Xeroderma pigmentosum genes: Functions inside and outside DNA repair
Open accessAbstract
Xeroderma pigmentosum (XP) is an autosomal recessive disease, which is characterized by susceptibility to ultraviolet light (UV)-induced skin cancer. Among eight genes so far identified as responsible for XP, XPA through XPG are involved in nucleotide excision repair of DNA damage induced by UV as well as various chemical carcinogens. Since this repair system removes a major UV photoproduct, the cyclobutane pyrimidine dimer, quite slowly from the global genome, this lesion must be accurately bypassed during replication by DNA polymerase eta, encoded by the XPV gene. Recent studies have revealed that each of these XP genes possesses additional functions, some of which are concerned with other DNA repair pathways and/or cellular DNA damage responses. Such differential functions not only explain clinical heterogeneity among different genetic complementation groups but also have implications for the promotion of carcinogenic processes in XP patients.
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Studies using XPA-deficient cells showed defects in ATR signaling upon DNA damage and suggest an additional role of XPA in damage signaling.
“Studies using XPA-deficient cells showed defects in ATR signaling upon DNA damage and suggest an additional role of XPA (to that observed in NER pathway) in damage signaling [73].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [73]
XPA and XPD are thought to have a dualistic nature and were shown to affect cell cycle checkpoint signaling.
“These include proteins of the NER system, such as XPA and XPD, that are thought to have a dualistic nature and were shown to affect cell cycle checkpoint signaling [73,74].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [73]
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Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage
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DNA nucleotide excision repair-dependent signaling to checkpoint activation
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Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint
Giannattasio, M., Lazzaro, F., Longhese, M. P., Plevani, P., & Muzi‐Falconi, M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600051 · Cited by 113 · see citing works
Somatic immunoglobulin hypermutation
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An Affinity of Human Replication Protein A for Ultraviolet-damaged DNA
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Flagged first, then by citations
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Cited by
Sorted by citations
Bradford, P. T., Goldstein, A. M., Tamura, D., Khan, S. G., Ueda, T., Boyle, J., Oh, K.-S., Imoto, K., Inui, H., Moriwaki, S.-I., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.083022 · Cited by 480 · see citing works
DNA repair deficiency and neurological disease
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Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
Cuevas, C., & Francesch, A. (2009) · Natural Product Reports · doi:10.1039/b808331m · Cited by 325 · see citing works
Kim, I., & He, Y. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.08.005 · Cited by 224 · see citing works
“We know that XPC abundance is critical for efficient GG-NER and thus for preventing UVBinduced skin carcinogenesis.(26,27) The regulation of XPC is an area of active investigation and will be reviewed here.”
BackgroundFocus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works
“Studies using XPA-deficient cells showed defects in ATR signaling upon DNA damage and suggest an additional role of XPA (to that observed in NER pathway) in damage signaling [73].”
BackgroundPolygenic model of DNA repair genetic polymorphisms in human breast cancer risk
Smith, T. R., Levine, E. A., Freimanis, R. I., Akman, S. A., Allen, G. O., Hoang, K. N., Liu‐Mares, W., & Hu, J. J. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn193 · Cited by 163 · see citing works
“XPC plays a critical role in DNA damage recognition ( 15 ).”
BackgroundRegulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
Ming, M., Shea, C. R., Guo, X., Li, X., Soltani, K., Han, W., & He, Y.-Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010377108 · Cited by 145 · see citing works
“Considerable evidence has shown that XPC abundance is critical for efficient GG-NER, and thus for preventing UVB-induced skin carcinogenesis (7, 39, 40).”
BackgroundMETTL14 facilitates global genome repair and suppresses skin tumorigenesis
Yang, Z., Yang, S., Cui, Y., Wei, J., Shah, P., Park, G., Cui, X., He, C., & He, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025948118 · Cited by 133 · see citing works
Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair
Polak, P., Lawrence, M. S., Haugen, E., Stoletzki, N., Stojanov, P., Thurman, R., Garraway, L., Mirkin, S., Getz, G., Stamatoyannopoulos, J., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2778 · Cited by 142 · see citing works
Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin Cancer
Lee, J. W., Ratnakumar, K., Hung, K., Rokunohe, D., & Kawasumi, M. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13245 · Cited by 112 · see citing works
“NER consists of two subpathways that differ in initial damage recognition: global genome repair (GGR) and transcription-coupled repair (TCR) (96,98).”
BackgroundInfluentialAutophagy positively regulates DNA damage recognition by nucleotide excision repair
Qiang, L., Zhao, B., Shah, P., Sample, A., Yang, S., & He, Y. (2015) · Autophagy · doi:10.1080/15548627.2015.1110667 · Cited by 101 · see citing works
“1E), an NER protein essential for both CPD and 6-4PP repair.(31) However, autophagy deficiency had no effect on the protein levels of other NER factors (Fig.”
BackgroundAbbasi, R., Ramroth, H., Becher, H., Dietz, A., Schmezer, P., & Popanda, O. (2009) · International Journal of Cancer · doi:10.1002/ijc.24442 · Cited by 96 · see citing works
“This generates an open DNA structure around the lesion making place for the RPA-XPA complex which stabilizes the open DNA structure and assembles the preincision complex.(20) ERCC5 (XPG) and the ERCC1-ERCC4 (XPF) heterodimer are structure specific endonucleases that incise the DNA at the 30 and 50 junctions between si…”
BackgroundInvolvement of Nucleotide Excision and Mismatch Repair Mechanisms in Double Strand Break Repair
Zhang, Y., Rohde, L. H., & Wu, H. (2009) · Current Genomics · doi:10.2174/138920209788488544 · Cited by 93 · see citing works
“NER is capable of recognizing and repairing a large variety of DNA helix-distorting lesions, including UV induced pyrimidine dimers and DNA intrastrand cross-links [14, 15].”
BackgroundHead and neck squamous cell carcinoma in young patients
van Monsjou, H. S., Wreesmann, V. B., van den Brekel, M. W. M., & Balm, A. J. M. (2013) · Oral Oncology · doi:10.1016/j.oraloncology.2013.09.001 · Cited by 93 · see citing works
Guirouilh‐Barbat, J., Redon, C. E., & Pommier, Y. G. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0215 · Cited by 75 · see citing works
“…TCR repairs bulky DNA adducts (such UV photoproducts, cisplatin, and carcinogenic base adducts) in transcribing genes using a set of factors that belong to the XP family of nucleotide excision repair (NER) factors (for review see de Laat et al., 1999; Sancar et al., 2004; Sugasawa, 2008).”
From the Rarest to the Most Common: Insights from Progeroid Syndromes into Skin Cancer and Aging
Capell, B. C., Tlougan, B. E., & Orlow, S. J. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.103 · Cited by 64 · see citing works
“G) are likewise involved in TC-NER, and in addition to the distinct phenotypic entities of XP, CS, and TTD, there are combined syndromes such as XP-CS and XP-TTD caused by mutations in certain XP genes (for example, XPB, XPD, and XPG).”
BackgroundRomano, M., Frapolli, R., Zangarini, M., Bello, E., Porcu, L., Galmarini, C. M., García‐Fernández, L., Cuevas, C., Allavena, P., Erba, E., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28213 · Cited by 63 · see citing works
Bartolucci, R., Wei, J., Sánchez, J. J., Perez‐Roca, L., CHAIB-OUKADOUR, I., Puma, F., Farabi, R., Méndez, P., Roila, F., Okamoto, T., et al. (2009) · Clinical Lung Cancer · doi:10.3816/clc.2009.n.007 · Cited by 60 · see citing works
Rey-Campos, M., Moreira, R., Gerdol, M., Pallavicini, A., Novoa, B., & Figueras, A. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01894 · Cited by 59 · see citing works
“Moreover, hemocytes seem to avoid cellular impairment caused by DNA damage resulting from previous oxidative stress (54), with the overexpression after the second injection of the DNA repair protein XPA (55).”
BackgroundDual role of SIRT1 in UVB-induced skin tumorigenesis
Ming, M. E., Soltani, K., Shea, C. R., Li, X., & He, Y. (2014) · Oncogene · doi:10.1038/onc.2013.583 · Cited by 56 · see citing works
“It is noteworthy that XPC abundance is critical for efficient GG-NER, and thus for preventing UVB-induced skin carcinogenesis (35, 36).”
MultiVERSE: a multiplex and multiplex-heterogeneous network embedding approach
Pio‐Lopez, L., Valdeolivas, A., Tichit, L., Rémy, É., & Baudot, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-87987-1 · Cited by 54 · see citing works
Silibinin and non-melanoma skin cancers
Prasad, R. R., Paudel, S., Raina, K., & Agarwal, R. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.02.003 · Cited by 42 · see citing works
Rechkunova, N. I., & Lavrik, O. I. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_13 · Cited by 41 · see citing works
A role for SUMO in nucleotide excision repair
Silver, H. R., Nissley, J. A., Reed, S. H., Hou, Y., & Johnson, E. S. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.09.013 · Cited by 41 · see citing works
Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors
Langie, S. A. S., Wilms, L. C., Hämäläinen, S., Kleinjans, J. C. S., Godschalk, R., & van Schooten, F. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992066 · Cited by 36 · see citing works
“Thus NER is a versatile DNA repair system, involving the joint action of a variety of enzymes such as XPC–RAD23B, CSB, XPA, XPF–ERCC1, and others((8,9)).”
BackgroundInfluentialXPC silencing sensitizes glioma cells to arsenic trioxide via increased oxidative damage.
Liu, S.-Y., Wen, C.-Y., Lee, Y.-J., & Lee, T.-C. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq113 · Cited by 36 · see citing works
“XPE/DDB2 also interacts with a variety of transcriptional regulatory proteins (Sugasawa, 2008), and XPC interacts with other repair proteins (Li et al.”
BackgroundHua, R., Zhuo, Z., Zhu, J., Jiang, D.-H., Xue, W., Zhang, S.-D., Zhang, J., Li, X., Zhang, P., Jia, W.-H., et al. (2016) · Aging · doi:10.18632/aging.101119 · Cited by 34 · see citing works
“Scherly D, Nouspikel T, Corlet J, Ucla C, Bairoch A, Clarkson SG. Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2.”
InfluentialTGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair
Qiang, L., Shah, P., Barcellos‐Hoff, M. H., & He, Y. Y. (2015) · Oncogene · doi:10.1038/onc.2015.390 · Cited by 29 · see citing works
“Mammalian NER consists of two distinct subpathways: global genome NER (GG-NER), which operates throughout the entire genome, and transcription-coupled NER (TC-NER), which specifically removes lesions on the transcribed DNA strand of active genes (4, 5, 8-10).”
Expression of XPG Protein in the Development, Progression and Prognosis of Gastric Cancer
Deng, N., Liu, J., Sun, L. L., Xu, Q., Duan, Z., Dong, N., & Yuan, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108704 · Cited by 29 · see citing works
“XPG is an indispensable member of the NER pathway responsible for the 39 excision of DNA damage in mammals [13].”
BackgroundGuillermo-Lagae, R., Deep, G., Ting, H., Agarwal, C., & Agarwal, R. (2015) · Oncotarget · doi:10.18632/oncotarget.5519 · Cited by 26 · see citing works
Combined Genetic and Nutritional Risk Models of Triple Negative Breast Cancer
Lee, E., Levine, E. A., Franco, V. I., Allen, G. O., Gong, F., Zhang, Y., & Hu, J. J. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.932397 · Cited by 25 · see citing works
“ERCC4/XPF functions as a 50endonuclease and forms a tight complex with ERCC1 in NER and it has been implicated in homologous recombination (HR) and inter-strand cross-link repair (27), and XPC plays a critical role in DNA damage recognition (28).”
BackgroundSantiago, K. M., Castro, L. P., Neto, J. P. D., de Nóbrega, A. F., Pinto, C. A. L., Ashton‐Prolla, P., Vairo, F. P. E., de Medeiros, P. F. V., Ribeiro, E. M., Ribeiro, B. F. R., et al. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16405 · Cited by 24 · see citing works
Research on Plants for the Understanding of Diseases of Nuclear and Mitochondrial Origin
Spampinato, C. P., & Gomez‐Casati, D. F. (2012) · BioMed Research International · doi:10.1155/2012/836196 · Cited by 22 · see citing works
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Schäfer, A., Hofmann, L., Gratchev, A. N., Laspe, P., Schubert, S., Schürer, K. A., Ohlenbusch, A., Tzvetkov, M. V., Hallermann, C., Reichrath, J., et al. (2012) · Experimental Dermatology · doi:10.1111/exd.12052 · Cited by 21 · see citing works
Qin, X., Yao, W., Li, W., Feng, X., Huo, X., Yang, S., Zhao, H., & Gu, X. (2014) · Tumor Biology · doi:10.1007/s13277-014-1615-8 · Cited by 19 · see citing works
Rosell, R., Vergnenégre, A., Liu, B., Cobo, M., Massutí, B., Wei, J., Molina‐Vila, M. Á., Costa, C., Queralt, C., & Tarón, M. (2010) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2010.05.003 · Cited by 16 · see citing works
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“As an indispensable factor in DNA damage recognition, XPA interacts with a series of NER proteins to initiate repair process [6, 11, 12].”
BackgroundReal-Time Quantification of Xeroderma pigmentosum mRNA From the Mammalian Cochlea
Guthrie, O. W., & Carrero-Martínez, F. A. (2010) · Ear and Hearing · doi:10.1097/aud.0b013e3181ddf5a3 · Cited by 14 · see citing works
“XPA plays a critical role in protecting both active and inactive genes, whereas XPC only protects inactive genes (Thoma & Vasquez 2003; Sugasawa 2008).”
BackgroundKanamitsu, K., & Ikeda, S. (2011) · Genes & Genetic Systems · doi:10.1266/ggs.86.83 · Cited by 14 · see citing works
“NER is a versatile DNA repair system that eliminates a broad spectrum of DNA lesions that tend to distort the double helix (Friedberg et al., 2006; Sugasawa, 2008).”
BackgroundInfluentialAnálise da natureza genotípica de pacientes Xeroderma pigmentosum brasileiros.
Soltys, D. T. (2010) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2010.tde-05082010-114429 · Cited by 13 · see citing works
Effects of DNA Lesions on Transcription Elongation by RNA Polymerases
Kuraoka, I. (2008) · Genes and Environment · doi:10.3123/jemsge.30.63 · Cited by 12 · see citing works
Ocular Manifestations of Xeroderma Pigmentosum at a Tertiary Eye Care Center in Saudi Arabia
Alfawaz, A. M., & Al-Hussain, H. M. (2011) · Ophthalmic Plastic and Reconstructive Surgery · doi:10.1097/iop.0b013e31821c7323 · Cited by 12 · see citing works
“Seven of these groups, XP-A through XP-G, are associated with defective NER, whereas the remaining group, a variant form of XP (XP-V), has plentiful NER but is deficient in a specialized DNA polymerase (pol ) involved in translesion DNA synthesis.(8) After skin, eyes are the second most common organ involved in XP bec…”
BackgroundVerbinnen, I., Boens, S., Ferreira, M., Szekér, K., Wijk, L. V., Eynde, A. V., & Bollen, M. (2020) · Oncogenesis · doi:10.1038/s41389-020-0214-3 · Cited by 10 · see citing works
Wang, Y.-C., Huang, J.-L., Lee, K., Lu, H.-H., Lin, Y.-J., Chen, L.-F., Wang, C.-S., Cheng, Y.-C., Zeng, Z.-T., Chu, P., et al. (2020) · Cancers · doi:10.3390/cancers12082053 · Cited by 10 · see citing works
“The following GGNER steps include DNA unwinding (by XPB and XPD), excision (by XPF, ERCC1, XPG, and XPA), synthesis (by DNA polymerase δ and ε), and ligation (by DNA ligase 1) [34].”
BackgroundInfluentialAcetaldehyde induces NER repairable mutagenic DNA lesions
Sonohara, Y., Takatsuka, R., Masutani, C., Iwai, S., & Kuraoka, I. (2021) · Carcinogenesis · doi:10.1093/carcin/bgab087 · Cited by 9 · see citing works
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Low, G. K. M., Ting, A. P. L., Fok, E. D. Z., Gopalakrishnan, K., Zeegers, D., Khaw, A. K., Jayapal, M., Martínez‐López, W., & Hande, M. P. (2022) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2022.503444 · Cited by 8 · see citing works
Lin, C., Chiou, W., Lee, K., Chen, T.-F., Lin, Y.-J., & Huang, J.-L. (2016) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2015.1104271 · Cited by 8 · see citing works
“Xeroderma pigmentosum, complementation group D (XPD) encodes a DNA helicase, which is an essential factor for NER and a subunit of the basal transcription factor TFIIH (Sugasawa 2008).”
BackgroundInfluentialGenetic Determinants of Cancer Susceptibility
Angel, J. M., Abel, E. L., & DiGiovanni, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01419-6 · Cited by 8 · see citing works
Sehgal, M., & Singh, T. R. (2014) · Gene · doi:10.1016/j.gene.2014.03.057 · Cited by 7 · see citing works
“If the mutations in any of the above genes are not rectified, the damage by UV may also cause mutations in the cell's DNA (Sugasawa, 2008).”
BackgroundAssociation between the XPG gene rs2094258 polymorphism and risk of gastric cancer
Zhang, Z., Yin, J., Xu, Q., & Shi, J. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22564 · Cited by 7 · see citing works
Mutagenicity Profile Induced by UVB Light in Human Xeroderma Pigmentosum Group C Cells†
Ruiz, N. Q., Corradi, C., Moreno, N. C., de Souza, T. A., Castro, L. P., Rocha, C. R. R., & Menck, C. F. M. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13516 · Cited by 7 · see citing works
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk
Ghaderi-Zefrehi, H., Rezaei, M., Sadeghi, F., & Heiat, M. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103196 · Cited by 6 · see citing works
Association of XPG rs2094258 polymorphism with gastric cancer prognosis
Wang, X., Terry, P., Li, Y., Zhang, Y., Kou, W.-J., & Wang, M.-X. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i34.5152 · Cited by 6 · see citing works
Genetic Determinants of Cancer Susceptibility
Angel, J. M., & DiGiovanni, J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65251-0 · Cited by 6 · see citing works
XPGgene rs751402 C>T polymorphism and cancer risk: Evidence from 22 publications
Zhou, H., Shi, T.-Y., Zhang, W., Li, Q., Zhu, J., He, J., & Ruan, J. (2017) · Oncotarget · doi:10.18632/oncotarget.19421 · Cited by 6 · see citing works
Pereira, T. D. S. F., Castro, L. P., Menck, C. F. M., Maia, M. H. T., de Souza, L. L., Fonseca, F. P., Pontes, H. A. R., Pontes, F. S. C., & Gomez, R. S. (2021) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2021.03.013 · Cited by 5 · see citing works
DNA Repair Perspectives in Thyroid and Breast Cancer: The Role of DNA Repair Polymorphisms
Susana, N., Costa, B., Rueff, J., & Francisco, J. (2011) · InTech eBooks · doi:10.5772/22944 · Cited by 4 · see citing works
“thymine DNA glycosylase (TDG)), initiators of BER, beyond their functions in NER pathway (Sugasawa, 2008).”
BackgroundInfluentialEvstratova, E. S., & Petin, V. G. (2017) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2017.11.006 · Cited by 4 · see citing works
“Human radiosensitive mutant cell lines such as Xeroderma pigmentosum, Fanconi's anemia and ataxiatelangiectasia have DNA repair defects and demonstrate genomic instability (Gatti et al., 1991; Kalb, Neveling, Nanda, Schindler, & Hoehn, 2006; Sugasawa, 2008).”
BackgroundChen, Z., Wei, D., Chen, X., Huang, Y., Shen, Z., & He, W. (2022) · Brain Research · doi:10.1016/j.brainres.2022.148078 · Cited by 3 · see citing works
Shrivastava, P., Gosavi, S. R., Ghatage, D. D., Naik, A., Marlapalle, A., & Krishna, A. (2022) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_236_22 · Cited by 3 · see citing works
“[11,12] In coordinating DNA repair, cell cycle arrest, and apoptosis, the XP gene plays an important role and hence contributes to the prevention of carcinogenesis through the maintenance of genome integrity and the exclusion of abnormal cells.[9]”
BackgroundInfluentialHan, X. T., Jing, H., Liu, C., & Zheng, J. (2015) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.143357 · Cited by 3 · see citing works
Danter, W. R. (2024) · medRxiv · doi:10.1101/2024.07.22.24310800 · Cited by 2 · see citing works
Nasir, M., Ahmad, N., Sieber, C. M. K., Latif, A., Malik, S. A., & Hameed, A. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-70 · Cited by 1 · see citing works
“Based on involvement of eight different genes and their protein products, XP has been sub-categorized into seven complementation groups plus one variant form (XP-A-XP-G and a variant XP-V) [7,8].”
BackgroundThe Association Between XPG Gene Polymorphism and Gastric Cancer Risk
Su, Y., Yang, C., & Zhang, Z. (2017) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2017.0056 · Cited by 1 · see citing works
“Multiple DNA damages due to genetic instability can be repaired by the versatile NER pathway (Sugasawa, 2008).”
Cardoso, G. P., Viana, A. J. D. N. F., Lucas, M. N., de Holanda, E. F., Pessoa, S. G. D. P., & Collaço, B. G. (2022) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-022-01159-4 · Cited by 1 · see citing works
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Drugs, Genomic Response Signatures, and Customized Cancer Therapy
Rosell, R., Morán, T., & Tarón, M. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139021500.028
González, E. A. P., Mudry, M. D., & Palermo, A. M. (2014) · Journal of Environmental Pathology Toxicology and Oncology · doi:10.1615/jenvironpatholtoxicoloncol.2014008234
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Zheng, J., Mo, H.-Y., & Wang, Z.-Z. (2014)
Beardmore, R. (2015) · Bangor University Research Portal (Bangor University)
Cancer prevention, the need to preserve the integrity of the genome at all cost
Nwagha, T. U., Okafor, M., Anusiem, C. A., Okoli, U. A., Nubila, N., Al-Alloosh, F., & Udeniya, I. J. (2018) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_272_17
Malignant Melanoma in Child with Xeroderma Pigmentosum: A Rare Case
Pramitha, R. J., & Sawitri, S. (2020) · Berkala Ilmu Kesehatan Kulit dan Kelamin · doi:10.20473/bikk.v32.1.2020.70-74
Genetic Determinants of Cancer Susceptibility
Williams, R. L., & Williams, K. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00196-0
DNA Proofreading, Damage, and Repair: Implications in Health and Disease
Minden, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-20529-2_23
- Authors
- Sugasawa, K.
- Affiliations
- Japan Science and Technology Agency (JP)
- Corresponding author
- Sugasawa, K.
- ORCID
- Sugasawa, K.
- Venue
- Carcinogenesis
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-04
- Volume
- 29
- Issue
- 3
- Pages
- 455-465
- ISSN
- 0143-3334 (ISSN-L)
- 1460-2180
- OpenAlex
- W2163014093
- Cited by
- 83
- References
- 260
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 9 · 2013: 4 · 2012: 4
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Carcinogenesis (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, other-oa)
- Kobe University Repository Kernel (Kobe University) (submittedVersion, other-oa)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Science and Technology Agency
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Keywords
- xeroderma pigmentosum, nucleotide excision repair, DNA repair genes, XPA, XPG, DNA polymerase eta, cyclobutane pyrimidine dimers, DNA damage response, chemical carcinogens
- MeSH terms
- DNA Damage, DNA Repair, Genetic Complementation Test, Humans, Neoplasms, Radiation-Induced, Skin Neoplasms, Transcription, Genetic, Ultraviolet Rays, Xeroderma Pigmentosum
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