Cited by 140DNA Repair MechanismsProtein Structure and DynamicsEnzyme Structure and Function

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Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA

Ikegami, Takahisa, Kuraoka, Isao, Saijo, Masafumi, Kodo, Naohiko, Kyogoku, Yoshimasa, Morikawa, Kosuke, Tanaka, Kiyoji, Shirakawa, Masahiro·1998·Nature Structural & Molecular Biology

DOI 10.1038/1400

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Abstract

The solution structure of the central domain of the human nucleotide excision repair protein XPA, which binds to damaged DNA and replication protein A (RPA), was determined by nuclear magnetic resonance (NMR) spectroscopy. The central domain consists of a zinc-containing subdomain and a C-terminal subdomain. The zinc-containing subdomain has a compact globular structure and is distinct from the zinc-fingers found in transcription factors. The C-terminal subdomain folds into a novel alpha/beta structure with a positively charged superficial cleft. From the NMR spectra of the complexes, DNA and RPA binding surfaces are suggested.

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Authors: Ikegami, T., Kuraoka, I., Saijo, M., Kodo, N., Kyogoku, Y., Morikawa, K., Tanaka, K., & Shirakawa, M.
Affiliations: Nara Institute of Science and Technology (JP)
The University of Osaka (JP)
Institute for Protein Research, The University of Osaka (JP)
Biomolecular Engineering Research Institute (Japan) (JP)
Corresponding author: Shirakawa, Masahiro
ORCID: Ikegami, Takahisa
Kuraoka, Isao
Morikawa, Kosuke
Venue: Nature Structural & Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 1998-08
Volume: 5
Issue: 8
Pages: 701-706
ISSN: 1545-9985 (ISSN-L)
1545-9993
DOI: 10.1038/1400
OpenAlex: W2020761966
Cited by: 139
References: 27
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 2 · 2012: 2
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Locations: Nature Structural & Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: XPA, nucleotide excision repair, DNA repair, replication protein A, DNA binding, alpha/beta fold, protein structure, solution structure, protein-DNA complex
MeSH terms: Amino Acid Sequence, Binding Sites, DNA Repair, DNA-Binding Proteins, Humans, Metalloproteins, Models, Molecular, Molecular Sequence Data, Protein Conformation, Xeroderma Pigmentosum, Zinc, RNA-Binding Proteins, Sequence Homology, Amino Acid, Nuclear Magnetic Resonance, Biomolecular, Replication Protein A, Xeroderma Pigmentosum Group A Protein

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Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA

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