by 15 · see citing works
Cacciaglia, R., Krause-Utz, A., Vogt, M. A., Schmahl, C. G., Flor, H., & Gass, P. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.583270 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Patki, G., Solanki, N., Atrooz, F., Allam, F., & Salim, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.033 · Cited by 380 · see citing works
Exercise as a novel treatment for drug addiction: A neurobiological and stage-dependent hypothesis
Lynch, W. J., Peterson, A. B., Sánchez, V., Abel, J. M., & Smith, M. A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.011 · Cited by 377 · see citing works
Salim, S., Chugh, G., & Asghar, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00001-5 · Cited by 315 · see citing works
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
Intlekofer, K. A., & Cotman, C. W. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.06.011 · Cited by 286 · see citing works
The role of oxidative stress in anxiety disorder: cause or consequence?
Fedoce, A. G., Ferreira, F. R., Bota, R. G., Bonet-Costa, V., Sun, P. Y., & Davies, K. J. A. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1475733 · Cited by 235 · see citing works
Patten, A. R., Fontaine, C. J., & Christie, B. R. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00093 · Cited by 218 · see citing works
Self-citationThe Effects and Mechanisms of Exercise on the Treatment of Depression
Xie, Y., Wu, Z., Sun, L., Zhou, L., Wang, G., Xiao, L., & Wang, H. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.705559 · Cited by 194 · see citing works
Novel Therapeutic Targets in Depression and Anxiety: Antioxidants as a Candidate Treatment
Xu, Y., Wang, C., Klabnik, J., & Donnell, J. O. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120231448 · Cited by 139 · see citing works
Li, Y., Gonzalez, P., & Zhang, L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.010 · Cited by 131 · see citing works
da Silva, L. A., Tortelli, L., Motta, J. V. D. S., Menguer, L., Mariano, S., Tasca, G. M., Silveira, G. D. B., Pinho, R. A., & Silveira, P. C. L. (2019) · Clinics · doi:10.6061/clinics/2019/e322 · Cited by 161 · see citing works
Sciolino, N. R., & Holmes, P. V. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.005 · Cited by 116 · see citing works
Cullen, C. L., Burne, T. H. J., Lavidis, N. A., & Moritz, K. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054924 · Cited by 105 · see citing works
Patten, A. R., Brocardo, P. S., & Christie, B. R. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.04.003 · Cited by 104 · see citing works
Self-citationBalmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“It also appears that lithium can boost GSH rates and also the expression of glutamatecysteine ligase [31], while also helping antioxidant defense mechanisms through the management of GST [260].”
BackgroundInfluentialMotaghinejad, M., Motevalian, M., Fatima, S., Hashemi, H., & Gholami, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.020 · Cited by 98 · see citing works
Zhao, T., Li, Y., Wei, W., Savage, S., Zhou, L., & Ma, D. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.02.009 · Cited by 97 · see citing works
Exercise Regulation of Cognitive Function and Neuroplasticity in the Healthy and Diseased Brain
Hamilton, G. F., & Rhodes, J. S. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.004 · Cited by 83 · see citing works
Fontaine, C. J., Patten, A. R., Sickmann, H. M., Helfer, J. L., & Christie, B. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.014 · Cited by 79 · see citing works
Self-citationEvaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice
Gugliandolo, E., Peritore, A. F., D’Amico, R., Licata, P., & Crupi, R. (2020) · Animals · doi:10.3390/ani10050898 · Cited by 80 · see citing works
Zhou, Y., Zhao, M., Zhou, C., & Li, R. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.07.001 · Cited by 74 · see citing works
Oxidative Imbalance and Anxiety Disorders
Krolow, R., Arcego, D. M., Noschang, C. G., Weis, S. N., & Dalmaz, C. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223530 · Cited by 74 · see citing works
James, M. H., Campbell, E. J., Walker, F. R., Smith, D. W., Richardson, H. N., Hodgson, D. M., & Dayas, C. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00244 · Cited by 70 · see citing works
Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome
Söğüt, İ., Oğlakçı, A., Kartkaya, K., Ol, K. K., Söğüt, M. S., Kanbak, G., & İnal, M. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.2164 · Cited by 69 · see citing works
Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview
Almeida, L., Andreu-Férnández, V., Navarro‐Tapia, E., Aras‐López, R., Serra-Delgado, M., Martínez, L., García‐Algar, Ó., & Gómez‐Roig, M. D. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00359 · Cited by 67 · see citing works
Gender Differences in Oxidative Stress in Relation to Cancer Susceptibility and Survival
Allegra, A., Caserta, S., Genovese, S., Pioggia, G., & Gangemi, S. (2023) · Antioxidants · doi:10.3390/antiox12061255 · Cited by 68 · see citing works
Patten, A. R., Sickmann, H. M., Dyer, R., Innis, S. M., & Christie, B. R. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.051 · Cited by 68 · see citing works
Self-citationPrenatal ethanol exposure has sex-specific effects on hippocampal long-term potentiation
Sickmann, H. M., Patten, A. R., Morch, K., Sawchuk, S. D., Zhang, C., Parton, R., Szlavik, L., & Christie, B. R. (2013) · Hippocampus · doi:10.1002/hipo.22203 · Cited by 68 · see citing works
Self-citationTherapeutic potential of glutathione-enhancers in stress-related psychopathologies
Zalachoras, I., Hollis, F., Ramos‐Fernández, E., Trovò, L., Sonnay, S., Geiser, E., Preitner, N., Steiner, P., Sandi, C., & Morató, L. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.015 · Cited by 67 · see citing works
Paris, J. J., Singh, H. D., Ganno, M. L., Jackson, P., & McLaughlin, J. P. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3385-1 · Cited by 66 · see citing works
Patten, A. R., Yau, S. Y., Fontaine, C. J., Meconi, A., Wortman, R. C., & Christie, B. R. (2015) · Brain Plasticity · doi:10.3233/bpl-150016 · Cited by 64 · see citing works
Self-citationTorrens‐Mas, M., Pons, D. G., Sastre‐Serra, J., Oliver, J., & Roca, P. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101505 · Cited by 65 · see citing works
Sciolino, N. R., Dishman, R. K., & Holmes, P. V. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.001 · Cited by 60 · see citing works
Raineki, C., Bodnar, T. S., Holman, P. J., Baglot, S. L., Lan, N., & Weinberg, J. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.07.001 · Cited by 60 · see citing works
Boschen, K. E., & Klintsova, A. Y. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.10.008 · Cited by 57 · see citing works
Bashiri, H., Enayati, M., Bashiri, A., & Salari, A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113003 · Cited by 57 · see citing works
Meconi, A., Wortman, R. C., Wright, D. K., Neale, K. J., Clarkson, M., Shultz, S. R., & Christie, B. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197187 · Cited by 55 · see citing works
Self-citationRahimi, S., Peeri, M., Azarbayjani, M. A., Anoosheh, L., Ghasemzadeh, E., Khalifeh, N., Noroozi-Mahyari, S., Deravi, S., Saffari-Anaraki, S., Zangeneh, F. H., et al. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113130 · Cited by 54 · see citing works
Sex differences in resilience: Experiential factors and their mechanisms
Fallon, I. P., Tanner, M. K., Greenwood, B. N., & Baratta, M. V. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14639 · Cited by 56 · see citing works
Chang, G., Karatayev, O., Liang, S., Barson, J. R., & LEIBOWITZ, S. F. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.066 · Cited by 53 · see citing works
Ramlan, N. F., Sata, N. S. A. M., Hassan, S. N., Bakar, N. A., Ahmad, S., Zulkifli, S. Z., Abdullah, C. A. C., & Ibrahim, W. N. W. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.048 · Cited by 53 · see citing works
Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats
Naderi, R., Mohaddes, G., Mohammadi, M., Ghaznavi, R., Ghiasi, R., & Vatankhah, A. M. (2015) · Advanced Pharmaceutical Bulletin · doi:10.15171/apb.2015.032 · Cited by 51 · see citing works
Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease
Ruszkiewicz, J. A., Miranda‐Vizuete, A., Tinkov, A. A., Геннадиевна, С. М., Skalny, A. V., Tsatsakis, A. M., & Aschner, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1241-9 · Cited by 47 · see citing works
Keiver, K., Bertram, C. P., Orr, A. P., & Clarren, S. K. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.11.004 · Cited by 48 · see citing works
Patten, A. R., Brocardo, P. S., Sakiyama, C., Wortman, R. C., Noonan, A., Gil‐Mohapel, J., & Christie, B. R. (2013) · Hippocampus · doi:10.1002/hipo.22199 · Cited by 45 · see citing works
Self-citationWang, D., Chen, T., Lin, M., Jhong, Y.-C., & Chen, S. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.09.010 · Cited by 46 · see citing works
Miller‐Pinsler, L., Pinto, D. J., & Wells, P. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.09.026 · Cited by 45 · see citing works
Oberholzer, I., Möller, M., Holland, B. J., Dean, O. M., Berk, M., & Harvey, B. H. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0144-8 · Cited by 44 · see citing works
The therapeutic potential of exercise for neuropsychiatric diseases: A review
Swenson, S., Blum, K., McLaughlin, T., Gold, M. S., & Thanos, P. K. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116763 · Cited by 42 · see citing works
Serotonergic Neuroplasticity in Alcohol Addiction
Belmer, A., Patkar, O. L., Pitman, K. M., & Bartlett, S. E. (2015) · Brain Plasticity · doi:10.3233/bpl-150022 · Cited by 42 · see citing works
Moderate Maternal Alcohol Exposure on Gestational Day 12 Impacts Anxiety-Like Behavior in Offspring
Rouzer, S. K., Cole, J. M., Johnson, J. M., Varlinskaya, E. I., & Diaz, M. R. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00183 · Cited by 43 · see citing works
Klintsova, A. Y., Hamilton, G. F., & Boschen, K. E. (2012) · Brain Sciences · doi:10.3390/brainsci3010001 · Cited by 40 · see citing works
Lam, V. Y. Y., Raineki, C., Ellis, L. A., Yu, W. K., & Weinberg, J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.06.018 · Cited by 42 · see citing works
Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?
Mul, J. D. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0165 · Cited by 41 · see citing works
Aglawe, M. M., Kale, M. B., Rahangdale, S. R., Kotagale, N. R., Umekar, M. J., & Taksande, B. G. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.11.015 · Cited by 40 · see citing works
Louth, E. L., Bignell, W., Taylor, C. L., & Bailey, C. D. C. (2016) · eNeuro · doi:10.1523/eneuro.0267-16.2016 · Cited by 40 · see citing works
Moradikor, N., Dadkhah, M., Ghanbari, A., Rashidipour, H., Bandegi, A. R., Barati, M., Kokhaei, P., & Rashidy‐Pour, A. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s247599 · Cited by 38 · see citing works
Brocardo, P. S., Gil‐Mohapel, J., Wortman, R. C., Noonan, A., McGinnis, E., Patten, A. R., & Christie, B. R. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13266 · Cited by 38 · see citing works
Self-citationDiaz, M. R., Mooney, S. M., & Varlinskaya, E. I. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.003 · Cited by 37 · see citing works
Puty, B., Maximino, C., Brasil, A., Luz, W. L., Gouvêia, A., Oliveira, K. R. M., Batista, E. D. J. O., Lopez, M. E. C., Rocha, F. A. D. F., & Herculano, A. M. (2014) · Zebrafish · doi:10.1089/zeb.2013.0947 · Cited by 37 · see citing works
Xu, H., Li, H., Liu, D., Wen, W., Xu, M., Frank, J. A., Chen, J., Zhu, H., Grahame, N. J., & Luo, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.614396 · Cited by 34 · see citing works
Liang, J., Shen, Y., Shao, X. M., Scott, M., Ly, E., Wong, S. C., Nguyen, A. T., Tan, K., Kwon, O. J., Olsen, R. W., et al. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1291-5 · Cited by 35 · see citing works
Cullen, C. L., Burne, T. H. J., Lavidis, N. A., & Moritz, K. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101482 · Cited by 34 · see citing works
Sickmann, H. M., Arentzen, T. S., Dyrby, T. B., Plath, N., & Kristensen, M. P. (2015) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174415001282 · Cited by 33 · see citing works
Ghorbanzadeh, V., Mohammadi, M., Mohaddes, G., Dariushnejad, H., Chodari, L., & Mohammadi, S. (2016) · Physiology International · doi:10.1556/2060.103.2016.4.6 · Cited by 33 · see citing works
Queiroz, M. P., Lima, M. D. S., de Melo, M. F. F. T., Bertozzo, C. C. D. M. S., Araújo, D. F. D. S., Guerra, G. C. B., Queiroga, R. D. C. R. D. E., & Soares, J. K. B. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.020 · Cited by 33 · see citing works
Arazi, H., Dadvand, S. S., & Suzuki, K. (2022) · Biomedical Human Kinetics · doi:10.2478/bhk-2022-0015 · Cited by 32 · see citing works
Lam, V. Y. Y., Raineki, C., Wang, L. Y., Chiu, M., Lee, G., Ellis, L. A., Yu, W. K., & Weinberg, J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.008 · Cited by 32 · see citing works
Zhang, L., & Yuan, T. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.07.007 · Cited by 31 · see citing works
Kajimoto, K., Allan, A. M., & Cunningham, L. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073788 · Cited by 29 · see citing works
Contreras, M. L., de la Fuente-Ortega, E., Vargas-Robert, S., Muñoz, D. C., Goic, C. A., & Haeger, P. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00338 · Cited by 29 · see citing works
Gupta, G. L., & Sharma, L. K. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.048 · Cited by 30 · see citing works
Ilješ, A. P., Kastelic, M., Porcelli, S., Serretti, A., Makovec, M. R., Plesničar, B. K., & Dolžan, V. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu088 · Cited by 29 · see citing works
Fuß, J., Vogt, M. A., Weber, K.-J., Burke, T. F., Gass, P., & Hensler, J. G. (2013) · Synapse · doi:10.1002/syn.21666 · Cited by 28 · see citing works
Ghyasi, R., Mohaddes, G., & Naderi, R. (2019) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2019.10 · Cited by 28 · see citing works
Swart, P., Currin, C. B., Russell, V. A., & Dimatelis, J. J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23894 · Cited by 28 · see citing works
Wille‐Bille, A., Bellia, F., Jiménez-García, A., Miranda‐Morales, R. S., D’Addario, C., & Pautassi, R. M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107917 · Cited by 28 · see citing works
Pinna, A., & Colasanti, A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.689473 · Cited by 26 · see citing works
Oxidative stress and neuroinflammation in a rat model of co-morbid obesity and psychogenic stress
Santiago, J. M., Vega-Torres, J. D., Ontiveros‐Ángel, P., Lee, J. B., Torres, Y. A., Gonzalez, A. Y. C., Boria, E. A., Ortiz, D. Z., Carmona, C. A., & Figueroa, J. D. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112995 · Cited by 25 · see citing works
Antidepressant-like activity of Embelin isolated from Embelia ribes
Gupta, G., Kazmi, I. A., Afzal, M., Upadhyay, G., Singh, R. K., & Habtemariam, S. (2013) · Greenwich Academic Literature Archive (University of Greenwich) · Cited by 25 · see citing works
Miller, L., Shapiro, A. M., Cheng, J., & Wells, P. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.015 · Cited by 25 · see citing works
Boschen, K. E., Keller, S. M., Roth, T. L., & Klintsova, A. Y. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.12.009 · Cited by 24 · see citing works
Gräfe, E. L., Wade, M. M. M., Hodson, C. E., Thomas, J. D., & Christie, B. R. (2022) · Nutrients · doi:10.3390/nu14102004 · Cited by 24 · see citing works
Self-citationMohseni, F., Garmabi, B., & Khaksari, M. (2021) · Neuropeptides · doi:10.1016/j.npep.2021.102130 · Cited by 23 · see citing works
Batallé, G., Bai, X., Pouso-Vázquez, E., Roch, G., Rodríguez, L., & Pol, O. (2021) · Antioxidants · doi:10.3390/antiox10101632 · Cited by 23 · see citing works
Kleiber, M. L., Laufer, B. I., Stringer, R., & Singh, S. M. (2014) · Developmental Neuroscience · doi:10.1159/000365549 · Cited by 23 · see citing works
Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats
Choi, M., Kwak, S. M., Bang, S. H., Jeong, J.-E., & Kim, D. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.09.002 · Cited by 23 · see citing works
Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis
Rojas-Mayorquín, A. E., Padilla-Velarde, E., & Ortuño‐Sahagún, D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00565 · Cited by 23 · see citing works
Liu, W., Wang, H., Xue, X., Xia, J., Liu, J., Qi, Z., & Ji, L. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.09.053 · Cited by 23 · see citing works
TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila
Lin, R., Rittenhouse, D., Sweeney, K. M., Potluri, P., & Wallace, D. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005366 · Cited by 22 · see citing works
Lucia, D., Burgess, D. J., Cullen, C. L., Dorey, E. S., Rawashdeh, O., & Moritz, K. M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.009 · Cited by 22 · see citing works
Naghibi, S., Barzegari, A., Shariatzadeh, M., Vatandoust, M., Ahmadi, M., Mahdinia, E., Neghabi, F., Rajabpour, A., Aleahmad, A. S., Balaghati, F. S., et al. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147880 · Cited by 20 · see citing works
Oubraim, S., Wang, R., Hausknecht, K. A., Kaczocha, M., Shen, R., & Haj‐Dahmane, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02210-7 · Cited by 21 · see citing works
Kim, T.-K., & Han, P. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.007 · Cited by 20 · see citing works
Prenatal alcohol exposure and developmental programming of mental illness
Burgess, D. J., & Moritz, K. M. (2020) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174420000082 · Cited by 20 · see citing works
Subbanna, S., & Basavarajappa, B. S. (2022) · Brain Sciences · doi:10.3390/brainsci12060793 · Cited by 19 · see citing works
Nagayach, A., Bhaskar, R., & Patro, I. K. (2022) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2022.102160 · Cited by 18 · see citing works
Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder
Gasparyan, A., Navarro, D., Navarrete, F., Austrich-Olivares, A., Scoma, E. R., Hambardikar, V. D., Acosta, G. B., Solesio, M. E., & Manzanares, J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106655 · Cited by 19 · see citing works
von Hellfeld, R., Gade, C., Baumann, L., Leist, M., & Braunbeck, T. A. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27662-2 · Cited by 19 · see citing works
Patten, A. R., Gil‐Mohapel, J., Wortman, R. C., Noonan, A., Brocardo, P. S., & Christie, B. R. (2013) · Brain Sciences · doi:10.3390/brainsci3031076 · Cited by 19 · see citing works
Self-citationNeonatal Ethanol Exposure Causes Behavioral Deficits in Young Mice
Xu, W., Hawkey, A. B., Li, H., Dai, L., Brim, H. H., Frank, J. A., Luo, J., Barron, S., & Chen, G. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13598 · Cited by 19 · see citing works
- Authors
- Brocardo, P. S., Boehme, F., Patten, A., Cox, A., Gil-Mohapel, J., & Christie, B. R.
- Affiliations
- University of Victoria (CA)
- University of British Columbia (CA)
- Corresponding author
- Christie, Brian R.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 62
- Issue
- 4
- Pages
- 1607-1618
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2073811030
- Cited by
- 186
- References
- 107
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 12 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 17 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 8 · 2014: 22 · 2013: 14 · 2012: 9
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Michael Smith Foundation for Health Research
- Canadian Bureau for International Education
- Canada Foundation for Innovation
- University of Victoria
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- fetal alcohol spectrum disorders, prenatal alcohol exposure, anxiety-like behavior, depression-like behavior, oxidative stress, voluntary wheel running, aerobic exercise, glutathione, lipid peroxidation, protein oxidation, hippocampus, cerebellum, sex differences, redox state, neuroprotection
- MeSH terms
- Ethanol, Animals, Anxiety, Behavior, Animal, Depression, Female, Male, Physical Conditioning, Animal, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Lipid Peroxidation, Rats, Sprague-Dawley, Oxidative Stress, Rats, Fetal Alcohol Spectrum Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review