Essential role of mouse telomerase in highly proliferative organs

Lee, Han-Woong, Blasco, Maria A., Gottlieb, Geoffrey J., Horner, James W., Greider, Carol W., DePinho, Ronald A.·1998·Nature

Cited by (999)

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  13. Functional characterization of telomerase RNA variants found in patients with hematologic disorders
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  16. Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres
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  17. A metabolic signature predicts biological age in mice
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  18. Telomere Length Dynamics in Normal Individuals and in Patients with Hematopoietic Stem Cell‐Associated Disorders
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  20. DNA-Dependent Protein Kinase Catalytic Subunit Is Not Required for Dysfunctional Telomere Fusion and Checkpoint Response in the Telomerase-Deficient Mouse
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  23. CHIP Promotes Human Telomerase Reverse Transcriptase Degradation and Negatively Regulates Telomerase Activity
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  31. Telomere regulation and function during meiosis
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  50. Male Infertility and the Genetics of Spermatogenesis
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  61. High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells
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  63. Sequence‐specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1)
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