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Cited by 45Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsMemory Processes and Influences

Individuals with posttraumatic stress disorder show a selective deficit in generalization of associative learning.

Levy-Gigi, Einat, Kéri, Szabolcs, Myers, Catherine E., Lencovsky, Zvi, Sharvit-Benbaji, Hadas, Orr, Scott P., Gilbertson, Mark W., Servatius, Richard J. +2 more·2012·Neuropsychology
DOI 10.1037/a0029361
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Abstract

Objective Drawing on two different populations, Israeli police and Hungarian civilians, the present study assessed the ability of individuals with posttraumatic stress disorder (PTSD) to generalize previous learning to novel situations. Past neuroimaging studies have demonstrated diminished medial temporal lobe (MTL) activation and/or reduced hippocampal volume in individuals with PTSD. Our earlier computational models of cortico-hippocampal function and subsequent experimental tests of these models in MTL-impaired clinical populations argue that even mild hippocampal dysfunction may result in subtle impairments in generalization. Therefore, we predicted that individuals with PTSD would show impaired generalization. Method We compared the performance of five groups from two countries, including 19 Israeli police with PTSD and 22 trauma-exposed police without PTSD, and 22 Hungarian civilians with PTSD, 25 trauma-exposed civilians without PTSD, and 25 individuals without PTSD unexposed to the same trauma. Participants were tested on a two-phase learning paradigm, the Acquired Equivalence Task, which measures the ability to generalize past learning to novel situations. Results We found that both PTSD and non-PTSD participants were capable of learning the initial stimulus-outcome associations, F(4, 108) = 1.79, p = .14. However, as predicted, only individuals with PTSD showed a selective deficit in generalization of this learning to novel situations (F(4, 108) = 8.35, p Conclusio…

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  • PTSD patients are equivalent to controls in learning initial stimulus-outcome associations but show a selective deficit in generalizing this learning to novel situations.

    “The prediction that PTSD patients should therefore be equivalent to controls in learning initial stimulus-outcome associations but show a selective deficit in generalizing this learning to novel situations was recently confirmed”

    From Episodic memory, perceptual memory, and their interaction: Foundations for a theory of posttraumatic stress disorder. (2014) · cites this paper as Levy-Gigi et al., 2012

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Authors
Levy-Gigi, E., Kéri, S., Myers, C. E., Lencovsky, Z., Sharvit-Benbaji, H., Orr, S. P., Gilbertson, M. W., Servatius, R. J., Tsao, J. W., & Gluck, M. A.
Affiliations
  • University of Szeged (HU)
  • Rutgers, The State University of New Jersey (US)
  • Harvard University (US)
  • United States Department of Veterans Affairs (US)
  • United States Department of the Navy (US)
ORCID
Venue
Neuropsychology
Publisher
American Psychological Association (APA)
Published
2012
Volume
26
Issue
6
Pages
758-767
ISSN
  • 0894-4105 (ISSN-L)
  • 1931-1559
DOI
10.1037/a0029361
OpenAlex
W2115514898
Cited by
45
References
75
Citations by year
2026: 2 · 2025: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 3
FWCI
5.79
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
post-traumatic stress disorder, associative learning, generalization, hippocampal dysfunction, medial temporal lobe, learning disabilities, trauma-exposed individuals, police officers, computational models of learning
MeSH terms
Workforce, Adult, Association Learning, Cognition Disorders, Cross-Cultural Comparison, Female, Generalization, Psychological, Hippocampus, Humans, Hungary, Israel, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Temporal Lobe, Police

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