Cited by 117DNA Repair MechanismsNuclear Structure and FunctionGenetic factors in colorectal cancer

XPA: A key scaffold for human nucleotide excision repair

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Sugitani, Norie, Sivley, Robert M., Perry, Kelly E., Capra, John A., Chazin, Walter J.·2016·DNA Repair

Abstract

Nucleotide excision repair (NER) is essential for removing many types of DNA lesions from the genome, yet the mechanisms of NER in humans remain poorly understood. This review summarizes our current understanding of the structure, biochemistry, interaction partners, mechanisms, and disease-associated mutations of one of the critical NER proteins, XPA.

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Crossref · 10.1016/j.dnarep.2016.05.018

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Research works printed but not linked: 5

  1. Cleaver JE States JC The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein Biochem J 1997 12 328 1 12 9359827 PMC1218880
  2. Tanaka Kiyoji Miura Naoyuki Satokata Ichiro Miyamoto Iwai Yoshida Michihiro C. Satoh Yoshiaki Kondo Seiji Yasui Akira Okayama Hiroto O Y Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain Nature 1990 348 73 76 2234061
  3. States JC Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein Human mutation 1998 12 2 103 113 9671271
  4. Takahashi Y XPA gene mutations resulting in subtle truncation of protein in xeroderma pigmentosum group A patients with mild skin symptoms The Journal of investigative dermatology 2010 130 10 2481 8 20574439
  5. Wakasugi M Physical and functional interaction between DDB and XPA in nucleotide excision repair Nucleic acids research 2009 37 2 516 25 19056823 PMC2632899

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Authors
Sugitani, N., Sivley, R. M., Perry, K. E., Capra, J. A., & Chazin, W. J.
Affiliations
Vanderbilt University (US)
Corresponding author
Chazin, Walter J.
Venue
DNA Repair
Publisher
Elsevier BV
Published
2016-08
Volume
44
Pages
123-135
ISSN
  • 1568-7856 (ISSN-L)
  • 1568-7864
OpenAlex
W2400580371
Cited by
116
References
131
Citations by year
2026: 10 · 2025: 5 · 2024: 10 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 13
FWCI
1.30
Type
journal article
Language
en
Open access
Locations
  • DNA repair (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (ES1065561, CA092584)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
XPA, nucleotide excision repair, DNA repair proteins, DNA damage recognition, protein structure, protein-protein interaction, disease-associated mutations, DNA lesions
MeSH terms
Protein Domains, Amino Acid Sequence, Animals, DNA, DNA Damage, DNA Repair, Humans, Models, Molecular, Mutation, Protein Binding, Severity of Illness Index, Xeroderma Pigmentosum, Protein Structure, Secondary, Protein Interaction Mapping, Xeroderma Pigmentosum Group A Protein

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