The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor
Abstract
The most common single nucleotide polymorphism in the coding region of the human mu opioid receptor gene is the A118G variant, an adenine to guanine transition at nucleotide position 118 of the coding sequence of the gene. This polymorphism codes for an asparagine to aspartic acid substitution at amino acid 40 in the amino‐terminus, thereby removing a potential extracellular glycosylation site. Using in vitro cellular expression assays, this variant has been reported to change binding of the endogenous agonist beta‐endorphin and signaling of the receptor following binding of beta‐endorphin. Three clinical studies report that A118G genotype affects opioid antagonist‐mediated increases in cortisol levels. These studies demonstrate a functional role of this variant in responses to endogenous and exogenous opioids. To further characterize function, we expressed the prototype and variant receptors in two types of cells (human 293 embryonic kidney cells and Syrian hamster adenovirus‐12‐induced tumor cells). Stable expression of variant and prototype receptors was characterized by differences in levels of cell surface binding capacity (Bmax), forskolin‐induced cAMP accumulation, as well as agonist‐induced accumulation of cAMP (EC 50) for several agonists, but not for beta‐endorphin. In contrast, transiently expressed variant receptors showed only a minor difference in cell surface binding capacity compared to the prototype, and no differences in cAMP EC 50 values.
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The A118G variant of the MOR gene has enhanced binding and signaling properties but low expression of mRNA.
“The A118G variant has enhanced binding and signaling properties, but low expression of mRNA (Zhang et al 2005; Kroslak et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kroslak et al 2007
Cites
Bond, C. E., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J. H., Strong, J. A., Leal, S. M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9608 · Cited by 1,072 · see citing works
Self-citationKreek, M. J., Nielsen, D. A., Butelman, E. R., & LaForge, K. S. (2005) · Nature Neuroscience · doi:10.1038/nn1583 · Cited by 1,024 · see citing works
Self-citationOslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., & O'Brien, C. P. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300219 · Cited by 571 · see citing works
Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G
Zhang, Y., Wang, D., Johnson, A. D., Papp, A. C., & Sadée, W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504942200 · Cited by 563 · see citing works
Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works
Self-citationPharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments
Kreek, M. J., Bart, G., Lilly, C., Laforge, K. S., & Nielsen, D. A. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.1 · Cited by 391 · see citing works
Self-citationKreek, M. J., LaForge, K. S., & Butelman, E. R. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd897 · Cited by 371 · see citing works
Self-citationHoehe, M. R. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2895 · Cited by 288 · see citing works
μ opioid receptor gene variants: lack of association with alcohol dependence
Bergen, A. W., Kokoszka, J., Peterson, R. J., Long, J. C., Virkkunen, M. E., Linnoila, M., & Goldman, D. A. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000331 · Cited by 271 · see citing works
Beyer, A., Koch, T., Schröder, H., Schulz, S., & Höllt, V. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02340.x · Cited by 258 · see citing works
Wand, G. S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00294-9 · Cited by 246 · see citing works
Befort, K., Filliol, D., Décaillot, F. M., Gavériaux‐Ruff, C., Hoehe, M. R., & Kieffer, B. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006352200 · Cited by 241 · see citing works
Gelernter, J. E., Kranzler, H. R., & Cubells, J. F. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000556 · Cited by 241 · see citing works
Bart, G. B., Kreek, M. J., Ott, J., LaForge, K. S., Proudnikov, D., Pollak, L., & Heilig, M. A. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300598 · Cited by 220 · see citing works
Self-citationRathz, D. A., Brown, K. M., Kramer, L. A., & Liggett, S. B. (2002) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200202000-00001 · Cited by 208 · see citing works
Bart, G. B., Heilig, M. A., LaForge, K. S., Pollak, L., Leal, S. M., Ott, J., & Kreek, M. J. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001504 · Cited by 177 · see citing works
Self-citationRay, K., Clapp, P., Goldsmith, P. K., & Spiegel, A. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34558 · Cited by 156 · see citing works
Opioid receptor and peptide gene polymorphisms: potential implications for addictions
LaForge, K. S., Yuferov, V. P., & Kreek, M. J. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00819-0 · Cited by 152 · see citing works
Self-citationAssociation between mu opioid receptor gene polymorphisms and Chinese heroin addicts
Szeto, C. Y.-K., Tang, N. L. S., Lee, D. T. S., & Stadlin, A. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00011 · Cited by 145 · see citing works
Hernández–Ávila, C. A., Wand, G. S., Luο, X., Gelernter, J. E., & Kranzler, H. R. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10054 · Cited by 144 · see citing works
Bart, G. B., Schluger, J. H., Borg, L., Ho, A., Bidlack, J. M., & Kreek, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300811 · Cited by 143 · see citing works
Self-citationThe Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress
Chong, R. Y., Oswald, L. M., Yang, X., Uhart, M., Lin, P., & Wand, G. S. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300856 · Cited by 138 · see citing works
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
Kim, K.-S., Lee, K.-W., Lee, K.-W., Im, J.-Y., Yoo, J. Y., Kim, S.-W., Lee, J.-K., Nestler, E. J., & Han, P.-L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508812103 · Cited by 123 · see citing works
Franke, P. E., Wang, T., Nöthen, M. M., Knapp, M., Neidt, H., Albrecht, S., Jahnes, E., Propping, P., & Maier, W. (2001) · PubMed · Cited by 119 · see citing works
The Carboxyl Terminus of the Human Calcium Receptor
Ray, K., Fan, G.-F., Goldsmith, P. K., & Spiegel, A. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31355 · Cited by 118 · see citing works
Luο, X., Kranzler, H. R., Zhao, H., & Gelernter, J. E. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20034 · Cited by 107 · see citing works
Oligomerization of opioid receptors
Gomes, I., Filipovska, J., Jordan, B. A., & Devi, L. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00094-4 · Cited by 96 · see citing works
Schluger, J. H., Ho, A., Borg, L., Porter, M., Maniar, S., Gunduz, M., Perret, G., King, A. C., & Kreek, M. J. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03931.x · Cited by 93 · see citing works
Self-citationFan, G., Goldsmith, P. K., Collins, R. M., Dunn, C., Krapcho, K. J., ROGERS, K. V., & Spiegel, A. M. (1997) · Endocrinology · doi:10.1210/endo.138.5.5131 · Cited by 88 · see citing works
Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse
Berrettini, W. H., Hoehe, M. R., Ferraro, T. N., DeMaria, P. A., & Gottheil, E. (1997) · Addiction Biology · doi:10.1080/13556219772598 · Cited by 77 · see citing works
Association of Functional Opioid Receptor Genotypes With Alcohol Dependence in Koreans
Kim, S., Kim, C., Kang, D., Kim, Y., Byun, W., Kim, S., Park, J., Kim, M.-J., & Oslin, D. W. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000130803.62768.ab · Cited by 74 · see citing works
Koch, T., Kroslak, T., Averbeck, M., Mayer, P. E., Schröder, H., Raulf, E., & Höllt, V. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.2.328 · Cited by 73 · see citing works
Self-citationKarpa, K. D., Lidow, M. S., Pickering, M., Levenson, R. G., & Bergson, C. M. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.5.1071 · Cited by 61 · see citing works
Rodríguez, C. G., Cundell, D. R., TUOMANEN, E. I., Kolakowski, L. F., Gerard, C. J., & Gerard, N. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.25178 · Cited by 60 · see citing works
Glycosylation of the Human Prostacyclin Receptor: Role in Ligand Binding and Signal Transduction
Zhang, Z., Austin, S. C., & Smyth, E. M. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12609-0 · Cited by 57 · see citing works
Margas, W., Zubkoff, I., Schuler, H. G., Janicki, P. K., & Ruiz-Velasco, V. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01007.2006 · Cited by 52 · see citing works
μ Opioid receptor: role for the amino terminus as a determinant of ligand binding affinity
Chaturvedi, K., Shahrestanifar, M., & Howells, R. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00332-0 · Cited by 51 · see citing works
Böer, U., Neuschäfer‐Rube, F., Möller, U., & Püschel, G. P. (2000) · Biochemical Journal · doi:10.1042/bj3500839 · Cited by 43 · see citing works
Functional role of N‐linked glycosylation on the rat melanin‐concentrating hormone receptor 1
Saito, Y., Tetsuka, M., Li, Y., Kawamura, Y., & Maruyama, K. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03744-4 · Cited by 35 · see citing works
Bühlmann, N., Aldecoa, A., Leuthäuser, K., Gujer, R., Muff, R., Fischer, J. A., & Born, W. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02259-6 · Cited by 26 · see citing works
Tan, E., Chong, S., Mahendran, R., Tan, C. H., & Teo, Y. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00491-7 · Cited by 17 · see citing works
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Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802 · see citing works
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 582 · see citing works
Opioid receptors: drivers to addiction?
Darcq, E., & Kieffer, B. L. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0028-x · Cited by 354 · see citing works
Davis, C. A., Levitan, R. D., Reid, C., Carter, J. C., Kaplan, A. S., Patte, K. A., King, N., Curtis, C., & Kennedy, J. L. (2009) · Obesity · doi:10.1038/oby.2009.52 · Cited by 314 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“The A118G variant has enhanced binding and signaling properties, but low expression of mRNA (Zhang et al. 2005; Kroslak et al. 2007).”
The Interpersonal Dimension of Borderline Personality Disorder: Toward a Neuropeptide Model
Stanley, B., & Siever, L. J. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09050744 · Cited by 291 · see citing works
Way, B. M., Taylor, S. E., & Eisenberger, N. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812612106 · Cited by 264 · see citing works
Genetics and the placebo effect: the placebome
Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.009 · Cited by 271 · see citing works
Pharmacogenetic approaches to the treatment of alcohol addiction
Heilig, M. A., Goldman, D. A., Berrettini, W. H., & O’Brien, C. P. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3110 · Cited by 249 · see citing works
Opiate addiction and cocaine addiction: underlying molecular neurobiology and genetics
Kreek, M. J., Levran, O., Reed, B., Schlussman, S. D., Zhou, Y., & Butelman, E. R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60390 · Cited by 220 · see citing works
Self-citationMeta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment
Walter, C., & Lötsch, J. (2009) · Pain · doi:10.1016/j.pain.2009.07.013 · Cited by 200 · see citing works
The genetics of addiction—a translational perspective
Arpana Agrawal, A., Verweij, K. J. H., Gillespie, N. A., Heath, A. C., Lessov‐Schlaggar, C. N., Martin, N. G., Nelson, E. C., Slutske, W. S., Whitfield, J. B., & Lynskey, M. T. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.54 · Cited by 198 · see citing works
Barr, C. S., Schwandt, M. L., Lindell, S. G., Higley, J. D., Maestripieri, D., Goldman, D., Suomi, S. J., & Heilig, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710225105 · Cited by 191 · see citing works
Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches
Peciña, M., Karp, J. F., Mathew, S. J., Todtenkopf, M. S., Ehrich, E. W., & Zubieta, J.-K. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0117-2 · Cited by 188 · see citing works
Peciña, M., Love, T., Stohler, C. S., Goldman, D. A., & Zubieta, J.-K. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.272 · Cited by 161 · see citing works
Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
Mague, S. D., Isiegas, C., Huang, P., Liu‐Chen, L., Lerman, C. E., & Blendy, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901800106 · Cited by 160 · see citing works
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Hwang, I. C., Park, J. Y., Myung, S., Ahn, H. Y., Fukuda, K., & Liao, Q. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000405 · Cited by 151 · see citing works
Oertel, B. G., Kettner, M., Scholich, K., Renné, C., Roskam, B., Geißlinger, G., Schmidt, P. H., & Lötsch, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807030200 · Cited by 148 · see citing works
Landau, R., Kern, C., Columb, M. O., Smiley, R. M., & Blouin, J. (2008) · Pain · doi:10.1016/j.pain.2008.02.023 · Cited by 147 · see citing works
The genetics of the opioid system and specific drug addictions
Levran, O., Yuferov, V. P., & Kreek, M. J. (2012) · Human Genetics · doi:10.1007/s00439-012-1172-4 · Cited by 143 · see citing works
Self-citationHayashida, M., Nagashima, M., Satoh, Y., Katoh, R., Tagami, M., Ide, S., Kasai, S., Nishizawa, D., Ogai, Y., Hasegawa, J., et al. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.11.1605 · Cited by 140 · see citing works
OPRM1 SNP (A118G): Involvement in disease development, treatment response, and animal models
Mague, S. D., & Blendy, J. A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.12.016 · Cited by 136 · see citing works
Fukuda, K., Hayashida, M., Ide, S., Saita, N., Kokita, Y., Kasai, S., Nishizawa, D., Ogai, Y., Hasegawa, J., Nagashima, M., et al. (2009) · Pain · doi:10.1016/j.pain.2009.09.004 · Cited by 135 · see citing works
Tan, E.-C., Lim, E. C., Teo, Y.-Y., Lim, Y., Law, H.-Y., & Sia, A. T. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-32 · Cited by 133 · see citing works
Genetics of Opioid Dependence: A Review of the Genetic Contribution to Opioid Dependence
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A review of opioid addiction genetics
Crist, R. C., Reiner, B. C., & Berrettini, W. H. (2018) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.07.014 · Cited by 131 · see citing works
Deumens, R., Steyaert, A., Forget, P., Schubert, M., Lavand'homme, P. M., Hermans, E., & Kock, M. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.01.002 · Cited by 123 · see citing works
Troisi, A., Frazzetto, G., Carola, V., Di Lorenzo, G., Coviello, M., D'Amato, F. R., Moles, A., Siracusano, A., & Gross, C. (2011) · Social Neuroscience · doi:10.1080/17470919.2010.482786 · Cited by 118 · see citing works
Tissue-Specific Glycosylation at the Glycopeptide Level
Medzihradszky, K. F., Kaasik, K., & Chalkley, R. J. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.050393 · Cited by 118 · see citing works
μ opioid receptor, social behaviour and autism spectrum disorder: reward matters
Pellissier, L. P., Gandía, J., Laboute, T., Becker, J. A. J., & Merrer, J. L. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13808 · Cited by 111 · see citing works
Huang, P., Chen, C., Mague, S. D., Blendy, J. A., & Liu‐Chen, L. (2011) · Biochemical Journal · doi:10.1042/bj20111050 · Cited by 113 · see citing works
Crist, R. C., & Berrettini, W. H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.018 · Cited by 112 · see citing works
Yuferov, V. P., Levran, O., Proudnikov, D., Nielsen, D. A., & Kreek, M. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05275.x · Cited by 104 · see citing works
Self-citationConsequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?
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Deb, I., Chakraborty, J., Gangopadhyay, P. K., Choudhury, S. R., & Das, S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06472.x · Cited by 104 · see citing works
Neuropathic and chronic pain stimuli downregulate central μ -opioid and dopaminergic transmission
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Self-citationThe opioid system in depression
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Epigenetic Variation in the Mu-Opioid Receptor Gene in Infants with Neonatal Abstinence Syndrome
Wachman, E. M., Hayes, M. J., Lester, B. M., Terrin, N. C., Brown, M. S., Nielsen, D. A., & Davis, J. M. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.05.040 · Cited by 100 · see citing works
Self-citationBruehl, S., Burns, J. W., Chung, O. Y., & Chont, M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.12.003 · Cited by 88 · see citing works
Common single nucleotide variants underlying drug addiction: more than a decade of research
Bühler, K., Giné, E., Echeverry‐Alzate, V., Calleja‐Conde, J., de Fonseca, F. R., & López‐Moreno, J. A. (2015) · Addiction Biology · doi:10.1111/adb.12204 · Cited by 88 · see citing works
The evolution of vertebrate opioid receptors
Craig, W. S. (2009) · Frontiers in bioscience · doi:10.2741/3306 · Cited by 89 · see citing works
Patriquin, M. A., Bauer, I. E., Soares, J. C., Graham, D. P., & Nielsen, D. A. (2015) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000095 · Cited by 86 · see citing works
Self-citationRay, L. A., Barr, C. S., Blendy, J. A., Oslin, D. W., Goldman, D. A., & Anton, R. F. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01633.x · Cited by 80 · see citing works
Burns, J. A., Kroll, D. S., Feldman, D. E., Liu, C. K., Manza, P., Wiers, C. E., Volkow, N. D., & Wang, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00626 · Cited by 72 · see citing works
Hancock, D. B., Levy, J. L., Gaddis, N., Glasheen, C., Saccone, N. L., Page, G. P., Hulse, G. K., Wildenauer, D., Kelty, E. A., Schwab, S. G., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.003 · Cited by 70 · see citing works
Nielsen, L. M., Olesen, A. E., Branford, R., Christrup, L. L., Sato, H., & Drewes, A. M. (2014) · Pain Practice · doi:10.1111/papr.12232 · Cited by 70 · see citing works
Higham, J. P., Barr, C. S., Hoffman, C. L., Mandalaywala, T. M., Parker, K. J., & Maestripieri, D. (2011) · Behavioral Neuroscience · doi:10.1037/a0022695 · Cited by 69 · see citing works
“The G allele for this gene causes an amino acid substitution in the N-terminal arm of the receptor, which was originally reported to increase their affinity for -endorphin (Bond et al., 1998), although this effect may be cell-line dependent (Kroslak et al., 2007).”
Current evidence for a modulation of low back pain by human genetic variants
Tegeder, I., & Lötsch, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00703.x · Cited by 69 · see citing works
Pharmacogenetic Treatments for Drug Addiction: Alcohol and Opiates
Haile, C. N., Kosten, T. A., & Kosten, T. R. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990802122564 · Cited by 71 · see citing works
Hermann, D., Hirth, N., Reimold, M., Batra, A., Smolka, M. N., Hoffmann, S., Kiefer, F., Noori, H. R., Sommer, W. H., Reischl, G., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.145 · Cited by 64 · see citing works
Recent Developments in the Study of Opioid Receptors
Cox, B. M. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083279 · Cited by 64 · see citing works
Mahmoud, S., Thorsell, A., Sommer, W. H., Heilig, M. A., Holgate, J. K., Bartlett, S. E., & Ruiz-Velasco, V. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318231fc11 · Cited by 62 · see citing works
Zhang, Y., Picetti, R., Butelman, E. R., Ho, A., Blendy, J. A., & Kreek, M. J. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.286 · Cited by 61 · see citing works
Self-citationPharmacogenomics of the Human µ-Opioid Receptor
Kasai, S., & Ikeda, K. (2011) · Pharmacogenomics · doi:10.2217/pgs.11.68 · Cited by 61 · see citing works
Hao, Y., Huang, W., Nielsen, D. A., & Kosten, T. A. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00021 · Cited by 59 · see citing works
Self-citationZhou, Y., Proudnikov, D., Yuferov, V., & Kreek, M. J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.015 · Cited by 58 · see citing works
Self-citationBilbao, A., Robinson, J. E., Heilig, M. A., Malanga, C. J., Spanagel, R., Sommer, W. H., & Thorsell, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.021 · Cited by 58 · see citing works
Sia, A. T. H., Lim, Y., Lim, E. C. P., Ocampo, C. E., Lim, W.-Y., Cheong, P., & Tan, E. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.008 · Cited by 58 · see citing works
Pharmacogenomic considerations in opioid analgesia
Landau, R. (2012) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s23422 · Cited by 57 · see citing works
Common and specific liability to addiction: Approaches to association studies of opioid addiction
Nielsen, D. A., & Kreek, M. J. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.03.026 · Cited by 55 · see citing works
Self-citationThe Role of Hydromorphone and OPRM1 in Postoperative Pain Relief with Hydrocodone
Jortani, S. A. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e227 · Cited by 55 · see citing works
Wu, W. D., Wang, Y., Fang, Y., & Zhou, H. (2009) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256337 · Cited by 55 · see citing works
Lovallo, W. R., Enoch, M., Acheson, A., Cohoon, A. J., Sorocco, K. H., Hodgkinson, C. A., Vincent, A. S., Glahn, D. C., & Goldman, D. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.101 · Cited by 54 · see citing works
Xu, J., Lu, Z., Xu, M., Pan, L., Deng, Y., Xie, X., Liu, H., Ding, S., Hurd, Y. L., Pasternak, G. W., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3986-13.2014 · Cited by 55 · see citing works
Wasilewski, A., Lewandowska, U., Mosińska, P., Watała, C. W., Storr, M., Fichna, J., & Venkatesan, T. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.73 · Cited by 55 · see citing works
Opiates, overeating and obesity: a psychogenetic analysis
Davis, C. A., Zai, C. C. H., Levitan, R. D., Kaplan, A. S., Carter, J. C., Reid‐Westoby, C., Curtis, C., Wight, K., & Kennedy, J. L. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.276 · Cited by 51 · see citing works
Child μ-Opioid Receptor Gene Variant Influences Parent–Child Relations
Copeland, W., Sun, H., Costello, E. J., Angold, A. C., Heilig, M. A., & Barr, C. S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.251 · Cited by 50 · see citing works
Endogenous opiates and behavior: 2007
Bodnar, R. J. (2008) · Peptides · doi:10.1016/j.peptides.2008.09.007 · Cited by 51 · see citing works
Chidambaran, V., Mavi, J., Esslinger, H. R., Pilipenko, V. V., Martin, L. J., Zhang, K., & Sadhasivam, S. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2014.59 · Cited by 47 · see citing works
Mechanisms of the placebo effect in pain and psychiatric disorders
Holmes, R. D., Tiwari, A. K., & Kennedy, J. (2016) · The Pharmacogenomics Journal · doi:10.1038/tpj.2016.15 · Cited by 46 · see citing works
Reed, B., Butelman, E. R., Yuferov, V. P., Randesi, M., & Kreek, M. J. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0504-6 · Cited by 46 · see citing works
Self-citationDomino, E. F., Evans, C., Ni, L., Guthrie, S. K., Koeppe, R. A., & Zubieta, J. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.04.003 · Cited by 43 · see citing works
Immune Response Activation and Immunomodulation
Tyagi, R. K., & Bisen, P. S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.73708 · Cited by 44 · see citing works
Analgesia and central side‐effects: two separate dimensions of morphine response
Droney, J., Gretton, S. K., Sato, H., Ross, J. R., Branford, R., Welsh, K. I., Cookson, W., & Riley, J. L. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12008 · Cited by 40 · see citing works
Bailey, A., Metaxas, A., Al‐Hasani, R., Keyworth, H. L., Forster, D. M., & Kitchen, I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07104.x · Cited by 40 · see citing works
Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons
Halikere, A., Popova, D., Scarnati, M. S., Hamod, A., Swerdel, M. R., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0507-0 · Cited by 37 · see citing works
Hartwell, E. E., Feinn, R., Morris, P. E., Gelernter, J. E., Krystal, J. H., Arias, A. J., Hoffman, M., Petrakis, I. L., Gueorguieva, R. V., Schacht, J. P., et al. (2020) · Addiction · doi:10.1111/add.14975 · Cited by 39 · see citing works
Clarke, T., Crist, R. C., Kampman, K. M., Dackis, C. A., Pettinati, H. M., O’Brien, C. P., Oslin, D. W., Ferraro, T. N., Lohoff, F. W., & Berrettini, W. H. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.02.018 · Cited by 39 · see citing works
Schwandt, M. L., Lindell, S. G., Higley, J. D., Suomi, S. J., Heilig, M. A., & Barr, C. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.002 · Cited by 37 · see citing works
Woodcock, E. A., Lundahl, L. H., Burmeister, M., & Greenwald, M. K. (2015) · American Journal on Addictions · doi:10.1111/ajad.12187 · Cited by 38 · see citing works
Ducat, E. A., Ray, B. M., Bart, G. B., Umemura, Y., Varon, J., Ho, A., & Kreek, M. J. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00313.x · Cited by 37 · see citing works
Self-citationWalter, C., Doehring, A., Oertel, B. G., & Lötsch, J. (2013) · Pharmacogenomics · doi:10.2217/pgs.13.187 · Cited by 36 · see citing works
Hirasawa-Fujita, M., Bly, M. J., Ellingrod, V. L., Dalack, G. W., & Domino, E. F. (2017) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/1935-1232-11.1.39 · Cited by 35 · see citing works
Variable response to opioid treatment: any genetic predictors within sight?
Skorpen, F., Laugsand, E., Klepstad, P., & Kaasa, S. (2008) · Palliative Medicine · doi:10.1177/0269216308089302 · Cited by 35 · see citing works
Alcohol: A stimulant activating brain stress responsive systems with persistent neuroadaptation
Zhou, Y., & Kreek, M. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.044 · Cited by 33 · see citing works
Self-citationA118G Polymorphism of OPRM1 Gene is Associated with Schizophrenia
Šerý, O., Přikryl, R., Častulík, L., & Šťastný, F. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9327-z · Cited by 33 · see citing works
Pharmacogenomics for personalized pain medicine
Ko, T., Wong, C., Wu, J.-Y., & Chen, Y.-T. (2016) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2016.02.001 · Cited by 32 · see citing works
Are Opioids Effective in Relieving Neuropathic Pain?
Schembri, E. (2018) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-018-0009-4 · Cited by 32 · see citing works
Pharmacogenetics of Addiction Therapy
Nielsen, D. A., Nielsen, E. M., Dasari, T., & Spellicy, C. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0956-8_15 · Cited by 31 · see citing works
Self-citationPlacebo effects and the molecular biological components involved
Cai, L., & He, L. (2019) · General Psychiatry · doi:10.1136/gpsych-2019-100089 · Cited by 32 · see citing works
Carbamidomethylation Side Reactions May Lead to Glycan Misassignments in Glycopeptide Analysis
Darula, Z., & Medzihradszky, K. F. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b01121 · Cited by 31 · see citing works
Knapman, A., Santiago, M., & Connor, M. A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12785 · Cited by 29 · see citing works
Lötsch, J., & Ultsch, A. (2013) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2013.07.010 · Cited by 29 · see citing works
Nicotine-specific and non-specific effects of cigarette smoking on endogenous opioid mechanisms
Nuechterlein, E. B., Ni, L., Domino, E. F., & Zubieta, J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.04.006 · Cited by 28 · see citing works
Bidirectional translational research: Progress in understanding addictive diseases
Kreek, M. J., Schlussman, S. D., Reed, B., Zhang, Y., Nielsen, D. A., Levran, O., Zhou, Y., & Butelman, E. R. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.042 · Cited by 28 · see citing works
Self-citationRobinson, J. E., Vardy, E., DiBerto, J. F., Chefer, V. I., White, K. L., Fish, E. W., Chen, M., Gigante, E. D., Krouse, M. C., Sun, H., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.109 · Cited by 28 · see citing works
Lee, M. R., Gallen, C. L., Zhang, X., Hodgkinson, C. A., Goldman, D., Stein, E. A., & Barr, C. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024203 · Cited by 27 · see citing works
Association study of OPRM1 polymorphisms with Schizophrenia in Han Chinese population
Ding, S., Chen, B., Zheng, Y., Lu, Q., Liu, L., & Zhuge, Q. C. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-107 · Cited by 27 · see citing works
Pharmacogenetics of Methadone Response
Fonseca, F., & Torrens, M. (2017) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-017-0311-y · Cited by 26 · see citing works
Capraris, A. D., Cinnella, G., Marolla, A., Salatto, P., Lima, S. D., Vetuschi, P., Consoletti, L., Gesualdo, L., & DAMBROSIO, M. (2011) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201102400417 · Cited by 26 · see citing works
- Authors
- Kroslak, T., LaForge, K. S., Gianotti, R. J., Ho, A., Nielsen, D. A., & Kreek, M. J.
- Affiliations
- Rockefeller University (US)
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2007-06-03
- Volume
- 103
- Issue
- 1
- Pages
- 77-87
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2039877085
- Cited by
- 213
- References
- 42
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 16 · 2014: 21 · 2013: 17 · 2012: 23
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Biotechnology and Biological Sciences Research Council (C17893)
- National Institute on Drug Abuse (R01DA012848, P60 DA 05130, P60DA005130, R01-DA-12848)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mu-opioid receptor, A118G polymorphism, single nucleotide polymorphisms, cAMP signaling, forskolin, cell surface binding
- MeSH terms
- Cyclic AMP, Analgesics, Opioid, Animals, Binding, Competitive, Cell Line, Cell Membrane, Dose-Response Relationship, Drug, Fibroblasts, Colforsin, Cricetinae, Humans, Kidney, Mesocricetus, Receptors, Opioid, mu, Gene Transfer Techniques, Polymorphism, Single Nucleotide, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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