Treatment refusal and premature termination in psychotherapy, pharmacotherapy, and their combination: A meta-analysis of head-to-head comparisons.
Abstract
The purpose of this meta-analysis was to examine rates of treatment refusal and premature termination for pharmacotherapy alone, psychotherapy alone, pharmacotherapy plus psychotherapy, and psychotherapy plus pill placebo treatments. A systematic review of the literature resulted in 186 comparative trials that included a report of treatment refusal and/or premature termination for at least 2 of the 4 treatment conditions. The data from these studies were pooled using a random-effects analysis. Odds Ratio effect sizes were then calculated to compare the rates between treatment conditions, once across all studies and then again for specific client disorder categories. An average treatment refusal rate of 8.2% was found across studies. Clients who were assigned to pharmacotherapy were 1.76 times more likely to refuse treatment compared with clients who were assigned psychotherapy. Differences in refusal rates for pharmacotherapy and psychotherapy were particularly evident for depressive disorders, panic disorder, and social anxiety disorder. On average, 21.9% of clients prematurely terminated their treatment. Across studies, clients who were assigned to pharmacotherapy were 1.20 times more likely to drop out compared with clients who were assigned to psychotherapy. Pharmacotherapy clients with anorexia/bulimia and depressive disorders dropped out at higher rates compared with psychotherapy clients with these disorders. Treatment refusal and dropout are significant problems in both psychotherapy and pharmacotherapy and providers of these treatments should seek to employ strategies to reduce their occurrence. (PsycINFO Database Record
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Non-adherence can have negative consequences for patients and can increase health care costs.
“Therefore, non-adherence can have negative consequences for patients and can increase health care costs [17].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
If a treatment is not acceptable to patients despite demonstrated positive outcomes, it may not be effective in practice.
“If a treatment is not acceptable to patients despite demonstrated positive outcomes, it may not be effective in practice [17].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
Specific forms of drop-out rates are seldom reported, and a consistent definition of drop-out is lacking.
“Currently, in study reports, specific forms of drop-out rates are seldom reported [17], and a consistent definition of drop-out is lacking [28].”
From Efficacy and Acceptance of Cognitive Behavioral Therapy in Adults with Chronic Fatigue Syndrome: A Meta-analysis. (2024) · cites this paper as [17]
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“The discontinuation rate in pharmacotherapy is still 1.76 times higher than in psychotherapy (Swift et al., 2017).”
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“…disorders (DR disaggregated by disorder) Individual, group and online Gersh et al. (2017) 45 2224 GAD Individual Swift, Greenberg, Tompkins, and Parkin (2017) 182 17891 Various disorders Individual and group Leeuwerik, Cavanagh and Strauss (2019) 123 5627 OCD Individual and group Lewis,…”
Backgroundvan Dijk, D. A., Deen, M. L., van den Boogaard, T. M., Ruhé, H. G., Spijker, J., & Peeters, F. P. M. L. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01499-1 · Cited by 16 · see citing works
“Second and related, this lack of information on the content of the treatment and the reasons for dropout prevents a more detailed analysis of an association between treatment type and dropout, and their potential interaction with sociodemographic variables; this would be relevant given the difference in dropout betwee…”
BackgroundResultThe Efficacy of Experiential Dynamic Therapies: A 10‐Year Systematic Review and Meta‐Analysis Update
Lilliengren, P., Mechler, J., Lindqvist, K., Maroti, D., & Johansson, R. (2025) · Clinical Psychology and Psychotherapy · doi:10.1002/cpp.70086 · Cited by 15 · see citing works
“The average dropout rate of 13% suggests that EDT is tolerated similarly to psychotherapy in general (Swift et al. 2017), and we found no indication of differences in dropout rates compared to active control conditions.”
Scanavino, M. D. T., Guirado, A. G., Marques, J. M., do Amaral, M. L. S., Messina, B., dos Reis, S. C., Barros, V. B., Abdo, C. H. N., Tavares, H., & Parsons, J. T. (2023) · Journal of Behavioral Addictions · doi:10.1556/2006.2023.00004 · Cited by 15 · see citing works
Swift, J. K., Spencer, J., & Goode, J. (2018) · Psychotherapy Research · doi:10.1080/10503307.2018.1439192 · Cited by 13 · see citing works
Self-citationLorenzo‐Luaces, L., Howard, J., Jesús-Romero, R. D., Peipert, A., Buss, J., Lind, C. M., Botts, K., & Starvaggi, I. (2022) · Cognitive Therapy and Research · doi:10.1007/s10608-022-10338-5 · Cited by 13 · see citing works
“Most individuals with internalizing disorder symptoms prefer, and are more likely to adhere to (Swift et al., 2017), treatment with psychological interventions than with medications (Löwe et al.”
BackgroundPsychotherapy Trends in the United States
Olfson, M., McClellan, C. B., Zuvekas, S. H., Wall, M. M., & Blanco, C. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240492 · Cited by 12 · see citing works
An introduction to the special issue on psychotherapy termination.
Hilsenroth, M. J. (2017) · Psychotherapy · doi:10.1037/pst0000106 · Cited by 12 · see citing works
Therapist Interventions and Skills as Predictors of Dropout in Outpatient Psychotherapy
Poster, K., Bennemann, B., Hofmann, S. G., & Lutz, W. (2021) · Behavior Therapy · doi:10.1016/j.beth.2021.05.001 · Cited by 10 · see citing works
Poor suitability for psychotherapy – a risk factor for treatment non-attendance?
Knekt, P., Grandell, L., Sares‐Jäske, L., & Lindfors, O. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.09.020 · Cited by 10 · see citing works
Psychological distress and infertility: prevalence, impact, and interventions
Clifton, J., & Domar, A. D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818309-0.00013-7 · Cited by 9 · see citing works
Beyond Pharmacology: A Narrative Review of Alternative Therapies for Anxiety Disorders
Antos, Z., Zackiewicz, K., Tomaszek, N., Modzelewski, S., & Waszkiewicz, N. (2024) · Diseases · doi:10.3390/diseases12090216 · Cited by 9 · see citing works
“For example, aerobic exercise, as a form of exposure therapy, allows patients to confront their fears in a controlled environment while taking advantage of the anxiolytic properties of physical activity [59].”
BackgroundMorrin, H., Yeung, J. A., Agnew, Z. K., Østergaard, S. D., & Pollak, T. A. (2026) · JMIR Mental Health · doi:10.2196/91454 · Cited by 10 · see citing works
“Meta-ana-lytic syntheses report substantial dropout and show that resolving alliance ruptures relates to better trajectories [35-38].”
Stange, J. P., Jenkins, L. M., Bessette, K. L., Kling, L. R., Bark, J. S., Shepard, R., Hamlat, E. J., DelDonno, S. R., Phan, K. L., Passarotti, A. M., et al. (2018) · Brain Connectivity · doi:10.1089/brain.2018.0619 · Cited by 9 · see citing works
“A common challenge in conducting longitudinal studies, including those involving neuroimaging methods, is attrition, or the loss of study participants over time (Carter et al., 2008; Swift et al., 2017; Young et al., 2006).”
BackgroundHall, S. B., Bartley, A. G., Wenk, J., Connor, A., Dugger, S. M., & Casazza, K. (2022) · Journal of Counseling & Development · doi:10.1002/jcad.12439 · Cited by 8 · see citing works
“A high rate of TR may reflect a mismatch between client preferences and the available service or the presence of barriers including inconvenience, cost, or negative outcome expectations (Swift et al., 2017).”
BackgroundRagucci, F., Dragan, M., Cuomo, A., Fagiolini, A. M., & Pozza, A. (2024) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2024.100802 · Cited by 11 · see citing works
Jacobsen, C. F., Karstoft, K., Falkenström, F., Nielsen, J., Lunn, S., & Poulsen, S. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2353358 · Cited by 7 · see citing works
“Studies show that community and client samples alike tend to prefer psychotherapy over pharmacotherapy (Swift et al., 2017), and that laypersons tend to prefer therapy activities high on therapist directive-ness, emotional intensity and unconditional support (Cooper et al., 2019; Heinze et al.,…”
Gumz, A., Kästner, D., Reuter, L., Moura, C. M., Ehlers, K., Daubmann, A., Eubanks, C. F., Muran, J., Anderson, T., Stöckl, R., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-098343 · Cited by 6 · see citing works
Mital, R., Hay, P., Conti, J., & Mannan, H. R. (2022) · Journal of Eating Disorders · doi:10.1186/s40337-022-00601-1 · Cited by 8 · see citing works
“A further meta-analysis that utilised the data of 186 comparative trials found that both treatment refusal and premature treatment termination were linked with a non-preferred treatment modality [12].”
MethodVancampfort, D., Damme, T. V., McGrath, R. L., Hemmings, L., Gillis, V., Bernar, K., dos Santos, E. B., & Schuch, F. B. (2024) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2024.02.735 · Cited by 7 · see citing works
Schmalbach, I., Witthöft, M., Strauss, B. M., Joraschky, P., & Petrowski, K. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02882-3 · Cited by 7 · see citing works
Predictors of CBT-pretreatment intervention engagement and completion: Evidence for peer support.
Nelson, C. B., Lusk, R. K., Cawood, C. D., Boore-Clor, L., Ranganathan, A., & Lyubkin, M. (2018) · Psychological Services · doi:10.1037/ser0000268 · Cited by 7 · see citing works
Garland, M. M., Wilson, R., Thompson, W. K., Stein, M. B., Paulus, M. P., Feinstein, J. S., & Khalsa, S. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0286899 · Cited by 7 · see citing works
“Notwithstanding this limitation, these levels of adherence are broadly comparable to traditional behavioral interventions for anxiety and depression, whose treatment completion rates hover around 80% [30].”
Austad, C. S., & Gendron, M. S. (2018) · Professional Psychology Research and Practice · doi:10.1037/pro0000197 · Cited by 7 · see citing works
Trainieren und Messen therapeutischer Beziehungskompetenzen
Gumz, A. (2023) · PDP – Psychodynamische Psychotherapie · doi:10.21706/pdp-22-3-204 · Cited by 6 · see citing works
Stephenson, C., Moghimi, E., Shao, Y., Kumar, A., Yee, C. S., Miller, S., Stefatos, A., Gholamzadehmir, M., Abbaspour, Z., Jagayat, J., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1194955 · Cited by 6 · see citing works
Uckelstam, C.-J. (2021) · Linköping studies in behavioural science · doi:10.3384/diss.diva-172754 · Cited by 6 · see citing works
Martsevich, S. Y., Петровна, З. Н., Zagrebelnyy, A. V., Кутишенко, Н. П., Lukina, Y. V., Ginzburg, М. L., & Drapkina, O. M. (2023) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2023-2988 · Cited by 6 · see citing works
McChrystal, R., Lees, J. S., Gillies, K., McAllister, D., & Hanlon, P. (2025) · Trials · doi:10.1186/s13063-025-08794-x · Cited by 5 · see citing works
Sin, P. Y., Li, W. H. C., Fan, M. S. N., Ng, S. C., & Choi, K. C. (2025) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2025.105081 · Cited by 5 · see citing works
Lei, S., Liu, Q., Leong, I., Fan, J., Tsang, Y., Liu, X., Xu, X., & Zhuang, L. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1330054 · Cited by 5 · see citing works
Goldman, R. E., Hilsenroth, M. J., Gold, J. R., Cersosimo, B. H., Levy, S. R., & Owen, J. J. (2018) · Journal of Psychotherapy Integration · doi:10.1037/int0000124 · Cited by 5 · see citing works
Psychotherapy for Mixed Depression and Mixed Mania
O’Brien, B., Lee, D. J., Swann, A. C., Mathew, S. J., & Lijffijt, M. (2019) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2019.10.014 · Cited by 5 · see citing works
Kan, K., Feenstra, T., de Vries, S. O., Visser, E., Schoevers, R. A., & Jörg, F. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.010 · Cited by 5 · see citing works
A cohort study of engagement in telehealth psychotherapy versus in-person services
Gibbons, M. B. C., Duong, L. A., Chiu, R. Y., Crits-Christoph, P. F., Gallop, R., Mandell, D. S., Barg, O., Newman, C. F., Brown, L. A., & Oquendo, M. A. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2375231 · Cited by 4 · see citing works
“An estimated 19% of individuals receiving mental health services in a nationally representative sample (Olfson et al., 2009) and 22% of individuals receiving psychotherapy as part of randomized controlled trials (Swift et al., 2017) terminate psychotherapy prematurely.”
Lipner, L. M., Katz, M., Tzor, K., Amar, A., & Yonatan‐Leus, R. (2025) · Psychotherapy Research · doi:10.1080/10503307.2025.2551067 · Cited by 4 · see citing works
“…termination from psychotherapy ranges from 19.7% to 46.86% across different populations and treatment contexts (Sharf et al., 2010; Swift & Greenberg, 2012; Swift et al., 2017; Wierzbicki & Pekarik, 1993), representing a substantial percentage of patients whose treatment outcomes remain unclear.”
InfluentialUrmanche, A. A., Lipner, L. M., Bloch‐Elkouby, S., Hunter, E., Kaufmann, J., Warren, J. T., Weil, G. T., Eubanks, C. F., & Muran, J. C. (2021) · Counselling Psychology Quarterly · doi:10.1080/09515070.2021.1997916 · Cited by 4 · see citing works
“Based on recommendations to evaluate the session(s) preceding premature termination (Swift et al., 2017), some promising and innovative work has been conducted with Turkish students (Gülüm, Soygüt, & Safran, 2018) and adolescents (O’Keeffe, Martin, Target, & Midgley, 2019), and we hope to…”
MethodGorrell, S., Rienecke, R. D., Duffy, A., Huston, E. M., Mehler, P. S., Johnson, C., Manwaring, J. L., McClanahan, S. F., Blalock, D. V., & Grange, D. L. (2022) · Eating Disorders · doi:10.1080/10640266.2021.2011648 · Cited by 4 · see citing works
“A considerable literature has examined premature termination from psychotherapy treatment across broader patient populations (Swift et al., 2017).”
BackgroundGumz, A., Daubmann, A., Erices, R., Berger, J., Reuter, L., & Kästner, D. (2024) · Psychotherapy Research · doi:10.1080/10503307.2024.2327443 · Cited by 4 · see citing works
“At the same time, there are still many patients who do not adequately benefit from their psychotherapy (Barkham & Lambert, 2021; Cuijpers et al., 2021), and on average up to a quarter of all patients drop out of therapy prematurely (Fernandez et al., 2015; Swift et al., 2017).”
Neurobiological Foundations of Psychotherapies
Guina, J., Kay, J., & Yatim, F. (2024) · Springer eBooks · doi:10.1007/978-3-030-51366-5_168 · Cited by 3 · see citing works
Moments of disappointment in art therapy: patients’ perspectives
Vulcan, M., & Goldner, L. (2025) · International Journal of Art Therapy · doi:10.1080/17454832.2025.2468377 · Cited by 3 · see citing works
“Premature termination of psychotherapy or drop-out, i.e. a patient’s unilateral termination of services prior to completion of a recommended course of psychological treatment (Swift et al., 2012; Swift et al., 2017), is a widespread clinical phenomenon.”
Tait, J., Kellett, S., & Delgadillo, J. (2025) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2025.103003 · Cited by 4 · see citing works
Leonidaki, V., & Constantinou, M. (2021) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2669 · Cited by 3 · see citing works
Pfund, R. A., Valencia, A. J., Hudson, E., Ginley, M. K., & Whelan, J. P. (2024) · Journal of Gambling Studies · doi:10.1007/s10899-024-10349-9 · Cited by 3 · see citing works
“The continued enhancement of engaging prospective clients yielded another 9% gain and a show rate approaching the 92% attendance rate for initial sessions for other mental health concerns (Swift et al., 2017).”
Generation of fundamental soliton in the presence of initial linear chirp
Kaczmarek, T. (2004) · Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu · Cited by 3 · see citing works
Lenz, L., König, H., Leitner, M., & Hajek, A. (2025) · BJPsych Open · doi:10.1192/bjo.2025.10849 · Cited by 2 · see citing works
“In their meta-analysis, Swift et al 12 found an overall treatment refusal rate of 8.2% and an overall premature termination rate of 21.9%.”
InfluentialTakahashi, N., Takatsuki, K., Kasahara, S., & Yabuki, S. (2021) · Journal of Back and Musculoskeletal Rehabilitation · doi:10.3233/bmr-200292 · Cited by 2 · see citing works
Physiological effects of Therapeutic Body Wraps in healthy volunteers: An observational study
Korogod, N., Skuza, K., Bangerter, G., & Opsommer, E. (2022) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2022.07.020 · Cited by 2 · see citing works
Muñoz‐Navarro, R., Pérez‐Jover, V., Esteller-Collado, G., Román, C. J. V.-D. H., Salgueiro, M., Llorca, A., Malonda-Vidal, E., Canet-Cortell, V., Moraga-García, M. J., Coloma‐Carmona, A., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320857 · Cited by 2 · see citing works
“A meta-analysis by Swift et al. [49] found that patients on pharmacotherapy had a higher dropout rate than patients receiving psychotherapy alone.”
Cunningham, C. E., Rimas, H. L., Sivayoganathan, T., Stewart, B., Munn, C., Zipursky, R. B., Christensen, B. K., & Furimsky, I. (2020) · Emerging Adulthood · doi:10.1177/2167696820946894 · Cited by 2 · see citing works
“Systematic reviews conclude that patients offered medication are more likely to refuse treatment or to subsequently drop out of treatment than those offered psychotherapy (Swift et al., 2017).”
BackgroundMotivational Interviewing Enhances Group Cognitive Behavioral Therapy for Anxiety Disorders
Strodl, E. S., & Yang, J. (2021) · Journal of Cognitive Psychotherapy · doi:10.1891/jcpsy-d-20-00025 · Cited by 3 · see citing works
Treating Later-Life Depression
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · doi:10.1093/med-psych/9780190068431.001.0001 · Cited by 2 · see citing works
Ryttinger, R., Serralta, F. B., Pires, N., Basto, I., Melo, G. R., & Ribeiro, E. (2022) · Studies in Psychology Estudios de Psicología · doi:10.1080/02109395.2022.2132750 · Cited by 2 · see citing works
“In the current study, dropout is defined as a premature and unilateral discontinuation after the client begins the psychotherapy, before recovering from their suffering and without the agreement of the therapist (Swift et al., 2017).”
BackgroundInfluentialJohnson, R. J. (2020) · Psychology and Mental Health Care · doi:10.31579/2637-8892/067 · Cited by 2 · see citing works
Cascia, C. L., Ferraro, L., Seminerio, F., Scaglione, A., Maniaci, G., Matranga, D., Sideli, L., Colli, G., Sartorio, C., Paglia, F. L., et al. (2020) · Minerva Psichiatrica · doi:10.23736/s0391-1772.20.02092-0 · Cited by 2 · see citing works
„Talking cures“ – Sprache als Medium in Psychotherapien
Gumz, A., & Strauss, B. M. (2022) · Psychotherapeut · doi:10.1007/s00278-022-00578-x · Cited by 2 · see citing works
“Immerhin bis zu ein Viertel aller Patienten im Durchschnitt bricht die Therapie vorzeitig ab (Cahill et al. 2003; Fernandez et al. 2015; Swift und Greenberg 2012; Swift et al. 2017).”
BackgroundPreventing Dropout in Research, Assessment and Treatment with Refugees - a guidelinePreprint
Semmlinger, V., & Ehring, T. W. (2020) · doi:10.31234/osf.io/nukv3 · Cited by 2 · see citing works
Cognitive-Behavioral Therapies 101
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · Oxford University Press eBooks · doi:10.1093/med-psych/9780190068431.003.0004 · Cited by 2 · see citing works
Professional Development Resources
Steffen, A. M., Thompson, L. W., & Gallagher-Thompson, D. E. (2021) · Oxford University Press eBooks · doi:10.1093/med-psych/9780190068431.005.0001 · Cited by 2 · see citing works
- Authors
- Swift, J. K., Greenberg, R. P., Tompkins, K. A., & Parkin, S. R.
- Affiliations
- Idaho State University (US)
- SUNY Upstate Medical University (US)
- University of Alaska Anchorage (US)
- ORCID
- Swift, Joshua K.
- Venue
- Psychotherapy
- Published
- 2017-03
- Volume
- 54
- Issue
- 1
- Pages
- 47-57
- ISSN
- 0033-3204 (ISSN-L)
- 1939-1536
- OpenAlex
- W2593514681
- Cited by
- 167
- References
- 45
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 22 · 2023: 10 · 2022: 21 · 2021: 44 · 2020: 13 · 2019: 9 · 2018: 17 · 2017: 3
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- treatment refusal, early termination, treatment discontinuation, pharmacotherapy, combined psychotherapy and pharmacotherapy, depressive disorders, panic disorder, social anxiety disorder, anorexia nervosa, bulimia nervosa, medication adherence
- MeSH terms
- Combined Modality Therapy, Humans, Object Attachment, Patient Dropouts, Psychotherapy, Psychotropic Drugs, Psychotherapeutic Processes, Placebo Effect, Treatment Refusal
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