XPA: A key scaffold for human nucleotide excision repair
Open accessAbstract
Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.
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XPA's nuclear localization sequence contains basic residues at positions 30-34 of the 273-amino-acid protein.
“The targeting of XPA to the nucleus occurs via its nuclear localization sequence (NLS) which contains basic residues located at positons 30–34 of the 273 amino acid protein 62, 63, 82, 68.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [82]
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- Authors
- Sugitani, N., Sivley, R. M., Perry, K. E., Capra, J. A., & Chazin, W. J.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Chazin, Walter J.
- Venue
- DNA Repair
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 44
- Pages
- 123-135
- ISSN
- 1568-7856 (ISSN-L)
- 1568-7864
- PMC
- PMC4958585
- OpenAlex
- W2400580371
- Cited by
- 116
- References
- 131
- Citations by year
- 2026: 10 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 13
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- DNA repair (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (ES1065561, CA092584)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- XPA, nucleotide excision repair, DNA repair proteins, DNA damage recognition, protein structure, protein-protein interaction, disease-associated mutations, DNA lesions
- MeSH terms
- Protein Domains, Amino Acid Sequence, Animals, DNA, DNA Damage, DNA Repair, Humans, Models, Molecular, Mutation, Protein Binding, Severity of Illness Index, Xeroderma Pigmentosum, Protein Structure, Secondary, Protein Interaction Mapping, Xeroderma Pigmentosum Group A Protein
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