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Cited by 51Substance Abuse Treatment and OutcomesChild and Adolescent Psychosocial and Emotional DevelopmentMental Health Treatment and Access

Onset of alcohol or substance use disorders following treatment for adolescent depression.

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Curry, John, Silva, Susan, Rohde, Paul, Ginsburg, Golda, Kennard, Betsy, Kratochvil, Christopher, Simons, Anne, Kirchner, Jerry +15 more·2012·Journal of Consulting and Clinical Psychology
DOI 10.1037/a0026929PMC PMC3314095
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Abstract

OBJECTIVE: This study tested whether positive response to short-term treatment for adolescent major depressive disorder (MDD) would have the secondary benefit of preventing subsequent alcohol use disorders (AUD) or substance use disorders (SUD). METHOD: For 5 years, we followed 192 adolescents (56.2% female; 20.8% minority) who had participated in the Treatment for Adolescents with Depression Study (TADS; TADS Team, 2004) and who had no prior diagnoses of AUD or SUD. TADS initial treatments were cognitive behavior therapy (CBT), fluoxetine alone (FLX), the combination of CBT and FLX (COMB), or clinical management with pill placebo (PBO). We used both the original TADS treatment response rating and a more restrictive symptom count rating. During follow-up, diagnostic interviews were completed at 6- or 12-month intervals to assess onset of AUD or SUD as well as MDD recovery and recurrence. RESULTS: Achieving a positive response to MDD treatment was unrelated to subsequent AUD but predicted a lower rate of subsequent SUD, regardless of the measure of positive response (11.65% vs. 24.72%, or 10.0% vs. 24.5%, respectively). Type of initial MDD treatment was not related to either outcome. Prior to depression treatment, greater involvement with alcohol or drugs predicted later AUD or SUD, as did older age (for AUD) and more comorbid disorders (for SUD). Among those with recurrent MDD and AUD, AUD preceded MDD recurrence in 24 of 25 cases. CONCLUSION: Effective short-term adolescent depression treatment significantly reduces the rate of subsequent SUD but not AUD. Alcohol or drug use should be assessed prior to adolescent MDD treatment and monitored even after MDD recovery.

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  • Curry et al. (2012) reported that combined treatment significantly reduced the rate of subsequent drug use disorders (11.6% vs. 24.7%), but not alcohol use disorder.

    “The authors reported that the combined treatment significantly reduced the rate of subsequent drug use disorders (11.6% vs. 24.7%), but not alcohol use disorder.”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Curry et al. 2012

    The Results (Treatment Response Analysis) give 11.6% versus 24.7% for adolescents who responded to depression treatment versus those who did not—not for combined treatment versus another treatment. The Abstract (Results) states that the type of initial treatment was unrelated to either subsequent disorder. The paper does report no association between treatment response and later alcohol use disorder. (LLM, conf=0.90)

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  • Curry et al. (2012) treated 12-18 year old patients with cognitive behavioral therapy and fluoxetine.

    “Curry et al. (2012) treated 12-18 years old patients with Cognitive Behavioral Therapy and fluoxetine (Curry et al. 2012).”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Curry et al. 2012

    The Abstract (Method) says the adolescents had received cognitive behavior therapy, fluoxetine, their combination, or placebo in TADS. The Method (Relation of TADS to the present study) identifies Curry et al.’s study as a follow-up of those participants, rather than the trial that administered the treatments. The Method (Sample Description) gives a mean age at TADS entry but does not establish the claimed 12–18-year age range. (LLM, conf=0.83)

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  • Similar findings were reported for non-bipolar depressive disorders in both prospective and retrospective between-group examinations.

    “Similar findings were reported for non-bipolar depressive disorders in both prospective and retrospective between-group examinations (Curry et al. 2012; Carra ` et al. 2019).”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Curry et al. 2012

    The Method describes a five-year follow-up of adolescents with major depressive disorder, and the Results compare subsequent substance use disorder rates between depression-treatment responders and nonresponders. This supports a prospective between-group finding for non-bipolar depression. The cited paper does not report a corresponding retrospective between-group examination. (LLM, conf=0.79)

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  • Two studies examined the impact of antidepressants.

    “Two studies examined the impact of antidepressants (Curry et al. 2012; Goldstein et al. 2013).”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Curry et al. 2012

  • Two studies used psychotherapy in addition to medications, including cognitive behavior therapy.

    “Two studies used psychotherapy in addition to medications, including cognitive behavior therapy (Curry et al. 2012; Carra ` et al. 2019).”

    From The Impact of Pharmacotherapy of Childhood-Onset Psychiatric Disorders on the Development of Substance Use Disorders (2022) · cites this paper as Curry et al. 2012

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Research works printed but not linked: 1

  1. King CA Ghaziuddin N McGovern L Brand E Hill E Naylor M Predictors of comorbid alcohol and substance abuse in depressed adolescents Journal of the American Academy of Child and Adolescent Psychiatry 1996 35 743 751 8682755

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Authors
Curry, J., Silva, S., Rohde, P., Ginsburg, G., Kennard, B., Kratochvil, C., Simons, A., Kirchner, J., May, D., Mayes, T., Feeny, N., Albano, A. M., Lavanier, S., Reinecke, M., Jacobs, R., Becker-Weidman, E., Weller, E., Emslie, G., Walkup, J., Kastelic, E., Burns, B., Wells, K., & March, J.
Affiliations
  • Duke University (US)
  • Oregon Research Institute (US)
  • Johns Hopkins University (US)
  • The University of Texas at Austin (US)
  • University of Nebraska Medical Center (US)
  • Case Western Reserve University (US)
  • Columbia University (US)
  • Cincinnati Children's Hospital Medical Center (US)
  • Northwestern University (US)
  • University of Pennsylvania (US)
ORCID
Venue
Journal of Consulting and Clinical Psychology
Publisher
American Psychological Association (APA)
Published
2012
Volume
80
Issue
2
Pages
299-312
ISSN
  • 0022-006X (ISSN-L)
  • 1939-2117
DOI
10.1037/a0026929
PMC
PMC3314095
OpenAlex
W2045697835
Cited by
51
References
60
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 8 · 2012: 2
FWCI
4.07
Type
journal article
Language
en
Open access
Locations
  • Journal of Consulting and Clinical Psychology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • DigitalCommons@UNMC (submittedVersion)
Funders
National Institute of Mental Health (MH70494)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
adolescent depression, major depressive disorder, alcoholism, substance use disorders, treatment response, cognitive behavioral therapy, fluoxetine, Treatment for Adolescents with Depression Study, depression recurrence, comorbidities, secondary prevention
MeSH terms
Adolescent, Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Major, Major Depressive Disorder, Female, Fluoxetine, Follow-Up Studies, Humans, Male, Cognitive Behavioral Therapy, Treatment Outcome, Substance-Related Disorders

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