Cited by 19Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

The mu-opioid receptor and the evolution of mother–infant attachment: theoretical comment on Higham et al. (2011)

Curley, James P.·2011·Behavioral Neuroscience

Abstract

Genetic variation at a single nucleotide polymorphism (SNP) in the mu-opioid receptor gene (OPRM1) of both humans and rhesus macaques Macaca mulatta has been associated with differential affinity to the endogenous ligand beta-endorphin as well as alterations in pain sensitivity, drug and alcohol dependence, and social behaviors. The new study by Higham et al. (2011) presented in the current issue of this journal shows for the first time that some of the natural variation in maternal behavior observed in rhesus macaque populations can also be explained by genetic differences at this SNP. This work, in conjunction with other recent studies showing that genetic variability at this same locus are related to changes in infant attachment, provides unique insights into how opioids have been reutilized during evolution to coordinate the mother-infant relationship.

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Crossref · 10.1037/a0022939

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Authors
Curley, J. P.
Affiliations
Columbia University (US)
Corresponding author
Curley, James P.
Venue
Behavioral Neuroscience
Published
2011
Volume
125
Issue
2
Pages
273-278
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2146704029
Cited by
19
References
60
Citations by year
2024: 2 · 2023: 1 · 2021: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1 · 2012: 1
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
mu-opioid receptor, OPRM1, single nucleotide polymorphisms, rhesus monkeys, maternal behavior, maternal attachment, beta-endorphin, pain sensitivity, social behavior, genetic variation
MeSH terms
Animals, Female, Maternal Behavior, Object Attachment, Oxytocin, Genetic Variation, Receptors, Opioid, mu

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