Do outcomes of clinical trials resemble those of “real world” patients? A reanalysis of the STAR*D antidepressant data set.
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The patients in the STAR*D trial showed a low improvement on the HDRS of 6.6 points after 3 months of treatment with an SSRI, compared with a mean improvement of 14.8 points on the HDRS in conventional comparator trials.
“The patients in this trial showed a low improvement on the HDRS of 6.6 points after 3 months of treatment with an SSRI, compared with a mean improvement of 14.8 points on the HDRS in conventional comparator trials”
From Should antidepressants be used for major depressive disorder? (2020) · cites this paper as [43]
Cites
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Should antidepressants be used for major depressive disorder?
Jakobsen, J. C., Gluud, C., & Kirsch, I. (2020) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2019-111238 · Cited by 162 · see citing works
Self-citationPigott, H. E., Kim, T., Xu, C., Kirsch, I., & Amsterdam, J. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-063095 · Cited by 93 · see citing works
Self-citationPsychotherapeutic treatments for depression in older adults
Ang, L., Lee, M. S., Song, E., Lee, H. W., Cao, L., Zhang, J., Wang, Q., Jung, J., Jang, S., Gastaldon, C., et al. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015976
- Authors
- Kirsch, I., Huedo-Medina, T. B., Pigott, H. E., & Johnson, B. T.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Connecticut (US)
- Venue
- Psychology of Consciousness: Theory, Research, and Practice
- Published
- 2018-12
- Volume
- 5
- Issue
- 4
- Pages
- 339-345
- ISSN
- 2326-5523 (ISSN-L)
- 2326-5531
- OpenAlex
- W2890357936
- Cited by
- 24
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 5
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-09-07)
- Open access
- closed
- Locations
- Psychology of Consciousness Theory Research and Practice (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- STAR*D, antidepressants, clinical trial results, real-world patients, reanalysis, treatment response, depression
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