Essential role of mouse telomerase in highly proliferative organs

Lee, Han-Woong, Blasco, Maria A., Gottlieb, Geoffrey J., Horner, James W., Greider, Carol W., DePinho, Ronald A.·1998·Nature

Cited by (999)

Items 501–600 of 999

  1. Cellular senescence: unravelling complexity
    João F. Passos, Cédric Simillion, Jennifer Susan Hallinan, Anil Wipat, Thomas von Zglinicki · 2009 · AGE
  2. The shelterin complex and hematopoiesis
    Morgan Jones, Kamlesh Kumar Bisht, Sharon A. Savage, Jayakrishnan Nandakumar, Catherine E. Keegan, Ivan P. Maillard · 2016 · Journal of Clinical Investigation
  3. Positive and negative effects of cellular senescence during female reproductive aging and pregnancy
    Michael C. Velarde, Ramkumar Menon · 2016 · Journal of Endocrinology
  4. Telomeres in the chicken: genome stability and chromosome ends
    Mary E. Delany, L.M. Daniels, Susan E. Swanberg, HA Taylor · 2003 · Poultry Science
  5. Telomere dysfunction in hypertension
    José J. Fuster, Javier Dı́ez, Vicente Andrés · 2007 · Journal of Hypertension
  6. H2AX regulates meiotic telomere clustering
    Óscar Fernández-Capetillo, Bodo Liebe, Harry Scherthan, André Nussenzweig · 2003 · The Journal of Cell Biology
  7. Telomere structure, function and maintenance in Arabidopsis
    Karel Říha, Dorothy E. Shippen · 2003 · Chromosome Research
  8. Functional Impairment of Bone Formation in the Pathogenesis of Osteoporosis: The Bone Marrow Regenerative Competence
    J. Bidwell, M. Alvarez, Mark Hood, P. Childress · 2013 · Current Osteoporosis Reports
  9. A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis
    Imamura, Shintaro, Uchiyama, Junzo, Koshimizu, Eriko, Hanai, Jun-ichi, Raftopoulou, Christina, Murphey, Ryan D., Bayliss, Peter E., Imai, Yoichi, Burns, Caroline Erter, Masutomi, Kenkichi et al. · 2008 · PLoS ONE
  10. Association of Leukocyte Telomere Length with Colorectal Cancer Risk: Nested Case–Control Findings from the Shanghai Women's Health Study
    Yong Cui, Qiuyin Cai, Shimian Qu, Wong‐Ho Chow, Wanqing Wen, Yong-Bing Xiang, Jie Wu, Nathaniel Rothman, Gong Yang, Xiao‐Ou Shu et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention
  11. Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs
    Bettina Moehrle, Kalpana Nattamai, Andreas Brown, Maria Carolina Florian, Marnie A. Ryan, Mona Vogel, Corinna Bliederhaeuser, Karin Soller, Daniel R. Prows, Amir Abdollahi et al. · 2015 · Cell Reports
  12. Telomeres and genomic instability during early development
    David Lawrence Keefe · 2019 · European Journal of Medical Genetics
  13. Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase
    Homayoun Vaziri, Samuel Benchimol · 1999 · Oncogene
  14. Stem cells, telomerase and dyskeratosis congenita
    Philip J. Mason · 2003 · BioEssays
  15. Chronic Obstructive Pulmonary Disease and Lung Cancer: A Lethal Association
    Peter John Barnes, Ian Michael Adcock · 2011 · American Journal of Respiratory and Critical Care Medicine
  16. Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells
    Rongrong Le, Zhaohui Kou, Yonghua Jiang, Ming Li, Bo Sheng Huang, Wenqiang Liu, Hui Li, Xiaochen Kou, Wanzhong He, K. Lenhard Rudolph et al. · 2013 · Cell stem cell
  17. Telomeres and cancer: a tale with many endings
    Marı́a A. Blasco · 2003 · Current Opinion in Genetics & Development
  18. Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors
    Shuji Kishi, Gerburg M. Wulf, Masafumi Nakamura, Kun Ping Lu · 2001 · Oncogene
  19. Ageing theories unified
    Daniel P. Kelly · 2011 · Nature
  20. Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations
    Stefan Schoeftner, Raquel Blanco, Isabel López de Silanes, Purificacı́on Muñoz, Gonzalo Goméz-López, Juana María Flores, Marı́a A. Blasco · 2009 · Proceedings of the National Academy of Sciences
  21. Adult hippocampal neurogenesis in aging and Alzheimer's disease
    Lorena Varela‐Nallar, Florencia C. Aránguiz, Ana C. Abbott, Paula G. Slater, Nibaldo C. Inestrosa · 2010 · Birth Defects Research Part C Embryo Today Reviews
  22. Concise Review: Telomere Biology in Normal and Leukemic Hematopoietic Stem Cells
    Mark W. Drummond, Stefan Balabanov, Tessa L. Holyoake, Tim H. Brümmendorf · 2007 · Stem Cells
  23. Rearrangements of ribosomal DNA clusters in late generation telomerase-deficient Arabidopsis
    Jiří Široký, Jitka Žlůvová, Karel Říha, Dorothy E. Shippen, Boris Vyskot · 2003 · Chromosoma
  24. Crisis intervention: The role of telomerase
    Arthur J. Lustig · 1999 · Proceedings of the National Academy of Sciences
  25. Telomerase RNA Levels Limit the Telomere Length Equilibrium
    Carol W. Greider · 2006 · Cold Spring Harbor Symposia on Quantitative Biology
  26. Unlocking longevity: the role of telomeres and its targeting interventions
    Marlies Schellnegger, Elisabeth Hofmann, Martina Carnieletto, Lars‐Peter Kamolz · 2024 · Frontiers in Aging
  27. Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility
    Marika F. Walter, Max R. Biessmann, Cecil Mayra Benitez, Tibor Tőrők, James M. Mason, Harald Biessmann · 2006 · Chromosoma
  28. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer
    Samanthi A. Perera, Richard S. Maser, Huili Xia, Kate L. McNamara, Alexei I. Protopopov, Liang Chen, Aram F. Hezel, Carla F. Kim, Roderick Terry Bronson, Diego H. Castrillón et al. · 2008 · Carcinogenesis
  29. DNA-Protein Kinase Catalytic Subunit-interacting Protein KIP Binds Telomerase by Interacting with Human Telomerase Reverse Transcriptase
    Gun Eui Lee, Eun Young Yu, Chae Hyun Cho, Junho Lee, Mark Twain Muller, In Kwon Chung · 2004 · Journal of Biological Chemistry
  30. The Fanconi anaemia genome stability and tumour suppressor network
    Massimo Bogliolo · 2002 · Mutagenesis
  31. Regulation of Senescence in Cancer and Aging
    Yahui Kong, Hang Cui, Charusheila Ramkumar, Hong Zhang · 2011 · Journal of Aging Research
  32. Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise
    Rumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou · 2024 · ACS Chemical Neuroscience
  33. Telomere function and regulation from mouse models to human ageing and disease
    Corey Winston Jones-Weinert, Laura Mainz, Jan Karlseder · 2024 · Nature Reviews Molecular Cell Biology
  34. Immunosenescence phenotypes in the telomerase knockout mouse
    María A. Blasco · 2002 · Springer Seminars in Immunopathology
  35. Telomerase Activity in Germ Cell Cancers and Mature Teratomas
    Joan Albanell, George J. Bosl, Victor E. Reuter, Monika Martha Engelhardt, Sonia Franco, Malcolm A.S. Moore, Ethan Dmitrovsky · 1999 · JNCI Journal of the National Cancer Institute
  36. <i>Ink4a</i> / <i>Arf</i> tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse
    Khoo, Christine M., Carrasco, Daniel R., Bosenberg, Marcus W., Paik, Ji-Hye, DePinho, Ronald A. · 2007 · Proceedings of the National Academy of Sciences
  37. The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems
    Stefan Tümpel, K. Lenhard Rudolph · 2012 · Annals of the New York Academy of Sciences
  38. Genes, telomeres and mammalian ageing
    Malcolm H. Goyns · 2002 · Mechanisms of Ageing and Development
  39. Dynamic rearrangement of telomeres during spermatogenesis in mice
    Kentaro Tanemura, Atsuo Ogura, Cheolho Cheong, Hideo Gotoh, Kazuya Matsumoto, Eimei Sato, Yoshihiro Hayashi, Han‐Woong Lee, Takashi Kondo · 2005 · Developmental Biology
  40. Telomerase deficiency does not alter bleomycin-induced fibrosis in mice
    Amber L. Degryse, Xiaochuan C. Xu, John Newman, Daphne B. Mitchell, Harikrishna Tanjore, Vasiliy V. Polosukhin, Brittany R. Jones, Frank B. McMahon, Linda A. Gleaves, John A. Phillips et al. · 2012 · Experimental Lung Research
  41. Telomere chromatin establishment and its maintenance during mammalian development
    Mathieu Tardat, Jérôme Déjardin · 2017 · Chromosoma
  42. The human telomere and its relationship to human disease, therapy, and tissue engineering
    Ian, K. Moon · 2007 · Frontiers in bioscience
  43. Cyclin-dependent kinase inhibitor p16INK4a and telomerase may co-modulate endothelial progenitor cells senescence
    Deguang Yang, Ling Liu, Xiaoyan Zheng · 2008 · Ageing Research Reviews
  44. Neural stem cells in aging and disease
    Tobi L. Limke, Mahendra S. Rao · 2002 · Journal of Cellular and Molecular Medicine
  45. Aging, Graying and Loss of Melanocyte Stem Cells
    Kavita Yang Sarin, Steven E. Artandi · 2007 · Stem Cell Reviews and Reports
  46. Telomere dysfunction: multiple paths to the same end
    Lea A. Harrington, Murray O. Robinson · 2002 · Oncogene
  47. Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice
    Song, Zhangfa, Wang, Jianwei, Guachalla, Luis Miguel, Terszowski, Grzegorz, Rodewald, Hans-Reimer, Ju, Zhenyu, Rudolph, K. Lenhard · 2010 · Blood
  48. Molecular regulation of telomerase activity in aging
    Craig Nicholls, He Li, Jian-Qiu Wang, Junping Liu · 2011 · Protein & Cell
  49. Telomerase Deficiency Affects Normal Brain Functions in Mice
    Jaehoon Lee, Yong Sang Jo, Young Hoon Sung, In Koo Hwang, Hyuk Kim, Song‐Yi Kim, Sun Shin Yi, June-Seek Choi, Woong Sun, Je Kyung Seong et al. · 2009 · Neurochemical Research
  50. Telomeres in Mammalian Male Germline Cells
    Irina A. Zalenskaya, Andrei O. Zalensky · 2002 · International review of cytology
  51. Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability
    Héloïse Coutelier, Zhou Xu, Mony Chenda Morisse, Maoussi Lhuillier‐Akakpo, Serge B. Pelet, Gilles Charvin, Karine Dubrana, Maria Teresa Teixeira · 2018 · Genes & Development
  52. Role of Inflammaging on the Reproductive Function and Pregnancy
    Alice Zavatta, Francesca Parisi, Chiara Mandò, Chiara Scaccabarozzi, Valeria Maria Savasi, Irene Cetin · 2022 · Clinical Reviews in Allergy & Immunology
  53. Genetic Interstitial Lung Disease
    Megan Devine, Christine Kim Garcia · 2011 · Clinics in Chest Medicine
  54. Mammalian telomeres and their partnership with lamins
    Romina Burla, Mattia La Torre, Isabella Saggio · 2016 · Nucleus
  55. Telomerase: Dr Jekyll or Mr Hyde?
    John C. Prescott, Elizabeth Helen Blackburn · 1999 · Current Opinion in Genetics & Development
  56. Anti‐senescence effects of DNA methyltransferase inhibitor RG108 in human bone marrow mesenchymal stromal cells
    Youn Seo Oh, Sin‐Gu Jeong, Goang‐Won Cho · 2015 · Biotechnology and Applied Biochemistry
  57. Lead Exposure Induces Telomere Instability in Human Cells
    Géraldine Pottier, Muriel Viau, Michelle Ricoul, Grace Shim, Marion Bellamy, Corina Cuceu, William M. Hempel, Laure Sabatier · 2013 · PLoS ONE
  58. Abnormal telomere metabolism in Fanconi's anaemia correlates with genomic instability and the probability of developing severe aplastic anaemia
    Xiaxin Li, François Leteurtre, Vanderson Rocha, Philippe Guardiola, Roland Berger, Marie‐Thérèse Daniel, Maria Helena Noguera, Odile Maarek, Gwenaëlle L. E. Roux, Pauline de La Salmonière et al. · 2003 · British Journal of Haematology
  59. Changes in Telomerase Activity in Experimentally Induced Atretic Follicles of Immature Rats.
    Yoshiaki Yamagata, Yasuhiko Nakamura, Kenji Umayahara, Ayako Harada, Hisako Takayama, Norihiro Sugino, Hiroshi Kato · 2002 · Endocrine Journal
  60. Association of TERC and OBFC1 Haplotypes with Mean Leukocyte Telomere Length and Risk for Coronary Heart Disease
    Cecilia G. Maubaret, Klelia D. Salpea, Casey E. Romanoski, Lasse Folkersen, Jackie A. Cooper, Coralea Stephanou, KaWah Li, Jutta Palmen, Anders Hamsten, Andrew Neil et al. · 2013 · PLoS ONE
  61. Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential
    Edo Džafić, Martin Štimpfel, Irma Virant‐Klun · 2013 · Journal of Assisted Reproduction and Genetics
  62. Human subtelomeric copy number variations
    Harold C. Riethman · 2008 · Cytogenetic and Genome Research
  63. Expression of Telomerase Reverse Transcriptase Subunit (TERT) and Telomere Sizing in Pig Ovarian Follicles
    Valentina Russo, Paolo Berardinelli, Alessandra Martelli, Oriana Di Giacinto, Delia Nardinocchi, Donatella Fantasia, Barboni Barbara · 2006 · Journal of Histochemistry & Cytochemistry
  64. 2009 Nobel Prize in Physiology or Medicine: telomeres and telomerase
    Elisa Varela, Marı́a A. Blasco · 2010 · Oncogene
  65. Hypothesis
    Abraham Aviv · 2001 · Hypertension
  66. The Biology of Aging and Longevity
    Calvin B. Harley · 2000 · Springer eBooks
  67. Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres
    Irene Siegl‐Cachedenier, Purificacı́on Muñoz, Juana María Flores, Peter Klatt, Marı́a A. Blasco · 2007 · Genes & Development
  68. The Role of Telomerase Expression and Telomere Length Maintenance in Human and Mouse
    Nan-PIng, Weng, Hodes, Richard J. · 2000 · Journal of Clinical Immunology
  69. Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration
    Rosalinda Madonna, Raffaele De Caterina, James T. Willerson, Y.-J. Geng · 2010 · European Heart Journal
  70. Isolation of neural stem cells from the forebrain of deceased early postnatal and adult rats with protracted post‐mortem intervals
    Yi Xu, Kazushi Kimura, Naoya Matsumoto, Chizuka Idé · 2003 · Journal of Neuroscience Research
  71. Telomere Length Analysis
    Andrés Canela, Peter Klatt, Marı́a A. Blasco · 2007 · Methods in molecular biology
  72. Telomerase regulation and telomere dynamics in germinal centers
    Karl‐Fredrik Norrback, Magnus Hultdin, Katarina Dahlenborg, Pia Osterman, Roland N.K. Carlsson, Göran Roos · 2001 · European Journal Of Haematology
  73. The African Turquoise Killifish: A Model for Exploring Vertebrate Aging and Diseases in the Fast Lane
    Itamar Harel, Anne Brunet · 2015 · Cold Spring Harbor Symposia on Quantitative Biology
  74. Adult stem cell and mesenchymal progenitor theories of aging
    So‐ichiro Fukada, Yuran Ma, Akiyoshi Uezumi · 2014 · Frontiers in Cell and Developmental Biology
  75. Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness?
    François Criscuolo, Steve Smith, Sandrine Zahn, Britt J. Heidinger, Mark F. Haussmann · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
  76. Age-Related Changes of Claudin Expression in Mouse Liver, Kidney, and Pancreas
    Theresa D’Souza, Cheryl A. Sherman‐Baust, Suresh Poosala, James M. Mullin, Patrice J. Morin · 2009 · The Journals of Gerontology Series A
  77. Down-regulation of telomerase activity via protein phosphatase 2A activation in salvicine-induced human leukemia HL-60 cell apoptosis
    Weijun Liu, Jian-Fei Jiang, Dong Xiao, Jian Ding · 2002 · Biochemical Pharmacology
  78. Telomeres, oxidative stress, and timing for spontaneous term and preterm labor
    Mark Phillippe · 2022 · American Journal of Obstetrics and Gynecology
  79. Structure of stem‐loop IV of Tetrahymena telomerase RNA
    Yu Chen, Jessica K. Fender, Jason D. Legassie, Michael B. Jarstfer, Tracy M. Bryan, Gabriele Varani · 2006 · The EMBO Journal
  80. Telomere Dysfunction, Chromosomal Instability and Cancer
    Jitendra Kumar Meena, K. Lenhard Rudolph, Çagatay Güneş · 2015 · Recent results in cancer research/Recent Results in Cancer Research
  81. A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance
    Paula Martínez, Gonzalo Goméz-López, David G. Pisano, Juana María Flores, Marı́a A. Blasco · 2016 · Aging Cell
  82. Telomerase and mammalian ageing: a critical appraisal
    Malcolm H. Goyns, W. Lindsay Lavery · 2000 · Mechanisms of Ageing and Development
  83. Telomerase and cancer: time to move from a promising target to a clinical reality
    W. Nicol Keith, Thomas R. Jeffry Evans, Rosalind Margaret Glasspool · 2001 · The Journal of Pathology
  84. Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation
    Christina Soohoo, Rong Shi, Tae Ho Lee, Pengyu Huang, Kun Ping Lu, Xiao Zhen Zhou · 2010 · Journal of Biological Chemistry
  85. Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis
    Ioannis P. Tomos, Konstantina Dimakopoulou, Effrosyni D. Manali, Spyros A. Papiris, Anna Karakatsani · 2021 · Environmental Health
  86. Regulation of telomerase activity by apparently opposing elements
    Junping Liu, Shiming Chen, Yu-Sheng Cong, Craig Nicholls, Shu-Feng Zhou, Zezhang Tao, He Li · 2010 · Ageing Research Reviews
  87. Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
    Mounir El Maï, Marta Marzullo, Inês Pimenta de Castro, Miguel Godinho Ferreira · 2020 · eLife
  88. Molecular pathways regulating the self-renewal of hematopoietic stem cells
    Matthew I. Stein, Jiang Zhu, Stephen G. Emerson · 2004 · Experimental Hematology
  89. An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres
    Yisong Wang, Natalie Erdmann, Richard J. Giannone, Jun Wu, Marla Gomez, Yie Liu · 2005 · Proceedings of the National Academy of Sciences
  90. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression <i>in vivo</i>
    Rajaraman, Sripriya, Choi, Jinkuk, Cheung, Peggie, Beaudry, Veronica, Moore, Helen, Artandi, Steven E. · 2007 · Proceedings of the National Academy of Sciences
  91. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat)
    Senthilkumar, P.K., Klingelhutz, A.J., Jacobus, J.A., Lehmler, H., Robertson, L.W., Ludewig, G. · 2011 · Toxicology Letters
  92. Clonal hematopoiesis: Pre-cancer PLUS
    Alexander J. Silver, Siddhartha Jaiswal · 2019 · Advances in cancer research
  93. Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma
    André Lechel, Michael Peter Manns, K. Lenhard Rudolph · 2004 · Journal of Hepatology
  94. Cytostatic concentrations of anticancer agents do not affect telomerase activity of leukaemic cells in vitro
    Masaharu Akiyama, Junko Horiguchi‐Yamada, Shinobu Saito, Y Hoshi, Osamu Yamada, Hiroyuki Mizoguchi, Hisashi Yamada · 1999 · European Journal of Cancer
  95. Telomerase: biology and phase I trials
    Lloyd R. Kèlland · 2001 · The Lancet Oncology
  96. DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging
    Sepe, Sara, Rossiello, Francesca, Cancila, Valeria, Iannelli, Fabio, Matti, Valentina, Cicio, Giada, Cabrini, Matteo, Marinelli, Eugenia, Alabi, Busola R, di Lillo, Alessia et al. · 2022 · The EMBO Reports
  97. Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology
    Suelves, Nuria, Saleki, Shirine, Ibrahim, Tasha, Palomares, Debora, Moonen, Sebastiaan, Koper, Marta J., Vrancx, Céline, Vadukul, Devkee M., Papadopoulos, Nicolas, Viceconte, Nikenza et al. · 2023 · Acta Neuropathologica Communications
  98. Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss
    Jayapalraja Thilagavathi, S Mishra, MITHILESH KUMAR, Kranthi Vemprala, D. Deka, Vatsla Dhadwal, Rima Dada · 2013 · Journal of Assisted Reproduction and Genetics
  99. Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice
    Kenji Sato, Kou Sueoka, Reiko Tanigaki, Hiroto Tajima, Akira Nakabayashi, Yasunori Yoshimura, Yoshihiko Hosoi · 2010 · Journal of Assisted Reproduction and Genetics
  100. RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1α as critical for telomerase function in murine embryonic stem cells
    Matthew J. Coussens, Philip M. C. Davy, Lancer Brown, Christopher Foster, William H. Andrews, Melissa Nagata, Richard Allsopp · 2010 · Proceedings of the National Academy of Sciences