Understanding factors associated with early therapeutic alliance in PTSD treatment: adherence, childhood sexual abuse history, and social support
Open accessAbstract
OBJECTIVE: Therapeutic alliance has been associated with better treatment engagement, better adherence, and less dropout across various treatments and disorders. In treatment of posttraumatic stress disorder (PTSD), it may be particularly important to establish a strong early alliance to facilitate treatment adherence. However, factors such as childhood sexual abuse (CSA) history and poor social support may impede the development of early alliance in those receiving PTSD treatment. We sought to examine treatment adherence, CSA history, and social support as factors associated with early alliance in individuals with chronic PTSD who were receiving either prolonged exposure therapy (PE) or sertraline. METHOD: At pretreatment, participants (76.6% female; 64.9% Caucasian; mean age = 37.1 years, SD = 11.3) completed measures of trauma history, general support (Inventory of Socially Supportive Behaviors), and trauma-related social support (Social Reactions Questionnaire). Over the course of 10 weeks of PE or sertraline, they completed early therapeutic alliance (Working Alliance Inventory) and treatment adherence measures. RESULTS: Early alliance was associated with PE adherence (r = .32, p < .05) and overall treatment completion (r = .19, p < .05). Only trauma-related social support predicted the strength of early alliance beyond the effects of treatment condition (β = .23, p < .05); CSA history was not predictive of a lower early alliance. CONCLUSIONS: Given the associations with adherence, clinicians may find it useful to routinely assess alliance early in treatment. Positive trauma support, not CSA history, may be particularly important in the development of a strong early therapeutic alliance.
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Low motivation for treatment and poor working alliance have often been associated with a poorer treatment response.
“Low motivation for treatment and poor working alliance, which are factors common to all psychotherapies, have often been associated with a poorer treatment response [42,48,49,50,51].”
From A Multisite Non-Inferiority Randomized Controlled Trial of the Efficacy of Cognitive-Behavior Therapy for Generalized Anxiety Disorder Delivered by Videoconference (2022) · cites this paper as [50]
The paper’s Conclusions (page unavailable) report a consistent association between stronger therapeutic alliance and better psychotherapy outcomes. Its Results (page unavailable) also link early alliance to homework adherence and treatment completion. The copy does not establish the claim that low motivation for treatment is associated with poorer response; a search for “motivation” found no relevant passage. (LLM, conf=0.86)
Experimental — accuracy not yet measuredExisting literature suggests that the rapport in PE is critical.
“existing literature suggests that the rapport in PE is critical (Keller et al., 2010; McLaughlin et al., 2014).”
From Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: a randomized, placebo-controlled pilot trial (2018) · cites this paper as Keller et al., 2010
The acute prosocial and interpersonal effects of MDMA may support the quality of the therapeutic alliance, a potentially important factor relating to PTSD treatment adherence and outcome.
“Additionally, the acute prosocial and interpersonal effects of MDMA25,29 may support the quality of the therapeutic alliance, a potentially important factor relating to PTSD treatment adherence30 and outcome31.”
From MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study (2021) · cites this paper as [30]
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- Authors
- Keller, S. M., Zoellner, L. A., & Feeny, N. C.
- Affiliations
- Case Western Reserve University (US)
- University of Washington (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2010-12
- Volume
- 78
- Issue
- 6
- Pages
- 974-979
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- PMC
- PMC3244206
- OpenAlex
- W2065591296
- Cited by
- 170
- References
- 22
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 28 · 2021: 12 · 2020: 15 · 2019: 13 · 2018: 7 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 9
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH066348, R01MH066347)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- therapeutic relationship, post-traumatic stress disorder, medication adherence, child sexual abuse, social support, prolonged exposure therapy, sertraline, chronic PTSD, treatment discontinuation
- MeSH terms
- Adolescent, Adult, Aged, Child, Child Abuse, Sexual, Depressive Disorder, Female, Humans, Implosive Therapy, Life Change Events, Male, Middle Aged, Patient Compliance, Surveys and Questionnaires, Social Support, Stress Disorders, Post-Traumatic, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Sertraline, Adult Survivors of Child Abuse
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