Essential role of mouse telomerase in highly proliferative organs

Lee, Han-Woong, Blasco, Maria A., Gottlieb, Geoffrey J., Horner, James W., Greider, Carol W., DePinho, Ronald A.·1998·Nature

DOI 10.1038/33345

Cited by (999)

Items 801–900 of 999

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Aksinya Derevyanko, Agnieszka Skowrońska, Mariusz T. Skowroński, Paweł Kordowitzki · 2022 · Cells
Telomere biology in aging and cancer: early history and perspectives
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Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity
Foong Lyn Chan, Benjamin Vinod, Karel Novy, Ralf B. Schittenhelm, Cheng Huang, Maheshi Udugama, Juan Nunez-Iglesias, Jane I. Lin, Linda L. Hii, Julie Chan et al. · 2017 · Nucleic Acids Research
Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice
Guachalla, Luis Miguel, Ju, Zhenyu, Koziel, Rafal, von Figura, Guido, Song, Zhangfa, Fusser, Markus, Epe, Bernd, Jansen-Dűrr, Pidder, Rudolph, K. Lenhard · 2009 · Aging
The telomerase challenge — an unusual problem in drug discovery
Anne E. Pitts, David R. Corey · 1999 · Drug Discovery Today
Telomeres: has cancer's Achilles' heel been exposed?
Louis A. Zumstein, Victoria Lundblad · 1999 · Nature Medicine
Telomeres and telomerase: at the end, it all comes together
Sara K. Evans, Alison A. Bertuch, Victoria Lundblad · 1999 · Trends in Cell Biology
Modulation of Telomere Length by Mediterranean Diet, Caloric Restriction, and Exercise: Results from PREDIMED-Plus Study
María Fernández de la Puente, Pablo Hernández‐Alonso, Sı́lvia Canudas, Amelia Martí, Montserrat Fitó, Cristina Razquín, Jordi Salas‐Salvadó · 2021 · Antioxidants
Telomere Biology in Stem Cells and Reprogramming
Luís F.Z. Batista · 2014 · Progress in molecular biology and translational science
Ei24-deficiency attenuates protein kinase Cα signaling and skin carcinogenesis in mice
Sushil Devkota, Young Hoon Sung, JungMin Choi, Jae‐Hoon Lee, Na Young Ha, Hyunki Kim, Byoung Chul Cho, Jaewhan Song, Han‐Woong Lee · 2012 · The International Journal of Biochemistry & Cell Biology
Engineering Stem Cells For Future Medicine
Leonardo Ricotti, Arianna Menciassi · 2013 · IEEE Transactions on Biomedical Engineering
A dual-functional probe for quantification and imaging of intracellular telomerase
Xiaoting Li, Beibei Chen, Man He, Bin Hu · 2018 · Sensors and Actuators B Chemical
Brca2 abrogation engages with the alternative lengthening of telomeres via break‐induced replication
Mi‐Sun Kwon, Jennifer J. Lee, Jaewon Min, Kwangwoo Hwang, Seung Gu Park, Eun‐Hye Kim, Byung Chul Kim, Jong Bhak, Hyun‐Sook Lee · 2019 · FEBS Journal
Role of Cellular Senescence in Lifestyle-Related Disease
Tohru Minamino · 2010 · Circulation Journal
Knockdown of Telomerase RNA Using Hammerhead Ribozymes and RNA Interference
Shang Li, Mehdi Nosrati, Mohammed Kashani–Sabet · 2007 · Methods in molecular biology
Telomerase in hematologic malignancies
Claudia Bruedigam, Steven Lane · 2016 · Current Opinion in Hematology
Stem cell ageing: does it happen and can we intervene?
Ilaria Bellantuono, W. Nicol Keith · 2007 · Expert Reviews in Molecular Medicine
Genetic control of lifespan: studies from animal models
Gary E. Van Zant, Gerald de Haan · 1999 · Expert Reviews in Molecular Medicine
Making the most of a little: dosage effects in eukaryotic telomere length maintenance
Lea A. Harrington · 2005 · Chromosome Research
Complex roles for telomeres and telomerase in breast carcinogenesis
Steven E. Artandi · 2002 · Breast Cancer Research
The chicken telomerase RNA gene: conservation of sequence, regulatory elements and synteny among viral, avian and mammalian genomes
Mary E. Delany, L.M. Daniels · 2003 · Cytogenetic and Genome Research
Stem cell function and maintenance – ends that matter: Role of telomeres and telomerase
Hamid Saeed, Mehwish Iqtedar · 2013 · Journal of Biosciences
Telomere length in human blastocysts
Anastasia Mania, Anna Mantzouratou, Joy D A Delhanty, Gianluca Baio, Paul F. Serhal, Sioban B SenGupta · 2014 · Reproductive BioMedicine Online
Reduced Serum Levels of Anti-Müllerian Hormone in Females With Inherited Bone Marrow Failure Syndromes
Martha M. Sklavos, Pamela Stratton, Neelam Giri, Blanche P. Alter, Sharon A. Savage, Lígia A. Pinto · 2014 · The Journal of Clinical Endocrinology & Metabolism
Birth and death: Evidence for the same biologic clock
Mark Phillippe, Shiela Phillippe · 2017 · American Journal of Reproductive Immunology
Telomere length across different UIP fibrotic-Interstitial Lung Diseases: a prospective Greek case-control study
Ioannis P. Tomos, Anna Karakatsani, Effrosyni D. Manali, Christine Kottaridi, Aris Spathis, Stylianos Argentos, Spyridon A. Papiris · 2020 · Pulmonology
Signaling on telomerase: a master switch in cell aging and immortalization
He Li, Junping Liu · 2002 · Biogerontology
Molecular imaging of telomerase and the enzyme activity-triggered drug release by using a conformation-switchable nanoprobe in cancerous cells
Hai Shi, Tao Gao, Shi Liu, Tianshu Chen, Yang Xiang, Yuanyang Li, Genxi Li · 2018 · Scientific Reports
Total Deletion of in Vivo Telomere Elongation Capacity: An Ambitious but Possibly Ultimate Cure for All Age‐Related Human Cancers
Aubrey D.N.J. de Grey, F C Campbell, Inderjeet S Dokal, LJ Fairbairn, Gerard J. Graham, Colin A.B. Jahoda, ANDREW C. G. PORTERG · 2004 · Annals of the New York Academy of Sciences
Taking the measure
Vicki Lundblad · 2003 · Nature
Telomerase: Not Just Black and White, but Shades of Gray
Junping Liu · 2000 · Molecular Cell Biology Research Communications
Aging and cancer in transgenic and mutant mice
Vladimir Nikolaevich Anisimov · 2003 · Frontiers in bioscience
Shedding light into the relevance of telomeres in human reproduction and male factor infertility†
Ana Catarina Lopes, Pedro Fontes Oliveira, Mário Sousa · 2018 · Biology of Reproduction
Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
Amanda J. Stock, Saipriya Ayyar, Amogh Kashyap, Yunong Wang, Hagai Yanai, Matthew F. Starost, Mayuri Tanaka-Yano, Monica Bodogai, Chongkui Sun, Yajun Wang et al. · 2023 · GeroScience
Role of Telomere Dysfunction in Genetic Intratumor Diversity
Anna Genescà, Judit Pampalona, Cristina Frías-López, Daniel Domínguez, Laura Tusell · 2011 · Advances in cancer research
Biochemical properties of Trypanosoma cruzi telomerase
Denise P. Muñoz · 2004 · Nucleic Acids Research
Adiponectin attenuates the premature senescence of vascular smooth muscle cells induced by high glucose through mTOR signaling pathway
Xing‐Jun Cui, Xiao Lin, Jia‐Yu Zhong, Shuang Li, Jieyu He, Yu‐Qing Ni, Junkun Zhan, You‐Shuo Liu · 2020 · Aging Medicine
How Does Cellular Senescence Prevent Cancer?
Magnus Lynch · 2006 · DNA and Cell Biology
Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs)
Hamid Saeed, Mehwish Iqtedar · 2015 · Journal of Biomedical Science
Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging
Yu‐Chang Huang, Shigeo Saito, Kazunari K. Yokoyama · 2010 · The Kaohsiung Journal of Medical Sciences
Telomerase as a novel and potentially selective target for cancer chemotherapy
Eric Kenneth Parkinson · 2003 · Annals of Medicine
“Till Death Do Us Part”: A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in the Adult Olfactory Bulb
Saad Omais, Carine Jaafar, Noël Ghanem · 2018 · Frontiers in Neuroscience
Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe
Alexandre Teixeira Vessoni, Tianpeng Zhang, Annabel Quinet, Ho‐Chang Jeong, Michael Munroe, Matthew D. Wood, Enzo Tedone, Alessandro Vindigni, Jerry W. Shay, Roger A. Greenberg et al. · 2021 · The Journal of Cell Biology
The Cell Biology of Stem Cells
Eran Meshorer, Kathrin Plath · 2010 · Advances in experimental medicine and biology
A comparison of normal and leukemic stem cell biology in Chronic Myeloid Leukemia
Heather G. Jørgensen, Tessa L. Holyoake · 2001 · Hematological Oncology
A Novel Telomere Elongation in an Adriamycin-resistant Stomach Cancer Cell Line with Decreased Telomerase Activity
Jun Hyun Kim, Gun Eui Lee, Jin Cheon Kim, Jun Ho Lee, In Kwon Chung · 2002 · Molecules and Cells
Telomere Length, Telomere-binding Proteins, and DNA Damage Signaling
Michael T. Hemann, Jennifer A. Hackett, Arne S. IJpma, Carol W. Greider · 2000 · Cold Spring Harbor Symposia on Quantitative Biology
Hematopoietic stem cells are acutely sensitive to Acd shelterin gene inactivation
Jones, Morgan, Osawa, Gail, Regal, Joshua A., Weinberg, Daniel N., Taggart, James, Kocak, Hande, Friedman, Ann, Ferguson, David O., Keegan, Catherine E., Maillard, Ivan · 2014 · Journal of Clinical Investigation
Idiopathic Pulmonary Fibrosis and Telomeres
Alba Mulet, Jaime Signes‐Costa · 2022 · Journal of Clinical Medicine
An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
Laura Soldovieri, Gianfranco Di Giuseppe, Gea Ciccarelli, Giuseppe Quero, Francesca Cinti, Michela Brunetti, Enrico Celestino Nista, Antonio Gasbarrini, Sergio Alfieri, Alfredo Pontecorvi et al. · 2023 · Molecular Metabolism
Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
Trevor H. Torigoe, D. Craig Willcox, Michio Shimabukuro, Moritake Higa, Mariana Gerschenson, Anastasia Andrukhiv, Makoto Suzuki, Brian J. Morris, Randi Chen, Greg S. Gojanovich et al. · 2024 · npj Aging
Clonal inactivation of TERT impairs stem cell competition
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces, Patrick Neuhöfer, Victoria M. Gillespie, Peggie Cheung, Julia A. Belk, Yung‐Hsin Huang, Yuning Wei et al. · 2024 · Nature
Telomere Dysfuction Promotes Metastasis in a TERC Null Mouse Model of Head and Neck Cancer
Bojana Bojović, David L. Crowe · 2011 · Molecular Cancer Research
Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma
Lawrence N. Kwong, Lihua Zou, Sharmeen Chagani, Chandra Sekhar Pedamallu, Mingguang Liu, Shan Jiang, Alexei I. Protopopov, Jianhua Zhang, Gad A. Getz, Lynda Chin · 2017 · Cell Reports
DNA-RNA Hybrid (R-Loop): From a Unified Picture of the Mammalian Telomere to the Genome-Wide Profile
Minoo Rassoulzadegan, Ali Sharifi‐Zarchi, Leila Kianmehr · 2021 · Cells
Telomeres and telomerase in normal and malignant B‐cells
Chiara Lobetti‐Bodoni, Elisa Bernocco, Elisa Genuardi, Mario Boccadoro, Marco Ladetto · 2010 · Hematological Oncology
Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype
Nouf Al-Ajmi, Gabriele Christine Saretzki, Colin G. Miles, Ioakim Spyridopoulos · 2014 · Experimental Gerontology
Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models
Sonia Franco, Andrés Canela, Peter Klatt, Marı́a A. Blasco · 2005 · Carcinogenesis
Rejuvenation: Turning back the clock of aging kidney
Shi-Yao Wei, Szu‐Yu Pan, Bing Li, Yung‐Ming Chen, Shuei‐Liong Lin · 2019 · Journal of the Formosan Medical Association
Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and aging
Tobias Else · 2009 · Journal of Molecular Endocrinology
Mouse models to study the role of telomeres in cancer, aging and DNA repair
Marı́a A. Blasco · 2002 · European Journal of Cancer
LINEAGE BIOLOGY AND LIVER
Arron S. L. Xu, Thomas L. Luntz, Jeffrey M. Macdonald, Hiroshi Kubota, Edward W. Hsu, Robert E. London, Lola McAdams Reid · 2000 · Elsevier eBooks
Renal phenotype of young and old telomerase-deficient mice
Schildhorn, Carolin, Jacobi, Christoph, Weißbrodt, Andrea, Hermstedt, Christine, Westhoff, Jens Hendrik, Hömme, Meike, Bhayadia, Raj, Gretz, Norbert, Falk, Christine Susanne, Schmitt, Roland et al. · 2015 · Mechanisms of Ageing and Development
Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
Sabrina Ghadaouia, Marc‐Alexandre Olivier, Aurélie Martinez, Tibila Kientega, Qin Jian, Patrick Lambert-Lanteigne, Guillaume B. Cardin, Chantal Autexier, Nicolas Malaquin, Françis Rodier · 2021 · Nucleic Acids Research
Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes
David Argilla, Koei Chin, Mallika Singh, J.Graeme Hodgson, Marcus Bosenberg, Carlos Ortíz-de-Solórzano, Stephen J. Lockett, Ronald Anthony DePinho, Joe W. Gray, Douglas Hanahan · 2004 · Cancer Cell
Hematopoietic stem cell development, aging and functional failure
Jichun Chen · 2011 · International Journal of Hematology
Telomerase reverse transcriptase as target for anti-tumor T cell responses in humans
Maurizio Zanetti, Javier Hernández, Pierre Langlade‐Demoyen · 2005 · Springer Seminars in Immunopathology
Low telomerase activity: Possible role in the progression of human medullary thyroid carcinoma
Guido Stadler, Matthias Wieser, Berthold Streubel, Anton Stift, Josef Friedl, Michael Gnant, Bruno Niederle, Alfred Beham, Hermann W. D. Katinger, Roswitha Pfragner et al. · 2008 · European Journal of Cancer
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Abraham Aviv, Calvin B. Harley · 2001 · Current Hypertension Reports
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy
Monia Souidi, Jessica Resta, Haikel Dridi, Yvonne Sleiman, Steven R. Reiken, Karina Formoso, Sarah Colombani, Pascal Amédro, Pierre Meyer, Azzouz Charrabi et al. · 2024 · Journal of Cachexia Sarcopenia and Muscle
Telomerase Reverse Transcriptase Deficiency Prevents Neointima Formation Through Chromatin Silencing of E2F1 Target Genes
Elizabeth B. Endorf, 青华, Jun Aono, Naoto Terami, Geneviève Doyon, Eric J. Hyzny, Karrie L. Jones, Hannes M. Findeisen, Dennis Bruemmer · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
Telomerase and oral cancer
T Sumida, Hiroyuki Hamakawa · 2001 · Oral Oncology
The Protective Function of Noncoding DNA in Genome Defense of Eukaryotic Male Germ Cells
Guo‐Hua Qiu, Cuiqin Huang, Xintian Zheng, Xiaoyan Yang · 2018 · Epigenomics
Regeneration of kidney tissue using in vitro cultured fetal kidney cells
Sang Soo Kim, So‐Jung Gwak, Joungho Han, Moon Hyang Park, Kang Won Song, Byung‐Soo Kim · 2008 · Experimental & Molecular Medicine
Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line
Paul Finnon, H.-P. Wong, Andrew R. Silver, Predrag Slijepčević, Simon D Bouffler · 2001 · International Journal of Radiation Biology
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Richard Faragher, Christopher J. Jones, David Kipling · 1998 · Nature Biotechnology
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Sheng Li, Zhihao Liu, Jing Zhang, Lan Li · 2023 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Telomere dysfunction in chronic liver disease: The link from aging
Daniel D. Penrice, Nidhi Jalan‐Sakrikar, Diana Jurk, João F. Passos, Douglas Alano Simonetto · 2023 · Hepatology
Cloned Cows with Short Telomeres Deliver Healthy Offspring with Normal-length Telomeres
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N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury
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Regeneration of the Exocrine Pancreas Is Delayed in Telomere-Dysfunctional Mice
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Cell Type–Specific Quantification of Telomere Length and DNA Double-strand Breaks in Individual Lung Cells by Fluorescence In Situ Hybridization and Fluorescent Immunohistochemistry
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Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase
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Cloning of rat telomerase catalytic subunit functional domains, reconstitution of telomerase activity and enzymatic profile of pig and chicken tissues
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The differentiation status of primary gonadal germ cell tumors correlates inversely with telomerase activity and the expression level of the gene encoding the catalytic subunit of telomerase
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Maria Kolioliou, Maroulio Talieri, Evi S. Lianidou · 2001 · Clinical Biochemistry
Genetic and Epigenetic Inheritance at Telomeres
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